{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T20:56:07Z","timestamp":1769201767413,"version":"3.49.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T00:00:00Z","timestamp":1097539200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T00:00:00Z","timestamp":1097539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intensive Care Med"],"published-print":{"date-parts":[[2004,12]]},"DOI":"10.1007\/s00134-004-2463-6","type":"journal-article","created":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T11:55:01Z","timestamp":1097495701000},"page":"2180-2187","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Sustained moderate reductions in arterial CO2 after brain trauma Time-course of cerebral blood flow velocity and intracranial pressure"],"prefix":"10.1007","volume":"30","author":[{"given":"Luzius A.","family":"Steiner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcella","family":"Balestreri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Czosnyka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan P.","family":"Coles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doris A.","family":"Chatfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Smielewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Pickard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David K.","family":"Menon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2004,10,12]]},"reference":[{"key":"2463_CR1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1748-1716.1987.tb08054.x","volume":"129","author":"Ellingsen","year":"1987","unstructured":"Ellingsen I, Hauge A, Nicolaysen G, Thoresen M, Walloe L (1987) Changes in human cerebral blood flow due to step changes in PAO2 and PACO2. Acta Physiol Scand 129:157\u2013163","journal-title":"Acta Physiol Scand"},{"key":"2463_CR2","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1152\/jappl.1998.85.2.388","volume":"85","author":"Poulin","year":"1998","unstructured":"Poulin MJ, Liang PJ, Robbins PA (1998) Fast and slow components of cerebral blood flow response to step decreases in end-tidal PCO2 in humans. J Appl Physiol 85:388\u2013397","journal-title":"J Appl Physiol"},{"key":"2463_CR3","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1001\/archneur.1970.00480290014002","volume":"23","author":"Raichle","year":"1970","unstructured":"Raichle ME, Posner JB, Plum F (1970) Cerebral blood flow during and after hyperventilation. Arch Neurol 23:394\u2013403","journal-title":"Arch Neurol"},{"key":"2463_CR4","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1176\/appi.neuropsych.13.1.22","volume":"13","author":"Maddock","year":"2001","unstructured":"Maddock RJ (2001) The lactic acid response to alkalosis in panic disorder : an integrative review. J Neuropsychiatry Clin Neurosci 13:22\u201334","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"2463_CR5","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1056\/NEJM197006252822606","volume":"282","author":"Shenkin","year":"1970","unstructured":"Shenkin HA, Bouzarth WF (1970) Clinical methods of reducing intracranial pressure. Role of the cerebral circulation. N Engl J Med 282:1465\u20131471","journal-title":"N Engl J Med"},{"key":"2463_CR6","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1097\/00000542-197510000-00010","volume":"43","author":"Shapiro","year":"1975","unstructured":"Shapiro HM (1975) Intracranial hypertension: therapeutic and anesthetic considerations. Anesthesiology 43:445\u2013471","journal-title":"Anesthesiology"},{"key":"2463_CR7","unstructured":"Ropper AH (1993) Treatment of intracranial hypertension. In: Ropper AH (ed) Neurological and Neurosurgical Intensive Care. Raven, New York, pp 29\u201352"},{"key":"2463_CR8","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0749-0704(05)70300-6","volume":"13","author":"Yundt","year":"1997","unstructured":"Yundt KD, Diringer MN (1997) The use of hyperventilation and its impact on cerebral ischemia in the treatment of traumatic brain injury. Crit Care Clin 13:163\u2013184","journal-title":"Crit Care Clin"},{"key":"2463_CR9","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3171\/jns.1984.61.2.0241","volume":"61","author":"Obrist","year":"1984","unstructured":"Obrist WD, Langfitt TW, Jaggi JL, Cruz J, Gennarelli TA (1984) Cerebral blood flow and metabolism in comatose patients with acute head injury. Relationship to intracranial hypertension. J Neurosurg 61:241\u2013253","journal-title":"J Neurosurg"},{"key":"2463_CR10","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1399-6576.1977.tb01232.x","volume":"21","author":"Cold","year":"1977","unstructured":"Cold GE, Jensen FT, Malmros R (1977) The cerebrovascular CO2 reactivity during the acute phase of brain injury. Acta Anaesthesiol Scand 21:222\u2013231","journal-title":"Acta Anaesthesiol Scand"},{"key":"2463_CR11","doi-asserted-by":"crossref","first-page":"731","DOI":"10.3171\/jns.1991.75.5.0731","volume":"75","author":"Muizelaar","year":"1991","unstructured":"Muizelaar JP, Marmarou A, Ward JD, Kontos HA, Choi SC, Becker DP, Gruemer H, Young HF (1991) Adverse effects of prolonged hyperventilation in patients with severe head injury: a randomized clinical trial. J Neurosurg 75:731\u2013739","journal-title":"J Neurosurg"},{"key":"2463_CR12","unstructured":"http:\/\/www2.braintrauma.org\/guidelines\/ (accessed 28th July 2004)."},{"key":"2463_CR13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3171\/jns.1999.91.1.0011","volume":"91","author":"Czosnyka","year":"1999","unstructured":"Czosnyka M, Smielewski P, Piechnik S, Schmidt EA, Al-Rawi PG, Kirkpatrick PJ, Pickard JD (1999) Hemodynamic characterization of intracranial pressure plateau waves in head-injury patients. J Neurosurg 91:11\u201319","journal-title":"J Neurosurg"},{"key":"2463_CR14","doi-asserted-by":"publisher","first-page":"P074","DOI":"10.1186\/cc1963","volume":"7","author":"Steiner","year":"2003","unstructured":"Steiner LA, Balestreri M, Johnston AJ, Czosnyka M, Coles JP, Pickard JD, Menon DK (2003) Hyperventilation-induced reductions in cerebral blood flow velocity outlive the reduction in intracranial pressure in head-injured patients. Crit Care 7:P074","journal-title":"Crit Care"},{"key":"2463_CR15","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1007\/s00134-002-1235-4","volume":"28","author":"Patel","year":"2002","unstructured":"Patel HC, Menon DK, Tebbs S, Hawker R, Hutchinson PJ, Kirkpatrick PJ (2002) Specialist neurocritical care and outcome from head injury. Intensive Care Med 28:547\u2013553","journal-title":"Intensive Care Med"},{"key":"2463_CR16","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/S0140-6736(75)92830-5","volume":"1","author":"Jennett","year":"1975","unstructured":"Jennett B, Bond M (1975) Assessment of outcome after severe brain damage. Lancet 1:480\u2013484","journal-title":"Lancet"},{"key":"2463_CR17","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1097\/00000542-199506000-00035","volume":"82","author":"Lam","year":"1995","unstructured":"Lam AM (1995) Intraoperative transcranial Doppler monitoring. Anesthesiology 82:1536\u20131537","journal-title":"Anesthesiology"},{"key":"2463_CR18","unstructured":"Zablotny W, Czosnyka M, Smielewski P (1994) Portable software for intracranial pressure recording and waveform analysis. In: Nagai H, Kamiya K, Ishii S (eds) Intracranial Pressure IX. Springer, Tokyo, pp 439\u2013440"},{"key":"2463_CR19","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1034\/j.1399-6576.2003.00078.x","volume":"47","author":"Johnston","year":"2003","unstructured":"Johnston AJ, Steiner LA, Balestreri M, Gupta AK, Menon DK (2003) Hyperoxia and the cerebral hemodynamic responses to moderate hyperventilation. Acta Anaesthesiol Scand 47:391\u2013396","journal-title":"Acta Anaesthesiol Scand"},{"key":"2463_CR20","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1161\/01.STR.28.12.2353","volume":"28","author":"Kastrup","year":"1997","unstructured":"Kastrup A, Thomas C, Hartmann C, Schabet M (1997) Sex dependency of cerebrovascular CO2 reactivity in normal subjects. Stroke 28:2353\u20132356","journal-title":"Stroke"},{"key":"2463_CR21","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1097\/00000542-199211000-00006","volume":"77","author":"Eng","year":"1992","unstructured":"Eng C, Lam AM, Mayberg TS, Lee C, Mathisen T (1992) The influence of propofol with and without nitrous oxide on cerebral blood flow velocity and CO2 reactivity in humans. Anesthesiology 77:872\u2013879","journal-title":"Anesthesiology"},{"key":"2463_CR22","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1213\/00000539-199405000-00009","volume":"78","author":"Strebel","year":"1994","unstructured":"Strebel S, Kaufmann M, Guardiola PM, Schaefer HG (1994) Cerebral vasomotor responsiveness to carbon dioxide is preserved during propofol and midazolam anesthesia in humans. Anesth Analg 78:884\u2013888","journal-title":"Anesth Analg"},{"key":"2463_CR23","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/jcbfm.1987.90","volume":"7","author":"Artru","year":"1987","unstructured":"Artru AA (1987) Reduction of cerebrospinal fluid pressure by hypocapnia: changes in cerebral blood volume, cerebrospinal fluid volume, and brain tissue water and electrolytes. J Cereb Blood Flow Metab 7:471\u2013479","journal-title":"J Cereb Blood Flow Metab"},{"key":"2463_CR24","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/00006123-199601000-00007","volume":"38","author":"van","year":"1996","unstructured":"van Santbrink H, Maas AI, Avezaat CJ (1996) Continuous monitoring of partial pressure of brain tissue oxygen in patients with severe head injury. Neurosurgery 38:21\u201331","journal-title":"Neurosurgery"},{"key":"2463_CR25","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.1097\/00003246-200009000-00024","volume":"28","author":"Carmona","year":"2000","unstructured":"Carmona Suazo JA, Maas AI, van den Brink WA, van Santbrink H, Steyerberg EW, Avezaat CJ (2000) CO2 reactivity and brain oxygen pressure monitoring in severe head injury. Crit Care Med 28:3268\u20133274","journal-title":"Crit Care Med"},{"key":"2463_CR26","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1097\/00006123-200101000-00043","volume":"95","author":"Lee","year":"2001","unstructured":"Lee JH, Kelly DF, Oertel M, McArthur DL, Glenn TC, Vespa P, Boscardin WJ, Martin NA (2001) Carbon dioxide reactivity, pressure autoregulation, and metabolic suppression reactivity after head injury: a transcranial Doppler study. J Neurosurg 95:222\u2013232","journal-title":"J Neurosurg"}],"container-title":["Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-004-2463-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00134-004-2463-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-004-2463-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-004-2463-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T01:34:12Z","timestamp":1744162452000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00134-004-2463-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10,12]]},"references-count":26,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["2463"],"URL":"https:\/\/doi.org\/10.1007\/s00134-004-2463-6","relation":{},"ISSN":["0342-4642","1432-1238"],"issn-type":[{"value":"0342-4642","type":"print"},{"value":"1432-1238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,10,12]]},"assertion":[{"value":"30 April 2004","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2004","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2004","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}