{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:13:52Z","timestamp":1767140032605,"version":"build-2238731810"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T00:00:00Z","timestamp":1594166400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T00:00:00Z","timestamp":1594166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Orthop\u00e4de"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Einleitung<\/jats:title>\n                    <jats:p>Die Transplantation humaner Femurk\u00f6pfe (FK) ist ein etabliertes Verfahren in der kn\u00f6chernen Defektrekonstruktion bei orthop\u00e4dischen und unfallchirurgischen Eingriffen, wobei eine standardisierte morphologische Qualit\u00e4tsbewertung des Femurkopfgewebes bisher kaum erfolgt.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material und Methoden<\/jats:title>\n                    <jats:p>Bei 105 Patienten wurde der jeweilige FK im Rahmen einer H\u00fcft-TEP standardisiert entnommen. Anhand klinischer und radiologischer Kriterien (Vorhandensein von Zysten, Nekrosen, Verkalkungen, Deformit\u00e4ten und Osteoporose) wurde der FK mittels des Tabea-FK-Scores in drei Kategorien (beste\/mittlere\/schlechte Qualit\u00e4t) eingeteilt. Hiernach erfolgte eine zweite, makroskopische Einteilung der Qualit\u00e4t des in drei Schichten aufges\u00e4gten FK. Dieser \u201eMakro-Score\u201c diente als Goldstandard. Erg\u00e4nzend wurden eine periphere quantitative Computertomographie (pQCT) sowie histologische Untersuchungen durchgef\u00fchrt. Die \u00dcbereinstimmung des Tabea-FK-Scores sowie der Ergebnisse der erg\u00e4nzenden Untersuchungen mit dem Makro-Score wurde mittels Sensitivit\u00e4ten und Spezifit\u00e4ten beurteilt.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ergebnisse<\/jats:title>\n                    <jats:p>\n                      Bei 91\/105 Patienten (Alter: 68,4\u202f\u00b1\u20099,9\u00a0Jahre,\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u200960\u00a0Frauen,\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u200931\u00a0M\u00e4nner) wurden die explantierten FK in die Studie eingeschlossen. Die \u00dcbereinstimmung zwischen dem prim\u00e4ren Tabea-FK-Score und dem Makro-Score in Bezug auf die Unterscheidung mittlere\/beste sowie schlechte\/mittlere Qualit\u00e4t ist als gut einzustufen (Sensitivit\u00e4t 77\u202f% sowie 81\u202f% und Spezifit\u00e4t 76\u202f% sowie 84\u202f%). Die \u00dcbereinstimmung des histologischen Befundes mit dem Makro-Score war insgesamt etwas schlechter und wies in Bezug auf die Unterscheidung mittlere\/beste sowie schlechte\/mittlere Qualit\u00e4t eine Sensitivit\u00e4t von 85\u202f% sowie 54\u202f% und eine Spezifit\u00e4t von 66\u202f% sowie 97\u202f% auf. Der pQCT-Score wies lediglich bei der Unterscheidung mittlere\/beste Qualit\u00e4t eine zufriedenstellende Sensitivit\u00e4t (82\u202f%) auf, w\u00e4hrend diese bei der Unterscheidung schlechte\/mittlere Qualit\u00e4t sowie schlechte\/mittlere\u202f+\u2009beste Qualit\u00e4t &lt;10\u202f% betrug.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Diskussion<\/jats:title>\n                    <jats:p>Die gute \u00dcbereinstimmung zwischen prim\u00e4rem Tabea-FK-Score und makroskopischer Zweitbewertung unterstreicht die F\u00e4higkeiten langj\u00e4hrig operativ t\u00e4tiger Orthop\u00e4den, die Qualit\u00e4t der Knochenspongiosa bereits anhand des R\u00f6ntgenbildes und des intraoperativen Befundes korrekt einzustufen. Insofern kann die Einf\u00fchrung des Tabea-FK-Scores in die Routineabl\u00e4ufe von Knochenbanken als Qualit\u00e4tssicherungsma\u00dfnahme empfohlen werden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00132-020-03941-5","type":"journal-article","created":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T17:02:53Z","timestamp":1594227773000},"page":"471-480","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ein klinisch-radiologischer Score f\u00fcr Femurkopftransplantate","A\u00a0clinical radiological score for femoral head grafts"],"prefix":"10.1007","volume":"50","author":[{"given":"Nicolaus","family":"Siemssen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Friesecke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Wolff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisela","family":"Beller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Wassilew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Neuner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helge","family":"Sch\u00f6nfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Pru\u00df","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,7,8]]},"reference":[{"issue":"4","key":"3941_CR1","first-page":"507","volume":"73","author":"G Abbas","year":"2007","unstructured":"Abbas\u00a0G, Bali\u00a0SL, Abbas\u00a0N, Dalton\u00a0DJ (2007) Demand and supply of bone allograft and the role of orthopaedic surgeons. 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C.\u00a0Wolff, G.\u00a0Beller, K.\u00a0Wassilew, B.\u00a0Neuner und H.\u00a0Sch\u00f6nfeld geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"Alle beschriebenen Untersuchungen am Menschen oder an menschlichem Gewebe wurden mit Zustimmung der zust\u00e4ndigen Ethikkommission, im Einklang mit nationalem Recht sowie gem\u00e4\u00df der Deklaration von Helsinki von 1975 (in der aktuellen, \u00fcberarbeiteten Fassung) durchgef\u00fchrt. Von allen beteiligten Patienten liegt eine Einverst\u00e4ndniserkl\u00e4rung vor.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}