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Neben einer ad\u00e4quaten chirurgischen Strategie kommt insbesondere einer m\u00f6glichst erregergerichteten sowie patientenindividuell angepassten antiinfektiven Therapie eine zentrale Bedeutung zu.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methoden<\/jats:title>\n                    <jats:p>Auf Grundlage einer umfassenden Literatur- und Leitlinienrecherche sowie einer anschlie\u00dfenden Konsensbildung innerhalb der interdisziplin\u00e4ren Arbeitsgruppe der \u201eDeutschen Gesellschaft f\u00fcr Endoprothetik e.\u202fV.\u201c wurden bestehende Therapieoptionen bewertet und konsentierte Handlungsempfehlungen zur antiinfektiven Therapie periprothetischer Infektionen erarbeitet.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ergebnisse<\/jats:title>\n                    <jats:p>Die Basis der Behandlung periprothetischer Infektionen bildet die chirurgische Sanierung in Kombination mit einer initial kalkulierten und anschlie\u00dfend gezielten Antibiotikatherapie. Staphylokokken stellen die h\u00e4ufigsten Erreger dar; hierbei kommt dem biofilmwirksamen Antibiotikum Rifampicin eine wesentliche Rolle zu. Fluorchinolone werden insbesondere bei Infektionen mit gramnegativen Erregern eingesetzt, finden jedoch auch als Kombinationspartner von Rifampicin bei Infektionen die durch Staphylokokken verursacht sind Anwendung. F\u00fcr weitere klinisch relevante Erregergruppen wurden differenzierte konsentierte Therapieempfehlungen formuliert. Die empfohlene Gesamtdauer der antibiotischen Therapie betr\u00e4gt in der Regel etwa 12\u00a0Wochen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Schlussfolgerung<\/jats:title>\n                    <jats:p>Die antiinfektive Therapie ist eine wichtige S\u00e4ule f\u00fcr die erfolgreiche Therapie der periprothetischen Infektion. Ein individualisiertes, an das chirurgische Behandlungskonzept angepasstes Vorgehen ist dabei erforderlich.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00132-026-04851-8","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T08:08:04Z","timestamp":1789114084000},"page":"812-821","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antiinfektive Therapie der periprothetischen Infektion","Antimicrobial therapy of periprosthetic joint infection"],"prefix":"10.1007","volume":"55","author":[{"given":"Susanne","family":"Feihl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Meller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Gramlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"von Eisenhart-Rothe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Hube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Rad\u00fcnzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Otchwemah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Hischebeth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"4851_CR1","unstructured":"Abele-Horn M, Novotny A, Bader L et\u00a0al. 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