{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T04:04:19Z","timestamp":1744257859695,"version":"3.40.4"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2012,5,11]],"date-time":"2012-05-11T00:00:00Z","timestamp":1336694400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2012,5,11]],"date-time":"2012-05-11T00:00:00Z","timestamp":1336694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intensive Care Med"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1007\/s00134-012-2576-2","type":"journal-article","created":{"date-parts":[[2012,5,10]],"date-time":"2012-05-10T10:20:50Z","timestamp":1336645250000},"page":"1205-1214","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Isoflurane\/nitrous oxide anesthesia and stress-induced procedures enhance neuroapoptosis in intrauterine growth-restricted piglets"],"prefix":"10.1007","volume":"38","author":[{"given":"Harald","family":"Schubert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Eiselt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Walter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Fritz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Brodhun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,5,11]]},"reference":[{"key":"2576_CR1","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/S0140-6736(87)91907-6","volume":"1","author":"KJ Anand","year":"1987","unstructured":"Anand KJ, Sippell WG, Aynsley-Green A (1987) Randomised trial of fentanyl anaesthesia in preterm babies undergoing surgery: effects on the stress response. Lancet 1:62\u201366","journal-title":"Lancet"},{"key":"2576_CR2","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.bpa.2010.02.016","volume":"24","author":"F Weber","year":"2010","unstructured":"Weber F (2010) Evidence for the need for anaesthesia in the neonate. Best Pract Res Clin Anaesthesiol 24:475\u2013484","journal-title":"Best Pract Res Clin Anaesthesiol"},{"key":"2576_CR3","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.bpa.2010.02.013","volume":"24","author":"GK Istaphanous","year":"2010","unstructured":"Istaphanous GK, Ward CG, Loepke AW (2010) The impact of the perioperative period on neurocognitive development, with a focus on pharmacological concerns. Best Pract Res Clin Anaesthesiol 24:433\u2013449","journal-title":"Best Pract Res Clin Anaesthesiol"},{"key":"2576_CR4","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1213\/ane.ob013e3181732c01","volume":"106","author":"C Wang","year":"2008","unstructured":"Wang C, Slikker W Jr (2008) Strategies and experimental models for evaluating anesthetics: effects on the developing nervous system. Anesth Analg 106:1643\u20131658","journal-title":"Anesth Analg"},{"key":"2576_CR5","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/j.bpobgyn.2009.05.003","volume":"23","author":"S Sankaran","year":"2009","unstructured":"Sankaran S, Kyle PM (2009) Aetiology and pathogenesis of IUGR. Best Pract Res Clin Obstet Gynaecol 23:765\u2013777","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"Suppl 1","key":"2576_CR6","doi-asserted-by":"publisher","first-page":"S40","DOI":"10.1016\/S0301-2115(03)00171-4","volume":"110","author":"R Bauer","year":"2003","unstructured":"Bauer R, Walter B, Brust P, Fuchtner F, Zwiener U (2003) Impact of asymmetric intrauterine growth restriction on organ function in newborn piglets. Eur J Obstet Gynecol Reprod Biol 110(Suppl 1):S40\u2013S49","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"2576_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000053079","volume":"49","author":"HA Wollmann","year":"1998","unstructured":"Wollmann HA (1998) Intrauterine growth restriction: definition and etiology. Horm Res 49:1\u20136","journal-title":"Horm Res"},{"key":"2576_CR8","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1111\/j.1471-0528.1977.tb12550.x","volume":"84","author":"S Campbell","year":"1977","unstructured":"Campbell S, Thoms A (1977) Ultrasound measurement of the fetal head to abdomen circumference ratio in the assessment of growth retardation. Br J Obstet Gynaecol 84:165\u2013174","journal-title":"Br J Obstet Gynaecol"},{"key":"2576_CR9","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.bpobgyn.2009.06.006","volume":"23","author":"P Cox","year":"2009","unstructured":"Cox P, Marton T (2009) Pathological assessment of intrauterine growth restriction. Best Pract Res Clin Obstet Gynaecol 23:751\u2013764","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"2576_CR10","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1111\/j.1471-0528.2008.01827.x","volume":"115","author":"B Jacobsson","year":"2008","unstructured":"Jacobsson B, Ahlin K, Francis A, Hagberg G, Hagberg H, Gardosi J (2008) Cerebral palsy and restricted growth status at birth: population-based case\u2013control study. BJOG 115:1250\u20131255","journal-title":"BJOG"},{"key":"2576_CR11","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1203\/00006450-199404000-00022","volume":"35","author":"L Spassov","year":"1994","unstructured":"Spassov L, Curzi-Dascalova L, Clairambault J, Kauffmann F, Eiselt M, Medigue C, Peirano P (1994) Heart rate and heart rate variability during sleep in small-for-gestational age newborns. Pediatr Res 35:500\u2013505","journal-title":"Pediatr Res"},{"key":"2576_CR12","doi-asserted-by":"publisher","first-page":"F322","DOI":"10.1136\/adc.2007.120485","volume":"93","author":"DM Walker","year":"2008","unstructured":"Walker DM, Marlow N (2008) Neurocognitive outcome following fetal growth restriction. Arch Dis Child Fetal Neonatal Ed 93:F322\u2013F325","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2576_CR13","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1542\/peds.50.3.403","volume":"50","author":"HP Chase","year":"1972","unstructured":"Chase HP, Welch NN, Dabiere CS, Vasan NS, Butterfield LJ (1972) Alterations in human brain biochemistry following intrauterine growth retardation. Pediatrics 50:403\u2013411","journal-title":"Pediatrics"},{"key":"2576_CR14","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/j.1471-0528.2004.00318.x","volume":"112","author":"KR Duncan","year":"2005","unstructured":"Duncan KR, Issa B, Moore R, Baker PN, Johnson IR, Gowland PA (2005) A comparison of fetal organ measurements by echo-planar magnetic resonance imaging and ultrasound. Bjog 112:43\u201349","journal-title":"Bjog"},{"key":"2576_CR15","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1007\/s00428-005-1251-1","volume":"446","author":"C Burke","year":"2005","unstructured":"Burke C, Gobe G (2005) Pontosubicular apoptosis (\u201cnecrosis\u201d) in human neonates with intrauterine growth retardation and placental infarction. Virchows Arch 446:640\u2013645","journal-title":"Virchows Arch"},{"key":"2576_CR16","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1097\/ALN.0b013e3181d049cd","volume":"112","author":"AM Brambrink","year":"2010","unstructured":"Brambrink AM, Evers AS, Avidan MS, Farber NB, Smith DJ, Zhang X, Dissen GA, Creeley CE, Olney JW (2010) Isoflurane-induced neuroapoptosis in the neonatal rhesus macaque brain. Anesthesiology 112:834\u2013841","journal-title":"Anesthesiology"},{"key":"2576_CR17","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.neuroscience.2003.07.012","volume":"122","author":"V Jevtovic-Todorovic","year":"2003","unstructured":"Jevtovic-Todorovic V, Beals J, Benshoff N, Olney JW (2003) Prolonged exposure to inhalational anesthetic nitrous oxide kills neurons in adult rat brain. Neuroscience 122:609\u2013616","journal-title":"Neuroscience"},{"key":"2576_CR18","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1213\/ane.0b013e31818cdb29","volume":"108","author":"AW Loepke","year":"2009","unstructured":"Loepke AW, Istaphanous GK, McAuliffe JJ 3rd, Miles L, Hughes EA, McCann JC, Harlow KE, Kurth CD, Williams MT, Vorhees CV, Danzer SC (2009) The effects of neonatal isoflurane exposure in mice on brain cell viability, adult behavior, learning, and memory. Anesth Analg 108:90\u2013104","journal-title":"Anesth Analg"},{"key":"2576_CR19","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/j.1749-6632.2009.05173.x","volume":"1199","author":"S Rizzi","year":"2010","unstructured":"Rizzi S, Ori C, Jevtovic-Todorovic V (2010) Timing versus duration: determinants of anesthesia-induced developmental apoptosis in the young mammalian brain. Ann N Y Acad Sci 1199:43\u201351","journal-title":"Ann N Y Acad Sci"},{"key":"2576_CR20","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1213\/00000539-199303000-00011","volume":"76","author":"JH Arnold","year":"1993","unstructured":"Arnold JH, Truog RD, Rice SA (1993) Prolonged administration of isoflurane to pediatric patients during mechanical ventilation. Anesth Analg 76:520\u2013526","journal-title":"Anesth Analg"},{"key":"2576_CR21","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.bpa.2003.12.010","volume":"18","author":"K Kinouchi","year":"2004","unstructured":"Kinouchi K (2004) Anaesthetic considerations for the management of very low and extremely low birth weight infants. Best Pract Res Clin Anaesthesiol 18:273\u2013290","journal-title":"Best Pract Res Clin Anaesthesiol"},{"key":"2576_CR22","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1111\/j.1460-9592.2009.02962.x","volume":"19","author":"J Lerman","year":"2009","unstructured":"Lerman J, Johr M (2009) Inhalational anesthesia vs total intravenous anesthesia (TIVA) for pediatric anesthesia. Paediatr Anaesth 19:521\u2013534","journal-title":"Paediatr Anaesth"},{"key":"2576_CR23","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S0940-2993(98)80071-7","volume":"50","author":"R Bauer","year":"1998","unstructured":"Bauer R, Walter B, Hoppe A, Gaser E, Lampe V, Kauf E, Zwiener U (1998) Body weight distribution and organ size in newborn swine (sus scrofa domestica)\u2014a study describing an animal model for asymmetrical intrauterine growth retardation. Exp Toxicol Pathol 50:59\u201365","journal-title":"Exp Toxicol Pathol"},{"key":"2576_CR24","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1159\/000241119","volume":"34","author":"L DeRoth","year":"1978","unstructured":"DeRoth L, Downie HG (1978) Basic cardiovascular parameters in the underweight neonatal swine. Biol Neonate 34:155\u2013160","journal-title":"Biol Neonate"},{"key":"2576_CR25","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1111\/j.1399-6576.1996.tb04468.x","volume":"40","author":"S Satas","year":"1996","unstructured":"Satas S, Haaland K, Thoresen M, Steen PA (1996) MAC for halothane and isoflurane during normothermia and hypothermia in the newborn piglet. Acta Anaesthesiol Scand 40:452\u2013456","journal-title":"Acta Anaesthesiol Scand"},{"key":"2576_CR26","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1097\/00000542-200408000-00033","volume":"101","author":"KJ Anand","year":"2004","unstructured":"Anand KJ, Soriano SG (2004) Anesthetic agents and the immature brain: are these toxic or therapeutic? Anesthesiology 101:527\u2013530","journal-title":"Anesthesiology"},{"key":"2576_CR27","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1126\/science.283.5398.70","volume":"283","author":"C Ikonomidou","year":"1999","unstructured":"Ikonomidou C, Bosch F, Miksa M, Bittigau P, Vockler J, Dikranian K, Tenkova TI, Stefovska V, Turski L, Olney JW (1999) Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science 283:70\u201374","journal-title":"Science"},{"key":"2576_CR28","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1523\/JNEUROSCI.23-03-00876.2003","volume":"23","author":"V Jevtovic-Todorovic","year":"2003","unstructured":"Jevtovic-Todorovic V, Hartman RE, Izumi Y, Benshoff ND, Dikranian K, Zorumski CF, Olney JW, Wozniak DF (2003) Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits. J Neurosci 23:876\u2013882","journal-title":"J Neurosci"},{"key":"2576_CR29","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/0378-3782(79)90022-7","volume":"3","author":"J Dobbing","year":"1979","unstructured":"Dobbing J, Sands J (1979) Comparative aspects of the brain growth spurt. Early Hum Dev 3:79\u201383","journal-title":"Early Hum Dev"},{"key":"2576_CR30","doi-asserted-by":"publisher","first-page":"e1053","DOI":"10.1542\/peds.2011-0351","volume":"128","author":"RP Flick","year":"2011","unstructured":"Flick RP, Katusic SK, Colligan RC, Wilder RT, Voigt RG, Olson MD, Sprung J, Weaver AL, Schroeder DR, Warner DO (2011) Cognitive and behavioral outcomes after early exposure to anesthesia and surgery. Pediatrics 128:e1053\u2013e1061","journal-title":"Pediatrics"},{"key":"2576_CR31","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1213\/ANE.0b013e3182147f42","volume":"113","author":"C DiMaggio","year":"2011","unstructured":"DiMaggio C, Sun LS, Li G (2011) Early childhood exposure to anesthesia and risk of developmental and behavioral disorders in a sibling birth cohort. Anesth Analg 113:1143\u20131151","journal-title":"Anesth Analg"}],"container-title":["Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-012-2576-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00134-012-2576-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-012-2576-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-012-2576-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T03:18:34Z","timestamp":1744168714000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00134-012-2576-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,11]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["2576"],"URL":"https:\/\/doi.org\/10.1007\/s00134-012-2576-2","relation":{},"ISSN":["0342-4642","1432-1238"],"issn-type":[{"type":"print","value":"0342-4642"},{"type":"electronic","value":"1432-1238"}],"subject":[],"published":{"date-parts":[[2012,5,11]]},"assertion":[{"value":"20 June 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2012","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2012","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}