{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:36:26Z","timestamp":1788881786593,"version":"build-2803163510"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,11,6]],"date-time":"2012-11-06T00:00:00Z","timestamp":1352160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intensive Care Med"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1007\/s00134-012-2734-6","type":"journal-article","created":{"date-parts":[[2012,11,5]],"date-time":"2012-11-05T14:01:16Z","timestamp":1352124076000},"page":"117-122","source":"Crossref","is-referenced-by-count":54,"title":["High-dose magnesium sulfate infusion protocol for status asthmaticus: a safety and pharmacokinetics cohort study"],"prefix":"10.1007","volume":"39","author":[{"given":"Tosha A.","family":"Egelund","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah K.","family":"Wassil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa M.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Linden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose E.","family":"Irazuzta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,11,6]]},"reference":[{"key":"2734_CR1","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/0002-9378(84)90676-8","volume":"150","author":"BM Sibai","year":"1984","unstructured":"Sibai BM, Graham JM, McCubbin JH (1984) A comparison of intravenous and intramuscular magnesium sulfate regimens in preeclampsia. Am J Obstet Gynecol 150:728\u2013733","journal-title":"Am J Obstet Gynecol"},{"key":"2734_CR2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.pcc.0000256620.55512.5f","volume":"8","author":"JE Natale","year":"2007","unstructured":"Natale JE, Guerguerian AM, Joseph JG, McCarter R, Shao C, Slomine B, Christensen J, Johnston MV, Shaffner DH (2007) Pilot study to determine the hemodynamic safety and feasibility of magnesium sulfate infusion in children with severe traumatic brain injury. Pediatr Crit Care Med 8:1\u20139","journal-title":"Pediatr Crit Care Med"},{"key":"2734_CR3","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1093\/tropej\/fmm101","volume":"54","author":"F Raimondi","year":"2008","unstructured":"Raimondi F, Migliaro F, Capasso L, Ausanio G, Bisceglia M, Giliberti P, Messina F, Salvia G, Paludetto R (2008) Intravenous magnesium sulphate vs. inhaled nitric oxide for moderate, persistent pulmonary hypertension of the newborn. A multicentre, retrospective study. J Trop Pediatr 54:196\u2013199","journal-title":"J Trop Pediatr"},{"key":"2734_CR4","doi-asserted-by":"crossref","first-page":"730","DOI":"10.3109\/02699051003610516","volume":"24","author":"L Ma","year":"2010","unstructured":"Ma L, Liu WG, Zhang JM, Chen G, Fan J, Sheng HS (2010) Magnesium sulphate in the management of patients with aneurysmal subarachnoid haemorrhage: a meta-analysis of prospective controlled trials. Brain Inj 24:730\u2013735","journal-title":"Brain Inj"},{"key":"2734_CR5","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1136\/adc.2004.050005","volume":"90","author":"DK Cheuk","year":"2005","unstructured":"Cheuk DK, Chau TC, Lee SL (2005) A meta-analysis on intravenous magnesium sulphate for treating acute asthma. Arch Dis Child 90:74\u201377","journal-title":"Arch Dis Child"},{"key":"2734_CR6","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1111\/j.1553-2712.2010.00913.x","volume":"17","author":"S Schuh","year":"2010","unstructured":"Schuh S, Macias C, Freedman SB, Plint AC, Zorc JJ, Bajaj L, Black KJ, Johnson DW, Boutis K (2010) North American practice patterns of intravenous magnesium therapy in severe acute asthma in children. Acad Emerg Med 17:1189\u20131196","journal-title":"Acad Emerg Med"},{"key":"2734_CR7","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1001\/archpedi.154.10.979","volume":"154","author":"L Ciarallo","year":"2000","unstructured":"Ciarallo L, Brousseau D, Reinert S (2000) Higher-dose intravenous magnesium therapy for children with moderate to severe acute asthma. Arch Pediatr Adolesc Med 154:979\u2013983","journal-title":"Arch Pediatr Adolesc Med"},{"key":"2734_CR8","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/00063110-199909000-00005","volume":"6","author":"F G\u00fcrkan","year":"1999","unstructured":"G\u00fcrkan F, Haspolat K, Bo\u015fnak M, Dikici B, Derman O, Ece A (1999) Intravenous magnesium sulphate in the management of moderate to severe acute asthmatic children nonresponding to conventional therapy. Eur J Emerg Med 6:201\u2013205","journal-title":"Eur J Emerg Med"},{"key":"2734_CR9","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1097\/00006565-199408000-00004","volume":"10","author":"H Pabon","year":"1994","unstructured":"Pabon H, Monem G, Kissoon N (1994) Safety and efficacy of magnesium sulfate infusions in children with status asthmaticus. Pediatr Emerg Care 10:200\u2013203","journal-title":"Pediatr Emerg Care"},{"key":"2734_CR10","doi-asserted-by":"crossref","unstructured":"Irazuzta J, Wassil SK, Egelund T (2012) Feasibility and safety of short term infusion of magnesium sulfate in status asthmaticus. J Pediatr Pharmacol Ther (Accepted)","DOI":"10.5863\/1551-6776-17.2.150"},{"key":"2734_CR11","unstructured":"Magnesium Sulfate Injection 50\u00a0% (2007). APP Pharmaceuticals. Package insert. Dec 2007"},{"key":"2734_CR12","first-page":"1677","volume":"23","author":"JC Rosello","year":"1936","unstructured":"Rosello JC, Pla HJ (1936) Sulfato de magnesio en la crisis de asma. Prensa Med Argentina 23:1677\u20131680","journal-title":"Prensa Med Argentina"},{"key":"2734_CR13","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1113\/jphysiol.1954.sp005114","volume":"124","author":"J Castillo Del","year":"1954","unstructured":"Del Castillo J, Engbaek L (1954) The nature of the neuromuscular block produced by magnesium. J Physiol 124:370\u2013384","journal-title":"J Physiol"},{"key":"2734_CR14","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1089\/089426801316970259","volume":"14","author":"KI Gourgoulianis","year":"2001","unstructured":"Gourgoulianis KI, Chatziparasidis G, Chatziefthimiou A, Molyvdas PA (2001) Magnesium as a relaxing factor of airway smooth muscles. J Aerosol Med 14:301\u2013307","journal-title":"J Aerosol Med"},{"key":"2734_CR15","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1172\/JCI103726","volume":"37","author":"LC Chesley","year":"1958","unstructured":"Chesley LC, Tepper I (1958) Some effects of magnesium loading upon renal excretion of magnesium and certain other electrolytes. J Clin Invest 37:1362\u20131372","journal-title":"J Clin Invest"},{"key":"2734_CR16","first-page":"389","volume":"34","author":"PR Devi","year":"1997","unstructured":"Devi PR, Kumar L, Singhi SC, Prasad R, Singh M (1997) Intravenous magnesium sulfate in acute severe asthma not responding to conventional therapy. Indian Pediatr 34:389\u2013397","journal-title":"Indian Pediatr"},{"key":"2734_CR17","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1447-0756.2007.00508.x","volume":"33","author":"BS Aali","year":"2007","unstructured":"Aali BS, Khazaeli P, Ghasemi F (2007) Ionized and total magnesium concentration in patients with severe preeclampsia-eclampsia undergoing magnesium sulfate therapy. J Obstet Gynaecol Res 33:138\u2013143","journal-title":"J Obstet Gynaecol Res"},{"key":"2734_CR18","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3109\/00016349509024381","volume":"74","author":"SM Handwerker","year":"1995","unstructured":"Handwerker SM, Altura BT, Chi DS, Altura BM (1995) Serum ionized magnesium levels during intravenous MgSO4 therapy of preeclamptic women. Acta Obstet Gynecol Scand 74:517\u2013519","journal-title":"Acta Obstet Gynecol Scand"},{"key":"2734_CR19","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ejogrb.2005.10.036","volume":"128","author":"M Yoshida","year":"2006","unstructured":"Yoshida M, Matsuda Y, Akizawa Y, Ono E, Ohta H (2006) Serum ionized magnesium during magnesium sulfate administration for preterm labor and preeclampsia. Eur J Obstet Gynecol Reprod Biol 128:125\u2013128","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"2734_CR20","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1034\/j.1399-6576.2001.045004435.x","volume":"45","author":"H Yoshioka","year":"2001","unstructured":"Yoshioka H, Hirota K, Sato T, Hashimoto Y, Ishihara H, Matsuki A (2001) Spasmolytic effect of magnesium sulfate on serotonin-induced pulmonary hypertension and bronchoconstriction in dogs. Acta Anaesthesiol Scand 45:435\u2013440","journal-title":"Acta Anaesthesiol Scand"},{"key":"2734_CR21","unstructured":"De Nicola L, Monem G, Saldejeno V (1995) Magnesium sulfate kinetics in children. In: Poster presented at University of Florida Pediatric Science Day. Gainesville, FL"},{"key":"2734_CR22","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1378\/chest.123.1.113","volume":"123","author":"E Zervas","year":"2003","unstructured":"Zervas E, Papatheodorou G, Psathakis K, Panagou P, Georgatou N, Loukides S (2003) Reduced intracellular Mg concentrations in patients with acute asthma. Chest 123:113\u2013118","journal-title":"Chest"},{"key":"2734_CR23","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1080\/00365510500333825","volume":"65","author":"R Sinert","year":"2005","unstructured":"Sinert R, Spektor M, Gorlin A, Doty C, Rubin A, Altura BT, Altura BM (2005) Ionized magnesium levels and the ratio of ionized calcium to magnesium in asthma patients before and after treatment with magnesium. Scand J Clin Lab Inves 65:659\u2013670","journal-title":"Scand J Clin Lab Inves"},{"key":"2734_CR24","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00134-004-2508-x","volume":"31","author":"MP Escuela","year":"2005","unstructured":"Escuela MP, Guerra M, A\u00f1\u00f3n JM, Mart\u00ednez-Vizca\u00edno V, Zapatero MD, Garc\u00eda-Jal\u00f3n A, Celaya S (2005) Total and ionized serum magnesium in critically ill patients. Intensive Care Med 31:151\u2013156","journal-title":"Intensive Care Med"},{"key":"2734_CR25","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1053\/jcrc.2002.36759","volume":"17","author":"ML Glover","year":"2002","unstructured":"Glover ML, Machado C, Totapally BR (2002) Magnesium sulfate administered via continuous intravenous infusion in pediatric patients with refractory wheezing. J Crit Care 17:255\u2013258","journal-title":"J Crit Care"},{"key":"2734_CR26","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1164\/rccm.200602-231PP","volume":"174","author":"DA Beuther","year":"2006","unstructured":"Beuther DA, Weiss ST, Sutherland ER (2006) Obesity and asthma. Am J Respir Crit Care Med 174:112\u2013119","journal-title":"Am J Respir Crit Care Med"},{"key":"2734_CR27","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1542\/peds.2007-0409","volume":"120","author":"CL Carroll","year":"2007","unstructured":"Carroll CL, Stoltz P, Raykov N, Smith SR, Zucker AR (2007) Childhood overweight increases hospital admission rates for asthma. Pediatrics 120:734\u2013740","journal-title":"Pediatrics"}],"container-title":["Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-012-2734-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00134-012-2734-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-012-2734-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T07:38:08Z","timestamp":1562312288000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00134-012-2734-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,6]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["2734"],"URL":"https:\/\/doi.org\/10.1007\/s00134-012-2734-6","relation":{},"ISSN":["0342-4642","1432-1238"],"issn-type":[{"value":"0342-4642","type":"print"},{"value":"1432-1238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,6]]}}}