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Im Gegensatz zur Revisionsendoprothetik ist es technisch weniger invasiv und kann bei geeigneter Indikation den Erhalt einer fest verankerten Endoprothese erm\u00f6glichen. Der Therapieerfolg h\u00e4ngt jedoch von einer Vielzahl patienten-, keim- und operationsbezogener Faktoren ab.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methoden<\/jats:title>\n            <jats:p>Basierend auf einer umfassenden Literaturrecherche aktueller internationaler Studien und Leitlinien wurden die entscheidenden Einflussgr\u00f6\u00dfen f\u00fcr den Erfolg eines DAIR-Verfahrens systematisch dargestellt. Zus\u00e4tzlich wurden klinische Erfahrungen aus der eigenen orthop\u00e4dischen Klinik, insbesondere bei Infektionen mit Staphylokokken, ausgewertet und eingebunden.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Ergebnisse<\/jats:title>\n            <jats:p>Die Analyse identifizierte entscheidende Erfolgsfaktoren f\u00fcr das DAIR-Verfahren: fr\u00fchzeitige Intervention innerhalb von 3\u00a0Wochen nach Symptombeginn, Austausch aller mobilen Komponenten, stabiles Implantat, intakter Weichteilmantel sowie die Ber\u00fccksichtigung von Risikofaktoren wie hohes Alter, immunsuppressive Therapie, COPD oder rheumatoide Arthritis. Die Wahl des antibiotischen Regimes, insbesondere die Kombination mit Rifampicin bei Staphylokokken-Infektionen, beeinflusst das Outcome wesentlich.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Schlussfolgerung<\/jats:title>\n            <jats:p>DAIR kann unter definierten Voraussetzungen eine effektive Therapieoption mit guten Heilungschancen darstellen. Eine sorgf\u00e4ltige Patientenselektion, multidisziplin\u00e4re Fallbesprechung und konsequente Umsetzung chirurgischer und antiinfektiver Standards sind essenziell, um die Erfolgsrate zu verbessern. Bei ung\u00fcnstiger Ausgangslage sollte jedoch ein direkter Prothesenwechsel in Erw\u00e4gung gezogen werden.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00132-025-04716-6","type":"journal-article","created":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T12:43:50Z","timestamp":1757162630000},"page":"777-784","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Debridement, antimikrobielle Therapie und Implantaterhalt bei akuten periprothetischen Infektionen","Debridement, antimicrobial therapy, and implant retention for acute periprosthetic infections"],"prefix":"10.1007","volume":"54","author":[{"given":"Dirk","family":"M\u00fcller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Kirschner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Schlo\u00dfmacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00fcdiger","family":"von Eisenhart-Rothe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Lazic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,6]]},"reference":[{"key":"4716_CR1","doi-asserted-by":"publisher","first-page":"S399","DOI":"10.1016\/j.arth.2018.09.025","volume":"34","author":"JN Argenson","year":"2019","unstructured":"Argenson\u00a0JN, Arndt\u00a0M, Babis\u00a0G et\u00a0al (2019) Hip and Knee Section, Treatment, Debridement and Retention of Implant: Proceedings of International Consensus on Orthopedic Infections. 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