{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T10:14:30Z","timestamp":1790331270776,"version":"4.1.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2010,5,22]],"date-time":"2010-05-22T00:00:00Z","timestamp":1274486400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2010,5,22]],"date-time":"2010-05-22T00:00:00Z","timestamp":1274486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intensive Care Med"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1007\/s00134-010-1908-3","type":"journal-article","created":{"date-parts":[[2010,5,21]],"date-time":"2010-05-21T06:30:14Z","timestamp":1274423414000},"page":"1532-1539","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":113,"title":["Gastric versus transpyloric feeding in severe traumatic brain injury: a prospective, randomized trial"],"prefix":"10.1007","volume":"36","author":[{"given":"Jose","family":"Acosta-Escribano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Fern\u00e1ndez-Vivas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teodoro","family":"Grau Carmona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Caturla-Such","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Garcia-Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ainhoa","family":"Menendez-Mainer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Solera-Suarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Sanchez-Pay\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,5,22]]},"reference":[{"key":"1908_CR1","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/S0140-6736(83)91980-3","volume":"1","author":"RK Chandra","year":"1983","unstructured":"Chandra RK (1983) Nutrition, immunity and infection: present knowledge and future directions. Lancet 1:688\u2013691","journal-title":"Lancet"},{"key":"1908_CR2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1093\/ajcn\/47.2.352","volume":"47","author":"DT Dempsey","year":"1988","unstructured":"Dempsey DT, Mullen JL, Buzby GP (1988) The link between nutritional status and clinical outcome: can nutritional intervention modify it? Am J Clin Nutr 47:351\u2013356","journal-title":"Am J Clin Nutr"},{"key":"1908_CR3","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1097\/00003246-198205000-00003","volume":"10","author":"K Apelgren","year":"1982","unstructured":"Apelgren K, Rombeau J, Twomey P, Miller R (1982) Comparison of nutritional indices and outcome in critically ill patients. Crit Care Med 10:305\u20133077","journal-title":"Crit Care Med"},{"key":"1908_CR4","first-page":"CD001530","volume":"4","author":"P Perel","year":"2006","unstructured":"Perel P, Yanagawa T, Bunn F, Roberts I, Wentz R, Pierro A (2006) Nutritional support for head-injured patients. Cochrane Database Syst Rev 4:CD001530","journal-title":"Cochrane Database Syst Rev"},{"key":"1908_CR5","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1093\/ajcn\/74.4.534","volume":"74","author":"C Braunschweig","year":"2001","unstructured":"Braunschweig C, Levy P, Sheean PM, Wang X (2001) Enteral compared with parenteral nutrition: a meta-analysis. Am J Clin Nutr 74:534\u2013542","journal-title":"Am J Clin Nutr"},{"key":"1908_CR6","doi-asserted-by":"publisher","first-page":"R46","DOI":"10.1186\/cc2190","volume":"7","author":"PE Marik","year":"2003","unstructured":"Marik PE, Zaloga GP (2003) Gastric versus post-pyloric feeding: a systematic review. Crit Care 7:R46\u2013R51","journal-title":"Crit Care"},{"key":"1908_CR7","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1007\/s00134-007-0942-2","volume":"34","author":"NQ Nguyen","year":"2008","unstructured":"Nguyen NQ, Chapman MJ, Fraser RJ, Bryant LK, Burgstad C, Ching K, Bellon M, Holloway RH (2008) The effects of sedation on gastric emptying and intra-gastric meal distribution in critical illness. Intensive Care Med 34:454\u2013460","journal-title":"Intensive Care Med"},{"key":"1908_CR8","doi-asserted-by":"publisher","unstructured":"Montejo-Gonzalez JC, Minambres E, Bordeje ML, Mesejo A, Acosta J, Heras A et al (2008) Gastric residual volume during enteral nutrition in ICU patients. The REGANE study. Preliminary results. Intensive Care Med. doi:10.1007\/s00134-010-1856-y","DOI":"10.1007\/s00134-010-1856-y"},{"key":"1908_CR9","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.clnu.2006.01.021","volume":"25","author":"KG Kreymann","year":"2006","unstructured":"Kreymann KG, Berger MM, Deutz NE, Hiesmayrd M, Jolliete P, Kazandjiev G, Nitenberg G, van den Berghe G, Wernerman J, Ebner C, Hartl W, Heymann C, Spies C (2006) ESPEN guidelines on enteral nutrition: intensive care. Clin Nutr 25:210\u2013223","journal-title":"Clin Nutr"},{"key":"1908_CR10","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1097\/00003246-200108000-00001","volume":"29","author":"DK Heyland","year":"2001","unstructured":"Heyland DK, Drover JW, Macdonald S, Novak F, Lam M (2001) Effect of postpyloric feeding on gastroesophageal regurgitation and pulmonary microaspiration: results of a randomized trial. Crit Care Med 29:1495\u20131501","journal-title":"Crit Care Med"},{"key":"1908_CR11","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1097\/00003246-200204000-00013","volume":"30","author":"JC Montejo","year":"2002","unstructured":"Montejo JC, Grau T, Acosta J, Ruiz-Santana S, Planas M, Garc\u00eda-De-Lorenzo A, Mesejo A, Cervera M, S\u00e1nchez-Alvarez C, N\u00fa\u00f1ez-Ruiz R, L\u00f3pez-Mart\u00ednez J, Nutritional and Metabolic Working Group of the Spanish Society of Intensive Care Medicine and Coronary Units (2002) Multicenter, prospective, randomized, single-blind study comparing the efficacy and gastrointestinal complications of early jejunal feeding with early gastric feeding in critically ill patients. Crit Care Med 30:796\u2013800","journal-title":"Crit Care Med"},{"key":"1908_CR12","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/S0749-0704(05)70114-7","volume":"16","author":"JL Vincent","year":"2000","unstructured":"Vincent JL, Ferreira F, Moreno R (2000) Scoring systems for assessing organ dysfunction and survival. Crit Care Clin 16:353\u2013366","journal-title":"Crit Care Clin"},{"key":"1908_CR13","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1097\/00005373-197607000-00001","volume":"16","author":"JA Moylan","year":"1976","unstructured":"Moylan JA, Detmer DE, Rose J, Schulz R (1976) Evaluation of the quality of hospital care for major trauma. J Trauma 16:517\u2013523","journal-title":"J Trauma"},{"key":"1908_CR14","first-page":"S1","volume":"24","author":"S Bratton","year":"2005","unstructured":"Bratton S, Bullock R, Carney N et al (2005) Guidelines for the management of severe traumatic brain injury. J Neurotrauma 24:S1\u2013106","journal-title":"J Neurotrauma"},{"key":"1908_CR15","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1016\/S0140-6736(00)03121-4","volume":"356","author":"AH Kaye","year":"2000","unstructured":"Kaye AH, Andrewas D (2000) Glasgow outcome scale: research scale or blunt instrument? Lancet 356:1541\u20131543","journal-title":"Lancet"},{"key":"1908_CR16","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/clinchem\/21.2.195","volume":"21","author":"M Bloom","year":"1975","unstructured":"Bloom M, Hjorne N (1975) Immunochemical determination of serum albumin with a centrifugal analyser. Clin Chem 21:195\u2013198","journal-title":"Clin Chem"},{"key":"1908_CR17","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1007\/s00134-008-1103-y","volume":"34","author":"PJ Andrews","year":"2008","unstructured":"Andrews PJ, Citerio G, Longhi L, Polderman K, Sahuquillo J, Vajkoczy P (2008) NICEM consensus on neurological monitoring in acute neurological diseases. Intensive Care Med 34:1362\u20131370","journal-title":"Intensive Care Med"},{"key":"1908_CR18","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1007\/s00134-002-1514-0","volume":"28","author":"RD Hubmayr","year":"2002","unstructured":"Hubmayr RD (2002) Statement of the 4th International Consensus Conference in Critical Care on ICU-acquired pneumonia\u2014Chicago, IIlinois, May 2002. Intensive Care Med 28:1521\u20131536","journal-title":"Intensive Care Med"},{"key":"1908_CR19","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1007\/s00134-007-0721-0","volume":"33","author":"J Valles","year":"2007","unstructured":"Valles J, Pobo A, Garcia-Esquirol O, Mariscal D, Real J, Fernandez R (2007) Excess ICU mortality attributable to ventilator-associated pneumonia: the role of early versus delayed onset. Intensive Care Med 33:1363\u20131368","journal-title":"Intensive Care Med"},{"key":"1908_CR20","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/0196-6553(88)90053-3","volume":"16","author":"JS Garner","year":"1988","unstructured":"Garner JS, Jarvis WR, Emori TG, Horan TC, Hughes JM (1988) CDC definitions for nosocomial infections. Am J Infect Control 16:128\u2013140","journal-title":"Am J Infect Control"},{"key":"1908_CR21","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1097\/01.CCM.0000168253.91200.83","volume":"33","author":"T Calandra","year":"2005","unstructured":"Calandra T, Cohen J (2005) The international sepsis forum consensus conference on definitions of infections in the intensive care unit. Crit Care Med 33:1538\u20131548","journal-title":"Crit Care Med"},{"key":"1908_CR22","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1097\/00003246-199908000-00006","volume":"27","author":"JC Montejo","year":"1999","unstructured":"Montejo JC, Nutritional and Metabolic Working Group of the Spanish Society of Intensive Care Medicine and Coronary Units (1999) Enteral nutrition-related gastrointestinal complications in critically ill patients. A multicenter study. Crit Care Med 27:1447\u20131453","journal-title":"Crit Care Med"},{"key":"1908_CR23","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1097\/01.TA.0000135158.42242.B1","volume":"58","author":"E Jeremitsky","year":"2005","unstructured":"Jeremitsky E, Omert LA, Dunham CM, Wilberger J, Rodriguez A (2005) The impact of hyperglycemia on patients with severe brain injury. J Trauma 58:47\u201350","journal-title":"J Trauma"},{"key":"1908_CR24","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1097\/01.TA.0000123267.39011.9F","volume":"56","author":"AM Laird","year":"2004","unstructured":"Laird AM, Miller PR, Kilgo PD, Meredith JW, Chang MC (2004) Relationship of early hyperglycemia to mortality in trauma patients. J Trauma 56:1058\u20131062","journal-title":"J Trauma"},{"key":"1908_CR25","first-page":"1711","volume":"153","author":"American Thoracic Society Ad Hoc Committee of the Scientific Assembly on Microbiology Tuberculosis and Pulmonary Infections","year":"1995","unstructured":"American Thoracic Society Ad Hoc Committee of the Scientific Assembly on Microbiology Tuberculosis and Pulmonary Infections (1995) Hospital acquired pneumonia in adults: diagnosis, assessment of severity, initial antimicrobial therapy and preventive strategies: a consensus statement. Am J Respir Crit Care Med 153:1711\u20131725","journal-title":"Am J Respir Crit Care Med"},{"key":"1908_CR26","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1177\/014860719201600159","volume":"16","author":"R Strong","year":"1992","unstructured":"Strong R, Condon S, Solinger M, Namihas BN, Ito-Wong LA, Leuty JE (1992) Equal aspiration rates from postpylorus and intragastric-placed small-bore nasoenteric feeding tubes: a randomized, prospective study. JPEN 16:59\u201363","journal-title":"JPEN"},{"key":"1908_CR27","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1097\/00003246-200006000-00007","volume":"28","author":"PJ Kearns","year":"2000","unstructured":"Kearns PJ, Chin D, Mueller L, Wallace K, Jensen WA, Kirsch CM (2000) The incidence of ventilator associated pneumonia and success in nutrient delivery with gastric versus small intestinal feeding: a randomized clinical trial. Crit Care Med 28:1742\u20131746","journal-title":"Crit Care Med"},{"key":"1908_CR28","first-page":"255","volume":"27","author":"DK Heyland","year":"2003","unstructured":"Heyland DK, Dhaliwal, Drover JW, Gramlich L, Dodek P (2003) Canadian clinical practice guidelines for nutrition support in mechanically ventilated, critically ill adult patients. JPEN 27:255\u2013273","journal-title":"JPEN"},{"key":"1908_CR29","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1007\/s00134-006-0128-3","volume":"32","author":"KM Ho","year":"2006","unstructured":"Ho KM, Dobb GJ, Webb SA (2006) A comparison of early gastric and post-pyloric feeding in critically ill patients: a meta-analysis. Intensive Care Med 32:639\u2013649","journal-title":"Intensive Care Med"},{"key":"1908_CR30","doi-asserted-by":"publisher","first-page":"62","DOI":"10.3171\/jns.1988.68.1.0062","volume":"68","author":"JA Norton","year":"1988","unstructured":"Norton JA, Ott LG, McClain C, Adams L, Dempsey RJ, Haack D, Tibbs PA, Young AB (1988) Intolerance to enteral feeding in the brain injured patient. J Neurosurgery 68:62\u201368","journal-title":"J Neurosurgery"},{"key":"1908_CR31","doi-asserted-by":"publisher","first-page":"2525","DOI":"10.1097\/00003246-199911000-00033","volume":"27","author":"SJ Taylor","year":"1999","unstructured":"Taylor SJ, Fettes SB, Jewkes C, Nelson RJ (1999) Prospective, randomized, controlled trial to determine the effect of early enhanced enteral nutrition on clinical outcome in mechanically ventilated patients suffering head injury. Crit Care Med 27:2525\u20132531","journal-title":"Crit Care Med"},{"key":"1908_CR32","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1177\/0115426503018005427","volume":"18","author":"P Ravasco","year":"2003","unstructured":"Ravasco P, Camilo M (2003) Tube feeding in mechanically ventilated critically ill patients: a prospective clinical audit. Nutr Clin Pract 18:427\u2013433","journal-title":"Nutr Clin Pract"},{"key":"1908_CR33","first-page":"278","volume":"20","author":"T Grau","year":"2005","unstructured":"Grau T, Bonet A, The Nutrition and Metabolism Working Group of the Spanish Society of Ctirical Care (SEMICYUC) (2005) Multicenter study on incidence of total parenteral nutrition complications in the critically-ill patient. ICOMEP study. Part II. Nutr Hosp 20:278\u2013285","journal-title":"Nutr Hosp"},{"key":"1908_CR34","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1177\/014860710202600603","volume":"26","author":"M DeMeo","year":"2002","unstructured":"DeMeo M, Bruninga K (2002) Physiology of the aerodigestive system and aberrations in that system resulting in aspiration. JPEN 26:S9\u2013S17","journal-title":"JPEN"},{"key":"1908_CR35","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1177\/0148607106030006503","volume":"30","author":"GV Bochicchio","year":"2006","unstructured":"Bochicchio GV, Bochicchio K, Nehman S, Casey C, Andrews P, Scalea TM (2006) Tolerance and efficacy of enteral nutrition in traumatic brain-injured patients induced into barbiturate coma. JPEN 30:503\u2013506","journal-title":"JPEN"},{"key":"1908_CR36","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1007\/s001340050325","volume":"23","author":"MM Tarling","year":"1997","unstructured":"Tarling MM, Toner CC, Withington PS, Baxter MK, Whelpton R, Goldhill DR (1997) A model of gastric emptying using paracetamol absorption in intensive care patients. Intensive Care Med 23:256\u2013260","journal-title":"Intensive Care Med"},{"key":"1908_CR37","first-page":"262","volume":"6","author":"JA Acosta","year":"2001","unstructured":"Acosta JA, Carrasco R, Fern\u00e1ndez M et al (2001) Intolerancia enteral g\u00e1strica en pacientes con lesi\u00f3n cerebral de origen traum\u00e1tico, ventilados mec\u00e1nicamente. Nutr Hosp 6:262\u2013267","journal-title":"Nutr Hosp"},{"key":"1908_CR38","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1097\/CCM.0b013e3181a40116","volume":"37","author":"RG Martindale","year":"2009","unstructured":"Martindale RG, McClave SA, Vanek VW, McCarthy M, Roberts P, Taylor B, Ochoa JB, Napolitano L, Cresci G, American College of Critical Care Medicine, A.S.P.E.N. Board of Directors (2009) Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine and American Society for Parenteral and Enteral Nutrition: executive summary. Crit Care Med 37:1757\u20131761","journal-title":"Crit Care Med"},{"key":"1908_CR39","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1227\/00006123-198609000-00006","volume":"19","author":"MN Hadley","year":"1986","unstructured":"Hadley MN, Grahm TW, Harrington T, Schiller WR, McDermott MK, Posillico DB (1986) Nutritional support and neurotrauma: a critical review of early nutrition in forty-five acute head injury patients. Neurosurgery 19:367\u2013373","journal-title":"Neurosurgery"},{"key":"1908_CR40","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1097\/00003246-200005000-00025","volume":"28","author":"DR Yavagal","year":"2000","unstructured":"Yavagal DR, Karnad DR, Oak JL (2000) Metoclopramide for preventing pneumonia in critically ill patients receiving enteral tube feeding: a randomized controlled trial. Crit Care Med 28:1408\u20131411","journal-title":"Crit Care Med"}],"container-title":["Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-010-1908-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00134-010-1908-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-010-1908-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-010-1908-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T23:36:47Z","timestamp":1744155407000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00134-010-1908-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,22]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["1908"],"URL":"https:\/\/doi.org\/10.1007\/s00134-010-1908-3","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.5281959.5226056","asserted-by":"object"}]},"ISSN":["0342-4642","1432-1238"],"issn-type":[{"value":"0342-4642","type":"print"},{"value":"1432-1238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,22]]},"assertion":[{"value":"19 July 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2010","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2010","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}