{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:26:23Z","timestamp":1790252783655,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T00:00:00Z","timestamp":1649289600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T00:00:00Z","timestamp":1649289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005296","name":"Universit\u00e4tsklinikum Regensburg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005296","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Orthop\u00e4die"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec><jats:title>Hintergrund und Fragestellung<\/jats:title><jats:p>Bei der pyogenen Spondylodiszitis gewinnen Infektionen mit Koagulase-negativen Staphylokokken zunehmend an Bedeutung. Eine empirische Antibiose ist insbesondere bei Patienten mit schweren oder progredienten neurologischen Ausf\u00e4llen sowie h\u00e4modynamischer Instabilit\u00e4t und im Falle von kulturnegativen Spondylodiszitiden notwendig. Ob es in Deutschland einheitliche, an das Resistenzprofil angepasste Standards der empirische Antibotikatherapie gibt, ist unklar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Studiendesign und Untersuchungsmethoden<\/jats:title><jats:p>Es wurde an deutschen Universit\u00e4ts- und berufsgenossenschaftlichen Kliniken, jeweils in den Fachbereichen Orthop\u00e4die und Unfallchirurgie, eine Umfrage zur empirischen Antibiotikatherapie bei pyogener Spondylodiszitis durchgef\u00fchrt. Die Umfrageergebnisse wurden auf das Resistenzprofil der Erreger von 45\u00a0Spondylodiszitispatienten, die zwischen 2013 und 2020 in unserer Klinik behandelt wurden, angewandt. Dadurch wurden potenzielle Sensibilit\u00e4ts- und Resistenzraten f\u00fcr die angegebenen antibiotischen Therapien errechnet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Ergebnisse<\/jats:title><jats:p>Von den 71\u00a0angefragten Kliniken antworteten insgesamt\u00a044 (62,0\u202f%). Sechzehn verschiedene Antibiotikatherapien wurden als jeweiliger Standard berichtet. Darunter wurden 14\u00a0verschiedene Kombinationstherapien als Therapiestandard angegeben. Die am h\u00e4ufigsten angegebenen empirischen Substanzen, n\u00e4mlich Amoxicillin-Clavulans\u00e4ure oder Ampicillin\/Sulbactam (29,5\u202f%) und Cephalosporine (18,2\u202f%) zeigten in Bezug auf das zuvor ver\u00f6ffentliche Resistenzprofil hohe potenzielle Resistenzraten von 20,0\u202f% bzw. 35,6\u202f%. Die h\u00f6chsten potenziellen Sensibilit\u00e4tsraten wurden durch die Kombinationen Vancomycin\u202f+\u2009Ampicillin\/Sulbactam (91,1\u202f% sensible Erreger), Vancomycin\u202f+\u2009Piperacillin\/Tazobactam (91,1\u202f% sensible Erreger) und Ampicillin\/Sulbactam\u202f+\u2009Teicoplanin (95,6\u202f% sensible Erreger) erreicht. Eine dieser Kombinationen wurde von drei Kliniken (6,8\u202f%) als Standard angegeben.<\/jats:p><\/jats:sec><jats:sec><jats:title>Schlussfolgerung<\/jats:title><jats:p>Die deutschlandweite Umfrage zur empirischen Antibiose bei pyogener Spondylodiszitis hat eine gro\u00dfe Heterogenit\u00e4t der Standardtherapien ergeben. Eine Kombination aus einem Breitspektrum-\u03b2-Laktam-Antibiotikum mit einem zus\u00e4tzlichen Glykopeptidantibiotikum kann sinnvoll sein.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00132-022-04240-x","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T20:02:40Z","timestamp":1649361760000},"page":"540-546","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Aktuelle Praxis der empirischen Antibiotikatherapie bei Spondylodiszitis","Current practice of empiric antibiotic treatment for spondylodiscitis"],"prefix":"10.1007","volume":"51","author":[{"given":"Siegmund","family":"Lang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nike","family":"Walter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"B\u00e4rtl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Ehrenschwender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Hitzenbichler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Alt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Rupp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,7]]},"reference":[{"key":"4240_CR1","doi-asserted-by":"publisher","first-page":"2152","DOI":"10.1016\/j.injury.2019.11.001","volume":"50","author":"V Alt","year":"2019","unstructured":"Alt\u00a0V, Giannoudis\u00a0PV (2019) Musculoskeletal infections\u2014a global burden and a\u00a0new subsection in injury. Injury 50:2152\u20132153. https:\/\/doi.org\/10.1016\/j.injury.2019.11.001","journal-title":"Injury"},{"key":"4240_CR2","unstructured":"Redaktion Deutsches \u00c4rzteblatt D\u00c4G (2020) Antibiotikaresistenzen: Ein heterogenes Bild. https:\/\/www.aerzteblatt.de\/archiv\/211751\/Antibiotikaresistenzen-Ein-heterogenes-Bild. Zugegriffen: 24. Nov. 2021"},{"key":"4240_CR3","doi-asserted-by":"publisher","first-page":"2725","DOI":"10.1093\/jac\/dkaa184","volume":"75","author":"I Bellos","year":"2020","unstructured":"Bellos\u00a0I, Daskalakis\u00a0G, Pergialiotis\u00a0V (2020) Relationship of vancomycin trough levels with acute kidney injury risk: an exposure-toxicity meta-analysis. J\u00a0Antimicrob Chemother 75:2725\u20132734. https:\/\/doi.org\/10.1093\/jac\/dkaa184","journal-title":"J Antimicrob Chemother"},{"key":"4240_CR4","doi-asserted-by":"publisher","first-page":"e26","DOI":"10.1093\/cid\/civ482","volume":"61","author":"EF Berbari","year":"2015","unstructured":"Berbari\u00a0EF, Kanj\u00a0SS, Kowalski\u00a0TJ et\u00a0al (2015) 2015 Infectious Diseases Society of America (IDSA) clinical practice guidelines for the diagnosis and treatment of native vertebral osteomyelitis in adults. Clin Infect Dis 61:e26\u2013e46. https:\/\/doi.org\/10.1093\/cid\/civ482","journal-title":"Clin Infect Dis"},{"key":"4240_CR5","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/S0140-6736(14)61233-2","volume":"385","author":"L Bernard","year":"2015","unstructured":"Bernard\u00a0L, Dinh\u00a0A, Ghout\u00a0I et al (2015) Antibiotic treatment for 6\u00a0weeks versus 12\u00a0weeks in patients with pyogenic vertebral osteomyelitis: an open-label, non-inferiority, randomised, controlled trial. Lancet 385:875\u2013882. https:\/\/doi.org\/10.1016\/S0140-6736(14)61233-2","journal-title":"Lancet"},{"key":"4240_CR6","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1007\/s100960050441","volume":"19","author":"E Bucher","year":"2000","unstructured":"Bucher\u00a0E, Trampuz\u00a0A, Donati\u00a0L, Zimmerli\u00a0W (2000) Spondylodiscitis associated with bacteraemia due to coagulase-negative staphylococci. Eur J Clin Microbiol Infect Dis 19:118\u2013120. https:\/\/doi.org\/10.1007\/s100960050441","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"4240_CR7","unstructured":"Clinical & Laboratory Standards Institute (2021) CLSI guidelines. https:\/\/clsi.org\/. Zugegriffen: 5. Dez. 2021"},{"key":"4240_CR8","doi-asserted-by":"publisher","first-page":"e227","DOI":"10.1017\/S0950268821002181","volume":"149","author":"Y Conan","year":"2021","unstructured":"Conan\u00a0Y, Laurent\u00a0E, Belin\u00a0Y et al (2021) Large increase of vertebral osteomyelitis in France: a\u00a02010-2019 cross-sectional study. Epidemiol Infect 149:e227. https:\/\/doi.org\/10.1017\/S0950268821002181","journal-title":"Epidemiol Infect"},{"key":"4240_CR9","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.ijantimicag.2015.07.022","volume":"46","author":"J-W Decousser","year":"2015","unstructured":"Decousser\u00a0J\u2011W, Desroches\u00a0M, Bourgeois-Nicolaos\u00a0N et al (2015) Susceptibility trends including emergence of linezolid resistance among coagulase-negative staphylococci and meticillin-resistant Staphylococcus aureus from invasive infections. Int J Antimicrob Agents 46:622\u2013630. https:\/\/doi.org\/10.1016\/j.ijantimicag.2015.07.022","journal-title":"Int J Antimicrob Agents"},{"key":"4240_CR10","doi-asserted-by":"publisher","first-page":"7700","DOI":"10.1128\/AAC.01516-15","volume":"59","author":"S Desoutter","year":"2015","unstructured":"Desoutter\u00a0S, Cottier\u00a0J\u2011P, Ghout\u00a0I et al (2015) Susceptibility pattern of microorganisms isolated by percutaneous needle biopsy in nonbacteremic pyogenic vertebral osteomyelitis. Antimicrob Agents Chemother 59:7700\u20137706. https:\/\/doi.org\/10.1128\/AAC.01516-15","journal-title":"Antimicrob Agents Chemother"},{"key":"4240_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.nmni.2015.04.008","volume":"7","author":"M Doutchi","year":"2015","unstructured":"Doutchi\u00a0M, Seng\u00a0P, Menard\u00a0A et\u00a0al (2015) Changing trends in the epidemiology of vertebral osteomyelitis in Marseille, France. New Microbes New Infect 7:1\u20137. https:\/\/doi.org\/10.1016\/j.nmni.2015.04.008","journal-title":"New Microbes New Infect"},{"key":"4240_CR12","unstructured":"EUCAST (2021) AST of bacteria. https:\/\/www.eucast.org\/ast_of_bacteria\/. Zugegriffen: 8. Nov. 2021"},{"key":"4240_CR13","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1055\/a-1324-4424","volume":"5","author":"C Herren","year":"2021","unstructured":"Herren\u00a0C, von der H\u00f6h\u00a0N (2021) Zusammenfassung der S2K-Leitlinie \u201eDiagnostik und Therapie der Spondylodiszitis\u201c (Stand 08\/2020). Wirbels\u00e4ule 5:18\u201320. https:\/\/doi.org\/10.1055\/a-1324-4424","journal-title":"Wirbels\u00e4ule"},{"key":"4240_CR14","doi-asserted-by":"publisher","first-page":"e0127126","DOI":"10.1371\/journal.pone.0127126","volume":"10","author":"S-J Kang","year":"2015","unstructured":"Kang\u00a0S\u2011J, Jang\u00a0H\u2011C, Jung\u00a0S\u2011I et al (2015) Clinical characteristics and risk factors of pyogenic spondylitis caused by gram-negative bacteria. PLoS ONE 10:e127126. https:\/\/doi.org\/10.1371\/journal.pone.0127126","journal-title":"PLoS ONE"},{"key":"4240_CR15","doi-asserted-by":"publisher","first-page":"ofaa176","DOI":"10.1093\/ofid\/ofaa176","volume":"7","author":"DY Kim","year":"2020","unstructured":"Kim\u00a0DY, Kim\u00a0UJ, Yu\u00a0Y et\u00a0al (2020) Microbial etiology of pyogenic vertebral osteomyelitis according to patient characteristics. Open Forum Infect Dis 7:ofaa176. https:\/\/doi.org\/10.1093\/ofid\/ofaa176","journal-title":"Open Forum Infect Dis"},{"key":"4240_CR16","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/9781118581742.ch21","volume-title":"Bone and joint infections: from microbiology to diagnostics and treatment","author":"T Kowalski","year":"2015","unstructured":"Kowalski\u00a0T (2015) Implant-associated vertebral osteomyelitis. In: Bone and joint infections: from microbiology to diagnostics and treatment, S 325\u2013345"},{"key":"4240_CR17","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.3390\/antibiotics10111410","volume":"10","author":"S Lang","year":"2021","unstructured":"Lang\u00a0S, Fr\u00f6mming\u00a0A, Walter\u00a0N et al (2021) Is there a\u00a0difference in clinical features, microbiological epidemiology and effective empiric antimicrobial therapy comparing healthcare-associated and community-acquired vertebral osteomyelitis? Antibiotics 10:1410. https:\/\/doi.org\/10.3390\/antibiotics10111410","journal-title":"Antibiotics"},{"key":"4240_CR18","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s00113-021-01002-w","volume":"124","author":"S Lang","year":"2021","unstructured":"Lang\u00a0S, Rupp\u00a0M, Hanses\u00a0F et al (2021) Infections of the spine: pyogenic spondylodiscitis and implant-associated vertebral osteomyelitis. Unfallchirurg 124:489\u2013504. https:\/\/doi.org\/10.1007\/s00113-021-01002-w","journal-title":"Unfallchirurg"},{"key":"4240_CR19","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1186\/s12879-017-2783-0","volume":"17","author":"J Lopez","year":"2017","unstructured":"Lopez\u00a0J, Tatar\u00a0Z, Tournadre\u00a0A et al (2017) Characteristics of spontaneous coagulase-negative staphylococcal spondylodiscitis: a\u00a0retrospective comparative study versus Staphylococcus aureus spondylodiscitis. BMC Infect Dis 17:683. https:\/\/doi.org\/10.1186\/s12879-017-2783-0","journal-title":"BMC Infect Dis"},{"key":"4240_CR20","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1086\/340102","volume":"34","author":"MC McHenry","year":"2002","unstructured":"McHenry\u00a0MC, Easley\u00a0KA, Locker\u00a0GA (2002) Vertebral osteomyelitis: long-term outcome for 253\u00a0patients from 7 Cleveland-area hospitals. Clin Infect Dis 34:1342\u20131350. https:\/\/doi.org\/10.1086\/340102","journal-title":"Clin Infect Dis"},{"key":"4240_CR21","doi-asserted-by":"publisher","first-page":"830","DOI":"10.3390\/microorganisms9040830","volume":"9","author":"R Michels","year":"2021","unstructured":"Michels\u00a0R, Last\u00a0K, Becker\u00a0SL, Papan\u00a0C (2021) Update on coagulase-negative staphylococci-what the clinician should know. Microorganisms 9:830. https:\/\/doi.org\/10.3390\/microorganisms9040830","journal-title":"Microorganisms"},{"key":"4240_CR22","doi-asserted-by":"publisher","first-page":"e0211888","DOI":"10.1371\/journal.pone.0211888","volume":"14","author":"K-H Park","year":"2019","unstructured":"Park\u00a0K\u2011H, Kim\u00a0DY, Lee\u00a0Y\u2011M et al (2019) Selection of an appropriate empiric antibiotic regimen in hematogenous vertebral osteomyelitis. PLoS ONE 14:e211888. https:\/\/doi.org\/10.1371\/journal.pone.0211888","journal-title":"PLoS ONE"},{"key":"4240_CR23","doi-asserted-by":"publisher","first-page":"e365","DOI":"10.1097\/MD.0000000000000365","volume":"94","author":"C Pigrau","year":"2015","unstructured":"Pigrau\u00a0C, Rodr\u00edguez-Pardo\u00a0D, Fern\u00e1ndez-Hidalgo\u00a0N et al (2015) Health care associated hematogenous pyogenic vertebral osteomyelitis: a\u00a0severe and potentially preventable infectious disease. Medicine 94:e365. https:\/\/doi.org\/10.1097\/MD.0000000000000365","journal-title":"Medicine"},{"key":"4240_CR24","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1007\/s00586-017-5043-5","volume":"26","author":"E Pola","year":"2017","unstructured":"Pola\u00a0E, Autore\u00a0G, Formica\u00a0VM et al (2017) New classification for the treatment of pyogenic spondylodiscitis: validation study on a\u00a0population of 250\u00a0patients with a\u00a0follow-up of 2\u00a0years. Eur Spine\u00a0J 26:479\u2013488. https:\/\/doi.org\/10.1007\/s00586-017-5043-5","journal-title":"Eur Spine J"},{"key":"4240_CR25","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1186\/s12889-017-4833-3","volume":"17","author":"M-T Puth","year":"2017","unstructured":"Puth\u00a0M\u2011T, Weckbecker\u00a0K, Schmid\u00a0M, M\u00fcnster\u00a0E (2017) Prevalence of multimorbidity in Germany: impact of age and educational level in a\u00a0cross-sectional study on 19,294 adults. BMC Public Health 17:826. https:\/\/doi.org\/10.1186\/s12889-017-4833-3","journal-title":"BMC Public Health"},{"key":"4240_CR26","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.diagmicrobio.2017.01.020","volume":"88","author":"N Renz","year":"2017","unstructured":"Renz\u00a0N, Haupenthal\u00a0J, Schuetz\u00a0MA, Trampuz\u00a0A (2017) Hematogenous vertebral osteomyelitis associated with intravascular device-associated infections\u2014a retrospective cohort study. Diagn Microbiol Infect Dis 88:75\u201381. https:\/\/doi.org\/10.1016\/j.diagmicrobio.2017.01.020","journal-title":"Diagn Microbiol Infect Dis"},{"key":"4240_CR27","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1302\/2046-3758.1011.BJR-2021-0371","volume":"10","author":"M Rupp","year":"2021","unstructured":"Rupp\u00a0M, Walter\u00a0N, Baertl\u00a0S et\u00a0al (2021) Terminology of bone and joint infection. Bone Joint Res 10:742\u2013743. https:\/\/doi.org\/10.1302\/2046-3758.1011.BJR-2021-0371","journal-title":"Bone Joint Res"},{"key":"4240_CR28","doi-asserted-by":"publisher","first-page":"4264","DOI":"10.1128\/AAC.00431-09","volume":"53","author":"E Tacconelli","year":"2009","unstructured":"Tacconelli\u00a0E, De Angelis\u00a0G, Cataldo\u00a0MA et al (2009) Antibiotic usage and risk of colonization and infection with antibiotic-resistant bacteria: a\u00a0hospital population-based study. Antimicrob Agents Chemother 53:4264\u20134269. https:\/\/doi.org\/10.1128\/AAC.00431-09","journal-title":"Antimicrob Agents Chemother"},{"key":"4240_CR29","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/s12879-021-05858-6","volume":"21","author":"M Tsutsuura","year":"2021","unstructured":"Tsutsuura\u00a0M, Moriyama\u00a0H, Kojima\u00a0N et al (2021) The monitoring of vancomycin: a\u00a0systematic review and meta-analyses of area under the concentration-time curve-guided dosing and trough-guided dosing. BMC Infect Dis 21:153. https:\/\/doi.org\/10.1186\/s12879-021-05858-6","journal-title":"BMC Infect Dis"},{"key":"4240_CR30","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1186\/s12879-017-2271-6","volume":"17","author":"J Walter","year":"2017","unstructured":"Walter\u00a0J, Noll\u00a0I, Feig\u00a0M et al (2017) Decline in the proportion of methicillin resistance among Staphylococcus aureus isolates from non-invasive samples and in outpatient settings, and changes in the co-resistance profiles: an analysis of data collected within the Antimicrobial Resistance Surveillance Network, Germany 2010 to 2015. BMC Infect Dis 17:169. https:\/\/doi.org\/10.1186\/s12879-017-2271-6","journal-title":"BMC Infect Dis"}],"container-title":["Die Orthop\u00e4die"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00132-022-04240-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00132-022-04240-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00132-022-04240-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T19:51:58Z","timestamp":1700423518000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00132-022-04240-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,7]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["4240"],"URL":"https:\/\/doi.org\/10.1007\/s00132-022-04240-x","relation":{},"ISSN":["2731-7145","2731-7153"],"issn-type":[{"value":"2731-7145","type":"print"},{"value":"2731-7153","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,7]]},"assertion":[{"value":"15 February 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"S.\u00a0Lang, N.\u00a0Walter, C.\u00a0Neumann, S.\u00a0B\u00e4rtl, M.\u00a0Simon, M.\u00a0Ehrenschwender, F.\u00a0Hitzenbichler, V.\u00a0Alt und M.\u00a0Rupp geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"Die Ethikkommission des Universit\u00e4tsklinikums Regensburg wurde \u00fcber die Forschungsarbeit in Kenntnis gesetzt und verzichtete daraufhin auf ein Ethik-Gutachten.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}