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Pr\u00e4klinischen Studien liefern ein vielversprechendes Bild der Wirksamkeit von Bakteriophagen zur Behandlung von Knochen- und Protheseninfektionen.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ziel der Arbeit<\/jats:title>\n                <jats:p>Die vorliegende Arbeit gibt eine systematische \u00dcbersicht \u00fcber die klinische Anwendung von Bakteriophagen zur Behandlung von Knochen- und Protheseninfektionen.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Material und Methoden<\/jats:title>\n                <jats:p>Eine systematische Suche wurde in PubMed zur Identifikation von prim\u00e4ren klinischen Daten zur Anwendung der Phagentherapie bei Patienten mit Knochen- und Protheseninfektion durchgef\u00fchrt.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnisse<\/jats:title>\n                <jats:p>Elf Studien wurden eingeschlossen, bestehend aus 8\u00a0Fallberichten und 3\u00a0Fallserien. Indikationen der Phagentherapie waren periprothetische Infektionen (<jats:italic>n<\/jats:italic>\u202f=\u200912, 52,2\u202f%), frakturassoziierte Infektionen (<jats:italic>n<\/jats:italic>\u202f=\u20099, 39,1\u202f%), Osteomyelitis (<jats:italic>n<\/jats:italic>\u202f=\u20091, 4,4\u202f%) und eine Iliosakralgelenkinfektion nach Zementaugmentation einer Metastase (<jats:italic>n<\/jats:italic>\u202f=\u20091, 4,4\u202f%). Die Interventionen waren heterogen, Phagen wurden intraven\u00f6s verabreicht, intraoperativ ins Gelenk injiziert, intraoperativ lokal angewendet oder \u00fcber Drainagen appliziert. In Kombination mit Antibiotikatherapie konnte eine vollst\u00e4ndige Infekteradikation bei 18\u00a0Patienten (78,3\u202f%) erreicht werden. Bei 91,3\u202f% der Patienten wurden keine Nebenwirkungen berichtet.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Schlussfolgerung<\/jats:title>\n                <jats:p>Bakteriophagen sind eine vielversprechende Behandlungsmethode von Knochen- und Protheseninfektionen in Kombination mit einer Antibiotikatherapie. Zuk\u00fcnftige klinische Studien mit h\u00f6herem Evidenzgrad werden ben\u00f6tigt, um eine erfolgreiche Translation der Bakteriophagentherapie in die klinische Praxis weiter zu etablieren.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00132-021-04148-y","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T08:02:42Z","timestamp":1631174562000},"page":"138-145","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Behandlung von Knochen- und Protheseninfektionen mit Bakteriophagen","Treatment of bone and periprosthetic infections with bacteriophages"],"prefix":"10.1007","volume":"51","author":[{"given":"Nike","family":"Walter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Brochhausen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker","family":"Alt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Rupp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,9,9]]},"reference":[{"issue":"4","key":"4148_CR1","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1002\/jor.23755","volume":"36","author":"ZZ Akanda","year":"2018","unstructured":"Akanda\u00a0ZZ, Taha\u00a0M, Abdelbary\u00a0H (2018) Current review. 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