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To address this question, we aim to estimate indirect effects of important mediators on the causal relationship between food insecurity and symptoms of postnatal depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used data from the control arm of the Africa Focus on Intervention Research for Mental health \u2013 South Africa (AFFIRM-SA) trial that included pregnant women with perinatal depression. Interventional effects (used for models that may have multiple correlated mediators) were used to decompose the total effect of food insecurity captured at baseline on symptoms of perinatal depression reducing by at least 40% (using the 17-item HDRS instrument - yes\/no) at three months after delivery of the baby, into the following indirect effects: number of antenatal visits attended; suicidality at eight months gestation; and levels of social support captured at eight months gestation using the Multidimensional Scale of Perceived Social Support.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Food insecurity was associated with a 15% reduced probability of symptoms of depression improving at three months post-delivery (-0\u00b7151, bias-corrected 95% CI: \u2212\u20090.267, -0\u00b7032), of which 48% was mediated through reduced levels of social support in women exposed to food insecurity (-0.073: bias-corrected 95% CI: -0.146, -0.029). There was no conclusive evidence to support the mediating effects of attending antenatal visits and suicidality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest that providing social support can help to reduce symptoms of postnatal depression. Future research should explore developing and evaluating a package of care for pregnant women with perinatal depression that improves food security and levels of social support. This research suggests that policy makers and practitioners have a renewed focus on increasing social support systems for women during the perinatal period, especially in cases of food insecurity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00127-025-02986-1","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T17:13:15Z","timestamp":1757092395000},"page":"381-390","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Food insecurity and postnatal depression: the mediating effect of perceived social support among women in Khayelitsha, South Africa"],"prefix":"10.1007","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3790-3274","authenticated-orcid":false,"given":"S.","family":"Mathew","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5159-8220","authenticated-orcid":false,"given":"C.","family":"Lund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4821-9437","authenticated-orcid":false,"given":"N.","family":"Seward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,5]]},"reference":[{"key":"2986_CR1","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.jad.2017.05.003","volume":"219","author":"CA Woody","year":"2017","unstructured":"Woody CA, Ferrari AJ, Siskind DJ, Whiteford HA, Harris MG (2017) A systematic review and meta-regression of the prevalence and incidence of perinatal depression. 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The content and views expressed is solely that of the authors and does not represent the views of the National Institute of Mental Health.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Financial support"}},{"value":"The authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national and institutional committees on human experimentation and with the Helsinki Declaration of 1975, as revised in 2000. Ethical approval for the AFFIRM-SA project was obtained from the Human Research Ethics Committee of the University of Cape Town Faculty of Health Sciences (HREC Ref: 226\/2011) and the Data and Safety Monitoring Board. Participants gave informed consent for the secondary use of data, with data being anonymised. Ethical approval for this secondary analysis was provided by the London School of Hygiene and Tropical Medicine Ethics Committee (Project ID: 25790).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent"}}]}}