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Matthieu Schmidt reports lecture fees from Getinge, Drager and Xenios outside the submitted work. The other authors declare that they have no conflicts of interest related to the purpose of this manuscript. The study protocol for the systematic review and IPD meta-analysis was approved by the relevant independent ethics committees: in France, Comit\u00e9 de Protection des Personnes CPP Ile de France VI, Piti\u00e9-Salp\u00eatri\u00e8re, on 04\/19\/2018, Ref #12 and in the UK by the Ethics committee of the London School of Hygiene and Tropical Medicine, on 04\/12\/2019, LSHTM Ethics Ref: 17159. Only patient characteristics and outcomes already evaluated in the trials were combined in this systematic review and meta-analysis.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}