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The acute toxicity, Probit method, revealed an LC<jats:sub>50<\/jats:sub> of 195.81 and 150.76\u00a0ppm for Aceta\/96\u00a0h and Imid\/72\u00a0h respectively. The fish were divided into three groups that were exposed, for 21\u00a0days (n\u2009=\u20095\/replicate), to 1\/10 of the LC<jats:sub>50<\/jats:sub> of either neonicotinoids, however, the third was an unexposed control group. Results of erythrocytic micronucleus (MN), and nuclear abnormalities (NA) showed that Aceta and Imid exposure caused a significant (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) increase in MN by\u2009~\u20092.2 and\u2009~\u200910 folds, respectively relative to control. NAs occurred at the order of kidney-shaped\u2009&gt;\u2009budding\u2009&gt;\u2009binucleated in Aceta, however, budding\u2009&gt;\u2009binucleated\u2009&gt;\u2009kidney-shaped was noticed in the Imid group. Histopathological changes in gills, liver, and muscles were observed significantly in both exposed groups with more severity in the Imid group. Collectively, Aceta and Imid have potential genotoxicity and histopathological alterations in <jats:italic>O. niloticus<\/jats:italic>.<\/jats:p>","DOI":"10.1007\/s00128-022-03611-6","type":"journal-article","created":{"date-parts":[[2022,9,18]],"date-time":"2022-09-18T17:02:39Z","timestamp":1663520559000},"page":"1001-1009","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The Effect of Neonicotinoids Exposure on Oreochromis niloticus Histopathological Alterations and Genotoxicity"],"prefix":"10.1007","volume":"109","author":[{"given":"Islam M.","family":"El-Garawani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsayed A.","family":"Khallaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa A.","family":"Alne-na-ei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehab G.","family":"Elgendy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan M.","family":"Sobhy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel","family":"Khairallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5084-8603","authenticated-orcid":false,"given":"Heba M. 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