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Rui from the University of Michigan for providing the MIN6 cells. We thank X. Liang from Tongji University School of Medicine for providing the\n                      Isl1\n                      flox\/flox mouse. We thank W. Yin from the Core Facilities at Zhejiang University School of Medicine for her technical support. We thank J. Xu from Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine for kindly providing the MafA antibody. We thank the members of the Meng lab for helpful discussions and technical support for this study. Schematic illustrations were created using BioRender.com (\n                      \n                      ).","order":1,"name":"Ethics","label":"Acknowledgements","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"The CUT&Tag dataset is available for the data presented in Fig.\n                      \n                      a and ESM Table\n                      \n                      . RNA-seq datasets are available for the data presented in Fig.\n                      \n                      l, ESM Tables\n                      \n                      and\n                      \n                      and ESM Fig.\n                      \n                      a. The scRNA-seq dataset is available for the data presented in Figs\n                      \n                      and\n                      \n                      . The ATAC-seq dataset is available for the data presented in Fig.\n                      \n                      a and ESM Table\n                      \n                      . The proteomics dataset is available for the data presented in Fig.\n                      \n                      g. These datasets have been deposited in Mendeley Data and are publicly accessible (\n                      \n                      ). All other data and image files are available from the corresponding authors upon reasonable request. All packages and codes used in this study are open-source and publicly available.","order":2,"name":"Ethics","label":"Data availability","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"This work was supported by the Noncommunicable Chronic Diseases-National Science and Technology Major Project (2023ZD0507000) and the National Natural Science Foundation of China (82500965) to SZ, and the National Natural Science Foundation of China (82300893) to R-RW. This study was also supported by the National Natural Science Foundation of China (92457301, 82425012, 32471170, 91857110), the Zhejiang Provincial Natural Science Foundation of China (D26C070011, LHDMD24H030001) and the Zhejiang University School of Basic Medical Sciences-Affiliated Huzhou Central Hospital Pre-Research Fund (YYJJ202203) to Z-XM.","order":3,"name":"Ethics","label":"Funding","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.","order":4,"name":"Ethics","label":"Authors' relationships and activities","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"Z-XM conceived the project, designed the research and supervised the project. SZ, ZZ, R-RW, WC, QX, XJ and RW performed the experiments. ZZ, XQ and RZ carried out the bioinformatics analysis. SZ, ZZ, R-RW, WC, XQ, HF, SY and Z-XM contributed to the discussion and data interpretation. Z-XM and SZ wrote the manuscript. All authors reviewed and approved the final version of the manuscript. Z-XM is the guarantor of this work.","order":5,"name":"Ethics","label":"Contribution statement","group":{"name":"EthicsHeading","label":"Ethics"}}]}}