{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:48:04Z","timestamp":1787845684248,"version":"build-2784847793"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2006,11,18]],"date-time":"2006-11-18T00:00:00Z","timestamp":1163808000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2006,11,18]],"date-time":"2006-11-18T00:00:00Z","timestamp":1163808000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intensive Care Med"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1007\/s00134-006-0460-7","type":"journal-article","created":{"date-parts":[[2006,11,17]],"date-time":"2006-11-17T10:46:20Z","timestamp":1163760380000},"page":"364-367","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Persistently low plasma thioredoxin is associated with meningococcal septic shock in children"],"prefix":"10.1007","volume":"33","author":[{"given":"Matthew E.","family":"Callister","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Burke-Gaffney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory J.","family":"Quinlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Betts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Nadel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy W.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,11,18]]},"reference":[{"key":"460_CR1","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1136\/adc.88.7.608","volume":"88","author":"SB Welch","year":"2003","unstructured":"Welch\u00a0SB, Nadel\u00a0S (2003) Treatment of meningococcal infection. Arch Dis Child 88:608\u2013614","journal-title":"Arch Dis Child"},{"key":"460_CR2","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1097\/00003246-200207000-00037","volume":"30","author":"M Festa","year":"2002","unstructured":"Festa\u00a0M, Mumby\u00a0S, Nadel\u00a0S, Gutteridge\u00a0JM, Quinlan\u00a0GJ (2002) Antioxidant protection against iron in children with meningococcal sepsis. Crit Care Med 30:1623\u20131629","journal-title":"Crit Care Med"},{"key":"460_CR3","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1002\/med.10051","volume":"24","author":"S Gromer","year":"2004","unstructured":"Gromer\u00a0S, Urig\u00a0S, Becker\u00a0K (2004) The thioredoxin system\u2014from science to clinic. Med Res Rev 24:40\u201389","journal-title":"Med Res Rev"},{"key":"460_CR4","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.tips.2005.06.005","volume":"26","author":"A Burke-Gaffney","year":"2005","unstructured":"Burke-Gaffney\u00a0A, Callister\u00a0ME, Nakamura\u00a0H (2005) Thioredoxin: friend or foe in human disease? Trends Pharmacol Sci 26:398\u2013404","journal-title":"Trends Pharmacol Sci"},{"key":"460_CR5","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1097\/00003246-198811000-00006","volume":"16","author":"MM Pollack","year":"1988","unstructured":"Pollack\u00a0MM, Ruttimann\u00a0UE, Getson\u00a0PR (1988) Pediatric risk of mortality (PRISM) score. Crit Care Med 16:1110\u20131116","journal-title":"Crit Care Med"},{"key":"460_CR6","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1093\/intimm\/8.4.603","volume":"8","author":"H Nakamura","year":"1996","unstructured":"Nakamura\u00a0H, De Rosa\u00a0S, Roederer\u00a0M, Anderson\u00a0MT, Dubs\u00a0JG, Yodoi\u00a0J, Holmgren\u00a0A, Herzenberg\u00a0LA (1996) Elevation of plasma thioredoxin levels in HIV-infected individuals. Int Immunol 8:603\u2013611","journal-title":"Int Immunol"},{"key":"460_CR7","doi-asserted-by":"publisher","first-page":"4071","DOI":"10.1021\/bi00612a031","volume":"17","author":"A Holmgren","year":"1978","unstructured":"Holmgren\u00a0A, Luthman\u00a0M (1978) Tissue distrubution and subcellular localization of bovine thioredoxin determined by radioimmunoassay. Biochemistry 17:4071\u20134077","journal-title":"Biochemistry"},{"key":"460_CR8","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1136\/thx.2005.053041","volume":"61","author":"ME Callister","year":"2006","unstructured":"Callister\u00a0ME, Burke-Gaffney\u00a0A, Quinlan\u00a0GJ, Nicholson\u00a0AG, Florio\u00a0R, Nakamura\u00a0H, Yodoi\u00a0J, Evans\u00a0TW (2006) Extracellular thioredoxin levels are increased in patients with acute lung injury. Thorax 61:521\u2013527","journal-title":"Thorax"},{"key":"460_CR9","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1056\/NEJM198808183190703","volume":"319","author":"E Girardin","year":"1988","unstructured":"Girardin\u00a0E, Grau\u00a0GE, Dayer\u00a0JM, Roux-Lombard\u00a0P, Lambert\u00a0PH (1988) Tumor necrosis factor and interleukin-1 in the serum of children with severe infectious purpura. N Engl J Med 319:397\u2013400","journal-title":"N Engl J Med"},{"key":"460_CR10","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/BF01720912","volume":"20","author":"JA Hazelzet","year":"1994","unstructured":"Hazelzet\u00a0JA, van der Voort\u00a0E, Lindemans\u00a0J, ter Heerdt\u00a0PG, Neijens\u00a0HJ (1994) Relation between cytokines and routine laboratory data in children with septic shock and purpura. Intensive Care Med 20:371\u2013374","journal-title":"Intensive Care Med"},{"key":"460_CR11","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1053\/plac.1999.0415","volume":"20","author":"K Ejima","year":"1999","unstructured":"Ejima\u00a0K, Koji\u00a0T, Nanri\u00a0H, Kashimura\u00a0M, Ikeda\u00a0M (1999) Expression of thioredoxin and thioredoxin reductase in placentae of pregnant mice exposed to lipopolysaccharide. Placenta 20:561\u2013566","journal-title":"Placenta"},{"key":"460_CR12","doi-asserted-by":"crossref","first-page":"15506","DOI":"10.1016\/S0021-9258(19)37617-3","volume":"263","author":"EE Wollman","year":"1988","unstructured":"Wollman\u00a0EE, d'Auriol\u00a0L, Rimsky\u00a0L, Shaw\u00a0A, Jacquot\u00a0JP, Wingfield\u00a0P, Graber\u00a0P, Dessarps\u00a0F, Robin\u00a0P, Galibert\u00a0F (1988) Cloning and expression of a\u00a0cDNA for human thioredoxin. J Biol Chem 263:15506\u201315:512","journal-title":"J Biol Chem"},{"key":"460_CR13","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.cca.2005.12.006","volume":"367","author":"H Lemarechal","year":"2006","unstructured":"Lemarechal\u00a0H, Allanore\u00a0Y, Chenevier-Gobeaux\u00a0C, Ekindjian\u00a0OG, Kahan\u00a0A, Borderie\u00a0D (2006) High redox thioredoxin but low thioredoxin reductase activities in the serum of patients with rheumatoid arthritis. Clin Chim Acta 367:156\u2013161","journal-title":"Clin Chim Acta"},{"key":"460_CR14","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/S0140-6736(99)02220-5","volume":"354","author":"PW Hermans","year":"1999","unstructured":"Hermans\u00a0PW, Hibberd\u00a0ML, Booy\u00a0R, Daramola\u00a0O, Hazelzet\u00a0JA, de Groot\u00a0R, Levin\u00a0M (1999) 4G\/5G promoter polymorphism in the plasminogen-activator-inhibitor-1 gene and outcome of meningococcal disease. Meningococcal Research Group. Lancet 354:556\u2013560","journal-title":"Lancet"}],"container-title":["Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-006-0460-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00134-006-0460-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-006-0460-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-006-0460-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T02:28:58Z","timestamp":1744165738000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00134-006-0460-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,18]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["460"],"URL":"https:\/\/doi.org\/10.1007\/s00134-006-0460-7","relation":{},"ISSN":["0342-4642","1432-1238"],"issn-type":[{"value":"0342-4642","type":"print"},{"value":"1432-1238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,18]]},"assertion":[{"value":"17 May 2006","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2006","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2006","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}