{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:05:13Z","timestamp":1791281113810,"version":"4.1.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2007,11,9]],"date-time":"2007-11-09T00:00:00Z","timestamp":1194566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2007,11,9]],"date-time":"2007-11-09T00:00:00Z","timestamp":1194566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intensive Care Med"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1007\/s00134-007-0921-7","type":"journal-article","created":{"date-parts":[[2007,11,8]],"date-time":"2007-11-08T10:56:07Z","timestamp":1194519367000},"page":"568-577","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Risk of death does not alter the efficacy of hydrocortisone therapy in a\u00a0mouse E. coli pneumonia model"],"prefix":"10.1007","volume":"34","author":[{"given":"Yan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xizhong","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven B.","family":"Solomon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Danner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Banks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Fitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djillali","family":"Annane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Natanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Q.","family":"Eichacker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,11,9]]},"reference":[{"key":"921_CR1","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1097\/00003246-199601000-00010","volume":"24","author":"WA Knaus","year":"1996","unstructured":"Knaus\u00a0WA, Harrell\u00a0FE, LaBrecque\u00a0JF, Wagner\u00a0DP, Pribble\u00a0JP, Draper\u00a0EA, Fisher\u00a0CJ, Soll\u00a0L (1996) Use of predicted mortality to evaluate the efficacy of anti-cytokine therapy in sepsis: the IL-1ra Phase III Sepsis Syndrome Study Group. Crit Care Med 24:46\u201356","journal-title":"Crit Care Med"},{"key":"921_CR2","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1097\/01.CCM.0000145229.59014.6C","volume":"32","author":"EA Panacek","year":"2004","unstructured":"Panacek\u00a0EA, Marshall\u00a0JC, Albertson\u00a0TE, Johnson\u00a0DH, Johnson\u00a0S, MacArthur\u00a0RD, Miller\u00a0M, Barchuk\u00a0WT, Fischkoff\u00a0S, Kaul\u00a0M, Teoh\u00a0L, Van Meter\u00a0L, Daum\u00a0L, Lemeshow\u00a0S, Hicklin\u00a0G, Doig\u00a0C, Monoclonal Anti-TNF: a\u00a0Randomized Controlled Sepsis Study Investigators (2004) Efficacy and safety of the monoclonal anti-tumor necrosis factor F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels. Crit Care Med 32:2173\u20132182","journal-title":"Crit Care Med"},{"key":"921_CR3","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1164\/rccm.200204-302OC","volume":"166","author":"PQ Eichacker","year":"2002","unstructured":"Eichacker\u00a0PQ, Parent\u00a0C, Kalil\u00a0A, Esposito\u00a0C, Cui\u00a0X, Banks\u00a0SM, Gerstenberger\u00a0EP, Fitz\u00a0Y, Danner\u00a0RL, Natanson\u00a0C (2002) Risk and efficacy of anti-inflammatory agents: retrospective and confirmatory studies of sepsis. Am J Respir Crit Care Med 166:1197\u20131205","journal-title":"Am J Respir Crit Care Med"},{"key":"921_CR4","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1152\/japplphysiol.01161.2003","volume":"97","author":"X Cui","year":"2004","unstructured":"Cui\u00a0X, Parent\u00a0C, Macarthur\u00a0H, Ochs\u00a0SD, Gerstenberg\u00a0E, Solomon\u00a0S, Fitz\u00a0Y, Danner\u00a0RL, Banks\u00a0SM, Natanson\u00a0C, Salvemini\u00a0D, Eichacker\u00a0PQ (2004) Severity of sepsis alters the effects of superoxide anion inhibition in a\u00a0rat sepsis model. J Appl Physiol 97:1349\u20131357","journal-title":"J Appl Physiol"},{"key":"921_CR5","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1056\/NEJM200103083441001","volume":"344","author":"GR Bernard","year":"2001","unstructured":"Bernard\u00a0GR, Vincent\u00a0JL, Laterre\u00a0PF, LaRosa\u00a0SP, Dhainaut\u00a0JF, Lopez-Rodriguez\u00a0A, Steingrub\u00a0JS, Garber\u00a0GE, Helterbrand\u00a0JD, Ely\u00a0EW, Fisher CJ Jr; Recombinant Human Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) Study Group (2001) Efficacy and safety of recombinant activated protein C for severe sepsis. N Engl J Med 344:699\u2013709","journal-title":"N Engl J Med"},{"key":"921_CR6","doi-asserted-by":"crossref","first-page":"47","DOI":"10.7326\/0003-4819-141-1-200407060-00014","volume":"141","author":"PC Minneci","year":"2004","unstructured":"Minneci\u00a0PC, Deans\u00a0KJ, Banks\u00a0SM, Eichacker\u00a0PQ, Natanson\u00a0C (2004) Meta-analysis: the effect of steroids on survival and shock during sepsis depended on dose. Ann Intern Med 141:47\u201356","journal-title":"Ann Intern Med"},{"key":"921_CR7","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1097\/00003246-199804000-00010","volume":"26","author":"PE Bollaert","year":"1998","unstructured":"Bollaert\u00a0PE, Charpentier\u00a0C, Levy\u00a0B, Debouverie\u00a0M, Audibert\u00a0G, Larcan\u00a0A (1998) Reversal of late septic shock with supraphysiologic dose hydrocortisone. Crit Care Med 26:645\u2013650","journal-title":"Crit Care Med"},{"key":"921_CR8","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1186\/cc1498","volume":"6","author":"O Yildiz","year":"2002","unstructured":"Yildiz\u00a0O, Doganay\u00a0M, Aygen\u00a0B, Guven\u00a0M, Keletimur\u00a0F, Tutus\u00a0A (2002) Physiological-dose steroid therapy in sepsis [ISRCTN36253388]. Crit Care 6:251\u2013259","journal-title":"Crit Care"},{"key":"921_CR9","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1001\/jama.288.7.862","volume":"288","author":"D Annane","year":"2002","unstructured":"Annane\u00a0D, Sebille\u00a0V, Charpentier\u00a0C, Bollaert\u00a0PE, Francois\u00a0B, Korach\u00a0JM, Capellier\u00a0G, Cohen\u00a0Y, Azoulay\u00a0E, Troche\u00a0G, Chaumet-Riffaut\u00a0P, Bellissant\u00a0E (2002) Effect of treatment with low doses of corticosteroid and fludrocortisone on mortality in patients with septic shock. JAMA 288:862\u2013871","journal-title":"JAMA"},{"key":"921_CR10","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1164\/rccm.200406-808OC","volume":"171","author":"M Confalonieri","year":"2005","unstructured":"Confalonieri\u00a0M, Urbino\u00a0R, Potena\u00a0A, Piattella\u00a0M, Parigi\u00a0P, Puccio\u00a0G, Della Porta\u00a0R, Giorgio\u00a0C, Blasi\u00a0F, Umberger\u00a0R, Meduri\u00a0GU (2005) Hydrocortisone infusion for severe community-acquired pneumonia. A\u00a0preliminary randomized study. Am J Respir Crit Care Med 171:242\u2013248","journal-title":"Am J Respir Crit Care Med"},{"key":"921_CR11","doi-asserted-by":"crossref","first-page":"A507","DOI":"10.1164\/rccm.200608-1079OC","volume":"175","author":"CL Sprung","year":"2007","unstructured":"Sprung\u00a0CL, Annane\u00a0D, Briegel\u00a0J, Keh\u00a0D, Moreno\u00a0R, Singer\u00a0M, Weiss\u00a0Y, Sorenson\u00a0F (2007) Corticosteroid therapy of septic shock (CORTICUS). Am J Respir Crit Care Med 175:A507","journal-title":"Am J Respir Crit Care Med"},{"key":"921_CR12","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1097\/00003246-200107000-00002","volume":"29","author":"DC Angus","year":"2001","unstructured":"Angus\u00a0DC, Linde-Zwirble\u00a0WT, Lidicker\u00a0J, Clermont\u00a0G, Carcillo\u00a0J, Pinsky\u00a0MR (2001) Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 29:1303\u20131310","journal-title":"Crit Care Med"},{"key":"921_CR13","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1111\/j.1469-0691.1998.tb00657.x","volume":"4","author":"TJ Marrie","year":"1998","unstructured":"Marrie\u00a0TJ, Fine\u00a0MJ, Obrosky\u00a0DS, Coley\u00a0C, Singer\u00a0DE, Kapoor\u00a0WN (1998) Community-acquired pneumonia due to Escherichia coli. Clin Microbiol Infect 4:717\u2013723","journal-title":"Clin Microbiol Infect"},{"key":"921_CR14","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1086\/502149","volume":"24","author":"HM Babcock","year":"2003","unstructured":"Babcock\u00a0HM, Zack\u00a0JE, Garrison\u00a0T, Trovillion\u00a0E, Kollef\u00a0MH, Fraser\u00a0VJ (2003) Ventilator-associated pneumonia in a\u00a0multi-hospital system: differences in microbiology by location. Infect Control Hosp Epidemiol 24:853\u2013858","journal-title":"Infect Control Hosp Epidemiol"},{"key":"921_CR15","unstructured":"http:\/\/www.globalrph.com\/corticocalc.htm"},{"key":"921_CR16","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1128\/iai.25.2.538-557.1979","volume":"25","author":"SE Greisman","year":"1979","unstructured":"Greisman\u00a0SE, DuBuy\u00a0JB, Woodward\u00a0CL (1979) Experimental gram-negative bacterial sepsis: prevention of mortality not preventable by antibiotics alone. Infect Immun 25:538\u2013557","journal-title":"Infect Immun"},{"key":"921_CR17","first-page":"172","volume":"97","author":"CA Johnston","year":"1984","unstructured":"Johnston\u00a0CA, Greisman\u00a0SE (1984) Endotoxemia induced by antibiotic therapy: a\u00a0mechanism for adrenal corticosteroid protection in gram-negative sepsis. Trans Assoc Am Physicians 97:172\u2013181","journal-title":"Trans Assoc Am Physicians"},{"key":"921_CR18","doi-asserted-by":"crossref","first-page":"436","DOI":"10.3181\/00379727-170-41455","volume":"170","author":"SE Greisman","year":"1982","unstructured":"Greisman\u00a0SE (1982) Experimental Gram-negative bacterial sepsis: optimal methylprednisolone requirements for prevention of mortality not preventable by antibiotics alone. Proc Soc Exp Biol Med 170:436\u2013442","journal-title":"Proc Soc Exp Biol Med"},{"key":"921_CR19","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1152\/jappl.1996.80.6.2066","volume":"80","author":"BD Freeman","year":"1996","unstructured":"Freeman\u00a0BD, Correa\u00a0R, Karzai\u00a0W, Natanson\u00a0C, Patterson\u00a0M, Banks\u00a0S, Fitz\u00a0Y, Danner\u00a0RL, Wilson\u00a0L, Eichacker\u00a0PQ (1996) Controlled trials of rG-CSF and CD11b-directed MAb during hyperoxia and E. coli pneumonia in rats. J Appl Physiol 80:2066\u20132076","journal-title":"J Appl Physiol"},{"key":"921_CR20","doi-asserted-by":"crossref","first-page":"R699","DOI":"10.1152\/ajpregu.00593.2003","volume":"286","author":"X Cui","year":"2004","unstructured":"Cui\u00a0X, Moayeri\u00a0M, Li\u00a0Y, Li\u00a0X, Haley\u00a0M, Fitz\u00a0Y, Correa-Araujo\u00a0R, Banks\u00a0SM, Leppla\u00a0SH, Eichacker\u00a0PQ (2004) Lethality during continuous anthrax lethal toxin infusion is associated with circulatory shock but not inflammatory cytokine or nitric oxide release in rats. Am J Physiol Regul Integr Comp Physiol 286:R699\u2013R709","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"921_CR21","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1007\/s00134-006-0234-2","volume":"32","author":"Y Li","year":"2006","unstructured":"Li\u00a0Y, Li\u00a0X, Haley\u00a0M, Fitz\u00a0Y, Gerstenberger\u00a0E, Banks\u00a0SM, Eichacker\u00a0PQ, Cui\u00a0X (2006) DTPA Fe(III) decreases cytokines and hypotension but worsens survival with Escherichia coli sepsis in rats. Intensive Care Med 32:1263\u20131270","journal-title":"Intensive Care Med"},{"key":"921_CR22","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1086\/510856","volume":"195","author":"X Cui","year":"2007","unstructured":"Cui\u00a0X, Li\u00a0Y, Li\u00a0X, Laird\u00a0MW, Subramanian\u00a0M, Moayeri\u00a0M, Leppla\u00a0SH, Fitz\u00a0Y, Su\u00a0J, Sherer\u00a0K, Eichacker\u00a0PQ (2007) Bacillus anthracis edema and lethal toxin have different hemodynamic effects but function together to worsen shock and outcome in a\u00a0rat model. J Infect Dis 195:572\u2013580","journal-title":"J Infect Dis"},{"issue":"1","key":"921_CR23","doi-asserted-by":"publisher","first-page":"A33","DOI":"10.1097\/00003246-199901001-00022","volume":"27","author":"K Chawla","year":"1999","unstructured":"Chawla\u00a0K, Kupfer\u00a0Y, Goldman\u00a0I (1999) Hydrocortisone reverses refractory septic shock [abstract]. Crit Care Med [Suppl] 27(1):A33","journal-title":"Crit Care Med [Suppl]"},{"key":"921_CR24","doi-asserted-by":"publisher","first-page":"2457","DOI":"10.1097\/01.CCM.0000186370.78639.23","volume":"33","author":"M Oppert","year":"2005","unstructured":"Oppert\u00a0M, Schindler\u00a0R, Husung\u00a0C, Offermann\u00a0K, Graf\u00a0KJ, Boenisch\u00a0O, Barckow\u00a0D, Frei\u00a0U, Eckardt\u00a0KU (2005) Low-dose hydrocortisone improves shock reversal and reduces cytokine levels in early hyperdynamic septic shock. Crit Care Med 33:2457\u20132464","journal-title":"Crit Care Med"},{"key":"921_CR25","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1681\/ASN.V12suppl_1s70","volume":"12","author":"J Briegel","year":"2001","unstructured":"Briegel\u00a0J, Jochum\u00a0M, Gippner-Steppert\u00a0C, Thiel\u00a0M (2001) Immunomodulation in septic shock: hydrocortisone differentially regulates cytokine responses. J Am Soc Nephrol 12:S70\u2013S74","journal-title":"J Am Soc Nephrol"},{"key":"921_CR26","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1164\/rccm.200205-446OC","volume":"167","author":"D Keh","year":"2003","unstructured":"Keh\u00a0D, Boehnke\u00a0T, Weber-Cartens\u00a0S, Schulz\u00a0C, Ahlers\u00a0O, Bercker\u00a0S, Volk\u00a0HD, Doecke\u00a0WD, Falke\u00a0KJ, Gerlach\u00a0H (2003) Immunologic and hemodynamic effects of \u201clow-dose\u201d hydrocortisone in septic shock. A\u00a0double-blind, randomized, placebo-controlled, crossover study. Am J Respir Crit Care Med 167:512\u2013520","journal-title":"Am J Respir Crit Care Med"},{"key":"921_CR27","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1097\/00003246-199904000-00025","volume":"27","author":"J Briegel","year":"1999","unstructured":"Briegel\u00a0J, Forst\u00a0H, Haller\u00a0M, Schelling\u00a0G, Kliger\u00a0E, Kuprat\u00a0G, Hemmer\u00a0B, Hummel\u00a0T, Lenhart\u00a0A, Heyduck\u00a0M, Stoll\u00a0C, Peter\u00a0K (1999) Stress doses of hydrocortisone reverse hyperdynamic septic shock: a\u00a0prospective, randomized, double-blind, single-center study. Crit Care Med 27:723\u2013731","journal-title":"Crit Care Med"},{"key":"921_CR28","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1097\/01.CCM.0000117317.18092.E4","volume":"32","author":"RP Dellinger","year":"2004","unstructured":"Dellinger\u00a0RP, Carlet\u00a0JM, Masur\u00a0H, Gerlach\u00a0H, Calandra\u00a0T, Cohen\u00a0J, Gea-Banacloche\u00a0J, Keh\u00a0D, Marshall\u00a0JC, Parker\u00a0MM, Ramsay\u00a0G, Zimmerman\u00a0JL, Vincent\u00a0JL, Levy\u00a0MM, Surviving Sepsis Campaign Management Guidelines Committee (2004) Surviving sepsis campaign guidelines for management of severe sepsis and septic shock. Crit Care Med 32:858\u2013873","journal-title":"Crit Care Med"},{"key":"921_CR29","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1097\/00024382-200301000-00008","volume":"19","author":"A Mansart","year":"2003","unstructured":"Mansart\u00a0A, Bollaert\u00a0PE, Seguin\u00a0C, Levy\u00a0B, Longrois\u00a0D, Mallie\u00a0JP (2003) Hemodynamic effects of early versus late glucocorticosteroid administration in experimental septic shock. Shock 19:38\u201344","journal-title":"Shock"},{"key":"921_CR30","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1046\/j.1365-2125.1998.00833.x","volume":"46","author":"D Annane","year":"1998","unstructured":"Annane\u00a0D, Bellissant\u00a0E, Sebille\u00a0V, Lesieur\u00a0O, Mathieu\u00a0B, Raphael\u00a0JC, Gajdos\u00a0P (1998) Impaired pressor sensitivity to noradrenaline in septic shock patients with and without impaired adrenal function reserve. Br J Clin Pharmacol 46:589\u2013597","journal-title":"Br J Clin Pharmacol"},{"key":"921_CR31","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1136\/bmj.38181.482222.55","volume":"329","author":"D Annane","year":"2004","unstructured":"Annane\u00a0D, Bellissant\u00a0E, Bollaert\u00a0PE, Briegel\u00a0J, Keh\u00a0D, Kupfer\u00a0Y (2004) Corticosteroids for severe sepsis and septic shock: a\u00a0systematic review and meta-analysis. BMJ 329:480","journal-title":"BMJ"},{"key":"921_CR32","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/BF01066519","volume":"15","author":"FH Hsu","year":"1987","unstructured":"Hsu\u00a0FH, Prueksaritanont\u00a0T, Lee\u00a0MG, Chiou\u00a0WL (1987) The phenomenon and cause of the dose-dependent oral absorption of chlorothiazide in rats: extrapolation to human data based on the body surface area concept. J Pharmacokinet Biopharm 15:369\u2013386","journal-title":"J Pharmacokinet Biopharm"},{"key":"921_CR33","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.ijpharm.2005.06.003","volume":"301","author":"MN Samtani","year":"2005","unstructured":"Samtani\u00a0MN, Jusko\u00a0WJ (2005) Stability of dexamethasone sodium phosphate in rat plasma. Int J Pharm 301:262\u2013266","journal-title":"Int J Pharm"},{"key":"921_CR34","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/0192-0561(79)90004-3","volume":"1","author":"H Van Dijk","year":"1979","unstructured":"Van Dijk\u00a0H, Bloksma\u00a0N, Rademaker\u00a0PM, Schouten\u00a0WJ, Willers\u00a0JM (1979) Differential potencies of corticosterone and hydrocortisone in immune and immune-related processes in the mouse. Int J Immmunopharmacol 1:285\u2013292","journal-title":"Int J Immmunopharmacol"},{"key":"921_CR35","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1128\/AAC.36.11.2375","volume":"36","author":"ML Van Ogtrop","year":"1992","unstructured":"Van Ogtrop\u00a0ML, Mattie\u00a0H, Sekh\u00a0BR, Van Strijen\u00a0E, Van Furth\u00a0R (1992) Comparison of antibacterial efficacies of ampicillin and ciprofloxacin against experimental infections with Listeria monocytogenes in hydrocortisone-treated mice. Antimicrob Agents Chemother 36:2375\u20132380","journal-title":"Antimicrob Agents Chemother"}],"container-title":["Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-007-0921-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00134-007-0921-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-007-0921-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-007-0921-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T09:01:29Z","timestamp":1744102889000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00134-007-0921-7"}},"subtitle":["Risk and corticosteroids in sepsis"],"short-title":[],"issued":{"date-parts":[[2007,11,9]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["921"],"URL":"https:\/\/doi.org\/10.1007\/s00134-007-0921-7","relation":{},"ISSN":["0342-4642","1432-1238"],"issn-type":[{"value":"0342-4642","type":"print"},{"value":"1432-1238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11,9]]},"assertion":[{"value":"26 June 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2007","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2007","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}