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Particularly in elective surgery, preoperative compensation of deficiencies is advisable to avoid negative postoperative consequences. This study examined the nutritional and protein balance of patients with periprosthetic hip and knee joint infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Patients with periprosthetic hip or knee joint infections constituted the study group (SG). Control group\u00a0I (CG\u00a0I) included patients with primary implants and CG\u00a0II included patients who required revision surgery because of aseptic loosening. Relevant nutritional and protein parameters were determined via analysis of peripheral venous blood samples. In addition, a\u00a0questionnaire was used to evaluate the nutritional and eating patterns of all patients. The nutritional risk screening (NRS) 2002 score and body mass index (BMI) were also calculated for all participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Differences were found in the albumin level (SG: 36.23\u202f\u00b1\u20097.34, CG\u00a0I: 44.37\u202f\u00b1\u20093.32,<jats:italic>p<\/jats:italic>\u202f&lt;\u20090.001, CG\u00a0II: 44.06\u202f\u00b1\u20094.24,<jats:italic>p<\/jats:italic>\u202f&lt;\u20090.001) and total protein in serum (SG: 65.42\u202f\u00b1\u20098.66, CG\u00a0I: 70.80\u202f\u00b1\u20095.33,<jats:italic>p<\/jats:italic>\u202f=\u20090.004, CG\u00a0II: 71.22\u202f\u00b1\u20095.21,<jats:italic>p<\/jats:italic>\u202f=\u20090.004). The number of patients with lowered albumin levels (SG\u00a019\/61, CG\u00a0I\u00a01\/78, CG\u00a0II\u00a02\/55) and total protein in serum (SG:\u00a012\/61, CG\u00a0I\u00a05\/78, CG\u00a0II\u00a02\/55) also showed considerable variation. The number of patients with a NRS 2002 score \u22653 differed significantly between SG and both CGs (SG:\u00a05\/61, CG\u00a0I\u00a01\/78, CG\u00a0II\u00a00\/55); however, these differences could not be confirmed using BMI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>As expected, lowered albumin and total protein levels were observed in PJI due to the acute phase reaction. The NRS can be performed to exclude nutritional deficiency, which cannot be excluded based on BMI. In cases of periprosthetic joint infection it is reasonable to compensate the nutritional deficiency with dietary supplements.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00132-020-03922-8","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T21:02:50Z","timestamp":1589835770000},"page":"188-197","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Significance of nutritional status in the development of periprosthetic infections","Bedeutung des Ern\u00e4hrungszustands bei der Entstehung von periprothetischen Infektionen"],"prefix":"10.1007","volume":"50","author":[{"given":"Dirk","family":"Zajonz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros","family":"Daikos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Prager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Edel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"M\u00f6bius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes K. 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The committee is listed on the Institutional Review Board of the Office for Human Research Protections (OHRP) IORG0001320, IRB00001750. All procedures performed in studies involving human participants or on human tissue were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1975 Helsinki declaration and its later amendments or comparable ethical standards. Prior to study initiation, all patients provided written informed consent for the treatment contract, study, and publication of the anonymized data.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}