{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:13:03Z","timestamp":1790518383284,"version":"4.1.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2016,9,16]],"date-time":"2016-09-16T00:00:00Z","timestamp":1473984000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,9,16]],"date-time":"2016-09-16T00:00:00Z","timestamp":1473984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P050HL73994, R01HL088045, and K24HL088551"],"award-info":[{"award-number":["P050HL73994, R01HL088045, and K24HL088551"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"INSTITUTIONAL NATIONAL RESEARCH SERVICE AWARD","award":["T32HP10025B0"],"award-info":[{"award-number":["T32HP10025B0"]}]},{"name":"Institute for Clinical and Translational Research, Johns Hopkins University","award":["UL1 TR 000424-06"],"award-info":[{"award-number":["UL1 TR 000424-06"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intensive Care Med"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1007\/s00134-016-4530-1","type":"journal-article","created":{"date-parts":[[2016,9,16]],"date-time":"2016-09-16T05:28:46Z","timestamp":1474003726000},"page":"1557-1566","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":160,"title":["Physical declines occurring after hospital discharge in ARDS survivors: a 5-year longitudinal study"],"prefix":"10.1007","volume":"42","author":[{"given":"Elizabeth R.","family":"Pfoh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy W.","family":"Wozniak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Colantuoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor D.","family":"Dinglas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro A.","family":"Mendez-Tellez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Shanholtz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy D.","family":"Ciesla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Pronovost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale M.","family":"Needham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,9,16]]},"reference":[{"key":"4530_CR1","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.ccc.2009.04.005","volume":"25","author":"JC Jackson","year":"2009","unstructured":"Jackson JC, Mitchell N, Hopkins RO (2009) Cognitive functioning, mental health, and quality of life in ICU survivors: an overview. Crit Care Clin 25:615\u2013628. doi:\n                    10.1016\/j.ccc.2009.04.005","journal-title":"Crit Care Clin"},{"key":"4530_CR2","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1056\/NEJMoa1011802","volume":"364","author":"MS Herridge","year":"2011","unstructured":"Herridge MS, Tansey CM, Matt\u00e9 A et al (2011) Functional disability 5\u00a0years after acute respiratory distress syndrome. N Engl J Med 364:1293\u20131304. doi:\n                    10.1056\/NEJMoa1011802","journal-title":"N Engl J Med"},{"key":"4530_CR3","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1007\/s00134-006-0217-3","volume":"32","author":"DW Dowdy","year":"2006","unstructured":"Dowdy DW, Eid MP, Dennison CR et al (2006) Quality of life after acute respiratory distress syndrome: a meta-analysis. Intensive Care Med 32:1115\u20131124. doi:\n                    10.1007\/s00134-006-0217-3","journal-title":"Intensive Care Med"},{"key":"4530_CR4","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1097\/CCM.0b013e3181fd66e5","volume":"39","author":"SV Desai","year":"2011","unstructured":"Desai SV, Law TJ, Needham DM (2011) Long-term complications of critical care. Crit Care Med 39:371\u2013379. doi:\n                    10.1097\/CCM.0b013e3181fd66e5","journal-title":"Crit Care Med"},{"key":"4530_CR5","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1097\/CCM.0000000000000040","volume":"42","author":"E Fan","year":"2014","unstructured":"Fan E, Dowdy DW, Colantuoni E et al (2014) Physical complications in acute lung injury survivors: a two-year longitudinal prospective study. Crit Care Med 42:849\u2013859. doi:\n                    10.1097\/CCM.0000000000000040","journal-title":"Crit Care Med"},{"key":"4530_CR6","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1164\/rccm.201206-1138ED","volume":"186","author":"TJ Iwashyna","year":"2012","unstructured":"Iwashyna TJ (2012) Trajectories of recovery and dysfunction after acute illness, with implications for clinical trial design. Am J Respir Crit Care Med 186:302\u2013304. doi:\n                    10.1164\/rccm.201206-1138ED","journal-title":"Am J Respir Crit Care Med"},{"key":"4530_CR7","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1513\/AnnalsATS.201409-422OC","volume":"12","author":"AP Ruhl","year":"2015","unstructured":"Ruhl AP, Lord RK, Panek JA et al (2015) Health care resource use and costs of two-year survivors of acute lung injury. An observational cohort study. Ann Am Thorac Soc 12:392\u2013401. doi:\n                    10.1513\/AnnalsATS.201409-422OC","journal-title":"Ann Am Thorac Soc"},{"key":"4530_CR8","doi-asserted-by":"publisher","unstructured":"Lone NI, Gillies MA, Haddow C et al (2016) Five year mortality and hospital costs associated with surviving intensive care. Am J Respir Crit Care Med 194(2):198\u2013208. doi:\n                    10.1164\/rccm.201511-2234OC","DOI":"10.1164\/rccm.201511-2234OC"},{"key":"4530_CR9","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s13054-016-1185-9","volume":"20","author":"I van Beusekom","year":"2016","unstructured":"van Beusekom I, Bakhshi-Raiez F, de Keizer NF et al (2016) Reported burden on informal caregivers of ICU survivors: a literature review. Crit Care 20:16. doi:\n                    10.1186\/s13054-016-1185-9","journal-title":"Crit Care"},{"key":"4530_CR10","doi-asserted-by":"crossref","unstructured":"Bernard GR, Artigas A, Brigham KL et al (1994) The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 149:818\u2013824","DOI":"10.1164\/ajrccm.149.3.7509706"},{"key":"4530_CR11","doi-asserted-by":"publisher","first-page":"R9","DOI":"10.1186\/cc3948","volume":"10","author":"DM Needham","year":"2006","unstructured":"Needham DM, Dennison CR, Dowdy DW et al (2006) Study protocol: the improving care of acute lung injury patients (ICAP) study. Crit Care 10:R9. doi:\n                    10.1186\/cc3948","journal-title":"Crit Care"},{"key":"4530_CR12","first-page":"2526","volume":"307","author":"VM Ranieri","year":"2012","unstructured":"ARDS Definition Task Force, Ranieri VM, Rubenfeld GD et al (2012) Acute respiratory distress syndrome: the Berlin definition. JAMA 307:2526\u20132533","journal-title":"JAMA"},{"key":"4530_CR13","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1055\/s-0032-1321982","volume":"33","author":"TJ Iwashyna","year":"2012","unstructured":"Iwashyna TJ, Netzer G (2012) The burdens of survivorship: an approach to thinking about long-term outcomes after critical illness. Semin Respir Crit Care Med 33:327\u2013338. doi:\n                    10.1055\/s-0032-1321982","journal-title":"Semin Respir Crit Care Med"},{"key":"4530_CR14","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1007\/s00134-010-1796-6","volume":"36","author":"E Fan","year":"2010","unstructured":"Fan E, Ciesla ND, Truong AD et al (2010) Inter-rater reliability of manual muscle strength testing in ICU survivors and simulated patients. Intensive Care Med 36:1038\u20131043. doi:\n                    10.1007\/s00134-010-1796-6","journal-title":"Intensive Care Med"},{"key":"4530_CR15","doi-asserted-by":"publisher","first-page":"2859","DOI":"10.1001\/jama.288.22.2859","volume":"288","author":"B De Jonghe","year":"2002","unstructured":"De Jonghe B, Sharshar T, Lefaucheur J-P et al (2002) Paresis acquired in the intensive care unit: a prospective multicenter study. JAMA 288:2859\u20132867","journal-title":"JAMA"},{"key":"4530_CR16","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1164\/ajrccm.166.1.at1102","volume":"166","author":"ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories","year":"2002","unstructured":"ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories (2002) ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med 166:111\u2013117. doi:\n                    10.1164\/ajrccm.166.1.at1102","journal-title":"Am J Respir Crit Care Med"},{"key":"4530_CR17","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1378\/chest.14-1808","volume":"147","author":"KS Chan","year":"2015","unstructured":"Chan KS, Pfoh ER, Denehy L et al (2015) Construct validity and minimal important difference of 6-minute walk distance in survivors of acute respiratory failure. Chest 147:1316\u20131326. doi:\n                    10.1378\/chest.14-1808","journal-title":"Chest"},{"key":"4530_CR18","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1164\/ajrccm.158.5.9710086","volume":"158","author":"PL Enright","year":"1998","unstructured":"Enright PL, Sherrill DL (1998) Reference equations for the six-minute walk in healthy adults. Am J Respir Crit Care Med 158:1384\u20131387. doi:\n                    10.1164\/ajrccm.158.5.9710086","journal-title":"Am J Respir Crit Care Med"},{"key":"4530_CR19","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1164\/rccm.201103-0503OC","volume":"185","author":"OJ Bienvenu","year":"2012","unstructured":"Bienvenu OJ, Colantuoni E, Mendez-Tellez PA et al (2012) Depressive symptoms and impaired physical function after acute lung injury: a 2-year longitudinal study. Am J Respir Crit Care Med 185:517\u2013524. doi:\n                    10.1164\/rccm.201103-0503OC","journal-title":"Am J Respir Crit Care Med"},{"key":"4530_CR20","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1007\/s00134-015-4028-2","volume":"41","author":"DK Heyland","year":"2015","unstructured":"Heyland DK, Garland A, Bagshaw SM et al (2015) Recovery after critical illness in patients aged 80\u00a0years or older: a multi-center prospective observational cohort study. Intensive Care Med 41:1911\u20131920. doi:\n                    10.1007\/s00134-015-4028-2","journal-title":"Intensive Care Med"},{"key":"4530_CR21","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1037\/0022-006X.59.1.12","volume":"59","author":"NS Jacobson","year":"1991","unstructured":"Jacobson NS, Truax P (1991) Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. J Consult Clin Psychol 59:12\u201319","journal-title":"J Consult Clin Psychol"},{"key":"4530_CR22","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.2522\/ptj.20110410","volume":"92","author":"JA Alison","year":"2012","unstructured":"Alison JA, Kenny P, King MT et al (2012) Repeatability of the six-minute walk test and relation to physical function in survivors of a critical illness. Phys Ther 92:1556\u20131563. doi:\n                    10.2522\/ptj.20110410","journal-title":"Phys Ther"},{"key":"4530_CR23","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.jcrc.2007.02.001","volume":"22","author":"DM Needham","year":"2007","unstructured":"Needham DM, Wang W, Desai SV et al (2007) Intensive care unit exposures for long-term outcomes research: development and description of exposures for 150 patients with acute lung injury. J Crit Care 22:275\u2013284. doi:\n                    10.1016\/j.jcrc.2007.02.001","journal-title":"J Crit Care"},{"key":"4530_CR24","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","volume":"40","author":"ME Charlson","year":"1987","unstructured":"Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40:373\u2013383","journal-title":"J Chronic Dis"},{"key":"4530_CR25","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.jclinepi.2004.10.018","volume":"58","author":"DL Groll","year":"2005","unstructured":"Groll DL, To T, Bombardier C, Wright JG (2005) The development of a comorbidity index with physical function as the outcome. J Clin Epidemiol 58:595\u2013602. doi:\n                    10.1016\/j.jclinepi.2004.10.018","journal-title":"J Clin Epidemiol"},{"key":"4530_CR26","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1097\/00003246-198510000-00009","volume":"13","author":"WA Knaus","year":"1985","unstructured":"Knaus WA, Draper EA, Wagner DP, Zimmerman JE (1985) APACHE II: a severity of disease classification system. Crit Care Med 13:818\u2013829","journal-title":"Crit Care Med"},{"key":"4530_CR27","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1007\/BF01709751","volume":"22","author":"JL Vincent","year":"1996","unstructured":"Vincent JL, Moreno R, Takala J et al (1996) The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction\/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 22:707\u2013710","journal-title":"Intensive Care Med"},{"key":"4530_CR28","doi-asserted-by":"publisher","unstructured":"Hermans G, De Jonghe B, Bruyninckx F, Van den Berghe G (2009) Interventions for preventing critical illness polyneuropathy and critical illness myopathy. Cochrane Database Syst Rev (1):CD006832. doi:\n                    10.1002\/14651858.CD006832.pub2","DOI":"10.1002\/14651858.CD006832.pub2"},{"key":"4530_CR29","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1001\/jama.1992.03480070065032","volume":"267","author":"WC Wilson","year":"1992","unstructured":"Wilson WC, Smedira NG, Fink C et al (1992) Ordering and administration of sedatives and analgesics during the withholding and withdrawal of life support from critically ill patients. JAMA 267:949\u2013953","journal-title":"JAMA"},{"key":"4530_CR30","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1097\/00003246-200201000-00020","volume":"30","author":"J Jacobi","year":"2002","unstructured":"Jacobi J, Fraser GL, Coursin DB et al (2002) Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult. Crit Care Med 30:119\u2013141","journal-title":"Crit Care Med"},{"key":"4530_CR31","volume-title":"Goodman and Gilman\u2019s the pharmacological basis of therapeutics","author":"L Brunton","year":"2011","unstructured":"Brunton L, Chabner B, Knollman B (2011) Goodman and Gilman\u2019s the pharmacological basis of therapeutics, 12th edn. McGraw Hill Educational, New York","edition":"12"},{"key":"4530_CR32","doi-asserted-by":"publisher","first-page":"2983","DOI":"10.1001\/jama.289.22.2983","volume":"289","author":"EW Ely","year":"2003","unstructured":"Ely EW, Truman B, Shintani A et al (2003) Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS). JAMA 289:2983\u20132991. doi:\n                    10.1001\/jama.289.22.2983","journal-title":"JAMA"},{"key":"4530_CR33","doi-asserted-by":"publisher","first-page":"2703","DOI":"10.1001\/jama.286.21.2703","volume":"286","author":"EW Ely","year":"2001","unstructured":"Ely EW, Inouye SK, Bernard GR et al (2001) Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU). JAMA 286:2703\u20132710","journal-title":"JAMA"},{"key":"4530_CR34","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1037\/1082-989X.7.2.147","volume":"7","author":"JL Schafer","year":"2002","unstructured":"Schafer JL, Graham JW (2002) Missing data: our view of the state of the art. Psychol Methods 7:147\u2013177","journal-title":"Psychol Methods"},{"key":"4530_CR35","doi-asserted-by":"publisher","first-page":"2657","DOI":"10.1017\/S0033291713000214","volume":"43","author":"OJ Bienvenu","year":"2013","unstructured":"Bienvenu OJ, Gellar J, Althouse BM et al (2013) Post-traumatic stress disorder symptoms after acute lung injury: a 2-year prospective longitudinal study. Psychol Med 43:2657\u20132671. doi:\n                    10.1017\/S0033291713000214","journal-title":"Psychol Med"},{"key":"4530_CR36","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1097\/EDE.0b013e3181e5b06a","volume":"21","author":"BJ Swihart","year":"2010","unstructured":"Swihart BJ, Caffo B, James BD et al (2010) Lasagna plots: a saucy alternative to spaghetti plots. Epidemiology 21:621\u2013625. doi:\n                    10.1097\/EDE.0b013e3181e5b06a","journal-title":"Epidemiology"},{"key":"4530_CR37","volume-title":"Generalized linear models and extensions","author":"JW Hardin","year":"2007","unstructured":"Hardin JW, Hilbe JM, Hilbe J (2007) Generalized linear models and extensions, 2nd edn. STATA Press, College Station","edition":"2nd"},{"key":"4530_CR38","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1001\/jamainternmed.2014.7889","volume":"175","author":"LE Ferrante","year":"2015","unstructured":"Ferrante LE, Pisani MA, Murphy TE et al (2015) Functional trajectories among older persons before and after critical illness. JAMA Intern Med 175:523\u2013529. doi:\n                    10.1001\/jamainternmed.2014.7889","journal-title":"JAMA Intern Med"},{"key":"4530_CR39","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201506-1256OC","author":"LE Ferrante","year":"2016","unstructured":"Ferrante LE, Pisani MA, Murphy TE et al (2016) Factors associated with functional recovery among older ICU survivors. Am J Respir Crit Care Med. doi:\n                    10.1164\/rccm.201506-1256OC\n                    \n                   (rccm.201506\u20131256OC)","journal-title":"Am J Respir Crit Care Med"},{"key":"4530_CR40","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1186\/cc10362","volume":"15","author":"MS Herridge","year":"2011","unstructured":"Herridge MS (2011) The challenge of designing a post-critical illness rehabilitation intervention. Crit Care 15:1002. doi:\n                    10.1186\/cc10362","journal-title":"Crit Care"},{"key":"4530_CR41","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201512-2343OC","author":"MS Herridge","year":"2016","unstructured":"Herridge MS, Chu LM, Matt\u00e9 A et al (2016) The recover program: disability risk groups & 1\u00a0year outcome after \u22657 days of mechanical ventilation. Am J Respir Crit Care Med. doi:\n                    10.1164\/rccm.201512-2343OC","journal-title":"Am J Respir Crit Care Med"},{"key":"4530_CR42","doi-asserted-by":"publisher","unstructured":"Howden LM, Meyer JA (2010) Age and sex composition: 2010. 2010 census briefs. U.S. Department of Commerce\nEconomics and Statistics Administration\nU.S. Census Bureau. doi: \n                    10.1234\/12345678\n                    \n                  . Available at: \n                    http:\/\/www.census.gov\/prod\/cen2010\/briefs\/c2010br-03.pdf","DOI":"10.1234\/12345678"},{"key":"4530_CR43","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1016\/S0140-6736(12)62087-X","volume":"381","author":"B Rechel","year":"2013","unstructured":"Rechel B, Grundy E, Robine JM et al (2013) Ageing in the European Union. Lancet 381:1312\u20131322. doi:\n                    10.1016\/S0140-6736(12)62087-X","journal-title":"Lancet"},{"key":"4530_CR44","doi-asserted-by":"publisher","first-page":"R142","DOI":"10.1186\/cc10265","volume":"15","author":"D Elliott","year":"2011","unstructured":"Elliott D, McKinley S, Alison J et al (2011) Health-related quality of life and physical recovery after a critical illness: a multi-centre randomised controlled trial of a home-based physical rehabilitation program. Crit Care 15:R142. doi:\n                    10.1186\/cc10265","journal-title":"Crit Care"},{"key":"4530_CR45","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1001\/jamainternmed.2015.0822","volume":"175","author":"TS Walsh","year":"2015","unstructured":"Walsh TS, Salisbury LG, Merriweather JL et al (2015) Increased hospital-based physical rehabilitation and information provision after intensive care unit discharge: the recover randomized clinical trial. JAMA Intern Med 175:901\u2013910. doi:\n                    10.1001\/jamainternmed.2015.0822","journal-title":"JAMA Intern Med"},{"key":"4530_CR46","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1111\/jgs.12840","volume":"62","author":"D Legrand","year":"2014","unstructured":"Legrand D, Vaes B, Mathe\u00ef C et al (2014) Muscle strength and physical performance as predictors of mortality, hospitalization, and disability in the oldest old. J Am Geriatr Soc 62:1030\u20131038. doi:\n                    10.1111\/jgs.12840","journal-title":"J Am Geriatr Soc"},{"key":"4530_CR47","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1164\/rccm.201312-2257OC","volume":"190","author":"G Hermans","year":"2014","unstructured":"Hermans G, Van Mechelen H, Clerckx B et al (2014) Acute outcomes and 1-year mortality of intensive care unit-acquired weakness. A cohort study and propensity-matched analysis. Am J Respir Crit Care Med 190:410\u2013420. doi:\n                    10.1164\/rccm.201312-2257OC","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-016-4530-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00134-016-4530-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-016-4530-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T14:06:19Z","timestamp":1589551579000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00134-016-4530-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,16]]},"references-count":47,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["4530"],"URL":"https:\/\/doi.org\/10.1007\/s00134-016-4530-1","relation":{},"ISSN":["0342-4642","1432-1238"],"issn-type":[{"value":"0342-4642","type":"print"},{"value":"1432-1238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,16]]},"assertion":[{"value":"3 June 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors declare that they have no conflict of interest to disclosure.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"This research was supported by the National Institutes of Health (P050HL73994, R01HL088045, and K24HL088551) along with the Johns Hopkins Institute for Clinical and Translational Research (ICTR) (UL1 TR 000424-06). Dr. Pfoh\u2019s time was supported by an Institutional National Research Service Award (T32HP10025B0) to Johns Hopkins School of Medicine. The funder played no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and the decision to submit the manuscript for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Sources of funding"}}]}}