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However, previous studies have primarily focused on depression, with limited exploration of other mental disorders and demographic variations. This study investigates the association between social disconnection and a range of subsequent mental disorders in a large, population-based cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cohort study was conducted using data from 162,483 participants of the Danish National Health Survey, linked to national health registers. Social disconnection was assessed through survey measures of loneliness, social isolation, and low social support. Incident cases of mental disorders were identified using hospital-based diagnoses and included in seven categories. Poisson regression was applied to estimate incidence rate ratios (IRRs) adjusted for demographics, country of birth, and socio-economic resources.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Individuals who were socially disconnected had a higher incidence rate of mental disorders in all seven categories: substance use disorders, schizophrenia spectrum disorders, bipolar disorder, major depressive disorder, neurotic and anxiety-related disorders, personality disorders, and a combined category of any aforementioned disorder. Loneliness overall showed the strongest associations (range of IRRs, 2.94 to 4.94) compared to social isolation (range of IRRs, 1.47 to 4.80) and low social support (range of IRRs, 1.32 to 2.82). While associations were generally similar across sexes, contrasting age trends were indicated for loneliness and social isolation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Strong associations were consistently found between social disconnection and subsequent mental disorders, highlighting the potential for targeted public health interventions. Future research should investigate causal mechanisms and directional relations to refine prevention strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00127-026-03046-y","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T11:59:20Z","timestamp":1770379160000},"page":"925-936","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Social disconnection and subsequent mental disorders: a population-based cohort study"],"prefix":"10.1007","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1856-2748","authenticated-orcid":false,"given":"Katrine Brandt","family":"Alsner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1007-7557","authenticated-orcid":false,"given":"Lisbeth M\u00f8lgaard","family":"Laustsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5808-8883","authenticated-orcid":false,"given":"Mathias","family":"Lasgaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7049-0952","authenticated-orcid":false,"given":"Marie Stjerne","family":"Gr\u00f8nkj\u00e6r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6470-7465","authenticated-orcid":false,"given":"Oleguer","family":"Plana-Ripoll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"3046_CR1","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.puhe.2017.07.035","volume":"152","author":"N Leigh-Hunt","year":"2017","unstructured":"Leigh-Hunt N, Bagguley D, Bash K, Turner V, Turnbull S, Valtorta N et al (2017) An overview of systematic reviews on the public health consequences of social isolation and loneliness. 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Clin Psychol Rev 22(3):383\u2013442","journal-title":"Clin Psychol Rev"}],"container-title":["Social Psychiatry and Psychiatric Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00127-026-03046-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00127-026-03046-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00127-026-03046-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T09:38:58Z","timestamp":1778578738000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00127-026-03046-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,6]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["3046"],"URL":"https:\/\/doi.org\/10.1007\/s00127-026-03046-y","relation":{},"ISSN":["0933-7954","1433-9285"],"issn-type":[{"value":"0933-7954","type":"print"},{"value":"1433-9285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,6]]},"assertion":[{"value":"29 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study was registered with the Danish Data Protection Agency at Aarhus University (No 2016-051-000001-2587) and approved by Statistics Denmark and the Danish Health Data Authority. According to Danish law, informed consent or ethical approval is not required for register-based studies in Denmark. For survey participants, information about the survey was provided to potential participants in writing. All survey participants were informed that participation was voluntary and that their survey data would be linked to the registers for research purposes. The respondents\u2019 full or partial completion of the survey constituted implied consent. Linking the survey data and register data was done by Statistics Denmark. All data were pseudonymized and not recognisable at an individual level and analysed on the secure platform of Statistics Denmark.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The respondents\u2019 full or partial completion of the survey constituted implied consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}