{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T11:04:22Z","timestamp":1760439862808},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[1994,5,1]],"date-time":"1994-05-01T00:00:00Z","timestamp":767750400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetologia"],"published-print":{"date-parts":[[1994,5]]},"DOI":"10.1007\/s001250050133","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T07:30:30Z","timestamp":1030260630000},"page":"466-470","source":"Crossref","is-referenced-by-count":2,"title":["Serum biopterin \u2014 a novel marker for immune activation during pre-diabetes in the BB rat"],"prefix":"10.1007","volume":"37","author":[{"given":"A. J.","family":"Davies","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"Bone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. J.","family":"Wilkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. R.","family":"Cole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Rokos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"370500466_CR1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3109\/08916938909003049","volume":"4","author":"T Mandrup-Poulsen","year":"1989","unstructured":"Mandrup-Poulsen T, Helquist S, Molvig J, Wogensen LD, Nerup J (1989) Cytokines as immune effector molecules in autoimmune endocrine diseases, with special reference to insulin-dependent diabetes mellitus. Autoimmunity 4: 191\u2013218","journal-title":"Autoimmunity"},{"key":"370500466_CR2","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.2337\/diab.37.9.1301","volume":"37","author":"R Walker","year":"1988","unstructured":"Walker R, Bone AJ, Cooke A, Baird JD (1988) Distinct mac-rophage sub-populations in pancreases of pre-diabetic BB\/E rats: possible role for macrophages in the pathogenesis of IDDM. Diabetes 37: 1301\u20131304","journal-title":"Diabetes"},{"key":"370500466_CR3","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3109\/08916938909019963","volume":"3","author":"V Kolb-Bachofen","year":"1989","unstructured":"Kolb-Bachofen V, Kolb H (1989) A role for macrophages in the pathogenesis of type 1 diabetes. Autoimmunity 3: 145\u2013154","journal-title":"Autoimmunity"},{"key":"370500466_CR4","doi-asserted-by":"crossref","first-page":"717","DOI":"10.2337\/diab.33.8.717","volume":"33","author":"S Srikanta","year":"1984","unstructured":"Srikanta S, Ganda OP, Gleason RE, Jackson RA, Soeldner JS, Eisenbarth GS (1984) Pre-type 1 diabetes: linear loss of cell response to intravenous glucose. Diabetes 33: 717\u2013720","journal-title":"Diabetes"},{"key":"370500466_CR5","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1136\/bmj.3.5671.631","volume":"3","author":"DR Gamble","year":"1969","unstructured":"Gamble DR (1969) Seasonal incidence of diabetes mellitus. BMJ 3: 631\u2013633","journal-title":"BMJ"},{"key":"370500466_CR6","doi-asserted-by":"crossref","first-page":"549","DOI":"10.2337\/diab.39.5.549","volume":"39","author":"DK McCulloch","year":"1990","unstructured":"McCulloch DK, K1aff LJ, Kohn SE et al. (1990) Non-progression of subclinical beta-cell dysfunction among first degree relatives of IDDM patients. Diabetes 39: 549\u2013556","journal-title":"Diabetes"},{"key":"370500466_CR7","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1056\/NEJM199207303270502","volume":"327","author":"J Karjalainen","year":"1992","unstructured":"Karjalainen J, Martin JM, Knip M et al. (1992) Evidence for a bovine albumin peptide as a candidate trigger of type 1 diabetes. N Eng J Med 327:302\u2013307","journal-title":"N Eng J Med"},{"key":"370500466_CR8","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1084\/jem.160.1.310","volume":"160","author":"Ch Huber","year":"1984","unstructured":"Huber Ch, Batchelor JR, Fuchs D et al. (1984) Immune-response associated production of neopterin. J Exp Med 160: 310\u2013316","journal-title":"J Exp Med"},{"key":"370500466_CR9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0065-2423(08)60182-1","volume":"27","author":"H Wachter","year":"1989","unstructured":"Wachter H, Fuchs D, Hansen A, Reibnegger G, Werner ER (1989) Neopterin as a marker for activation of cellular immunity: immunologic basis and clinical application. Adv Clin Chem 27: 81\u2013141","journal-title":"Adv Clin Chem"},{"key":"370500466_CR10","first-page":"353","volume-title":"Biochem Clin Aspects Pteridines","author":"R Manna","year":"1987","unstructured":"Manna R, Gambassi G, Papa G (1987) Urinary neopterin levels of insulin dependent diabetes mellitus (IDDM) at onset. In: Pfleiderer W, Wachter H, Blair JA (eds) Biochem Clin Aspects Pteridines. de Gruyter, NY, pp 353\u2013358"},{"issue":"21","key":"370500466_CR11","first-page":"26","volume":"68","author":"GF Bottazzo","year":"1990","unstructured":"Bottazzo GF, Bonifacio E, Wagner R, al-Sakkaf L, Dean BM, Mirakian R (1990) Onthe pathogenesisoftype 1 (insulin-dependent) diabetes mellitus: facts, areas still under development and new perspectives. Klin Wochenschr 68 [Suppl 21]: 26\u201327","journal-title":"Klin Wochenschr"},{"key":"370500466_CR12","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/BF00541281","volume":"6","author":"G Maerker-Alzer","year":"1986","unstructured":"Maerker-Alzer G, Diemer O, Struemper R, Rohe M (1986) Neopterin production in inflamed knee joints: high levels in synovial fluids. Rheumatol Int 6: 151\u2013154","journal-title":"Rheumatol Int"},{"key":"370500466_CR13","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/0167-5699(88)91203-0","volume":"9","author":"D Fuchs","year":"1988","unstructured":"Fuchs D, Hansen A, Reibnegger G, Werner ER, Dierich MP, Wachter H (1988) Neopterin as a marker for activated cell-mediated immunity. Immunol Today 9: 150\u2013155","journal-title":"Immunol Today"},{"key":"370500466_CR14","doi-asserted-by":"crossref","first-page":"19654","DOI":"10.1016\/S0021-9258(19)47163-9","volume":"264","author":"MA Tayeh","year":"1989","unstructured":"Tayeh MA, Marietta MA (1989) Macrophage oxidation of L-arginine to nitric oxide, nitrite and nitrate. J Biol Chem 264: 19654\u201319658","journal-title":"J Biol Chem"},{"key":"370500466_CR15","doi-asserted-by":"crossref","first-page":"897","DOI":"10.2337\/diab.41.8.897","volume":"41","author":"JA Corbett","year":"1992","unstructured":"Corbett JA, McDaniel ML (1992) Does nitric oxide mediate autoimmune destruction of cells? Diabetes 41: 897\u2013903","journal-title":"Diabetes"},{"key":"370500466_CR16","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1007\/BF00429103","volume":"35","author":"H Kolb","year":"1992","unstructured":"Kolb H, Kolb-Bachofen {GNV} (1992) Type 1 (insulin-dependent) diabetes mellitus and nitric oxide. Diabetologia 35: 796","journal-title":"Diabetologia"},{"key":"370500466_CR17","doi-asserted-by":"crossref","first-page":"508","DOI":"10.2337\/diab.39.4.508","volume":"39","author":"AJ Bone","year":"1990","unstructured":"Bone AJ, Walker R, Varey AM, Cooke A, Baird JD (1990) Effect of cyclosporine on pancreatic events and development of diabetes in BB\/E rats. Diabetes 39: 508\u2013514","journal-title":"Diabetes"},{"key":"370500466_CR18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2337\/diab.33.1.33","volume":"33","author":"J Logothetopoulos","year":"1984","unstructured":"Logothetopoulos J, Valequette N, Madura E, Cuet {GND} (1984) The onset and progression of pancreatic insulitis in the overt, spontaneously diabetic, young adult BB rat studied by pancreatic biopsy. Diabetes 33: 33\u201336","journal-title":"Diabetes"},{"key":"370500466_CR19","first-page":"589","volume":"54","author":"CD Dijkstra","year":"1985","unstructured":"Dijkstra CD, Dopp EA, Joling P, Kraal G (1985) The heterogeneity of mononuclear phagocytes in lymphoid organs: distinct macrophage subpopulations in the rat recognised by monoclonal antibodies EDI, ED2 and ED3. Immunology 54: 589\u2013599","journal-title":"Immunology"},{"key":"370500466_CR20","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/0006-291X(91)91630-U","volume":"175","author":"KD Kroncke","year":"1991","unstructured":"Kroncke KD, Kolb-Bachofen V, Berschick B, Burkart V, Kolb H (1991) Activated macrophages kill pancreatic synge-neic islet cells via arginine-dependent nitric oxide generation. Biochem Biophys Res Commun 175: 752\u2013758","journal-title":"Biochem Biophys Res Commun"},{"key":"370500466_CR21","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/BF00401200","volume":"35","author":"LD Wogensen","year":"1992","unstructured":"Wogensen LD, Reimers J, Nerup J et al. (1992) Repetitive in-vitro treatment with human recombinant interleukin-1 modifies beta cell function in normal rats. Diabetologia 35: 331\u2013339","journal-title":"Diabetologia"},{"key":"370500466_CR22","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/BF00505185","volume":"32","author":"H Hanenberg","year":"1989","unstructured":"Hanenberg H, Kolb-Bachofen V, Kantwerk-Funke G, Kolb H (1989) Macrophage infiltration precedes, and is a prerequisite for, lymphocytic insulitis in pancreatic islets of pre-diabetic BB rats. Diabetologia 32: 126\u2013134","journal-title":"Diabetologia"}],"container-title":["Diabetologia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s001250050133.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s001250050133\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s001250050133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T19:16:50Z","timestamp":1680635810000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s001250050133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,5]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1994,5]]}},"alternative-id":["370500466"],"URL":"https:\/\/doi.org\/10.1007\/s001250050133","relation":{},"ISSN":["0012-186X","1432-0428"],"issn-type":[{"value":"0012-186X","type":"print"},{"value":"1432-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,5]]}}}