{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T10:32:18Z","timestamp":1774348338555,"version":"3.50.1"},"reference-count":6,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"},{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"}],"funder":[{"DOI":"10.13039\/501100014584","name":"Universit\u00e4tsmedizin der Johannes Gutenberg-Universit\u00e4t Mainz","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014584","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Orthop\u00e4die"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Denosumab ist f\u00fcr die Therapie der Osteoporose und ausgew\u00e4hlter Knochentumoren zugelassen, und seine Wirksamkeit ist in der Literatur gut dokumentiert. Bei Kindern erfolgt der Einsatz zur Behandlung benigner Knochentumoren jedoch off-label. Wir berichten \u00fcber einen 13-j\u00e4hrigen Jungen mit aneurysmatischer Knochenzyste des Humerus, der nach Beendigung einer supportiven Denosumab-Therapie eine ausgepr\u00e4gte Hyperkalz\u00e4mie entwickelte. Der Patient wurde erfolgreich mit intraven\u00f6ser Fl\u00fcssigkeitstherapie, Kaliumsubstitution, Zoledronat und Furosemid behandelt. Dieser Fall verdeutlicht die Notwendigkeit einer engmaschigen Kontrolle des Calcium- und Knochenstoffwechsels bei Kindern und Jugendlichen w\u00e4hrend und nach Denosumab-Therapie.<\/jats:p>","DOI":"10.1007\/s00132-025-04745-1","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T12:02:23Z","timestamp":1764072143000},"page":"328-332","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rebound-Hyperkalz\u00e4mie nach Denosumab-Therapie bei einem 13-j\u00e4hrigen Jungen mit aneurysmatischer Knochenzyste des Humerus\u00a0\u2013 ein Fallbericht","Rebound hypercalcemia after denosumab therapy in a 13-year-old boy with an aneurysmal bone cyst of the humerus\u2014a case report"],"prefix":"10.1007","volume":"55","author":[{"given":"Beatrice","family":"Jung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Traub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tilmann","family":"Busse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eren","family":"Demir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"issue":"10","key":"4745_CR1","first-page":"222","volume":"28","author":"HG Bone","year":"2013","unstructured":"Bone\u00a0HG et\u00a0al (2013) Denosumab treatment: adverse effects and comparison with bisphosphonates. J\u00a0Bone\u00a0Miner Res 28(10):222\u2013234","journal-title":"J Bone Miner Res"},{"issue":"2","key":"4745_CR2","first-page":"507","volume":"27","author":"MR McClung","year":"2016","unstructured":"McClung\u00a0MR (2016) Rebound phenomena after discontinuation of Denosumab therapy. Osteoporos Int 27(2):507\u2013511","journal-title":"Osteoporos Int"},{"key":"4745_CR3","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.bone.2017.04.015","volume":"101","author":"O Lamy","year":"2017","unstructured":"Lamy\u00a0O et\u00a0al (2017) Management of Denosumab discontinuation: prevention of rebound-associated fractures. Bone 101:123\u2013129","journal-title":"Bone"},{"issue":"11","key":"4745_CR4","doi-asserted-by":"publisher","first-page":"3954","DOI":"10.1210\/jc.2014-3072","volume":"99","author":"-","year":"2014","unstructured":"- (2014) J\u00a0Clin Endocrinol Metab 99(11):3954\u20133955. https:\/\/doi.org\/10.1210\/jc.2014-3072","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"4745_CR5","doi-asserted-by":"publisher","first-page":"2485","DOI":"10.1007\/s00198-020-05676-7","volume":"31","author":"-","year":"2020","unstructured":"- (2020) Osteoporos Int 31(12):2485\u20132491. https:\/\/doi.org\/10.1007\/s00198-020-05676-7","journal-title":"Osteoporos Int"},{"key":"4745_CR6","unstructured":"(2024) Annals of Clinical Case Reports. 9:2643"}],"container-title":["Die Orthop\u00e4die"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00132-025-04745-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00132-025-04745-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00132-025-04745-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T07:34:19Z","timestamp":1774337659000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00132-025-04745-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":6,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["4745"],"URL":"https:\/\/doi.org\/10.1007\/s00132-025-04745-1","relation":{},"ISSN":["2731-7145","2731-7153"],"issn-type":[{"value":"2731-7145","type":"print"},{"value":"2731-7153","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,25]]},"assertion":[{"value":"16 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"B.\u00a0Jung, F.\u00a0Traub, T.\u00a0Busse und E.\u00a0Demir geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autor\/-innen keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. F\u00fcr Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts, \u00fcber die Patient\/-innen zu identifizieren sind, liegt von ihnen und\/oder ihren gesetzlichen Vertretern\/Vertreterinnen eine schriftliche Einwilligung vor.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}