{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:35:14Z","timestamp":1761896114798,"version":"3.40.4"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2015,8,4]],"date-time":"2015-08-04T00:00:00Z","timestamp":1438646400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2015,8,4]],"date-time":"2015-08-04T00:00:00Z","timestamp":1438646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intensive Care Med"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1007\/s00134-015-4004-x","type":"journal-article","created":{"date-parts":[[2015,8,3]],"date-time":"2015-08-03T11:43:57Z","timestamp":1438602237000},"page":"1877-1885","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["ICU-acquired candidemia within selective digestive decontamination studies: a meta-analysis"],"prefix":"10.1007","volume":"41","author":[{"given":"James C.","family":"Hurley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,8,4]]},"reference":[{"issue":"4","key":"4004_CR1","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1097\/CCM.0b013e318206c1ca","volume":"39","author":"DH Kett","year":"2011","unstructured":"Kett DH, Azoulay E, Echeverria PM, Vincent JL (2011) Candida bloodstream infections in intensive care units: analysis of the extended prevalence of infection in intensive care unit study. Crit Care Med 39(4):665\u2013670","journal-title":"Crit Care Med"},{"issue":"3","key":"4004_CR2","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1007\/s001340050552","volume":"24","author":"JL Vincent","year":"1998","unstructured":"Vincent JL, Anaissie E, Bruining H, Demajo W, El-Ebiary M, Haber J, Solomkin J (1998) Epidemiology, diagnosis and treatment of systemic Candida infection in surgical patients under intensive care. Intensive Care Med 24(3):206\u2013216","journal-title":"Intensive Care Med"},{"issue":"4","key":"4004_CR3","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/BF00259435","volume":"10","author":"CP Stoutenbeek","year":"1984","unstructured":"Stoutenbeek CP, van Saene HK, Miranda DR, Zandstra DF (1984) The effect of selective decontamination of the digestive tract on colonisation and infection rate in multiple trauma patients. Intensive Care Med 10(4):185\u2013192","journal-title":"Intensive Care Med"},{"key":"4004_CR4","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1056\/NEJMoa0800394","volume":"360","author":"AMGA de Smet","year":"2009","unstructured":"de Smet AMGA, Kluytmans JAJW, Cooper BS et al (2009) Decontamination of the digestive tract and oropharynx in ICU patients. N Engl J Med 360:20\u201331","journal-title":"N Engl J Med"},{"key":"4004_CR5","doi-asserted-by":"publisher","unstructured":"Liberati A, D\u2019Amico R, Pifferi S, Torri V, Brazzi L, Parmelli E (2009) Antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving intensive care. Cochrane Database Syst Rev CD000022. doi:10.1002\/14651858.CD000022.pub3","DOI":"10.1002\/14651858.CD000022.pub3"},{"key":"4004_CR6","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/0140-6736(91)91510-2","volume":"338","author":"CM Vandenbroucke-Grauls","year":"1991","unstructured":"Vandenbroucke-Grauls CM, Vandenbroucke JP (1991) Effect of selective decontamination of the digestive tract on respiratory tract infections and mortality in the intensive care unit. Lancet 338:859\u2013862","journal-title":"Lancet"},{"issue":"4","key":"4004_CR7","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1128\/AAC.39.4.941","volume":"39","author":"JC Hurley","year":"1995","unstructured":"Hurley JC (1995) Prophylaxis with enteral antibiotics in ventilated patients: selective decontamination or selective cross-infection? Antimicrob Agents Chemother 39(4):941\u2013947","journal-title":"Antimicrob Agents Chemother"},{"key":"4004_CR8","doi-asserted-by":"publisher","first-page":"R155","DOI":"10.1186\/cc10285","volume":"15","author":"C Pileggi","year":"2011","unstructured":"Pileggi C, Bianco A, Flotta D, Nobile CG, Pavia M (2011) Prevention of ventilator-associated pneumonia, mortality and all intensive care unit acquired infections by topically applied antimicrobial or antiseptic agents: a meta-analysis of randomized controlled trials in intensive care units. Crit Care 15:R155","journal-title":"Crit Care"},{"issue":"7","key":"4004_CR9","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1007\/s00134-005-2654-9","volume":"31","author":"L Silvestri","year":"2005","unstructured":"Silvestri L, Van Saene HK, Milanese M, Gregori D (2005) Impact of selective decontamination of the digestive tract on fungal carriage and infection: systematic review of randomized controlled trials. Intensive Care Med 31(7):898\u2013910","journal-title":"Intensive Care Med"},{"key":"4004_CR10","doi-asserted-by":"publisher","first-page":"R126","DOI":"10.1186\/cc6191","volume":"11","author":"JO van Till","year":"2007","unstructured":"van Till JO, van Ruler O, Lamme B, Weber RJ, Reitsma JB, Boermeester MA (2007) Single-drug therapy or selective decontamination of the digestive tract as antifungal prophylaxis in critically ill patients: a systematic review. Crit Care 11:R126","journal-title":"Crit Care"},{"issue":"3","key":"4004_CR11","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1097\/CCM.0000000000000746","volume":"43","author":"JUS Jensen","year":"2015","unstructured":"Jensen JUS, Hein L, Lundgren B et al (2015) Invasive Candida infections and the harm from antibacterial drugs in critically ill patients: data from a randomized, controlled trial to determine the role of ciprofloxacin, piperacillin-tazobactam, meropenem, and cefuroxime. Crit Care Med 43(3):594\u2013602","journal-title":"Crit Care Med"},{"key":"4004_CR12","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1093\/jac\/dkn086","volume":"61","author":"JC Hurley","year":"2008","unstructured":"Hurley JC (2008) Profound effect of study design factors on ventilator-associated pneumonia incidence of prevention studies: benchmarking the literature experience. J Antimicrob Chemother 61:1154\u20131161","journal-title":"J Antimicrob Chemother"},{"key":"4004_CR13","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1086\/502555","volume":"26","author":"JC Hurley","year":"2005","unstructured":"Hurley JC (2005) Inapparent outbreaks of ventilator-associated pneumonia: an ecologic analysis of prevention and cohort studies. Infect Control Hosp Epidemiol 26:374\u2013390","journal-title":"Infect Control Hosp Epidemiol"},{"key":"4004_CR14","doi-asserted-by":"crossref","unstructured":"Hurley JC (2014) Topical antibiotics as a major contextual hazard toward bacteremia within selective digestive decontamination studies: a meta-analysis. BMC Infect Dis 14:714. http:\/\/www.biomedcentral.com\/content\/pdf\/s12879-014-0714-x.pdf","DOI":"10.1186\/s12879-014-0714-x"},{"issue":"4","key":"4004_CR15","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1378\/chest.13-2926","volume":"146","author":"JC Hurley","year":"2014","unstructured":"Hurley JC (2014) Ventilator associated pneumonia prevention methods using topical antibiotics: herd protection or herd peril? Chest 146(4):890\u2013898","journal-title":"Chest"},{"key":"4004_CR16","unstructured":"Hurley JC (2015) Candidemia and selective digestive decontamination (SDD) in the ICU: herd protection or herd peril? A meta-analysis. Poster number 314, 19th Congress International Society for Human and Animal Mycology. Melbourne, 3\u20138 May 2015. http:\/\/www.isham2015.com.au\/images\/isham\/ISHAM15%20POSTER%20Author%20List%20.pdf. Accessed 15 June 2015"},{"key":"4004_CR17","first-page":"652","volume-title":"Modern epidemiology","author":"S Greenland","year":"2008","unstructured":"Greenland S, O\u2019Rourke K (2008) Meta-analysis. In: Rothman KJ, Greenland S, Lash TL (eds) Modern epidemiology, 3rd edn. Lippincott Williams and Wilkins, Philadelphia, pp 652\u2013682","edition":"3"},{"key":"4004_CR18","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/1536867X0800800102","volume":"8","author":"RJ Harris","year":"2008","unstructured":"Harris RJ, Bradburn MJ, Deeks JJ, Harbord RM, Altmamn DG, Sterne JAC (2008) Metan: fixed- and random-effects meta-analysis. Stata J 8:3\u201328","journal-title":"Stata J"},{"key":"4004_CR19","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1177\/1536867X0800800403","volume":"8","author":"RM Harbord","year":"2008","unstructured":"Harbord RM, Higgins JPT (2008) Meta-regression in Stata. Stata J 8:493\u2013519","journal-title":"Stata J"},{"key":"4004_CR20","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/S1473-3099(02)00240-2","volume":"2","author":"F Mutapi","year":"2002","unstructured":"Mutapi F, Roddam A (2002) P values for pathogens: statistical inference from infectious-disease data. Lancet Infect Dis 2:219\u2013230","journal-title":"Lancet Infect Dis"},{"key":"4004_CR21","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.1097\/01.CCM.0000181731.53912.D9","volume":"33","author":"N Safdar","year":"2005","unstructured":"Safdar N, Dezfulian C, Collard HR, Saint S (2005) Clinical and economic consequences of ventilator-associated pneumonia: a systematic review. Crit Care Med 33:2184\u20132193","journal-title":"Crit Care Med"},{"key":"4004_CR22","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1136\/bmj.39136.528160.BE","volume":"334","author":"EY Chan","year":"2007","unstructured":"Chan EY, Ruest A, Meade MO, Cook DJ (2007) Oral decontamination for prevention of pneumonia in mechanically ventilated adults: systematic review and meta-analysis. BMJ 334:889\u2013900","journal-title":"BMJ"},{"issue":"5","key":"4004_CR23","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1164\/rccm.200908-1210OC","volume":"181","author":"EA Oostdijk","year":"2010","unstructured":"Oostdijk EA, de Smet AM, Blok HE et al (2010) Ecological effects of selective decontamination on resistant gram-negative bacterial colonization. Am J Respir Crit Care Med 181(5):452\u2013457","journal-title":"Am J Respir Crit Care Med"},{"key":"4004_CR24","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1001\/jama.1983.03330370053031","volume":"249","author":"JA Hanley","year":"1983","unstructured":"Hanley JA, Lippman-Hand A (1983) If nothing goes wrong, is everything all right? Interpreting zero numerators. JAMA 249:1743\u20131745","journal-title":"JAMA"},{"key":"4004_CR25","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1080\/13693780410001731619","volume":"43","author":"NI Paphitou","year":"2005","unstructured":"Paphitou NI, Ostrosky-Zeichner L, Rex J (2005) Rules for identifying patients at increased risk for candidal infections in the surgical intensive care unit: approach to developing practical criteria for systematic use in antifungal prophylaxis trials. Med Mycol 43:235\u2013243","journal-title":"Med Mycol"},{"issue":"4","key":"4004_CR26","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s10096-007-0270-z","volume":"26","author":"L Ostrosky-Zeichner","year":"2007","unstructured":"Ostrosky-Zeichner L, Sable C, Sobel J, Alexander BD, Donowitz G, Kan V, Rex JH (2007) Multicenter retrospective development and validation of a clinical prediction rule for nosocomial invasive candidiasis in the intensive care setting. Eur J Clin Microbiol Infect Dis 26(4):271\u2013276","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"2","key":"4004_CR27","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1086\/321811","volume":"33","author":"HM Blumberg","year":"2001","unstructured":"Blumberg HM, Jarvis WR, Soucie JM, Edwards JE, Patterson JE, Pfaller MA, Wenzel RP, The NEMIS study group (2001) Risk factors for candidal bloodstream infections in surgical intensive care unit patients: the NEMIS prospective multicenter study. Clin Infect Dis 33(2):177\u2013186","journal-title":"Clin Infect Dis"},{"key":"4004_CR28","doi-asserted-by":"publisher","first-page":"4524","DOI":"10.1128\/AAC.00424-13","volume":"57","author":"JC Hurley","year":"2013","unstructured":"Hurley JC (2013) The perfidious effect of topical placebo: calibration of Staphylococcus aureus ventilator-associated pneumonia incidence within selective digestive decontamination studies versus the broader evidence base. Antimicrob Agents Chemother 57:4524\u20134531","journal-title":"Antimicrob Agents Chemother"},{"issue":"12","key":"4004_CR29","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1007\/BF01690507","volume":"15","author":"A Voss","year":"1996","unstructured":"Voss A, Kluytmans JAJW, Koeleman JGM, Spanjaard L, Vandenbroucke-Grauls CMJE, Verbrugh HA, Meis JFGM (1996) Occurrence of yeast bloodstream infections between 1987 and 1995 in five Dutch university hospitals. Eur J Clin Microbiol Infect Dis 15(12):909\u2013912","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"11","key":"4004_CR30","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1001\/archinte.1995.00430110089009","volume":"155","author":"D Pittet","year":"1995","unstructured":"Pittet D, Wenzel RP (1995) Nosocomial bloodstream infections: secular trends in rates, mortality, and contribution to total hospital deaths. Arch Int Med 155(11):1177\u20131184","journal-title":"Arch Int Med"},{"issue":"9","key":"4004_CR31","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1007\/s00134-014-3408-3","volume":"40","author":"O Lortholary","year":"2014","unstructured":"Lortholary O, Renaudat C, Sitbon K, Madec Y, Denoeud-Ndam L, Wolff M, French Mycosis Study Group (2014) Worrisome trends in incidence and mortality of candidemia in intensive care units (Paris area, 2002\u20132010). Intensive Care Med 40(9):1303\u20131312","journal-title":"Intensive Care Med"},{"issue":"10","key":"4004_CR32","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1007\/s00134-014-3400-y","volume":"40","author":"AL Colombo","year":"2014","unstructured":"Colombo AL, Guimar\u00e3es T, Sukienik T, Pasqualotto AC, Andreotti R, Queiroz-Telles F, Nucci M (2014) Prognostic factors and historical trends in the epidemiology of candidemia in critically ill patients: an analysis of five multicenter studies sequentially conducted over a 9-year period. Intensive Care Med 40(10):1489\u20131498","journal-title":"Intensive Care Med"},{"issue":"1","key":"4004_CR33","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1471-2334-6-21","volume":"6","author":"M Bassetti","year":"2006","unstructured":"Bassetti M, Righi E, Costa A, Fasce R, Molinari MP, Rosso R, Viscoli C (2006) Epidemiological trends in nosocomial candidemia in intensive care. BMC Infect Dis 6(1):21","journal-title":"BMC Infect Dis"},{"issue":"10","key":"4004_CR34","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1007\/s00134-014-3355-z","volume":"40","author":"P Eggimann","year":"2014","unstructured":"Eggimann P, Pittet D (2014) Candida colonization index and subsequent infection in critically ill surgical patients: 20\u00a0years later. Intensive Care Med 40(10):1429\u20131448","journal-title":"Intensive Care Med"},{"issue":"6470","key":"4004_CR35","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1136\/bmj.290.6470.746","volume":"290","author":"JP Burnie","year":"1985","unstructured":"Burnie JP, Odds FC, Lee W, Webster C, Williams JD (1985) Outbreak of systemic Candida albicans in intensive care unit caused by cross infection. BMJ 290(6470):746\u2013748","journal-title":"BMJ"},{"issue":"2","key":"4004_CR36","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1007\/s00134-007-0865-y","volume":"34","author":"ME Bougnoux","year":"2008","unstructured":"Bougnoux ME, Kac G, Aegerter P, d\u2019Enfert C, Fagon JY, CandiRea Study Group (2008) Candidemia and candiduria in critically ill patients admitted to intensive care units in France: incidence, molecular diversity, management and outcome. Intensive Care Med 34(2):292\u2013299","journal-title":"Intensive Care Med"},{"issue":"1","key":"4004_CR37","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1053\/jhin.2001.1023","volume":"49","author":"P Hamal","year":"2001","unstructured":"Hamal P, Kappe R, Rimek D (2001) Rate of transmission and endogenous origin of Candida albicans and Candida glabrata on adult intensive care units studied by pulsed field gel electrophoresis. J Hosp Infect 49(1):37\u201342","journal-title":"J Hosp Infect"},{"issue":"5","key":"4004_CR38","doi-asserted-by":"publisher","first-page":"R233","DOI":"10.1186\/cc13056","volume":"17","author":"DS Ong","year":"2013","unstructured":"Ong DS, Klouwenberg PMK, Spitoni C, Bonten MJ, Cremer O (2013) Nebulised amphotericin B to eradicate Candida colonisation from the respiratory tract in critically ill patients receiving selective digestive decontamination: a cohort study. Crit Care 17(5):R233","journal-title":"Crit Care"},{"issue":"1","key":"4004_CR39","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1186\/s12879-014-0575-3","volume":"14","author":"PJ Van der Geest","year":"2014","unstructured":"Van der Geest PJ, Dieters EI, Rijnders B, Groeneveld JA (2014) Safety and efficacy of amphotericin-B deoxycholate inhalation in critically ill patients with respiratory Candida spp. colonization: a retrospective analysis. BMC Infect Dis 14(1):575","journal-title":"BMC Infect Dis"},{"issue":"10","key":"4004_CR40","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1007\/s00134-006-0290-7","volume":"32","author":"A Valentin","year":"2006","unstructured":"Valentin A, Capuzzo M, Guidet B, Moreno RP, Dolanski L, Bauer P, Metnitz PG (2006) Patient safety in intensive care: results from the multinational Sentinel Events Evaluation (SEE) study. Intensive Care Med 32(10):1591\u20131598","journal-title":"Intensive Care Med"}],"container-title":["Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-015-4004-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00134-015-4004-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-015-4004-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-015-4004-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T04:52:29Z","timestamp":1744174349000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00134-015-4004-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,4]]},"references-count":40,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["4004"],"URL":"https:\/\/doi.org\/10.1007\/s00134-015-4004-x","relation":{},"ISSN":["0342-4642","1432-1238"],"issn-type":[{"type":"print","value":"0342-4642"},{"type":"electronic","value":"1432-1238"}],"subject":[],"published":{"date-parts":[[2015,8,4]]},"assertion":[{"value":"8 May 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The author declares that he has no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"This work was supported by the Australian Government Department of Health and Ageing through the Rural Clinical Training and Support (RCTS) program.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}}]}}