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She has also previously served on the advisory board for Nycomed. K.Brohi and R.Davenport have received research grant support from TEM International in the form of device and reagent support. K.Brohi has previously served on external advisory panels for Haemonetics Corp, TEM International, CSL Behring, Bayer and Astra Zeneca.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The study was designed by the authors, and the design was approved by the trial sponsor (Queen Mary University of London) and the national research ethics committees of participating institutions. 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