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AT has no conflicts to report. BS reports receiving funding from PIPRA AG, outside of the submitted work. KEAB is supported by a Physician Services Incorporated-50 Mid-Career Clinical Award. EF reports receiving personal fees from ALung Technologies, Baxter, Boehringer-Ingelheim, Fresenius Medical Care, and MC3 Cardiopulmonary, outside of the submitted work. DB reports receiving research support from ALung Technologies, outside of the submitted work, and was previously on their medical advisory board. He has been on the medical advisory boards for Baxter, Abiomed, Xenios, and Hemovent. LM has no conflicts to report. ECG is supported by an Early Career Investigator Award from the Canadian Institutes of Health Research. DJC is supported by a Canada Research Chair in Critical Care Knowledge Translation. RAF is the H. Barrie Fairley Professor of Critical Care at the University Healthy Network and Interdepartmental Division of Critical Care Medicine at the University of Toronto. MSH has no conflicts to report. PC has no conflicts to report. SJ reports receiving personal fees from Drager, Fisher & Paykel, Medtronic, and Baxter, outside of the submitted work. MHM has no conflicts to report. AWT reports receiving grants from the French Ministry of Health and personal fees from Fisher & Paykel, Maquet-Getinge, GE Healthcare, and Covidien, outside of the submitted work. NDF reports consulting for Baxter and Xenios, outside of the submitted work. ASS reports consulting for Baxter and Xenios, outside of the submitted work. LJB has no conflicts to report. AJES holds patents related to multiorgan variability analysis, and has shares in Therapeutic Monitoring Systems Inc., outside of the submitted work. BR has no conflicts to report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"Not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}