{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:31:04Z","timestamp":1790620264000,"version":"4.1.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T00:00:00Z","timestamp":1682294400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T00:00:00Z","timestamp":1682294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Orthop\u00e4die"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The aim of this clinical investigation was to assess the physical performance in osteoporotic patients undergoing drug treatment (DT) for years by measuring hand grip strength (HGS) and bone mineral density (BMD). A\u00a0further aim was to detect the time until the occurrence of vertebral fractures (VF) and influencing factors.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Material and methods<\/jats:title>\n                <jats:p>The investigation comprised 346 persons (276\u00a0women, 70\u00a0men) aged on average 66.9\u202f\u00b1\u200910.7\u00a0years with confirmed osteoporosis (OP). Over a\u00a0mean period of 1384\u202f\u00b1\u2009727\u00a0days, OP was assessed every 2 years, including a\u00a0bone densitometry by dual X\u2011ray absorptiometry and HGS measurement. In subgroups OP patients were analyzed with and without a\u00a0bone density (BMD) increase, and with and without VFs.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Under DT, calcium and vitamin\u00a0D substitution, the median T\u2011score improved in the entire group from \u22123.2 to \u22123.1 standard deviations (SD; <jats:italic>p<\/jats:italic>\u202f=\u20090.002). HGS was reduced (median) from 26\u202fkg to 24\u202fkg (<jats:italic>p<\/jats:italic>\u202f&lt;\u20090.001). The median interval until the occurrence of VF was 2652\u00a0days (95% confidence interval [CI] 1825.2\u20133478.8\u00a0days) and 1461\u00a0days (95% CI 1246.5\u20131675.5, <jats:italic>p<\/jats:italic>\u202f&lt;\u20090.001) in those with and without a\u00a0BMD increase, respectively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Discussion<\/jats:title>\n                <jats:p>Guideline-based DT improves bone density and causes a\u00a0longer interval without VF. The HGS falls independent of BMD. The association between bone and muscle in patients with a\u00a0deterioration of the musculoskeletal system is known as osteosarcopenia. Early muscle exercises would be meaningful in this setting.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphic abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1007\/s00132-023-04367-5","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T20:29:31Z","timestamp":1682368171000},"page":"992-1004","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of bone density and hand grip strength in the course of drug treatment for osteoporosis","Evaluierung von Knochendichte und Handgriffkraft im Verlauf einer medikament\u00f6sen Osteoporosetherapie"],"prefix":"10.1007","volume":"52","author":[{"given":"Guido","family":"Schr\u00f6der","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivonne","family":"Hoth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Flachsmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Dutzke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian Ramin","family":"Andresen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reimer","family":"Andresen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Christof","family":"Schober","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,24]]},"reference":[{"issue":"7","key":"4367_CR1","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1007\/s00113-003-0642-5","volume":"106","author":"R Bartl","year":"2003","unstructured":"Bartl\u00a0R, Bartl\u00a0C, Mutschler\u00a0W (2003) Diagnostik und Therapie der Osteoporose. Strategie f\u00fcr eine effiziente Pr\u00e4vention von Folgefrakturen. Unfallchirurg 106(7):526\u2013541. https:\/\/doi.org\/10.1007\/s00113-003-0642-5","journal-title":"Unfallchirurg"},{"issue":"5","key":"4367_CR2","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1055\/s-0031-1277977","volume":"46","author":"H-D Basler","year":"2011","unstructured":"Basler\u00a0H\u2011D (2011) Akutschmerztherapie in P\u00e4diatrie und Geriatrie \u2013 Schmerzmessung: Welche Schmerzskala bei welchen Patienten? Anasthesiol Intensivmed Notfallmed Schmerzther 46(5):334\u2013341. https:\/\/doi.org\/10.1055\/s-0031-1277977 (quiz 342)","journal-title":"Anasthesiol Intensivmed Notfallmed Schmerzther"},{"issue":"2","key":"4367_CR3","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1093\/pubmed\/fds076","volume":"35","author":"K B\u00e4ssgen","year":"2013","unstructured":"B\u00e4ssgen\u00a0K, Westphal\u00a0T, Haar\u00a0P, Kundt\u00a0G, Mittlmeier\u00a0T, Schober\u00a0H\u2011C (2013) Population-based prospective study on the incidence of osteoporosis-associated fractures in a\u00a0German population of 200,413 inhabitants. J\u00a0Public Health (Oxf) 35(2):255\u2013261. https:\/\/doi.org\/10.1093\/pubmed\/fds076","journal-title":"J Public Health (Oxf)"},{"issue":"4","key":"4367_CR4","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1002\/jbmr.3641","volume":"34","author":"ML Bouxsein","year":"2019","unstructured":"Bouxsein\u00a0ML, Eastell\u00a0R, Lui\u00a0L\u2011Y, Wu\u00a0LA, de Papp\u00a0AE, Grauer\u00a0A, Marin\u00a0F, Cauley\u00a0JA, Bauer\u00a0DC, Black\u00a0DM (2019) Change in bone density and reduction in fracture risk: a meta-regression of published trials. J\u00a0Bone Miner Res 34(4):632\u2013642. https:\/\/doi.org\/10.1002\/jbmr.3641","journal-title":"J Bone Miner Res"},{"issue":"1","key":"4367_CR5","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s11657-017-0324-5","volume":"12","author":"J Compston","year":"2017","unstructured":"Compston\u00a0J, Cooper\u00a0A, Cooper\u00a0C, Gittoes\u00a0N, Gregson\u00a0C, Harvey\u00a0N, Hope\u00a0S, Kanis\u00a0JA, McCloskey\u00a0EV, Poole\u00a0KES, Reid\u00a0DM, Selby\u00a0P, Thompson\u00a0F, Thurston\u00a0A, Vine\u00a0N (2017) UK clinical guideline for the prevention and treatment of osteoporosis. Arch Osteoporos 12(1):43. https:\/\/doi.org\/10.1007\/s11657-017-0324-5","journal-title":"Arch Osteoporos"},{"key":"4367_CR6","doi-asserted-by":"publisher","first-page":"c4467","DOI":"10.1136\/bmj.c4467","volume":"341","author":"R Cooper","year":"2010","unstructured":"Cooper\u00a0R, Kuh\u00a0D, Hardy\u00a0R (2010) Objectively measured physical capability levels and mortality: systematic review and meta-analysis. BMJ 341:c4467. https:\/\/doi.org\/10.1136\/bmj.c4467","journal-title":"BMJ"},{"issue":"3","key":"4367_CR7","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s00223-013-9757-z","volume":"93","author":"C Cooper","year":"2013","unstructured":"Cooper\u00a0C, Fielding\u00a0R, Visser\u00a0M, van Loon\u00a0LJ, Rolland\u00a0Y, Orwoll\u00a0E, Reid\u00a0K, Boonen\u00a0S, Dere\u00a0W, Epstein\u00a0S, Mitlak\u00a0B, Tsouderos\u00a0Y, Sayer\u00a0AA, Rizzoli\u00a0R, Reginster\u00a0JY, Kanis\u00a0JA (2013) Tools in the assessment of sarcopenia. Calcif Tissue Int 93(3):201\u2013210. https:\/\/doi.org\/10.1007\/s00223-013-9757-z","journal-title":"Calcif Tissue Int"},{"issue":"10191","key":"4367_CR8","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1016\/S0140-6736(19)31138-9","volume":"393","author":"AJ Cruz-Jentoft","year":"2019","unstructured":"Cruz-Jentoft\u00a0AJ, Sayer\u00a0AA (2019) Sarcopenia. Lancet 393(10191):2636\u20132646. https:\/\/doi.org\/10.1016\/S0140-6736(19)31138-9","journal-title":"Lancet"},{"issue":"1","key":"4367_CR9","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1093\/ageing\/afy169","volume":"48","author":"AJ Cruz-Jentoft","year":"2019","unstructured":"Cruz-Jentoft\u00a0AJ, Bahat\u00a0G, Bauer\u00a0J, Boirie\u00a0Y, Bruy\u00e8re\u00a0O, Cederholm\u00a0T, Cooper\u00a0C, Landi\u00a0F, Rolland\u00a0Y, Sayer\u00a0AA, Schneider\u00a0SM, Sieber\u00a0CC, Topinkova\u00a0E, Vandewoude\u00a0M, Visser\u00a0M, Zamboni\u00a0M (2019) Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 48(1):16\u201331. https:\/\/doi.org\/10.1093\/ageing\/afy169","journal-title":"Age Ageing"},{"issue":"4","key":"4367_CR10","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0002-9343(01)01124-X","volume":"112","author":"SR Cummings","year":"2002","unstructured":"Cummings\u00a0SR, Karpf\u00a0DB, Harris\u00a0F, Genant\u00a0HK, Ensrud\u00a0K, LaCroix\u00a0AZ, Black\u00a0DM (2002) Improvement in spine bone density and reduction in risk of vertebral fractures during treatment with antiresorptive drugs. Am J Med 112(4):281\u2013289. https:\/\/doi.org\/10.1016\/S0002-9343(01)01124-X","journal-title":"Am J Med"},{"issue":"12","key":"4367_CR11","doi-asserted-by":"publisher","first-page":"2252","DOI":"10.1111\/j.1532-5415.2008.02039.x","volume":"56","author":"RM Daly","year":"2008","unstructured":"Daly\u00a0RM, Ahlborg\u00a0HG, Ringsberg\u00a0K, Gardsell\u00a0P, Sernbo\u00a0I, Karlsson\u00a0MK (2008) Association between changes in habitual physical activity and changes in bone density, muscle strength, and functional performance in elderly men and women. J\u00a0Am Geriatr Soc 56(12):2252\u20132260. https:\/\/doi.org\/10.1111\/j.1532-5415.2008.02039.x","journal-title":"J Am Geriatr Soc"},{"issue":"5","key":"4367_CR12","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1093\/rheumatology\/keh569","volume":"44","author":"WG Dixon","year":"2005","unstructured":"Dixon\u00a0WG, Lunt\u00a0M, Pye\u00a0SR, Reeve\u00a0J, Felsenberg\u00a0D, Silman\u00a0AJ, O\u2019Neill\u00a0TW (2005) Low grip strength is associated with bone mineral density and vertebral fracture in women. Rheumatology 44(5):642\u2013646. https:\/\/doi.org\/10.1093\/rheumatology\/keh569","journal-title":"Rheumatology"},{"issue":"12","key":"4367_CR13","doi-asserted-by":"publisher","first-page":"e113637","DOI":"10.1371\/journal.pone.0113637","volume":"9","author":"RM Dodds","year":"2014","unstructured":"Dodds\u00a0RM, Syddall\u00a0HE, Cooper\u00a0R, Benzeval\u00a0M, Deary\u00a0IJ, Dennison\u00a0EM, Der\u00a0G, Gale\u00a0CR, Inskip\u00a0HM, Jagger\u00a0C, Kirkwood\u00a0TB, Lawlor\u00a0DA, Robinson\u00a0SM, Starr\u00a0JM, Steptoe\u00a0A, Tilling\u00a0K, Kuh\u00a0D, Cooper\u00a0C, Sayer\u00a0AA (2014) Grip strength across the life course: normative data from twelve British studies. PLoS ONE 9(12):e113637. https:\/\/doi.org\/10.1371\/journal.pone.0113637","journal-title":"PLoS ONE"},{"issue":"11","key":"4367_CR14","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.1002\/jbmr.1972","volume":"28","author":"MH Edwards","year":"2013","unstructured":"Edwards\u00a0MH, Gregson\u00a0CL, Patel\u00a0HP, Jameson\u00a0KA, Harvey\u00a0NC, Sayer\u00a0AA, Dennison\u00a0EM, Cooper\u00a0C (2013) Muscle size, strength, and physical performance and their associations with bone structure in the Hertfordshire cohort study. J\u00a0Bone Miner Res 28(11):2295\u20132304. https:\/\/doi.org\/10.1002\/jbmr.1972","journal-title":"J Bone Miner Res"},{"issue":"1","key":"4367_CR15","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1007\/s11657-019-0668-0","volume":"14","author":"Y Eguchi","year":"2019","unstructured":"Eguchi\u00a0Y, Toyoguchi\u00a0T, Orita\u00a0S, Shimazu\u00a0K, Inage\u00a0K, Fujimoto\u00a0K, Suzuki\u00a0M, Norimoto\u00a0M, Umimura\u00a0T, Shiga\u00a0Y, Inoue\u00a0M, Koda\u00a0M, Furuya\u00a0T, Maki\u00a0S, Hirosawa\u00a0N, Aoki\u00a0Y, Nakamura\u00a0J, Hagiwara\u00a0S, Akazawa\u00a0T, Takahashi\u00a0H, Takahashi\u00a0K, Shiko\u00a0Y, Kawasaki\u00a0Y, Ohtori\u00a0S (2019) Reduced leg muscle mass and lower grip strength in women are associated with osteoporotic vertebral compression fractures. Arch Osteoporos 14(1):112. https:\/\/doi.org\/10.1007\/s11657-019-0668-0","journal-title":"Arch Osteoporos"},{"issue":"3","key":"4367_CR16","doi-asserted-by":"publisher","first-page":"M146","DOI":"10.1093\/gerona\/56.3.m146","volume":"56","author":"LP Fried","year":"2001","unstructured":"Fried\u00a0LP, Tangen\u00a0CM, Walston\u00a0J, Newman\u00a0AB, Hirsch\u00a0C, Gottdiener\u00a0J, Seeman\u00a0T, Tracy\u00a0R, Kop\u00a0WJ, Burke\u00a0G, McBurnie\u00a0MA (2001) Frailty in older adults: evidence for a\u00a0phenotype. J\u00a0Gerontol A Biol Sci Med Sci 56(3):M146\u201356. https:\/\/doi.org\/10.1093\/gerona\/56.3.m146","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"2","key":"4367_CR17","doi-asserted-by":"publisher","first-page":"M85","DOI":"10.1093\/geronj\/49.2.m85","volume":"49","author":"JM Guralnik","year":"1994","unstructured":"Guralnik\u00a0JM, Simonsick\u00a0EM, Ferrucci\u00a0L, Glynn\u00a0RJ, Berkman\u00a0LF, Blazer\u00a0DG, Scherr\u00a0PA, Wallace\u00a0RB (1994) A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J\u00a0Gerontol 49(2):M85\u201394. https:\/\/doi.org\/10.1093\/geronj\/49.2.m85","journal-title":"J Gerontol"},{"issue":"4","key":"4367_CR18","doi-asserted-by":"publisher","first-page":"M221","DOI":"10.1093\/gerona\/55.4.m221","volume":"55","author":"JM Guralnik","year":"2000","unstructured":"Guralnik\u00a0JM, Ferrucci\u00a0L, Pieper\u00a0CF, Leveille\u00a0SG, Markides\u00a0KS, Ostir\u00a0GV, Studenski\u00a0S, Berkman\u00a0LF, Wallace\u00a0RB (2000) Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery. J\u00a0Gerontol A Biol Sci Med Sci 55(4):M221\u201331. https:\/\/doi.org\/10.1093\/gerona\/55.4.m221","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"1","key":"4367_CR19","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.jhsb.2003.09.012","volume":"29","author":"SG Haidar","year":"2004","unstructured":"Haidar\u00a0SG, Kumar\u00a0D, Bassi\u00a0RS, Deshmukh\u00a0SC (2004) Average versus maximum grip strength: which is more consistent? J\u00a0Hand Surg Br 29(1):82\u201384. https:\/\/doi.org\/10.1016\/j.jhsb.2003.09.012","journal-title":"J Hand Surg Br"},{"issue":"1","key":"4367_CR20","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s00198-006-0206-y","volume":"18","author":"B H\u00e4ussler","year":"2007","unstructured":"H\u00e4ussler\u00a0B, Gothe\u00a0H, G\u00f6l\u00a0D, Glaeske\u00a0G, Pientka\u00a0L, Felsenberg\u00a0D (2007) Epidemiology, treatment and costs of osteoporosis in Germany\u2014the BoneEVA study. Osteoporos Int 18(1):77\u201384. https:\/\/doi.org\/10.1007\/s00198-006-0206-y","journal-title":"Osteoporos Int"},{"issue":"12","key":"4367_CR21","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1007\/s00198-006-0172-4","volume":"17","author":"O Johnell","year":"2006","unstructured":"Johnell\u00a0O, Kanis\u00a0JA (2006) An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 17(12):1726\u20131733. https:\/\/doi.org\/10.1007\/s00198-006-0172-4","journal-title":"Osteoporos Int"},{"issue":"1","key":"4367_CR22","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1007\/s11657-020-00871-9","volume":"16","author":"JA Kanis","year":"2021","unstructured":"Kanis\u00a0JA, Norton\u00a0N, Harvey\u00a0NC, Jacobson\u00a0T, Johansson\u00a0H, Lorentzon\u00a0M, McCloskey\u00a0EV, Willers\u00a0C, Borgstr\u00f6m\u00a0F (2021) SCOPE 2021: a\u00a0new scorecard for osteoporosis in Europe. Arch Osteoporos 16(1):82. https:\/\/doi.org\/10.1007\/s11657-020-00871-9","journal-title":"Arch Osteoporos"},{"issue":"2","key":"4367_CR23","doi-asserted-by":"publisher","first-page":"221.e1","DOI":"10.1016\/j.amjmed.2015.09.020","volume":"129","author":"DL Kendler","year":"2016","unstructured":"Kendler\u00a0DL, Bauer\u00a0DC, Davison\u00a0KS, Dian\u00a0L, Hanley\u00a0DA, Harris\u00a0ST, McClung\u00a0MR, Miller\u00a0PD, Schousboe\u00a0JT, Yuen\u00a0CK, Lewiecki\u00a0EM (2016) Vertebral fractures: clinical importance and management. Am J Med 129(2):221.e1\u2013221.10. https:\/\/doi.org\/10.1016\/j.amjmed.2015.09.020","journal-title":"Am J Med"},{"issue":"3","key":"4367_CR24","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1359\/jbmr.090807","volume":"25","author":"T Lang","year":"2010","unstructured":"Lang\u00a0T, Cauley\u00a0JA, Tylavsky\u00a0F, Bauer\u00a0D, Cummings\u00a0S, Harris\u00a0TB (2010) Computed tomographic measurements of thigh muscle cross-sectional area and attenuation coefficient predict hip fracture: the health, aging, and body composition study. J\u00a0Bone Miner Res 25(3):513\u2013519. https:\/\/doi.org\/10.1359\/jbmr.090807","journal-title":"J Bone Miner Res"},{"issue":"5","key":"4367_CR25","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1503\/cmaj.091278","volume":"182","author":"CHY Ling","year":"2010","unstructured":"Ling\u00a0CHY, Taekema\u00a0D, de Craen\u00a0AJM, Gussekloo\u00a0J, Westendorp\u00a0RGJ, Maier\u00a0AB (2010) Handgrip strength and mortality in the oldest old population: the Leiden 85-plus study. CMAJ 182(5):429\u2013435. https:\/\/doi.org\/10.1503\/cmaj.091278","journal-title":"CMAJ"},{"issue":"3","key":"4367_CR26","doi-asserted-by":"publisher","first-page":"9236","DOI":"10.4081\/ejtm.2020.9236","volume":"30","author":"EV Makarova","year":"2020","unstructured":"Makarova\u00a0EV, Marchenkova\u00a0LA, Eryomushkin\u00a0MA, Styazkina\u00a0EM, Chesnikova\u00a0EI (2020) Balance and muscle strength tests in patients with osteoporotic vertebral fractures to develop tailored rehabilitation programs. Eur J Transl Myol 30(3):9236. https:\/\/doi.org\/10.4081\/ejtm.2020.9236","journal-title":"Eur J Transl Myol"},{"issue":"3","key":"4367_CR27","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1017\/S0029665114000147","volume":"73","author":"C Martin-Ruiz","year":"2014","unstructured":"Martin-Ruiz\u00a0C, von Zglinicki\u00a0T (2014) Biomarkers of healthy ageing: expectations and validation. Proc Nutr Soc 73(3):422\u2013429. https:\/\/doi.org\/10.1017\/S0029665114000147","journal-title":"Proc Nutr Soc"},{"issue":"4","key":"4367_CR28","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1093\/ageing\/afr051","volume":"40","author":"HC Roberts","year":"2011","unstructured":"Roberts\u00a0HC, Denison\u00a0HJ, Martin\u00a0HJ, Patel\u00a0HP, Syddall\u00a0H, Cooper\u00a0C, Sayer\u00a0AA (2011) A review of the measurement of grip strength in clinical and epidemiological studies: towards a\u00a0standardised approach. Age Ageing 40(4):423\u2013429. https:\/\/doi.org\/10.1093\/ageing\/afr051","journal-title":"Age Ageing"},{"key":"4367_CR29","first-page":"3","volume-title":"F\u00fcnf Esslinger. Ein Bewegungsprogramm f\u00fcr Muskel-Knochen-Fitness","author":"M Runge","year":"2009","unstructured":"Runge\u00a0M (2009) F\u00fcnf Esslinger. Ein Bewegungsprogramm f\u00fcr Muskel-Knochen-Fitness, pp 3\u201313 (Patientenratgeber)"},{"issue":"1","key":"4367_CR30","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1055\/s-0040-1722121","volume":"30","author":"A Sallakhi","year":"2021","unstructured":"Sallakhi\u00a0A, Andresen\u00a0JR, Schr\u00f6der\u00a0G, Andresen\u00a0R, Schober\u00a0H\u2011C (2021) Abnehmende Handkraft als Indikator f\u00fcr eine erh\u00f6hte Sterblichkeit bei Patienten unter alleiniger spezifischer Osteoporosetherapie. Osteologie 30(1):62. https:\/\/doi.org\/10.1055\/s-0040-1722121","journal-title":"Osteologie"},{"issue":"1","key":"4367_CR31","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/s12891-018-2021-y","volume":"19","author":"B Stanghelle","year":"2018","unstructured":"Stanghelle\u00a0B, Bentzen\u00a0H, Giangregorio\u00a0L, Pripp\u00a0AH, Bergland\u00a0A (2018) Effect of a\u00a0resistance and balance exercise programme for women with osteoporosis and vertebral fracture: study protocol for a\u00a0randomized controlled trial. BMC Musculoskelet Disord 19(1):100. https:\/\/doi.org\/10.1186\/s12891-018-2021-y","journal-title":"BMC Musculoskelet Disord"},{"issue":"10","key":"4367_CR32","doi-asserted-by":"publisher","first-page":"e0163917","DOI":"10.1371\/journal.pone.0163917","volume":"11","author":"N Steiber","year":"2016","unstructured":"Steiber\u00a0N (2016) Strong or weak handgrip? Normative reference values for the German population across the life course stratified by sex, age, and body height. PLoS ONE 11(10):e163917. https:\/\/doi.org\/10.1371\/journal.pone.0163917","journal-title":"PLoS ONE"},{"issue":"2","key":"4367_CR33","doi-asserted-by":"publisher","first-page":"e8","DOI":"10.2106\/JBJS.L.00568","volume":"95","author":"A Unnanuntana","year":"2013","unstructured":"Unnanuntana\u00a0A, Saleh\u00a0A, Mensah\u00a0KA, Kleimeyer\u00a0JP, Lane\u00a0JM (2013) Atypical femoral fractures: what do we know about them?: AAOS exhibit selection. J\u00a0Bone Joint Surg Am 95(2):e8. https:\/\/doi.org\/10.2106\/JBJS.L.00568","journal-title":"J Bone Joint Surg Am"},{"issue":"4","key":"4367_CR34","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1111\/jgs.15716","volume":"67","author":"J Zanker","year":"2019","unstructured":"Zanker\u00a0J, Duque\u00a0G (2019) Osteoporosis in older persons: old and new players. J\u00a0Am Geriatr Soc 67(4):831\u2013840. https:\/\/doi.org\/10.1111\/jgs.15716","journal-title":"J Am Geriatr Soc"}],"container-title":["Die Orthop\u00e4die"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00132-023-04367-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00132-023-04367-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00132-023-04367-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T12:04:18Z","timestamp":1701432258000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00132-023-04367-5"}},"subtitle":["A\u00a0real-world study","Eine Real-World-Studie"],"short-title":[],"issued":{"date-parts":[[2023,4,24]]},"references-count":34,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["4367"],"URL":"https:\/\/doi.org\/10.1007\/s00132-023-04367-5","relation":{},"ISSN":["2731-7145","2731-7153"],"issn-type":[{"value":"2731-7145","type":"print"},{"value":"2731-7153","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,24]]},"assertion":[{"value":"7 February 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"G.\u00a0Schr\u00f6der, I.\u00a0Hoth, D.\u00a0Flachsmeyer, M.\u00a0Dutzke, J.R.\u00a0Andresen, R.\u00a0Andresen and H.-C.\u00a0Schober declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants or on human tissue were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1975 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}