{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T12:08:36Z","timestamp":1792325316134,"version":"4.4.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2009,3,18]],"date-time":"2009-03-18T00:00:00Z","timestamp":1237334400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2009,3,18]],"date-time":"2009-03-18T00:00:00Z","timestamp":1237334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intensive Care Med"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1007\/s00134-009-1456-x","type":"journal-article","created":{"date-parts":[[2009,3,17]],"date-time":"2009-03-17T11:07:16Z","timestamp":1237288036000},"page":"996-1003","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":162,"title":["Discomfort associated with underhumidified high-flow oxygen therapy in critically ill patients"],"prefix":"10.1007","volume":"35","author":[{"given":"Gerald","family":"Chanques","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Michel","family":"Constantin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"Sauter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustapha","family":"Sebbane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Verzilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Yves","family":"Lefrant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Jaber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,3,18]]},"reference":[{"key":"1456_CR1","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1056\/NEJM196711022771802","volume":"277","author":"JC Mithoefer","year":"1967","unstructured":"Mithoefer JC, Karetzky MS, Mead GD (1967) Oxygen therapy in respiratory failure. N Engl J Med 277:947\u2013949","journal-title":"N Engl J Med"},{"key":"1456_CR2","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1161\/01.CIR.52.3.360","volume":"52","author":"PR Maroko","year":"1975","unstructured":"Maroko PR, Radvany P, Braunwald E, Hale SL (1975) Reduction of infarct size by oxygen inhalation following acute coronary occlusion. Circulation 52:360\u2013368","journal-title":"Circulation"},{"key":"1456_CR3","first-page":"717","volume":"47","author":"TJ Kallstrom","year":"2002","unstructured":"Kallstrom TJ, American Association for Respiratory C (2002) AARC Clinical Practice Guideline: oxygen therapy for adults in the acute care facility\u20142002 revision & update. Respir Care 47:717\u2013720","journal-title":"Respir Care"},{"key":"1456_CR4","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1007\/s001340051091","volume":"25","author":"M Novaes","year":"1999","unstructured":"Novaes M, Knobel E, Bork A, Pav\u00e3o O, Nogueira-Martins L, Ferraz M (1999) Stressors in ICU: perception of the patient, relatives and health care team. Intensive Care Med 25:1421\u20131426","journal-title":"Intensive Care Med"},{"key":"1456_CR5","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1097\/01.anes.0000264747.09017.da","volume":"106","author":"JF Payen","year":"2007","unstructured":"Payen JF, Chanques G, Mantz J, Hercule C, Auriant I, Leguillou JL, Binhas M, Genty C, Rolland C, Bosson JL, Investigators ftD (2007) Current practices in sedation and analgesia for mechanically ventilated critically ill patients: a prospective multicenter patient-based study. Anesthesiology 106:687\u2013695","journal-title":"Anesthesiology"},{"key":"1456_CR6","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1097\/01.anes.0000287211.98642.51","volume":"107","author":"G Chanques","year":"2007","unstructured":"Chanques G, Sebbane M, Barbotte E, Viel E, Eledjam JJ, Jaber S (2007) A prospective study of pain at rest: incidence and characteristics of an unrecognized symptom in surgical and trauma versus medical intensive care unit patients. Anesthesiology 107:858\u2013859","journal-title":"Anesthesiology"},{"key":"1456_CR7","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1097\/01.CCM.0000108875.35298.D2","volume":"32","author":"K Puntillo","year":"2004","unstructured":"Puntillo K, Morris A, Thompson C, Stanik-Hutt J, White C, Wild L (2004) Pain behaviors observed during six common procedures: results from Thunder Project II. Crit Care Med 32:421\u2013427","journal-title":"Crit Care Med"},{"key":"1456_CR8","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1183\/09031936.93.01090852","volume":"1","author":"B Salah","year":"1988","unstructured":"Salah B, Dinh Xuan AT, Fouilladieu JL, Lockhart A, Regnard J (1988) Nasal mucociliary transport in healthy subjects is slower when breathing dry air. Eur Respir J 1:852\u2013855","journal-title":"Eur Respir J"},{"key":"1456_CR9","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1152\/jappl.1996.81.4.1739","volume":"81","author":"P Fontanari","year":"1996","unstructured":"Fontanari P, Burnet H, Zattara-Hartmann MC, Jammes Y (1996) Changes in airway resistance induced by nasal inhalation of cold dry, dry, or moist air in normal individuals. J Appl Physiol 81:1739\u20131743","journal-title":"J Appl Physiol"},{"key":"1456_CR10","first-page":"1143","volume":"25","author":"W Estey","year":"1980","unstructured":"Estey W (1980) Subjective effects of dry versus humidified low flow oxygen. Respir Care 25:1143\u20131144","journal-title":"Respir Care"},{"key":"1456_CR11","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1378\/chest.93.2.289","volume":"93","author":"EJ Campbell","year":"1988","unstructured":"Campbell EJ, Baker MD, Crites-Silver P (1988) Subjective effects of humidification of oxygen for delivery by nasal cannula. A prospective study. Chest 93:289\u2013293","journal-title":"Chest"},{"key":"1456_CR12","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1155\/1997\/296763","volume":"4","author":"D Andres","year":"1997","unstructured":"Andres D, Thurston N, Brant R, Flemons W, Fofonoff D, Ruttimann A, Sveinson S, Neil C (1997) Randomized double-blind trial of the effects of humidified compared with nonhumidified low flow oxygen therapy on the symptoms of patients. Can Respir J 4:76\u201380","journal-title":"Can Respir J"},{"key":"1456_CR13","doi-asserted-by":"publisher","first-page":"2703","DOI":"10.1001\/jama.286.21.2703","volume":"286","author":"EW Ely","year":"2001","unstructured":"Ely EW, Inouye SK, Bernard GR, Gordon S, Francis J, May L, Truman B, Speroff T, Gautam S, Margolin R, Hart RP, Dittus R (2001) Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU). JAMA 286:2703\u20132710","journal-title":"JAMA"},{"key":"1456_CR14","unstructured":"Roussel C, Massion P (2003) M\u00e9thode d\u2019Evaluation de la Confusion en Unit\u00e9 de Soins Intensifs. CAM-ICU. Available via http:\/\/www.icudelirium.org\/delirium\/training-pages\/French.pdf. Accessed 2006"},{"key":"1456_CR15","doi-asserted-by":"publisher","first-page":"2983","DOI":"10.1001\/jama.289.22.2983","volume":"289","author":"EW Ely","year":"2003","unstructured":"Ely EW, Truman B, Shintani A, Thomason JW, Wheeler AP, Gordon S, Francis J, Speroff T, Gautam S, Margolin R, Sessler CN, Dittus RS, Bernard GR (2003) Monitoring sedation status over time in ICU patients: reliability and validity of the richmond agitation-sedation scale (RASS). JAMA 289:2983\u20132991","journal-title":"JAMA"},{"key":"1456_CR16","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.annfar.2006.02.017","volume":"25","author":"G Chanques","year":"2006","unstructured":"Chanques G, Jaber S, Barbotte E, Verdier R, Henriette K, Lefrant J, Eledjam J (2006) Validation of the french translated Richmond vigilance-agitation scale. Ann Fr Anesth Reanim 25:696\u2013701","journal-title":"Ann Fr Anesth Reanim"},{"key":"1456_CR17","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.pain.2005.07.004","volume":"117","author":"L Gagliese","year":"2005","unstructured":"Gagliese L, Weizblit N, Ellis W, Chan V (2005) The measurement of postoperative pain: a comparison of intensity scales in younger and older surgical patients. Pain 117:412\u2013420","journal-title":"Pain"},{"key":"1456_CR18","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1097\/01.CCM.0000218416.62457.56","volume":"34","author":"G Chanques","year":"2006","unstructured":"Chanques G, Jaber S, Barbotte E, Violet S, Sebbane M, Perrigault P, Mann C, Lefrant J, Eledjam J (2006) Impact of systematic evaluation of pain and agitation in an intensive care unit. Crit Care Med 34:1691\u20131699","journal-title":"Crit Care Med"},{"key":"1456_CR19","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1097\/01.CCM.0000050443.45863.F5","volume":"31","author":"G Thi\u00e9ry","year":"2003","unstructured":"Thi\u00e9ry G, Boyer A, Pign\u00e9 E, Salah A, De Lassence A, Dreyfuss D, Ricard J (2003) Heat and moisture exchangers in mechanically ventilated intensive care unit patients: a plea for an independent assessment of their performance. Crit Care Med 31:699\u2013704","journal-title":"Crit Care Med"},{"key":"1456_CR20","doi-asserted-by":"publisher","first-page":"R281","DOI":"10.1186\/cc2904","volume":"8","author":"D Chiumello","year":"2004","unstructured":"Chiumello D, Pelosi P, Park G, Candiani A, Bottino N, Storelli E, Severgnini P, D\u2019Onofrio D, Gattinoni L, Chiaranda M (2004) In vitro and in vivo evaluation of a new active heat moisture exchanger. Crit Care 8:R281\u2013R288","journal-title":"Crit Care"},{"key":"1456_CR21","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1378\/chest.115.6.1646","volume":"115","author":"J Ricard","year":"1999","unstructured":"Ricard J, Markowicz P, Djedaini K, Mier L, Coste F, Dreyfuss D (1999) Bedside evaluation of efficient airway humidification during mechanical ventilation of the critically ill. Chest 115:1646\u20131652","journal-title":"Chest"},{"key":"1456_CR22","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/S0002-9343(96)00452-4","volume":"102","author":"NA Desbiens","year":"1997","unstructured":"Desbiens NA, Wu AW, Alzola C, Mueller-Rizner N, Wenger NS, Connors AF, Lynn J, Phillips RS (1997) Pain during hospitalization is associated with continued pain six months later in survivors of serious illness. The SUPPORT Investigators. Study to understand prognoses and preferences for outcomes and risks of treatments. Am J Med 102:269\u2013276","journal-title":"Am J Med"},{"key":"1456_CR23","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1097\/00003246-199804000-00011","volume":"26","author":"G Schelling","year":"1998","unstructured":"Schelling G, Stoll C, Haller M, Briegel J, Manert W, Hummel T, Lenhart A, Heyduck M, Polasek J, Meier M, Preuss U, Bullinger M, Sch\u00fcffel W, Peter K (1998) Health-related quality of life and posttraumatic stress disorder in survivors of the acute respiratory distress syndrome. Crit Care Med 26:651\u2013659","journal-title":"Crit Care Med"},{"key":"1456_CR24","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1097\/00003246-200103000-00019","volume":"29","author":"C Jones","year":"2001","unstructured":"Jones C, Griffiths RD, Humphris G, Skirrow PM (2001) Memory, delusions, and the development of acute posttraumatic stress disorder-related symptoms after intensive care. Crit Care Med 29:573\u2013580","journal-title":"Crit Care Med"},{"key":"1456_CR25","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1097\/00003246-199611000-00025","volume":"24","author":"R Williams","year":"1996","unstructured":"Williams R, Rankin N, Smith T, Galler D, Seakins P (1996) Relationship between the humidity and temperature of inspired gas and the function of the airway mucosa. Crit Care Med 24:1920\u20131929","journal-title":"Crit Care Med"},{"key":"1456_CR26","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1007\/s00134-002-1441-0","volume":"28","author":"S Jaber","year":"2002","unstructured":"Jaber S, Chanques G, Matecki S, Ramonatxo M, Souche B, Perrigault PF, Eledjam JJ (2002) Comparison of the effects of heat and moisture exchangers and heated humidifiers on ventilation and gas exchange during non-invasive ventilation. Intensive Care Med 28:1590\u20131594","journal-title":"Intensive Care Med"},{"key":"1456_CR27","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1007\/s00134-002-1518-9","volume":"28","author":"F Lellouche","year":"2002","unstructured":"Lellouche F, Maggiore SM, Deye N, Taill\u00e9 S, Pigeot J, Harf A, Brochard L (2002) Effect of the humidification device on the work of breathing during noninvasive ventilation. Intensive Care Med 28:1582\u20131589","journal-title":"Intensive Care Med"},{"key":"1456_CR28","first-page":"1","volume":"22","author":"K Brownson","year":"2000","unstructured":"Brownson K (2000) Hospital air is sick. Hosp Mater Manage Q 22:1\u20138","journal-title":"Hosp Mater Manage Q"},{"key":"1456_CR29","first-page":"47","volume":"2","author":"UM Hellgren","year":"2006","unstructured":"Hellgren UM, Reijula K (2006) Indoor-air-related complaints and symptoms among hospital workers. Scand J Work Environ Health Suppl 2:47\u201349","journal-title":"Scand J Work Environ Health Suppl"},{"key":"1456_CR30","unstructured":"Lellouche F, Qader S, Taille S, Aboab J, Thille A, Boussignac G, Brochard L (2004) Hygrometric measurements during CPAP with Boussignac CPAP and different humidification strategy in healthy subjects. Am J Respir Crit Care Med A254"},{"key":"1456_CR31","first-page":"41","volume":"27","author":"J Darin","year":"1982","unstructured":"Darin J, Broadwell J, MacDonell R (1982) An evaluation of water-vapor output from four brands of unheated, prefilled bubble humidifiers. Respir Care 27:41\u201350","journal-title":"Respir Care"},{"key":"1456_CR32","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S0749-0704(05)70038-5","volume":"15","author":"RJ Hamill-Ruth","year":"1999","unstructured":"Hamill-Ruth RJ, Marohn ML (1999) Evaluation of pain in the critically ill patient. Crit Care Clin 15:35\u201354","journal-title":"Crit Care Clin"},{"key":"1456_CR33","doi-asserted-by":"crossref","first-page":"238","DOI":"10.4037\/ajcc2001.10.4.238","volume":"10","author":"KA Puntillo","year":"2001","unstructured":"Puntillo KA, White C, Morris AB, Perdue ST, Stanik-Hutt J, Thompson CL, Wild LR (2001) Patients\u2019 perceptions and responses to procedural pain: results from Thunder Project II. Am J Crit Care 10:238\u2013251","journal-title":"Am J Crit Care"},{"key":"1456_CR34","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.1001\/jama.270.24.2957","volume":"270","author":"J Le Gall","year":"1993","unstructured":"Le Gall J, Lemeshow S, Saulnier F (1993) A new simplified acute physiology score (SAPS II) based on a European\/North American multicenter study. JAMA 270:2957\u20132963","journal-title":"JAMA"},{"key":"1456_CR35","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1097\/00003246-199811000-00016","volume":"26","author":"J Vincent","year":"1998","unstructured":"Vincent J, de Mendon\u00e7a A, Cantraine F, Moreno R, Takala J, Suter P, Sprung C, Colardyn F, Blecher S (1998) Use of the SOFA score to assess the incidence of organ dysfunction\/failure in intensive care units: results of a multicenter, prospective study. Working group on \u201csepsis-related problems\u201d of the European Society of Intensive Care Medicine. Crit Care Med 26:1793\u20131800","journal-title":"Crit Care Med"}],"container-title":["Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-009-1456-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00134-009-1456-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-009-1456-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-009-1456-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T03:09:31Z","timestamp":1744168171000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00134-009-1456-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,18]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["1456"],"URL":"https:\/\/doi.org\/10.1007\/s00134-009-1456-x","relation":{},"ISSN":["0342-4642","1432-1238"],"issn-type":[{"value":"0342-4642","type":"print"},{"value":"1432-1238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,18]]},"assertion":[{"value":"4 April 2008","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2009","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2009","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}