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Therein we present detailed clinical characterization of mood disorders patients from a university tertiary clinic established in the United Arab Emirates. The majority of patient experienced depressive and anxiety symptoms largely in the moderate range according to both self-rated and clinician rated scales, accompanied by significant co-morbidities, functional impairment, mild reduction in cognitive function, and a significant ruminative thinking style. These preliminary findings support the need for larger-scale research in the Middle East to address the burden of poor mental health affecting communities.<\/jats:p>","DOI":"10.1007\/s00127-025-02878-4","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T04:33:49Z","timestamp":1743827629000},"page":"2267-2269","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Characterisation of treatment resistant mood disorder patients in the United Arab Emirates"],"prefix":"10.1007","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3831-2301","authenticated-orcid":false,"given":"Danilo","family":"Arnone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2859-2100","authenticated-orcid":false,"given":"Emmanuel","family":"Stip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"key":"2878_CR1","doi-asserted-by":"publisher","unstructured":"Ibrahim NK (2021) Epidemiology of Mental Health Problems in the Middle East. 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