{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:48:44Z","timestamp":1792460924416,"version":"4.5.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T00:00:00Z","timestamp":1416528000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intensive Care Med"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1007\/s00134-014-3552-9","type":"journal-article","created":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T10:08:36Z","timestamp":1416564516000},"page":"77-85","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Thromboelastography in patients with severe sepsis: a prospective cohort study"],"prefix":"10.1007","volume":"41","author":[{"given":"Nicolai","family":"Haase","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisse Rye","family":"Ostrowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rn","family":"Wetterslev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theis","family":"Lange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten Hylander","family":"M\u00f8ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Tousi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Steensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Pott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"S\u00f8e-Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Buhl","family":"Hjortrup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e4r Ingemar","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Perner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,11,21]]},"reference":[{"key":"3552_CR1","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1056\/NEJMra1208623","volume":"369","author":"DC Angus","year":"2013","unstructured":"Angus DC, van der Poll T (2013) Severe sepsis and septic shock. N Engl J Med 369:840\u2013851. doi: 10.1056\/NEJMra1208623","journal-title":"N Engl J Med"},{"key":"3552_CR2","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1097\/01.CCM.0000147769.07699.E3","volume":"32","author":"K Bakhtiari","year":"2004","unstructured":"Bakhtiari K, Meijers JCM, de Jonge E, Levi M (2004) Prospective validation of the International Society of Thrombosis and Haemostasis scoring system for disseminated intravascular coagulation. Crit Care Med 32:2416\u20132421","journal-title":"Crit Care Med"},{"key":"3552_CR3","author":"SR Ostrowski","year":"2012","unstructured":"Ostrowski SR, Windel\u00f8v NA, Ibsen M et al (2012) Consecutive thrombelastography clot strength profiles in patients with severe sepsis and their association with 28-day mortality: a prospective study. J Crit Care. doi: 10.1016\/j.jcrc.2012.09.003","journal-title":"J Crit Care"},{"key":"3552_CR4","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/MBC.0b013e3283367882","volume":"21","author":"PI Johansson","year":"2010","unstructured":"Johansson PI, Stensballe J, Vindel\u00f8v N et al (2010) Hypocoagulability, as evaluated by thrombelastography, at admission to the ICU is associated with increased 30-day mortality. Blood Coagul Fibrinolysis 21:168\u2013174. doi: 10.1097\/MBC.0b013e3283367882","journal-title":"Blood Coagul Fibrinolysis"},{"key":"3552_CR5","doi-asserted-by":"crossref","first-page":"R30","DOI":"10.1186\/cc13721","volume":"18","author":"MC M\u00fcller","year":"2014","unstructured":"M\u00fcller MC, Meijers JC, Vroom MB, Juffermans NP (2014) Utility of thromboelastography and\/or thromboelastometry in adults with sepsis: a systematic review. Crit Care 18:R30. doi: 10.1186\/cc13721","journal-title":"Crit Care"},{"key":"3552_CR6","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1056\/NEJMoa1204242","volume":"367","author":"A Perner","year":"2012","unstructured":"Perner A, Haase N, Guttormsen AB et al (2012) Hydroxyethyl starch 130\/0.42 versus Ringer\u2019s acetate in severe sepsis. N Engl J Med 367:124\u2013134. doi: 10.1056\/NEJMoa1204242","journal-title":"N Engl J Med"},{"key":"3552_CR7","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1097\/00003246-199206000-00025","volume":"20","author":"American College of Chest Physicians\/Society of Critical Care Medicine","year":"1992","unstructured":"American College of Chest Physicians\/Society of Critical Care Medicine (1992) American College of Chest Physicians\/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 20:864\u2013874","journal-title":"Crit Care Med"},{"key":"3552_CR8","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1745-6215-12-24","volume":"12","author":"A Perner","year":"2011","unstructured":"Perner A, Haase N, Wetterslev J et al (2011) Comparing the effect of hydroxyethyl starch 130\/0.4 with balanced crystalloid solution on mortality and kidney failure in patients with severe sepsis (6S-Scandinavian starch for severe sepsis\/septic shock trial): study protocol, design and rationale fora double-blinded randomised clinical trial. Trials 12:24. doi: 10.1186\/1745-6215-12-24","journal-title":"Trials"},{"key":"3552_CR9","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1007\/s00134-013-3111-9","volume":"39","author":"N Haase","year":"2013","unstructured":"Haase N, Wetterslev J, Winkel P, Perner A (2013) Bleeding and risk of death with hydroxyethyl starch in severe sepsis: post hoc analyses of a randomized clinical trial. Intensive Care Med 39:2126\u20132134. doi: 10.1007\/s00134-013-3111-9","journal-title":"Intensive Care Med"},{"key":"3552_CR10","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jclinepi.2007.11.008","volume":"61","author":"E Elm Von","year":"2008","unstructured":"Von Elm E, Altman DG, Egger M et al (2008) The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol 61:344\u2013349. doi: 10.1016\/j.jclinepi.2007.11.008","journal-title":"J Clin Epidemiol"},{"key":"3552_CR11","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1001\/jama.1993.03510240069035","volume":"270","author":"JR Gall Le","year":"1993","unstructured":"Le Gall JR, Lemeshow S, Saulnier F (1993) A new Simplified Acute Physiology Score (SAPS II) based on a European\/North American multicenter study. JAMA 270:2957\u20132963","journal-title":"JAMA"},{"key":"3552_CR12","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/BF01709751","volume":"22","author":"JL Vincent","year":"1996","unstructured":"Vincent JL, Moreno R, Takala J et al (1996) The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction\/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 22:707\u2013710","journal-title":"Intensive Care Med"},{"key":"3552_CR13","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1177\/1460458209353558","volume":"16","author":"JL Nates","year":"2010","unstructured":"Nates JL, C\u00e1rdenas-Turanzas M, Wakefield C et al (2010) Automating and simplifying the SOFA score in critically ill patients with cancer. Health Informatics J 16:35\u201347. doi: 10.1177\/1460458209353558","journal-title":"Health Informatics J"},{"key":"3552_CR14","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/01.mbc.0000203859.62739.25","volume":"17","author":"JA Coppell","year":"2006","unstructured":"Coppell JA, Thalheimer U, Zambruni A et al (2006) The effects of unfractionated heparin, low molecular weight heparin and danaparoid on the thromboelastogram (TEG): an in vitro comparison of standard and heparinase-modified TEGs with conventional coagulation assays. Blood Coagul Fibrinolysis 17:97\u2013104. doi: 10.1097\/01.mbc.0000203859.62739.25","journal-title":"Blood Coagul Fibrinolysis"},{"key":"3552_CR15","doi-asserted-by":"crossref","DOI":"10.1201\/b12208","volume-title":"Joint models for longitudinal and time-to-event data","author":"D Rizopoulos","year":"2012","unstructured":"Rizopoulos D (2012) Joint models for longitudinal and time-to-event data, 1st edn. Chapman & Hall\/CRC Biostatistics Series, London","edition":"1"},{"key":"3552_CR16","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1056\/NEJMp1207437","volume":"367","author":"SE Gabriel","year":"2012","unstructured":"Gabriel SE, Normand S-LT (2012) Getting the methods right\u2014the foundation of patient-centered outcomes research. N Engl J Med 367:787\u2013790. doi: 10.1056\/NEJMp1207437","journal-title":"N Engl J Med"},{"key":"3552_CR17","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1191\/096228099671525676","volume":"8","author":"JL Schafer","year":"1999","unstructured":"Schafer JL (1999) Multiple imputation: a primer. Stat Method Med Res 8:3\u201315","journal-title":"Stat Method Med Res"},{"key":"3552_CR18","doi-asserted-by":"crossref","first-page":"R160","DOI":"10.1186\/cc5098","volume":"10","author":"C Gonano","year":"2006","unstructured":"Gonano C, Sitzwohl C, Meitner E et al (2006) Four-day antithrombin therapy does not seem to attenuate hypercoagulability in patients suffering from sepsis. Crit Care 10:R160. doi: 10.1186\/cc5098","journal-title":"Crit Care"},{"key":"3552_CR19","doi-asserted-by":"crossref","first-page":"R42","DOI":"10.1186\/cc7765","volume":"13","author":"F Daudel","year":"2009","unstructured":"Daudel F, Kessler U, Folly H et al (2009) Thromboelastometry for the assessment of coagulation abnormalities in early and established adult sepsis: a prospective cohort study. Crit Care 13:R42. doi: 10.1186\/cc7765","journal-title":"Crit Care"},{"key":"3552_CR20","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1097\/MBC.0b013e32832a76e1","volume":"20","author":"M Sivula","year":"2009","unstructured":"Sivula M, Pettil\u00e4 V, Niemi TT et al (2009) Thromboelastometry in patients with severe sepsis and disseminated intravascular coagulation. Blood Coagul Fibrinolysis 20:419\u2013426. doi: 10.1097\/MBC.0b013e32832a76e1","journal-title":"Blood Coagul Fibrinolysis"},{"key":"3552_CR21","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1111\/j.1399-6576.2012.02750.x","volume":"56","author":"T Brenner","year":"2012","unstructured":"Brenner T, Schmidt K, Delang M et al (2012) Viscoelastic and aggregometric point-of-care testing in patients with septic shock\u2014cross-links between inflammation and haemostasis. Acta Anaesthesiol Scand 56:1277\u20131290. doi: 10.1111\/j.1399-6576.2012.02750.x","journal-title":"Acta Anaesthesiol Scand"},{"key":"3552_CR22","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/SHK.0b013e318204bff6","volume":"35","author":"M Adamzik","year":"2011","unstructured":"Adamzik M, Langemeier T, Frey UH et al (2011) Comparison of thrombelastometry with simplified acute physiology score II and sequential organ failure assessment scores for the prediction of 30-day survival: a cohort study. Shock 35:339\u2013342. doi: 10.1097\/SHK.0b013e318204bff6","journal-title":"Shock"},{"key":"3552_CR23","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1007\/s00134-012-2620-2","volume":"38","author":"PB Massion","year":"2012","unstructured":"Massion PB, Peters P, Ledoux D et al (2012) Persistent hypocoagulability in patients with septic shock predicts greater hospital mortality: impact of impaired thrombin generation. Intensive Care Med 38:1326\u20131335. doi: 10.1007\/s00134-012-2620-2","journal-title":"Intensive Care Med"},{"key":"3552_CR24","author":"JL Nates","year":"2014","unstructured":"Nates JL, Cattano D, Chelly JE, Doursout M-F (2014) Study of acute hemocoagulation changes in a porcine endotoxemic shock model using thrombelastography. Transl Res. doi: 10.1016\/j.trsl.2014.09.002","journal-title":"Transl Res"},{"key":"3552_CR25","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1007\/s00134-011-2385-z","volume":"37","author":"CS Hartog","year":"2011","unstructured":"Hartog CS, Reuter D, Loesche W et al (2011) Influence of hydroxyethyl starch (HES) 130\/0.4 on hemostasis as measured by viscoelastic device analysis: a systematic review. Intensive Care Med 37:1725\u20131737. doi: 10.1007\/s00134-011-2385-z","journal-title":"Intensive Care Med"},{"key":"3552_CR26","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1213\/01.ane.0000280481.18570.27","volume":"105","author":"M Mittermayr","year":"2007","unstructured":"Mittermayr M, Streif W, Haas T et al (2007) Hemostatic changes after crystalloid or colloid fluid administration during major orthopedic surgery: the role of fibrinogen administration. Anesth Analg 105:905\u2013917. doi: 10.1213\/01.ane.0000280481.18570.27","journal-title":"Anesth Analg"},{"key":"3552_CR27","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/j.1538-7836.2009.03331.x","volume":"7","author":"C Fenger-Eriksen","year":"2009","unstructured":"Fenger-Eriksen C, Jensen TM, Kristensen BS et al (2009) Fibrinogen substitution improves whole blood clot firmness after dilution with hydroxyethyl starch in bleeding patients undergoing radical cystectomy: a randomized, placebo-controlled clinical trial. J Thromb Haemost 7:795\u2013802","journal-title":"J Thromb Haemost"},{"key":"3552_CR28","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1136\/bmj.330.7493.724","volume":"330","author":"C Gluud","year":"2005","unstructured":"Gluud C, Gluud LL (2005) Evidence based diagnostics. BMJ 330:724\u2013726","journal-title":"BMJ"},{"key":"3552_CR29","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.jhep.2007.01.003","volume":"46","author":"C Gluud","year":"2007","unstructured":"Gluud C, Brok J, Gong Y, Koretz R (2007) Hepatology may have problems with putative surrogate outcome measures. J Hepatol 46:734\u2013742","journal-title":"J Hepatol"},{"key":"3552_CR30","first-page":"CD007871","volume":"3","author":"A Afshari","year":"2011","unstructured":"Afshari A, Wikkels\u00f8 A, Brok J et al (2011) Thrombelastography (TEG) or thromboelastometry (ROTEM) to monitor haemotherapy versus usual care in patients with massive transfusion. Cochrane Database Syst Rev 3:CD007871. doi: 10.1002\/14651858.CD007871.pub2","journal-title":"Cochrane Database Syst Rev"}],"container-title":["Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-014-3552-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00134-014-3552-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-014-3552-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T09:00:13Z","timestamp":1558602013000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00134-014-3552-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,21]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["3552"],"URL":"https:\/\/doi.org\/10.1007\/s00134-014-3552-9","relation":{},"ISSN":["0342-4642","1432-1238"],"issn-type":[{"value":"0342-4642","type":"print"},{"value":"1432-1238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,21]]}}}