{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T01:49:25Z","timestamp":1777081765012,"version":"3.51.4"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2008,3,21]],"date-time":"2008-03-21T00:00:00Z","timestamp":1206057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2008,3,21]],"date-time":"2008-03-21T00:00:00Z","timestamp":1206057600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intensive Care Med"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1007\/s00134-008-1060-5","type":"journal-article","created":{"date-parts":[[2008,3,20]],"date-time":"2008-03-20T12:01:52Z","timestamp":1206014512000},"page":"1321-1329","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Dose-response effects of milrinone on hemodynamics of newborn pigs with hypoxia-reoxygenation"],"prefix":"10.1007","volume":"34","author":[{"given":"Chlo\u00eb","family":"Joynt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L.","family":"Bigam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Charrois","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence D.","family":"Jewell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Korbutt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Yin","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,3,21]]},"reference":[{"key":"1060_CR1","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1111\/j.1651-2227.1990.tb11551.x","volume":"79","author":"F Bel van","year":"1990","unstructured":"van Bel F, Walther\u00a0FJ (1990) Myocardial dysfunction and cerebral blood flow velocity following birth asphyxia. Acta Paediatr Scand 79:756\u2013762","journal-title":"Acta Paediatr Scand"},{"key":"1060_CR2","doi-asserted-by":"publisher","first-page":"e109","DOI":"10.1542\/neo.5-3-e109","volume":"5","author":"D Osborn","year":"2004","unstructured":"Osborn\u00a0D, Evans\u00a0N, Kluckow\u00a0M (2004) Diagnosis and treatment of low systemic blood flow in preterm infants. Neoreviews 5:e109\u2013e121","journal-title":"Neoreviews"},{"key":"1060_CR3","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/j.pcl.2004.01.016","volume":"51","author":"SR Leuthner","year":"2004","unstructured":"Leuthner\u00a0SR, Das\u00a0UG (2004) Low Apgar scores and the definition of birth asphyxia. Pediatr Clin North Am 51:737\u2013745","journal-title":"Pediatr Clin North Am"},{"key":"1060_CR4","doi-asserted-by":"publisher","first-page":"F105","DOI":"10.1136\/fn.78.2.F105","volume":"78","author":"N Evans","year":"1998","unstructured":"Evans\u00a0N, Kluckow\u00a0M, Currie\u00a0A (1998) Range of echocardiographic findings in term neonates with high oxygen requirements. Arch Dis Child Fetal Neonatal Ed 78:F105\u2013F111","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"1060_CR5","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/S0025-7125(02)00185-2","volume":"87","author":"K Chatterjee","year":"2003","unstructured":"Chatterjee\u00a0K, De Marco\u00a0T (2003) Role of nonglycoside inotropic agents: indications, ethics and limitations. Med Clin North Am 87:391\u2013418","journal-title":"Med Clin North Am"},{"key":"1060_CR6","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1007\/s001340101044","volume":"27","author":"DJ Penny","year":"2001","unstructured":"Penny\u00a0DJ, Sano\u00a0T, Smolich\u00a0JJ (2001) Increased systemic oxygen consumption offsets improved oxygen delivery during dobutamine infusion in newborn lambs. Intensive Care Med 27:1518\u20131525","journal-title":"Intensive Care Med"},{"key":"1060_CR7","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1097\/shk.0b013e318048554a","volume":"28","author":"Z Al-Salam","year":"2007","unstructured":"Al-Salam\u00a0Z, Johnson\u00a0ST, Abozaid\u00a0S, Bigam\u00a0D, Cheung\u00a0PY (2007) The hemodynamic effects of dobutamine during reoxygenation after hypoxia: a\u00a0dose response study in newborn pigs. Shock 28:317\u2013325","journal-title":"Shock"},{"key":"1060_CR8","doi-asserted-by":"publisher","first-page":"S220","DOI":"10.1097\/00003246-200110001-00004","volume":"29","author":"DL Wessel","year":"2001","unstructured":"Wessel\u00a0DL (2001) Managing low cardiac output syndrome after congenital heart surgery. Crit Care Med 29:S220\u2013S230","journal-title":"Crit Care Med"},{"key":"1060_CR9","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1161\/01.CIR.70.6.1030","volume":"70","author":"ES Monrad","year":"1984","unstructured":"Monrad\u00a0ES, McKay\u00a0RG, Baim\u00a0DS, Colucci\u00a0WS, Fifer\u00a0MA, Heller\u00a0GV, Royal\u00a0HD, Grossman\u00a0W (1984) Improvement in index of diastolic performance in patients with congestive heart failure treated with milrinone. Circulation 70:1030\u20131037","journal-title":"Circulation"},{"key":"1060_CR10","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1203\/00006450-198710000-00012","volume":"22","author":"JY Coe","year":"1987","unstructured":"Coe\u00a0JY, Olley\u00a0PM, Vella\u00a0G, Coceani\u00a0F (1987) Bipyridine derivatives lower arteriolar resistance and improve left ventricular function in newborn lambs. Pediatr Res 22:422\u2013428","journal-title":"Pediatr Res"},{"key":"1060_CR11","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1097\/00003246-199511000-00018","volume":"23","author":"AC Chang","year":"1995","unstructured":"Chang\u00a0AC, Atz\u00a0AM, Wernovsky\u00a0G, Burke\u00a0RP, Wessel\u00a0DL (1995) Milrinone: systemic and pulmonary hemodynamic effects in neonates after cardiac surgery. Crit Care Med 23:1907\u20131904","journal-title":"Crit Care Med"},{"key":"1060_CR12","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1161\/01.CIR.71.5.972","volume":"71","author":"ES Monrad","year":"1985","unstructured":"Monrad\u00a0ES, Baim\u00a0DS, Smith\u00a0HS, Lanoue\u00a0A, Brauwald\u00a0E, Grossman\u00a0W (1985) Effects of milrinone on coronary hemodynamics and myocardial energetics in patients with congestive heart failure. Circulation 71:972\u2013979","journal-title":"Circulation"},{"key":"1060_CR13","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.jpeds.2005.11.030","volume":"148","author":"M Paradisis","year":"2006","unstructured":"Paradisis\u00a0M, Evans\u00a0N, Kluckow\u00a0M, Osborn\u00a0D, McLachlan\u00a0AJ (2006) Pilot study of milrinone for low systemic blood flow in very preterm infants. J Pediatr 148:306\u2013313","journal-title":"J Pediatr"},{"key":"1060_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000088192","volume":"89","author":"D Bassler","year":"2006","unstructured":"Bassler\u00a0D, Choong\u00a0K, McNamara\u00a0P, Kirpalani\u00a0H (2006) Neonatal persistent pulmonary hypertension treated with milrinone: four case reports. Biol Neonate 89:1\u20135","journal-title":"Biol Neonate"},{"key":"1060_CR15","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/sj.jp.7211299","volume":"25","author":"O Danhaive","year":"2005","unstructured":"Danhaive\u00a0O, Margossian\u00a0R, Geva\u00a0T, Kourembanas\u00a0S (2005) Pulmonary hypertension and right ventricular dysfunction in growth restricted, extremely low birth weight neonates. J Perinatol 25:495\u2013499","journal-title":"J Perinatol"},{"key":"1060_CR16","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.jcrc.2006.01.001","volume":"21","author":"PJ McNamara","year":"2006","unstructured":"McNamara\u00a0PJ, Laique\u00a0F, Muang-In\u00a0S, Whyte\u00a0HE (2006) Milrinone improves oxygenation in neonates with severe persistent pulmonary hypertension of the newborn. J Crit Care 21:217\u2013222","journal-title":"J Crit Care"},{"key":"1060_CR17","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1161\/01.CIR.51.5.867","volume":"51","author":"GV Parr","year":"1975","unstructured":"Parr\u00a0GV, Blackstone\u00a0EH, Kirklin\u00a0JW (1975) Cardiac performance and mortality early after intracardiac surgery in infants and young children. Circulation 51:867\u2013874","journal-title":"Circulation"},{"key":"1060_CR18","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1097\/01.sla.0000133348.58450.e4","volume":"240","author":"E Haase","year":"2004","unstructured":"Haase\u00a0E, Bigam\u00a0DL, Nakonechny\u00a0QB, Jewell\u00a0LD, Korbutt\u00a0G, Cheung\u00a0PY (2004) Resuscitation with 100% oxygen causes intestinal glutathione oxidation and reoxygenation injury in asphyxiated newborn piglets. Ann Surg 240:364\u2013373","journal-title":"Ann Surg"},{"key":"1060_CR19","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-60327-407-4","volume-title":"Enzymatic analysis: a practical guide","author":"JV Passonneau","year":"1993","unstructured":"Passonneau\u00a0JV, Lowry\u00a0OH (1993) Enzymatic analysis: a\u00a0practical guide. Humana, Press Totowa"},{"key":"1060_CR20","first-page":"124","volume":"8","author":"DR Brocks","year":"2005","unstructured":"Brocks\u00a0DR, Spencer\u00a0TJ, Shayeganpour\u00a0A\u00a0(2005) A\u00a0sensitive and specific high performance liquid chromatographic assay for milrinone in rat and human plasma using a\u00a0commercially available internal standard and low sample volume. J Pharm Sci 8:124\u2013131","journal-title":"J Pharm Pharm Sci"},{"key":"1060_CR21","first-page":"574","volume":"100","author":"AG Rose","year":"1976","unstructured":"Rose\u00a0AG, Opie\u00a0LH, Bricknell\u00a0OL (1976) Early experimental myocardial infarction: evaluation of histologic criteria and comparison with biochemical and electrocardiographic measurements. Arch Pathol Lab Med 100:574\u2013580","journal-title":"Arch Pathol Lab Med"},{"key":"1060_CR22","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1007\/s00246-005-0881-z","volume":"26","author":"B Duggal","year":"2005","unstructured":"Duggal\u00a0B, Pratap\u00a0U, Slavik\u00a0Z, Kaplanova\u00a0J, Macrae\u00a0D (2005) Milrinone and low cardiac output following cardiac surgery in infants: is there a\u00a0direct myocardial effect. Pediatr Cardiol 26:642\u2013645","journal-title":"Pediatr Cardiol"},{"key":"1060_CR23","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1067\/mhj.2002.120305","volume":"143","author":"TM Hoffman","year":"2002","unstructured":"Hoffman\u00a0TM, Wernovsky\u00a0G, Atz\u00a0AM, Bailey\u00a0JM, Akbary\u00a0A, Kocsis\u00a0JF, Nelson\u00a0DP, Chang\u00a0AC, Kulik\u00a0TJ, Spray\u00a0TL, Wessel\u00a0DL (2002) Prophylactic intravenous use of milrinone after cardiac operation in pediatrics (PRIMACORP) study. Am Heart J 143:15\u201321","journal-title":"Am Heart J"},{"key":"1060_CR24","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1097\/01.shk.0000158962.83529.ce","volume":"23","author":"E Haase","year":"2005","unstructured":"Haase\u00a0E, Bigam\u00a0DL, Nakonechny\u00a0QB, Rayner\u00a0D, Korbutt\u00a0G, Cheung\u00a0PY (2005) Cardiac function, myocardial glutathione, and matrix metalloproteinase-2 levels in hypoxic newborn pigs reoxygenated by 21%, 50%, or 100% oxygen. Shock 23:383\u2013389","journal-title":"Shock"},{"key":"1060_CR25","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1161\/01.CIR.0000051365.81920.28","volume":"107","author":"TM Hoffman","year":"2003","unstructured":"Hoffman\u00a0TM, Wernovsky\u00a0G, Atz\u00a0AM, Kulik\u00a0TJ, Nelson\u00a0DP, Chang\u00a0AC, Bailey\u00a0JM, Akbary\u00a0A, Kocsis\u00a0JF, Kaczmarek\u00a0R, Spray\u00a0TL, Wessel\u00a0DL (2003) Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease. Circulation 107:996\u20131002","journal-title":"Circulation"},{"key":"1060_CR26","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1002\/ppul.20201","volume":"39","author":"S Dakshinamurti","year":"2005","unstructured":"Dakshinamurti\u00a0S (2005) Pathophysiologic mechanisms of persistent pulmonary hypertension of the newborn. Pediatr Pulmonol 39:492\u2013503","journal-title":"Pediatr Pulmonol"},{"key":"1060_CR27","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/S0008-6363(98)00080-7","volume":"39","author":"PY Cheung","year":"1998","unstructured":"Cheung\u00a0PY, Barrington\u00a0KJ, Bigam\u00a0DL (1998) Temporal effects of prolonged hypoxemia and reoxygenation on systemic, pulmonary and mesenteric perfusions in newborn piglets. Cardiovasc Res 39:451\u2013458","journal-title":"Cardiovasc Res"},{"key":"1060_CR28","first-page":"425","volume":"47","author":"EZ Phillipos","year":"1995","unstructured":"Phillipos\u00a0EZ, Robertson\u00a0MA (1995) A\u00a0randomized double blinded controlled trial of dopamine versus epinephrine on pulmonary arterial pressure in premature infants <\u202f1750 grams. Pediatr Res 47:425 (Abstract)","journal-title":"Pediatr Res"},{"key":"1060_CR29","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1186\/cc1016","volume":"5","author":"KJ Cheung PY. Barrington","year":"2001","unstructured":"Cheung PY. Barrington\u00a0KJ (2001) The effects of dopamine and epinephrine on hemodynamics and oxygen metabolism in hypoxic anesthetized piglets. Crit Care 5:158\u2013168","journal-title":"Crit Care"},{"key":"1060_CR30","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1542\/peds.106.4.625","volume":"106","author":"M Tsuji","year":"2000","unstructured":"Tsuji\u00a0M, Saul\u00a0JP, du Plessis\u00a0A, Eichenwald\u00a0E, Sobh\u00a0J, Crocker\u00a0R, Volpe\u00a0JJ (2000) Cerebral intravascular oxygenation correlates with mean arterial pressure in critically ill premature infants. Pediatrics 106:625\u2013632","journal-title":"Pediatrics"},{"key":"1060_CR31","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1203\/00006450-199705000-00003","volume":"41","author":"M Pourcyrous","year":"1997","unstructured":"Pourcyrous\u00a0M, Parfenova\u00a0H, Bada\u00a0HS, Korones\u00a0SB, Leffler\u00a0CW (1997) Changes in cerebral cyclic nucleotides and cerebral blood flow during prolonged asphyxia and recovery in newborn pigs. Pediatr Res 41:617\u2013623","journal-title":"Pediatr Res"},{"key":"1060_CR32","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/S0022-3476(05)72459-8","volume":"117","author":"O Pryds","year":"1990","unstructured":"Pryds\u00a0O, Greisen\u00a0G, Lou\u00a0H, Friis-Hansen\u00a0B (1990) Vasoparalysis is associated with brain damage in asphyxiated term infants. J Pediatr 117:119\u2013125","journal-title":"J Pediatr"},{"key":"1060_CR33","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1292\/jvms.64.499","volume":"64","author":"K Setoyama","year":"2002","unstructured":"Setoyama\u00a0K, Ota\u00a0H, Miura\u00a0N, Fujiki\u00a0M, Misumi\u00a0K, Sakamoto\u00a0H (2002) Effects of milrinone on hemodynamics and regional blood flow in the hypoxic dog. J Vet Med Sci 64:499\u2013503","journal-title":"J Vet Med Sci"},{"key":"1060_CR34","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/1071-5576(95)00047-X","volume":"3","author":"R Gratton","year":"1996","unstructured":"Gratton\u00a0R, Carmichael\u00a0L, Homan\u00a0J, Richardson\u00a0B (1996) Carotid arterial blood flow in the ovine fetus as a\u00a0continuous measure of cerebral blood flow. J Soc Gynecol Invest 3:60\u201365","journal-title":"J Soc Gynecol Invest"},{"key":"1060_CR35","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1111\/j.1440-1681.2006.04364.x","volume":"33","author":"L Bennet","year":"2006","unstructured":"Bennet\u00a0L, Booth\u00a0L, Malpas\u00a0SC, Quaedackers\u00a0JS, Jensen\u00a0E, Dean\u00a0J, Gunn\u00a0AJ (2006) Acute systemic complications in the preterm fetus after asphyxia: role of cardiovascular and blood flow responses. Clin Exp Pharmacol Physiol 33:291\u2013299","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"1060_CR36","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1159\/000047099","volume":"79","author":"AM Weindling","year":"2001","unstructured":"Weindling\u00a0AM, Kissack\u00a0CM (2001) Blood pressure and tissue oxygenation in the newborn baby at risk of brain damage. Biol Neonate 79:241\u2013245","journal-title":"Biol Neonate"},{"key":"1060_CR37","first-page":"235","volume-title":"Swine in biomedical research","author":"M Swindle","year":"1985","unstructured":"Swindle\u00a0M (1985) Porcine models in surgical research: an overview. In: Tumbleson\u00a0M (ed) Swine in biomedical research, vol 1. Plenum, New York, pp 235\u2013242"},{"key":"1060_CR38","first-page":"1161","volume-title":"Swine in biomedical research","author":"PM Gootman","year":"1985","unstructured":"Gootman\u00a0PM (1985) Cardiovascular regulation in developing swine. In: Tumbleson\u00a0M (ed) Swine in biomedical research, vol 2. Plenum, New York, pp 1161\u20131175"},{"key":"1060_CR39","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1203\/PDR.0b013e31811ead6e","volume":"62","author":"T Markus","year":"2007","unstructured":"Markus\u00a0T, Hansson\u00a0S, Am-W\u00e5hlin I, Hellstr\u00f6m-Westas\u00a0L, Saugstad\u00a0OD, Ley\u00a0D (2007) Cerebral inflammatory response after fetal asphyxia and hyperoxic resuscitation in newborn sheep. Pediatr Res 62:71\u201377","journal-title":"Pediatr Res"}],"container-title":["Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-008-1060-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00134-008-1060-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-008-1060-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-008-1060-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T21:32:23Z","timestamp":1744147943000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00134-008-1060-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,21]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["1060"],"URL":"https:\/\/doi.org\/10.1007\/s00134-008-1060-5","relation":{},"ISSN":["0342-4642","1432-1238"],"issn-type":[{"value":"0342-4642","type":"print"},{"value":"1432-1238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,21]]},"assertion":[{"value":"1 October 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 February 2008","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2008","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}