{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:29:36Z","timestamp":1787236176103,"version":"build-2736575974"},"reference-count":5,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T00:00:00Z","timestamp":1631577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T00:00:00Z","timestamp":1631577600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/501100009401","name":"Medizinischen Fakult\u00e4t, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009401","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007537","name":"Freie Universit\u00e4t Berlin","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007537","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intensive Care Med"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1007\/s00134-021-06487-y","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T09:02:57Z","timestamp":1631610177000},"page":"1332-1333","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["No clinically relevant removal of meropenem by cytokine adsorber CytoSorb\u00ae in critically ill patients with sepsis or septic shock"],"prefix":"10.1007","volume":"47","author":[{"given":"Uwe","family":"Liebchen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Scharf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Zoller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinand","family":"Weinelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9344-8514","authenticated-orcid":false,"given":"Charlotte","family":"Kloft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the CytoMero collaboration team","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Michelet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Schroeder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Paal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Vogeser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Irlbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Briegel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Zander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilhelm","family":"Huisinga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,14]]},"reference":[{"key":"6487_CR1","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"M Singer","year":"2016","unstructured":"Singer M, Deutschman CS, Seymour CW et al (2016) The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 315:801\u2013810. https:\/\/doi.org\/10.1001\/jama.2016.0287","journal-title":"JAMA"},{"key":"6487_CR2","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1007\/s00134-018-5464-6","volume":"45","author":"EC Poli","year":"2019","unstructured":"Poli EC, Rimmel\u00e9 T, Schneider AG (2019) Hemoadsorption with CytoSorb\u00ae. Intensive Care Med 45:236\u2013239. https:\/\/doi.org\/10.1007\/s00134-018-5464-6","journal-title":"Intensive Care Med"},{"key":"6487_CR3","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1177\/0391398818812601","volume":"42","author":"C K\u00f6nig","year":"2019","unstructured":"K\u00f6nig C, R\u00f6hr AC, Frey OR et al (2019) In vitro removal of anti-infective agents by a novel cytokine adsorbent system. Int J Artif Organs 42:57\u201364. https:\/\/doi.org\/10.1177\/0391398818812601","journal-title":"Int J Artif Organs"},{"key":"6487_CR4","doi-asserted-by":"publisher","first-page":"10493","DOI":"10.1038\/s41598-021-89965-z","volume":"11","author":"AG Schneider","year":"2021","unstructured":"Schneider AG, Andr\u00e9 P, Scheier J et al (2021) Pharmacokinetics of anti-infective agents during CytoSorb hemoadsorption. Sci Rep 11:10493. https:\/\/doi.org\/10.1038\/s41598-021-89965-z","journal-title":"Sci Rep"},{"key":"6487_CR5","doi-asserted-by":"publisher","first-page":"2169","DOI":"10.1093\/jac\/dkv068","volume":"70","author":"M Zoller","year":"2015","unstructured":"Zoller M, D\u00f6bbeler G, Maier B et al (2015) Can cytokine adsorber treatment affect antibiotic concentrations? A case report. J Antimicrob Chemother 70:2169\u20132171. https:\/\/doi.org\/10.1093\/jac\/dkv068","journal-title":"J Antimicrob Chemother"}],"container-title":["Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-021-06487-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00134-021-06487-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-021-06487-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T07:48:43Z","timestamp":1635234523000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00134-021-06487-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,14]]},"references-count":5,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["6487"],"URL":"https:\/\/doi.org\/10.1007\/s00134-021-06487-y","relation":{},"ISSN":["0342-4642","1432-1238"],"issn-type":[{"value":"0342-4642","type":"print"},{"value":"1432-1238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,14]]},"assertion":[{"value":"16 July 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 September 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"CK and WH report grants from an industry consortium (AbbVie Deutschland GmbH & Co. KG, AstraZeneca, Boehringer Ingelheim Pharma GmbH & Co. KG, Gr\u00fcnenthal GmbH, F. Hoffmann-La Roche Ltd, Merck KGaA and SANOFI) for the PharMetrX PhD program. CK reports grants from the Innovative Medicines Initiative-Joint Undertaking (\"DDMoRe\u201d), Diurnal Ltd., the Federal Ministry of Education and Research within the Joint Programming Initiative on Antimicrobial Resistance Initiative (JPIAMR) and the European Commission within the Horizon 2020 framework program (\u201cFAIR\u201d), all outside the submitted work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Ethical approval and consent were obtained from the Institutional Review Board of the Medical Faculty of the Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen (Munich, Germany) [registration No. 428-12 and 18-578].","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}