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In einer gro\u00dfen Studie untersuchen wir m\u00f6gliche Einflussfaktoren der PRP-Zusammensetzung. Die hier ausgegliederten Ergebnisse zeigen, dass die Konzentrationen von IL\u20116, nicht aber die von IGF\u20111 oder der zellul\u00e4ren Bestandteile, im PRP von Veganern gegen\u00fcber Omnivoren signifikant und gegen\u00fcber Vegetariern tendenziell verringert waren. Dies legt nahe, dass die Ern\u00e4hrung einen bedeutenden Einfluss auf therapeutisch aktive PRP-Bestandteile haben kann. Hingegen schienen die hier untersuchten Komponenten nicht wesentlich durch den Blutentnahmezeitpunkt beeinflusst zu sein. Die Identifikation wesentlicher Einflussgr\u00f6\u00dfen auf die PRP-Zusammensetzung wird essenziell sein, um eine ausreichende medizinische Evidenz f\u00fcr den therapeutischen Effekt von PRP bei orthop\u00e4dischen Erkrankungsbildern zu generieren.<\/jats:p>","DOI":"10.1007\/s00132-023-04442-x","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T14:02:06Z","timestamp":1697464926000},"page":"907-915","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["\u201ePlatelet-rich plasma\u201c (PRP)","Platelet-rich plasma (PRP)"],"prefix":"10.1007","volume":"52","author":[{"given":"Hadrian","family":"Platzer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina Dorothea","family":"Kubon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solvig","family":"Diederichs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alena","family":"Bork","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Gantz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Schiltenwolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Renkawitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannic","family":"Bangert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,16]]},"reference":[{"key":"4442_CR1","first-page":"1441","volume":"11","author":"NE Allen","year":"2002","unstructured":"Allen\u00a0NE, Appleby\u00a0PN, Davey\u00a0GK et al (2002) The associations of diet with serum insulin-like growth factor I and its main binding proteins in 292 women meat-eaters, vegetarians, and vegans. 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T.\u00a0Renkawitz gibt als finanzielle Interessen an: Forschungsf\u00f6rderung zur pers\u00f6nlichen Verf\u00fcgung: DePuy, Zimmer, Aesculap, Bundesministerium f\u00fcr Bildung und Forschung, Deutsche Arthrose-Hilfe, Otto-Bock-Stiftung, Bundesministerium f\u00fcr wirtschaftliche Zusammenarbeit und Entwicklung, Stiftung Oskar-Helene-Heim in Berlin, Vielberth-Stiftung, Deutsche Forschungsgemeinschaft (DFG). Kostenerstattungen: DePuy, Zimmer, Aesculap, Bundesministerium f\u00fcr Bildung und Forschung, Deutsche Arthrose-Hilfe, Otto-Bock-Stiftung, Bundesministerium f\u00fcr wirtschaftliche Zusammenarbeit und Entwicklung, Stiftung Oskar-Helene-Heim in Berlin, Vielberth-Stiftung, DGOOC, BVOU, DGOU. Kostenerstattungen f\u00fcr Schulungen\/Vortr\u00e4ge: DePuy, Zimmer, Aesculap, Deutsche Gesellschaft f\u00fcr Endoprothetik (AE), Bayerischer Haus\u00e4rzteverband. T.\u00a0Renkawitz gibt als nichtfinanzielle Interessen an: Lehrstuhlinhaber (W3) f\u00fcr Orthop\u00e4dische Chirurgie, Universit\u00e4t Heidelberg, Direktor der Orthop\u00e4dischen Universit\u00e4tsklinik Heidelberg. Mitgliedschaften: Vizepr\u00e4sident des Berufsverband f\u00fcr Orthop\u00e4die und Unfallchirurgie (BVOU), Gesamtvorstand der DGOOC, Leiter der \u201eArbeitsgemeinschaft Evidenzbasierte Medizin\u201c der DGOU, Herausgeberboard von <i>Die Orthop\u00e4die<\/i> und <i>Die Unfallchirurgie<\/i> (Springer Medizin), Schriftleitung der <i>Orthop\u00e4die und Unfallchirurgie\u00a0\u2013 Mitteilungen und Nachrichten<\/i> (OUMN), International Advisory Board des <i>Journal of the American Academy of Orthopaedic Surgeons<\/i> (AAOS).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"Alle beschriebenen Untersuchungen am Menschen oder an menschlichem Gewebe wurden mit Zustimmung der Ethikkommission der Medizinischen Fakult\u00e4t Heidelberg (Genehmigungsnummer: S 631\/2021) genehmigt, im Einklang mit nationalem Recht sowie gem\u00e4\u00df der Deklaration von Helsinki von 1975 (in der aktuellen, \u00fcberarbeiteten Fassung) durchgef\u00fchrt. Von allen beteiligten Probanden liegt eine Einverst\u00e4ndniserkl\u00e4rung vor.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}