{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:43:41Z","timestamp":1793317421346,"version":"4.5.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2008,9,20]],"date-time":"2008-09-20T00:00:00Z","timestamp":1221868800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intensive Care Med"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1007\/s00134-008-1283-5","type":"journal-article","created":{"date-parts":[[2008,9,19]],"date-time":"2008-09-19T02:25:24Z","timestamp":1221791124000},"page":"471-479","source":"Crossref","is-referenced-by-count":195,"title":["Sodium lactate versus mannitol in the treatment of intracranial hypertensive episodes in severe traumatic brain-injured patients"],"prefix":"10.1007","volume":"35","author":[{"given":"Carole","family":"Ichai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Armando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Orban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Berthier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Rami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corine","family":"Samat-Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Grimaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Leverve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,9,20]]},"reference":[{"key":"1283_CR1","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1097\/00003246-200208000-00033","volume":"30","author":"EM Bulger","year":"2002","unstructured":"Bulger EM, Nathens AB, Rivara FP, Moore M, MacKenzie EJ, Jurkovich GJ (2002) Management of severe head injury: institutional variations in care and effect on outcome. Crit Care Med 30:1870\u20131876","journal-title":"Crit Care Med"},{"key":"1283_CR2","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1089\/08977150260190456","volume":"19","author":"JY Jiang","year":"2002","unstructured":"Jiang JY, Gao GY, Li WP, Yu MK, Zhu C (2002) Early indicators of prognosis in 846 cases of severe traumatic brain injury. J Neurotrauma 19:869\u2013874","journal-title":"J Neurotrauma"},{"key":"1283_CR3","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1007\/s001340000825","volume":"27","author":"N Stocchetti","year":"2001","unstructured":"Stocchetti N, Penny KI, Dearden M, Braakman R, Cohadon F, Iannotti F, Lapierre F, Karimi A, Maas A Jr, Murray GD, Ohman J, Persson L, Servadei F, Teasdale GM, Trojanowski T, Unterberg A (2001) Intensive care management of head-injured patients in Europe: a survey from the European brain injury consortium. Intensive Care Med 27:400\u2013406","journal-title":"Intensive Care Med"},{"key":"1283_CR4","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s001340050860","volume":"25","author":"N Stocchetti","year":"1999","unstructured":"Stocchetti N, Rossi S, Buzzi F, Mattioli C, Paparella A, Colombo A (1999) Intracranial hypertension in head injury: management and results. Intensive Care Med 25:371\u2013376","journal-title":"Intensive Care Med"},{"key":"1283_CR5","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1001\/jama.291.11.1350","volume":"291","author":"DJ Cooper","year":"2004","unstructured":"Cooper DJ, Myles PS, McDermott FT, Murray LJ, Laidlaw J, Cooper G, Tremayne AB, Bernard SS, Ponsford J (2004) Prehospital hypertonic saline resuscitation of patients with hypotension and severe traumatic brain injury: a randomized controlled trial. Jama 291:1350\u20131357","journal-title":"Jama"},{"key":"1283_CR6","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/S0140-6736(04)17188-2","volume":"364","author":"I Roberts","year":"2004","unstructured":"Roberts I, Yates D, Sandercock P, Farrell B, Wasserberg J, Lomas G, Cottingham R, Svoboda P, Brayley N, Mazairac G, Laloe V, Munoz-Sanchez A, Arango M, Hartzenberg B, Khamis H, Yutthakasemsunt S, Komolafe E, Olldashi F, Yadav Y, Murillo-Cabezas F, Shakur H, Edwards P (2004) Effect of intravenous corticosteroids on death within 14\u00a0days in 10008 adults with clinically significant head injury (MRC CRASH trial): randomised placebo-controlled trial. Lancet 364:1321\u20131328","journal-title":"Lancet"},{"key":"1283_CR7","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1056\/NEJM200102223440803","volume":"344","author":"GL Clifton","year":"2001","unstructured":"Clifton GL, Miller ER, Choi SC, Levin HS, McCauley S, Smith KR Jr, Muizelaar JP, Wagner FC Jr, Marion DW, Luerssen TG, Chesnut RM, Schwartz M (2001) Lack of effect of induction of hypothermia after acute brain injury. N Engl J Med 344:556\u2013563","journal-title":"N Engl J Med"},{"key":"1283_CR8","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1007\/s00134-002-1511-3","volume":"28","author":"KH Polderman","year":"2002","unstructured":"Polderman KH, Tjong Tjin Joe R, Peerdeman SM, Vandertop WP, Girbes AR (2002) Effects of therapeutic hypothermia on intracranial pressure and outcome in patients with severe head injury. Intensive Care Med 28:1563\u20131573","journal-title":"Intensive Care Med"},{"key":"1283_CR9","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jcrc.2006.06.011","volume":"22","author":"W Qiu","year":"2007","unstructured":"Qiu W, Zhang Y, Sheng H, Zhang J, Wang W, Liu W, Chen K, Zhou J, Xu Z (2007) Effects of therapeutic mild hypothermia on patients with severe traumatic brain injury after craniotomy. J Crit Care 22:229\u2013235","journal-title":"J Crit Care"},{"key":"1283_CR10","unstructured":"Schierhout G, Roberts I (2000) Mannitol for acute traumatic brain injury. Cochrane Database Syst Rev CD001049"},{"key":"1283_CR11","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1378\/chest.122.2.699","volume":"122","author":"PE Marik","year":"2002","unstructured":"Marik PE, Varon J, Trask T (2002) Management of head trauma. Chest 122:699\u2013711","journal-title":"Chest"},{"key":"1283_CR12","doi-asserted-by":"crossref","unstructured":"Francony G, Fauvage B, Falcon D, Canet C, Dilou H, Lavagne P, Jacquot C, Payen JF (2008) Equimolar doses of mannitol and hypertonic saline in the treatment of increased intracranial pressure. Crit Care Med 36(3):795\u2013800","DOI":"10.1097\/CCM.0B013E3181643B41"},{"key":"1283_CR13","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1017\/S0317167100045960","volume":"11","author":"ML Schwartz","year":"1984","unstructured":"Schwartz ML, Tator CH, Rowed DW, Reid SR, Meguro K, Andrews DF (1984) The University of Toronto head injury treatment study: a prospective, randomized comparison of pentobarbital and mannitol. Can J Neurol Sci 11:434\u2013440","journal-title":"Can J Neurol Sci"},{"key":"1283_CR14","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3171\/JNS\/2008\/108\/01\/0080","volume":"108","author":"MD Sorani","year":"2008","unstructured":"Sorani MD, Manley GT (2008) Dose-response relationship of mannitol and intracranial pressure: a metaanalysis. J Neurosurg 108:80\u201387","journal-title":"J Neurosurg"},{"key":"1283_CR15","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1097\/00000542-199806000-00023","volume":"88","author":"ML McManus","year":"1998","unstructured":"McManus ML, Soriano SG (1998) Rebound swelling of astroglial cells exposed to hypertonic mannitol. Anesthesiology 88:1586\u20131591","journal-title":"Anesthesiology"},{"key":"1283_CR16","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3171\/jns.1985.63.1.0043","volume":"63","author":"AD Mendelow","year":"1985","unstructured":"Mendelow AD, Teasdale GM, Russell T, Flood J, Patterson J, Murray GD (1985) Effect of mannitol on cerebral blood flow and cerebral perfusion pressure in human head injury. J Neurosurg 63:43\u201348","journal-title":"J Neurosurg"},{"key":"1283_CR17","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0749-0704(05)70298-0","volume":"13","author":"RP Paczynski","year":"1997","unstructured":"Paczynski RP (1997) Osmotherapy. Basic concepts and controversies. Crit Care Clin 13:105\u2013129","journal-title":"Crit Care Clin"},{"key":"1283_CR18","first-page":"494","volume":"60","author":"S Berger","year":"1994","unstructured":"Berger S, Schurer L, Hartl R, Deisbock T, Dautermann C, Murr R, Messmer K, Baethmann A (1994) 7.2% NaCl\/10% dextran 60 versus 20% mannitol for treatment of intracranial hypertension. Acta Neurochir Suppl (Wien) 60:494\u2013498","journal-title":"Acta Neurochir Suppl (Wien)"},{"key":"1283_CR19","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1097\/00005373-200102000-00030","volume":"50","author":"JA Doyle","year":"2001","unstructured":"Doyle JA, Davis DP, Hoyt DB (2001) The use of hypertonic saline in the treatment of traumatic brain injury. J Trauma 50:367\u2013383","journal-title":"J Trauma"},{"key":"1283_CR20","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/00003246-199803000-00011","volume":"26","author":"AI Qureshi","year":"1998","unstructured":"Qureshi AI, Suarez JI, Bhardwaj A, Mirski M, Schnitzer MS, Hanley DF, Ulatowski JA (1998) Use of hypertonic (3%) saline\/acetate infusion in the treatment of cerebral edema: Effect on intracranial pressure and lateral displacement of the brain. Crit Care Med 26:440\u2013446","journal-title":"Crit Care Med"},{"key":"1283_CR21","doi-asserted-by":"crossref","unstructured":"Battison C, Andrews PJ, Graham C, Petty T (2005) Randomized, controlled trial on the effect of a 20% mannitol solution and a 7.5% saline\/6% dextran solution on increased intracranial pressure after brain injury. Crit Care Med 33:196\u2013202 (discussion 257\u2013198)","DOI":"10.1097\/01.CCM.0000150269.65485.A6"},{"key":"1283_CR22","first-page":"131","volume":"10","author":"A Schurr","year":"2002","unstructured":"Schurr A (2002) Lactate, glucose and energy metabolism in the ischemic brain (Review). Int J Mol Med 10:131\u2013136","journal-title":"Int J Mol Med"},{"key":"1283_CR23","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1046\/j.1471-4159.1997.69010423.x","volume":"69","author":"A Schurr","year":"1997","unstructured":"Schurr A, Payne RS, Miller JJ, Rigor BM (1997) Brain lactate is an obligatory aerobic energy substrate for functional recovery after hypoxia: further in vitro validation. J Neurochem 69:423\u2013426","journal-title":"J Neurochem"},{"key":"1283_CR24","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S0140-6736(94)90876-1","volume":"343","author":"A Maran","year":"1994","unstructured":"Maran A, Cranston I, Lomas J, Macdonald I, Amiel SA (1994) Protection by lactate of cerebral function during hypoglycaemia. Lancet 343:16\u201320","journal-title":"Lancet"},{"key":"1283_CR25","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1042\/cs0940157","volume":"94","author":"P King","year":"1998","unstructured":"King P, Kong MF, Parkin H, MacDonald IA, Barber C, Tattersall RB (1998) Intravenous lactate prevents cerebral dysfunction during hypoglycaemia in insulin-dependent diabetes mellitus. Clin Sci (Lond) 94:157\u2013163","journal-title":"Clin Sci (Lond)"},{"key":"1283_CR26","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1002\/jnr.10065","volume":"66","author":"A Schurr","year":"2001","unstructured":"Schurr A, Payne RS, Miller JJ, Tseng MT (2001) Preischemic hyperglycemia-aggravated damage: evidence that lactate utilization is beneficial and glucose-induced corticosterone release is detrimental. J Neurosci Res 66:782\u2013789","journal-title":"J Neurosci Res"},{"key":"1283_CR27","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S0006-8993(01)03299-1","volume":"928","author":"AC Rice","year":"2002","unstructured":"Rice AC, Zsoldos R, Chen T, Wilson MS, Alessandri B, Hamm RJ, Bullock MR (2002) Lactate administration attenuates cognitive deficits following traumatic brain injury. Brain Res 928:156\u2013159","journal-title":"Brain Res"},{"key":"1283_CR28","doi-asserted-by":"crossref","unstructured":"Holloway R, Zhou Z, Harvey HB, Levasseur JE, Rice AC, Sun D, Hamm RJ, Bullock MR (2007) Effect of lactate therapy upon cognitive deficits after traumatic brain injury in the rat. Acta Neurochir (Wien) 149:919\u2013927 (discussion 927)","DOI":"10.1007\/s00701-007-1241-y"},{"key":"1283_CR29","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1097\/00005373-199412000-00005","volume":"37","author":"SR Shackford","year":"1994","unstructured":"Shackford SR, Schmoker JD, Zhuang J (1994) The effect of hypertonic resuscitation on pial arteriolar tone after brain injury and shock. J Trauma 37:899\u2013908","journal-title":"J Trauma"},{"key":"1283_CR30","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3171\/jns.1992.76.1.0091","volume":"76","author":"SR Shackford","year":"1992","unstructured":"Shackford SR, Zhuang J, Schmoker J (1992) Intravenous fluid tonicity: effect on intracranial pressure, cerebral blood flow, and cerebral oxygen delivery in focal brain injury. J Neurosurg 76:91\u201398","journal-title":"J Neurosurg"},{"key":"1283_CR31","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/S0140-6736(75)92830-5","volume":"1","author":"B Jennett","year":"1975","unstructured":"Jennett B, Bond M (1975) Assessment of outcome after severe brain damage. Lancet 1:480\u2013484","journal-title":"Lancet"},{"key":"1283_CR32","first-page":"S287","volume":"9 Suppl 1","author":"LF Marshall","year":"1992","unstructured":"Marshall LF, Marshall SB, Klauber MR, Van Berkum Clark M, Eisenberg H, Jane JA, Luerssen TG, Marmarou A, Foulkes MA (1992) The diagnosis of head injury requires a classification based on computed axial tomography. J Neurotrauma 9 Suppl 1:S287\u2013S292","journal-title":"J Neurotrauma"},{"key":"1283_CR33","first-page":"421","volume":"60","author":"A Marmarou","year":"1994","unstructured":"Marmarou A (1994) Traumatic brain edema: an overview. Acta Neurochir Suppl (Wien) 60:421\u2013424","journal-title":"Acta Neurochir Suppl (Wien)"},{"key":"1283_CR34","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/00063110-200109000-00009","volume":"8","author":"N Stocchetti","year":"2001","unstructured":"Stocchetti N (2001) Risk prevention, avoidable deaths and mortality-morbidity reduction in head injury. Eur J Emerg Med 8:215\u2013219","journal-title":"Eur J Emerg Med"},{"key":"1283_CR35","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1212\/01.WNL.0000158442.08857.FC","volume":"64","author":"G Berghe Van den","year":"2005","unstructured":"Van den Berghe G, Schoonheydt K, Becx P, Bruyninckx F, Wouters PJ (2005) Insulin therapy protects the central and peripheral nervous system of intensive care patients. Neurology 64:1348\u20131353","journal-title":"Neurology"},{"key":"1283_CR36","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1097\/00000658-199904000-00009","volume":"229","author":"R Chiolero","year":"1999","unstructured":"Chiolero R, Tappy L, Gillet M, Revelly JP, Roth H, Cayeux C, Schneiter P, Leverve X (1999) Effect of major hepatectomy on glucose and lactate metabolism. Ann Surg 229:505\u2013513","journal-title":"Ann Surg"},{"key":"1283_CR37","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1007\/s00134-003-1860-6","volume":"29","author":"I Mustafa","year":"2003","unstructured":"Mustafa I, Roth H, Hanafiah A, Hakim T, Anwar M, Siregar E, Leverve XM (2003) Effect of cardiopulmonary bypass on lactate metabolism. Intensive Care Med 29:1279\u20131285","journal-title":"Intensive Care Med"},{"key":"1283_CR38","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/00024382-200210000-00003","volume":"18","author":"I Mustafa","year":"2002","unstructured":"Mustafa I, Leverve XM (2002) Metabolic and hemodynamic effects of hypertonic solutions: sodium-lactate versus sodium chloride infusion in postoperative patients. Shock 18:306\u2013310","journal-title":"Shock"},{"key":"1283_CR39","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1378\/chest.127.5.1812","volume":"127","author":"N Stocchetti","year":"2005","unstructured":"Stocchetti N, Maas AI, Chieregato A, van der Plas AA (2005) Hyperventilation in head injury: a review. Chest 127:1812\u20131827","journal-title":"Chest"},{"key":"1283_CR40","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1042\/bj3430281","volume":"343 Pt 2","author":"AP Halestrap","year":"1999","unstructured":"Halestrap AP, Price NT (1999) The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochem J 343 Pt 2:281\u2013299","journal-title":"Biochem J"},{"key":"1283_CR41","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1179\/016164105X25243","volume":"27","author":"H Chen","year":"2005","unstructured":"Chen H, Sun D (2005) The role of Na-K-Cl co-transporter in cerebral ischemia. Neurol Res 27:280\u2013286","journal-title":"Neurol Res"},{"key":"1283_CR42","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1469-7793.2001.0459i.x","volume":"531","author":"HL Cater","year":"2001","unstructured":"Cater HL, Benham CD, Sundstrom LE (2001) Neuroprotective role of monocarboxylate transport during glucose deprivation in slice cultures of rat hippocampus. J Physiol 531:459\u2013466","journal-title":"J Physiol"},{"key":"1283_CR43","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/sj.jcbfm.9600174","volume":"26","author":"A Schurr","year":"2006","unstructured":"Schurr A (2006) Lactate: the ultimate cerebral oxidative energy substrate? J Cereb Blood Flow Metab 26:142\u2013152","journal-title":"J Cereb Blood Flow Metab"},{"key":"1283_CR44","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/jnr.20307","volume":"79","author":"L Pellerin","year":"2005","unstructured":"Pellerin L, Bergersen LH, Halestrap AP, Pierre K (2005) Cellular and subcellular distribution of monocarboxylate transporters in cultured brain cells and in the adult brain. J Neurosci Res 79:55\u201364","journal-title":"J Neurosci Res"}],"container-title":["Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-008-1283-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00134-008-1283-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-008-1283-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T08:53:22Z","timestamp":1558601602000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00134-008-1283-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9,20]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["1283"],"URL":"https:\/\/doi.org\/10.1007\/s00134-008-1283-5","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1149872.618136","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1149872.606959","asserted-by":"object"}]},"ISSN":["0342-4642","1432-1238"],"issn-type":[{"value":"0342-4642","type":"print"},{"value":"1432-1238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9,20]]}}}