{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T13:15:33Z","timestamp":1793366133767,"version":"4.5.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T00:00:00Z","timestamp":1591920000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T00:00:00Z","timestamp":1591920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Orthop\u00e4de"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec>\n                <jats:title>Hintergrund<\/jats:title>\n                <jats:p>Bisherige Klassifikationen f\u00fcr Protheseninfektionen beurteilen die Heterogenit\u00e4t der Infektion nur unzureichend. Die PJI-TNM-Klassifikation ber\u00fccksichtigt auf Basis der onkologischen TNM-Klassifikation folgende entscheidende Kriterien bei Protheseninfektionen: Implantatart und -stabilit\u00e4t, Weichteilverh\u00e4ltnisse, Biofilmreife, Erregerart, Komorbidit\u00e4ten des Patienten und Infektrezidive. Ziel dieser Arbeit ist es, die neue PJI-TNM-Klassifikation auf deren Anwendbarkeit in der klinischen Praxis zu \u00fcberpr\u00fcfen.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methoden<\/jats:title>\n                <jats:p>Im Rahmen einer Konzeptionsstudie wurde die PJI-TNM-Klassifikation bei 20\u00a0Patienten mit periprothetischen Schulter\u2011, H\u00fcfte- oder Kniegelenksinfektion angewandt. Anhand der Patientenakte wurde die PJI-TNM-Klassifikation mit den \u00fcbergeordneten Parametern T\u00a0(\u201etissue and implants\u201c), N\u00a0(\u201enon-eucaryotic cells and fungi\u201c), M\u00a0(\u201emorbidity\u201c) und r\u00a0(\u201ereinfection\u201c), klassifiziert.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnisse<\/jats:title>\n                <jats:p>Alle 20\u00a0F\u00e4lle (12\u00a0m\u00e4nnlich, 8\u00a0weiblich, mittleres Alter\u00a072,2 [40\u201388\u00a0Jahre]), darunter 13\u00a0H\u00fcft-, 6\u00a0Knie- und eine Schulterprotheseninfektion, konnten mit der PJI-TNM-Klassifikation klassifiziert werden. Insgesamt zeigte sich eine gro\u00dfe Heterogenit\u00e4t der F\u00e4lle: 12\u00a0Prothesen waren fest (T0), 6\u00a0gelockert (T1) und bei zwei Prothesen ein Weichteildefekt (T2) vorhanden. Bei 7\u00a0Prothesen wurde von unreifem Biofilm (N0) ausgegangen. 13\u00a0Prothesen wurden entsprechend eines reifen Biofilms klassifiziert (N1+N2). 9\u00a0Patienten waren nur geringgradig (M0), 7\u00a0Patienten m\u00e4\u00dfig (M1) und 3\u00a0Patienten schwer vorerkrankt (M2). Ein Patient lehnte die chirurgische Therapie ab (M3a). Bei 3\u00a0F\u00e4llen handelte es sich um eine Reinfektion\u00a0(r).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Schlussfolgerungen<\/jats:title>\n                <jats:p>Die aus der Onkologie stammenden Prinzipien der TNM-Klassifikation lassen sich auch bei periprothetischen Infektionen anwenden. Schon bei einer geringen Fallzahl ist eine deutliche Heterogenit\u00e4t periprothetischer Infektionen, wie sie auch im klinischen Alltag generell beobachtet wird, feststellbar. Diese wird durch die PJI-TNM-Klassifikation gut abgebildet und kann dadurch zuk\u00fcnftig eventuell zur Verbesserung bei der Therapieentscheidung beitragen.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00132-020-03933-5","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T11:02:30Z","timestamp":1591959750000},"page":"198-206","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["PJI-TNM als neues Klassifikationssystem f\u00fcr Endoprotheseninfektionen","PJI-TNM as new classification system for periprosthetic joint infections"],"prefix":"10.1007","volume":"50","author":[{"given":"Markus","family":"Rupp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Kerschbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viola","family":"Freigang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"B\u00e4rtl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Baumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrej","family":"Trampuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Alt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,12]]},"reference":[{"key":"3933_CR1","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1302\/2046-3758.92.BJR-2019-0134.R1","volume":"9","author":"V Alt","year":"2020","unstructured":"Alt\u00a0V, Rupp\u00a0M, Langer\u00a0M et al (2020) Can the oncology classification system be used for prosthetic joint infection? 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Die Auswertung der Patientendaten wurde durch die zust\u00e4ndige Ethikkommission der Universit\u00e4t Regensburg genehmigt (EA: 20-1681-104).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}