{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:49:17Z","timestamp":1791888557955,"version":"4.3.4"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2006,2,17]],"date-time":"2006-02-17T00:00:00Z","timestamp":1140134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intensive Care Med"],"published-print":{"date-parts":[[2006,4]]},"DOI":"10.1007\/s00134-006-0070-4","type":"journal-article","created":{"date-parts":[[2006,2,16]],"date-time":"2006-02-16T08:28:55Z","timestamp":1140078535000},"page":"516-523","source":"Crossref","is-referenced-by-count":171,"title":["Sublingual capnometry tracks microcirculatory changes in septic patients"],"prefix":"10.1007","volume":"32","author":[{"given":"Jacques","family":"Creteur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"De Backer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser","family":"Sakr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Vincent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,2,17]]},"reference":[{"key":"70_CR1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/BF01704701","volume":"20","author":"MG Mythen","year":"1994","unstructured":"Mythen\u202fMG, Webb AR (1994) The role of gut mucosal hypoperfusion in the pathogenesis of post-operative organ dysfunction. Intensive Care Med 20:203\u2013209","journal-title":"Intensive Care Med"},{"key":"70_CR2","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1164\/ajrccm.157.6.9710029","volume":"157","author":"Y Nakagawa","year":"1998","unstructured":"Nakagawa Y, Weil MH, Tang W, Sun S, Yamaguchi H, Jin X, Bisera J (1998) Sublingual capnometry for diagnosis and quantitation of circulatory shock. Am J Respir Crit Care Med 157:1838\u20131843","journal-title":"Am J Respir Crit Care Med"},{"key":"70_CR3","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1378\/chest.118.4.1127","volume":"118","author":"HP Povoas","year":"2000","unstructured":"Povoas HP, Weil MH, Tang W, Moran B, Kamohara T, Bisera J (2000) Comparisons between sublingual and gastric tonometry during hemorrhagic shock. Chest 118:1127\u20131132","journal-title":"Chest"},{"key":"70_CR4","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1152\/jappl.1998.85.6.2360","volume":"85","author":"X Jin","year":"1998","unstructured":"Jin X, Weil MH, Sun S, Tang W, Bisera J, Mason EJ (1998) Decreases in organ blood flows associated with increases in sublingual PCO2 during hemorrhagic shock. J Appl Physiol 85:2360\u20132364","journal-title":"J Appl Physiol"},{"key":"70_CR5","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1097\/00003246-199907000-00001","volume":"27","author":"MH Weil","year":"1999","unstructured":"Weil MH, Nakagawa Y, Tang W, Sato Y, Ercoli F, Finegan R, Grayman G, Bisera J (1999) Sublingual capnometry: a new noninvasive measurement for diagnosis and quantitation of severity of circulatory shock. Crit Care Med 27:1225\u20131229","journal-title":"Crit Care Med"},{"key":"70_CR6","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1378\/chest.120.3.923","volume":"120","author":"PE Marik","year":"2001","unstructured":"Marik PE (2001) Sublingual capnography: a clinical validation study. Chest 120:923\u2013927","journal-title":"Chest"},{"key":"70_CR7","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1097\/01.CCM.0000054862.74829.EA","volume":"31","author":"PE Marik","year":"2003","unstructured":"Marik PE, Bankov A (2003) Sublingual capnometry versus traditional markers of tissue oxygenation in critically ill patients. Crit Care Med 31:818\u2013822","journal-title":"Crit Care Med"},{"key":"70_CR8","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1007\/s00134-004-2416-0","volume":"30","author":"AT Maciel","year":"2004","unstructured":"Maciel AT, Creteur J, Vincent JL (2004) Tissue capnometry: does the answer lie under the tongue? Intensive Care Med 30:2157\u20132165","journal-title":"Intensive Care Med"},{"key":"70_CR9","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1007\/s00134-003-1954-1","volume":"29","author":"R Knuesel","year":"2003","unstructured":"Knuesel R, Jakob SM, Brander L, Bracht H, Siegenthaler A, Takala J (2003) Changes in regional blood flow and pCO(2) gradients during isolated abdominal aortic blood flow reduction. Intensive Care Med 29:2255\u20132265","journal-title":"Intensive Care Med"},{"key":"70_CR10","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1097\/00003246-199507000-00011","volume":"23","author":"TJ VanderMeer","year":"1995","unstructured":"VanderMeer TJ, Wang H, Fink MP (1995) Endotoxemia causes ileal mucosal acidosis in the absence of mucosal hypoxia in a normodynamic porcine model of septic shock. Crit Care Med 23:1217\u20131226","journal-title":"Crit Care Med"},{"key":"70_CR11","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/13529","volume":"5","author":"W Groner","year":"1999","unstructured":"Groner W, Winkelman JW, Harris AG, Ince C, Bouma GJ, Messmer K, Nadeau RG (1999) Orthogonal polarization spectral imaging: a new method for study of the microcirculation. Nat Med 5:1209\u20131212","journal-title":"Nat Med"},{"key":"70_CR12","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1164\/rccm.200109-016OC","volume":"166","author":"D Backer de","year":"2002","unstructured":"De Backer D, Creteur J, Preiser JC, Dubois MJ, Vincent JL (2002) Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med 166:98\u2013104","journal-title":"Am J Respir Crit Care Med"},{"key":"70_CR13","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1097\/01.CCM.0000138558.16257.3F","volume":"32","author":"Y Sakr","year":"2004","unstructured":"Sakr Y, Dubois MJ, De Backer D, Creteur J, Vincent JL (2004) Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock. Crit Care Med 32:1825\u20131831","journal-title":"Crit Care Med"},{"key":"70_CR14","doi-asserted-by":"crossref","first-page":"S151","DOI":"10.1007\/s00134-004-2508-x","volume":"31","author":"J Creteur","year":"2005","unstructured":"Creteur J, De Backer D, Sakr Y, Koch M, Vincent JL (2005) Alterations in sublingual microcirculation are representative of other areas in septic shock. Intensive Care Med 31:S151 (abst)","journal-title":"Intensive Care Med"},{"key":"70_CR15","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1007\/s00134-003-1662-x","volume":"29","author":"MM Levy","year":"2003","unstructured":"Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G (2003) 2001 SCCM\/ESICM\/ACCP\/ATS\/SIS International Sepsis Definitions Conference. Intensive Care Med 29:530\u2013538","journal-title":"Intensive Care Med"},{"key":"70_CR16","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1097\/00003246-198510000-00009","volume":"13","author":"WA Knaus","year":"1985","unstructured":"Knaus WA, Draper EA, Wagner DP, Zimmerman JE (1985) APACHE II: A severity of disease classification system. Crit Care Med 13:818\u2013829","journal-title":"Crit Care Med"},{"key":"70_CR17","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/BF01709751","volume":"22","author":"JL Vincent","year":"1996","unstructured":"Vincent JL, Moreno R, Takala J, Willatts S, de Mendon\u00e7a A, Bruining H, Reinhart CK, Suter PM, Thijs LG (1996) The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction\/failure. Intensive Care Med 22:707\u2013710","journal-title":"Intensive Care Med"},{"key":"70_CR18","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0883-9441(97)90043-5","volume":"12","author":"A Secchi","year":"1997","unstructured":"Secchi A, Wellmann R, Martin E, Schmidt H (1997) Dobutamine maintains intestinal villus blood flow during normotensive endotoxemia: an intravital microscopic study in the rat. J Crit Care 12:137\u2013141","journal-title":"J Crit Care"},{"key":"70_CR19","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1097\/00003246-199902000-00048","volume":"27","author":"WS Madorin","year":"1999","unstructured":"Madorin WS, Martin CM, Sibbald WJ (1999) Dopexamine attenuates flow motion in ileal mucosal arterioles in normotensive sepsis. Crit Care Med 27:394\u2013400","journal-title":"Crit Care Med"},{"key":"70_CR20","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1097\/00003246-199607000-00028","volume":"24","author":"H Schmidt","year":"1996","unstructured":"Schmidt H, Secchi A, Wellmann R, Bach A, Bohrer H, Martin E (1996) Dopexamine maintains intestinal villus blood flow during endotoxemia in rats. Crit Care Med 24:1233\u20131237","journal-title":"Crit Care Med"},{"key":"70_CR21","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1097\/00003246-200103000-00023","volume":"29","author":"A Secchi","year":"2001","unstructured":"Secchi A, Ortanderl JM, Schmidt W, Walther A, Gebhard MM, Martin E, Schmidt H (2001) Effects of dobutamine and dopexamine on hepatic micro- and macrocirculation during experimental endotoxemia: an intravital microscopic study in the rat. Crit Care Med 29:597\u2013600","journal-title":"Crit Care Med"},{"key":"70_CR22","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1164\/ajrccm.154.6.8970355","volume":"154","author":"R Nevi\u00e8re","year":"1996","unstructured":"Nevi\u00e8re R, Mathieu D, Chagnon JL, Lebleu N, Wattel F (1996) The contrasting effects of dobutamine and dopamine on gastric mucosal perfusion in septic patients. Am J Respir Crit Care Med 154:1684\u20131688","journal-title":"Am J Respir Crit Care Med"},{"key":"70_CR23","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1097\/00003246-199905000-00021","volume":"27","author":"J Duranteau","year":"1999","unstructured":"Duranteau J, Sitbon P, Teboul JL, Vicaut E, Anguel N, Richard C, Samii K (1999) Effects of epinephrine, norepinephrine, or the combination of norepinephrine and dobutamine on gastric mucosa in septic shock. Crit Care Med 27:893\u2013900","journal-title":"Crit Care Med"},{"key":"70_CR24","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1136\/pgmj.67.783.42","volume":"67","author":"F Christ","year":"1991","unstructured":"Christ F, Gartside IB, Kox WJ, Gamble J (1991) The assessment of the microcirculatory effects of dobutamine using mercury in silastic strain gauge plethysmography in man. Postgrad Med J 67:S42-S50","journal-title":"Postgrad Med J"},{"key":"70_CR25","unstructured":"Fink MP (1998) Cytopathic hypoxia: mitochondrial dysfunction as a potential mechnism contributing to organ failure in sepsis. In: Sibbald WJ, Messmer K, Fink MP, (eds) Tissue oxygenation in acute medicine. Springer, Berlin Heidelberg New York, pp 128\u2013137"},{"key":"70_CR26","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s001340050651","volume":"24","author":"DM Rosser","year":"1998","unstructured":"Rosser DM, Manji M, Cooksley H, Bellingan G (1998) Endotoxin reduces maximal oxygen consumption in hepatocytes independent of any hypoxic insult. Intensive Care Med 24:725\u2013729","journal-title":"Intensive Care Med"},{"key":"70_CR27","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1097\/00003246-199911000-00032","volume":"27","author":"CJ King","year":"1999","unstructured":"King CJ, Tytgat S, Delude RL, Fink MP (1999) Ileal mucosal oxygen consumption is decreased in endotoxemic rats but is restored toward normal by treatment with aminoguanidine. Crit Care Med 27:2518\u20132524","journal-title":"Crit Care Med"},{"key":"70_CR28","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1097\/00003246-199608000-00013","volume":"24","author":"JP Revelly","year":"1996","unstructured":"Revelly JP, Ayuse T, Brienza N, Fessler HE, Robotham JL (1996) Endotoxic shock alters distribution of blood flow within the intestinal wall. Crit Care Med 24:1345\u20131351","journal-title":"Crit Care Med"},{"key":"70_CR29","first-page":"G667","volume":"270","author":"W Hasibeder","year":"1996","unstructured":"Hasibeder W, Germann R, Wolf HJ, Haisjackl M, Hausdorfer H, Riedmann B, Bonatti J, Pfaller K, Gruber E, Schwarz B, Waldenberger P, Furtner B (1996) The effects of short-term endotoxemia and dopamine on mucosal oxygenation in the porcine jejunum. Am J Physiol 270:G667-G675","journal-title":"Am J Physiol"},{"key":"70_CR30","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1097\/00003246-199708000-00026","volume":"25","author":"R Neviere","year":"1997","unstructured":"Neviere R, Chagnon JL, Vallet B, Lebleu N, Marechal X, Mathieu D, Wattel F, Dupuis B (1997) Dobutamine improves gastrointestinal mucosal blood flow in a porcine model of endotoxic shock. Crit Care Med 25:1371\u20131377","journal-title":"Crit Care Med"},{"key":"70_CR31","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1152\/jappl.1994.76.2.793","volume":"76","author":"B Vallet","year":"1994","unstructured":"Vallet B, Lund N, Curtis SE, Kelly D, Cain SM (1994) Gut and muscle tissue PO2 in endotoxemic dogs during shock and resuscitation. J Appl Physiol 76:793\u2013800","journal-title":"J Appl Physiol"},{"key":"70_CR32","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1006\/jsre.1996.0103","volume":"61","author":"I Farquhar","year":"1996","unstructured":"Farquhar I, Martin CM, Lam C, Potter R, Ellis CG, Sibbald WJ (1996) Decreased capillary density in vivo in bowel mucosa of rats with normotensive sepsis. J Surg Res 61:190\u2013196","journal-title":"J Surg Res"},{"key":"70_CR33","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1172\/JCI117562","volume":"94","author":"C Lam","year":"1994","unstructured":"Lam C, Tyml K, Martin C, Sibbald W (1994) Microvascular perfusion is impaired in a rat model of normotensive sepsis. J Clin Invest 94:2077\u20132083","journal-title":"J Clin Invest"},{"key":"70_CR34","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1006\/jsre.1996.0157","volume":"61","author":"H Schmidt","year":"1996","unstructured":"Schmidt H, Secchi A, Wellmann R, Bach A, Bohrer H, Gebhard MM, Martin E (1996) Effect of endotoxemia on intestinal villus microcirculation in rats. J Surg Res 61:521\u2013526","journal-title":"J Surg Res"},{"key":"70_CR35","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s001340100871","volume":"27","author":"IF Tugtekin","year":"2001","unstructured":"Tugtekin IF, Radermacher P, Theisen M, Matejovic M, Stehr A, Ploner F, Matura K, Ince C, Georgieff M, Trager K (2001) Increased ileal-mucosal-arterial PCO2 gap is associated with impaired villus microcirculation in endotoxic pigs. Intensive Care Med 27:757\u2013766","journal-title":"Intensive Care Med"},{"key":"70_CR36","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1097\/00003246-199805000-00011","volume":"26","author":"JI Elizalde","year":"1998","unstructured":"Elizalde JI, Hernandez C, Llach J, Monton C, Bordas JM, Pique JM, Torres A (1998) Gastric intramucosal acidosis in mechanically ventilated patients: role of mucosal blood flow. Crit Care Med 26:827\u2013832","journal-title":"Crit Care Med"},{"key":"70_CR37","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1164\/ajrccm.160.3.9807029","volume":"160","author":"J Creteur","year":"1999","unstructured":"Creteur J, De Backer D, Vincent JL (1999) A dobutamine test can disclose hepato-splanchnic hypoperfusion in septic patients. Am J Respir Crit Care Med 160:839\u2013845","journal-title":"Am J Respir Crit Care Med"},{"key":"70_CR38","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1152\/jappl.2000.89.4.1317","volume":"89","author":"B Vallet","year":"2000","unstructured":"Vallet B, Teboul JL, Cain S, Curtis S (2000) Venoarterial CO(2) difference during regional ischemic or hypoxic hypoxia. J Appl Physiol 89:1317\u20131321","journal-title":"J Appl Physiol"},{"key":"70_CR39","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s00134-003-1746-7","volume":"29","author":"D Backer de","year":"2003","unstructured":"De Backer D (2003) Lactic acidosis. Intensive Care Med 29:699\u2013702","journal-title":"Intensive Care Med"},{"key":"70_CR40","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1097\/00000542-199704000-00012","volume":"86","author":"H Reinelt","year":"1997","unstructured":"Reinelt H, Radermacher P, Fischer G, Geisser W, Wachter U, Wiedeck H, Georgieff M, Vogt J (1997) Effects of a dobutamine-induced increase in splanchnic blood flow on hepatic metabolic activity in patients with septic shock. Anesthesiology 86:818\u2013824","journal-title":"Anesthesiology"}],"container-title":["Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-006-0070-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00134-006-0070-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-006-0070-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T08:49:51Z","timestamp":1558601391000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00134-006-0070-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2,17]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["70"],"URL":"https:\/\/doi.org\/10.1007\/s00134-006-0070-4","relation":{},"ISSN":["0342-4642","1432-1238"],"issn-type":[{"value":"0342-4642","type":"print"},{"value":"1432-1238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2,17]]}}}