{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T14:13:20Z","timestamp":1793369600108,"version":"4.5.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T00:00:00Z","timestamp":1696809600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T00:00:00Z","timestamp":1696809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"Research Council of Rigshospitalet"},{"DOI":"10.13039\/501100009907","name":"Grosserer Jakob Ehrenreich og Hustru Grete Ehrenreichs Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009907","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007403","name":"Dagmar Marshalls Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007403","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007052","name":"Memorial Sloan-Kettering Cancer Center","doi-asserted-by":"publisher","award":["P30CA008748"],"award-info":[{"award-number":["P30CA008748"]}],"id":[{"id":"10.13039\/100007052","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Royal Library, Copenhagen University Library"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intensive Care Med"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1007\/s00134-023-07225-2","type":"journal-article","created":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T04:59:07Z","timestamp":1696827547000},"page":"1327-1338","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU)"],"prefix":"10.1007","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7740-700X","authenticated-orcid":false,"given":"Carl Thomas","family":"Anthon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3639-3849","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"P\u00e8ne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4668-0123","authenticated-orcid":false,"given":"Anders","family":"Perner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8162-1508","authenticated-orcid":false,"given":"Elie","family":"Azoulay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5742-6171","authenticated-orcid":false,"given":"Kathryn","family":"Puxty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andry","family":"Van De Louw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5408-7162","authenticated-orcid":false,"given":"Andreas","family":"Barratt-Due","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6840-7988","authenticated-orcid":false,"given":"Sanjay","family":"Chawla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6118-8970","authenticated-orcid":false,"given":"Pedro","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7069-7304","authenticated-orcid":false,"given":"Pedro","family":"P\u00f3voa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0701-3624","authenticated-orcid":false,"given":"Luis","family":"Coelho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4232-6845","authenticated-orcid":false,"given":"Victoria","family":"Metaxa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4766-4651","authenticated-orcid":false,"given":"Matthias","family":"Kochanek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Liebregts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5404-2981","authenticated-orcid":false,"given":"Thomas","family":"Kander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3613-7231","authenticated-orcid":false,"given":"Johanna","family":"H\u00e4stbacka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6615-4438","authenticated-orcid":false,"given":"Jo B\u00f8nding","family":"Andreasen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7356-7858","authenticated-orcid":false,"given":"Edwige","family":"P\u00e9ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0826-4126","authenticated-orcid":false,"given":"Lene Bjerregaard","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine Lodberg","family":"Hvas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3878-708X","authenticated-orcid":false,"given":"Etienne","family":"Dufranc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2143-8082","authenticated-orcid":false,"given":"Emmanuel","family":"Canet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Lundqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher John","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3034-6857","authenticated-orcid":false,"given":"Julien","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4946-8184","authenticated-orcid":false,"given":"Fabrice","family":"Uhel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2955-0183","authenticated-orcid":false,"given":"Hafid","family":"Ait-Oufella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5246-8727","authenticated-orcid":false,"given":"Mette","family":"Krag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabet","family":"Cos Badia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3046-7598","authenticated-orcid":false,"given":"C\u00e1ndido","family":"D\u00edaz-Lagares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Menat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2236-0288","authenticated-orcid":false,"given":"Guillaume","family":"Voiriot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4370-859X","authenticated-orcid":false,"given":"Niels Erikstrup","family":"Clausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian","family":"Lorentzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8839-6131","authenticated-orcid":false,"given":"Reidar","family":"Kv\u00e5le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7845-9899","authenticated-orcid":false,"given":"Thomas","family":"Hildebrandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7916-0717","authenticated-orcid":false,"given":"Aleksander Rygh","family":"Holten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1522-0941","authenticated-orcid":false,"given":"Kristian","family":"Strand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1650-0048","authenticated-orcid":false,"given":"Asterios","family":"Tzalavras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6585-2659","authenticated-orcid":false,"given":"Morten Heiberg","family":"Bestle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2804-8447","authenticated-orcid":false,"given":"P\u00e5l","family":"Klepstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2912-3357","authenticated-orcid":false,"given":"Sara","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Vimpere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5870-9544","authenticated-orcid":false,"given":"Carolina","family":"Paulino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6968-0903","authenticated-orcid":false,"given":"Carina","family":"Gra\u00e7a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9597-6142","authenticated-orcid":false,"given":"Catherina","family":"Lueck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7869-6536","authenticated-orcid":false,"given":"Christian Svendsen","family":"Juhl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per Martin","family":"B\u00e5dst\u00f8l\u00f8kken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1462-4263","authenticated-orcid":false,"given":"Lia Susana Aires","family":"L\u00eado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3170-3692","authenticated-orcid":false,"given":"Joao Carlos","family":"Sousa Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5799-7655","authenticated-orcid":false,"given":"Anders","family":"Granholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6378-9673","authenticated-orcid":false,"given":"Morten Hylander","family":"M\u00f8ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7352-8728","authenticated-orcid":false,"given":"Lene","family":"Russell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the\u00a0PLOT-ICU Collaborators and the Nine-I Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Khalil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Yehia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haney","family":"Salem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesham","family":"Farahat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manu","family":"Sudevan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Biggart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirmeen","family":"Fatima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Elkhonezy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Bunzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rine M.","family":"Siegumfeldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stine R.","family":"Vestergaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette","family":"Pelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh-Pierre","family":"L\u00ea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Vigneron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgane","family":"Bertrix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Cirera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Driss","family":"Laghlam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swann","family":"Bredin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Marin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Toppenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brice","family":"Benelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Seguin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Garret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Guillotin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gauthier","family":"Blonz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Baptiste","family":"Lascarrou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9mie","family":"Lemarie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Desmedt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u00eft\u00e9","family":"Agbakou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Carpentier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u00eblle","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na\u00efla","family":"Benkalfate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Zambon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Decamps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline L.","family":"Wilquin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soraya","family":"Benguerfi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Gardner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Remor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Carr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coralie","family":"Gernez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Thiry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louai","family":"Missri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz K. G.","family":"Denneborg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Casares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirka","family":"Sivula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elina","family":"Lappi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leena","family":"Pettil\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonna","family":"Heinonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minttu","family":"Saario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal K.","family":"Mecheri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alezandre","family":"Elabbadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrielle","family":"Desnos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Lafarge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olfa","family":"Mghirbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brit \u00c5.","family":"Sj\u00f8b\u00f8","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilie","family":"Christoffersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik H.","family":"Bestle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Lemos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiana V.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuno M. B.","family":"Jacinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica P.","family":"Anselmo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius M.","family":"Hoeper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marja","family":"Hoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro M.","family":"Sim\u00f5es Freire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,9]]},"reference":[{"key":"7225_CR1","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1097\/00003246-200208000-00015","volume":"30","author":"R Strauss","year":"2002","unstructured":"Strauss R, Wehler M, Mehler K et al (2002) Thrombocytopenia in patients in the medical intensive care unit: bleeding prevalence, transfusion requirements, and outcome. Crit Care Med 30:1765\u20131771. https:\/\/doi.org\/10.1097\/00003246-200208000-00015","journal-title":"Crit Care Med"},{"key":"7225_CR2","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.jcrc.2005.09.008","volume":"20","author":"MA Crowther","year":"2005","unstructured":"Crowther MA, Cook DJ, Meade MO et al (2005) Thrombocytopenia in medical-surgical critically ill patients: prevalence, incidence, and risk factors. J Crit Care 20:348\u2013353. https:\/\/doi.org\/10.1016\/j.jcrc.2005.09.008","journal-title":"J Crit Care"},{"key":"7225_CR3","doi-asserted-by":"publisher","first-page":"3032","DOI":"10.1182\/blood-2016-09-693655","volume":"128","author":"A Greinacher","year":"2016","unstructured":"Greinacher A, Selleng S (2016) How i evaluate and treat thrombocytopenia in the intensive care unit patient. Blood 128:3032\u20133042. https:\/\/doi.org\/10.1182\/blood-2016-09-693655","journal-title":"Blood"},{"key":"7225_CR4","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1378\/CHEST.10-2243","volume":"139","author":"P Hui","year":"2011","unstructured":"Hui P, Cook DJ, Lim W et al (2011) The frequency and clinical significance of thrombocytopenia complicating critical illness: a systematic review. Chest 139:271\u2013278. https:\/\/doi.org\/10.1378\/CHEST.10-2243","journal-title":"Chest"},{"key":"7225_CR5","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/AAS.13699","volume":"65","author":"AB Jonsson","year":"2021","unstructured":"Jonsson AB, Ryg\u00e5rd SL, Hildebrandt T et al (2021) Thrombocytopenia in intensive care unit patients: a scoping review. Acta Anaesthesiol Scand 65:2\u201314. https:\/\/doi.org\/10.1111\/AAS.13699","journal-title":"Acta Anaesthesiol Scand"},{"key":"7225_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2052-0492-1-9","volume":"1","author":"C Venkata","year":"2013","unstructured":"Venkata C, Kashyap R, Christopher Farmer J, Afessa B (2013) Thrombocytopenia in adult patients with sepsis: incidence, risk factors, and its association with clinical outcome. J Intensive Care 1:1\u201310. https:\/\/doi.org\/10.1186\/2052-0492-1-9","journal-title":"J Intensive Care"},{"key":"7225_CR7","doi-asserted-by":"publisher","first-page":"285","DOI":"10.3760\/cma.j.issn.0366-6999.2010.08.004","volume":"3","author":"SD Hanes","year":"1997","unstructured":"Hanes SD, Quarles DA, Boucher B (1997) Incidence and risk factors of thrombocytopenia in critically ill trauma patients. Ann Pharmacother 3:285\u2013289. https:\/\/doi.org\/10.3760\/cma.j.issn.0366-6999.2010.08.004","journal-title":"Ann Pharmacother"},{"key":"7225_CR8","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1378\/chest.115.5.1363","volume":"115","author":"F Stephan","year":"1999","unstructured":"Stephan F, Hollande J, Richard O et al (1999) Thrombocytopenia in a surgical ICU. Chest 115:1363\u20131370. https:\/\/doi.org\/10.1378\/chest.115.5.1363","journal-title":"Chest"},{"key":"7225_CR9","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1177\/0310057x0703500604","volume":"35","author":"B Sharma","year":"2007","unstructured":"Sharma B, Sharma M, Majumder M et al (2007) Thrombocytopenia in septic shock patients\u2014a prospective observational study of incidence, risk factors and correlation with clinical outcome. Anaesth Intensive Care 35:874\u2013880. https:\/\/doi.org\/10.1177\/0310057x0703500604","journal-title":"Anaesth Intensive Care"},{"key":"7225_CR10","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1182\/ASHEDUCATION-2010.1.135","volume":"2010","author":"A Greinacher","year":"2010","unstructured":"Greinacher A, Selleng K (2010) Thrombocytopenia in the intensive care unit patient. Hematology 2010:135\u2013143. https:\/\/doi.org\/10.1182\/ASHEDUCATION-2010.1.135","journal-title":"Hematology"},{"key":"7225_CR11","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1111\/J.1537-2995.2006.00892.X","volume":"46","author":"DM Arnold","year":"2006","unstructured":"Arnold DM, Crowther MA, Cook RJ et al (2006) Utilization of platelet transfusions in the intensive care unit: indications, transfusion triggers, and platelet count responses. Transfusion 46:1286\u20131291. https:\/\/doi.org\/10.1111\/J.1537-2995.2006.00892.X","journal-title":"Transfusion"},{"key":"7225_CR12","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1046\/J.1365-2044.2002.02514.X","volume":"57","author":"MP Rao","year":"2002","unstructured":"Rao MP, Boralessa H, Morgan C et al (2002) Blood component use in critically ill patients. Anaesthesia 57:530\u2013534. https:\/\/doi.org\/10.1046\/J.1365-2044.2002.02514.X","journal-title":"Anaesthesia"},{"issue":"46","key":"7225_CR13","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1007\/S00134-019-05884-8","volume":"464","author":"AP Vlaar","year":"2020","unstructured":"Vlaar AP, Oczkowski S, de Bruin S et al (2020) (2020) Transfusion strategies in non-bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine. Intensive Care Med 464(46):673\u2013696. https:\/\/doi.org\/10.1007\/S00134-019-05884-8","journal-title":"Intensive Care Med"},{"key":"7225_CR14","doi-asserted-by":"publisher","DOI":"10.1111\/TRF.17064","author":"CT Anthon","year":"2022","unstructured":"Anthon CT, Granholm A, Sivapalan P et al (2022) Prophylactic platelet transfusions versus no prophylaxis in hospitalized patients with thrombocytopenia: a systematic review with meta-analysis. Transfusion. https:\/\/doi.org\/10.1111\/TRF.17064","journal-title":"Transfusion"},{"key":"7225_CR15","doi-asserted-by":"publisher","first-page":"1956","DOI":"10.1056\/NEJMOA2214322","volume":"388","author":"FLF van Baarle","year":"2023","unstructured":"van Baarle FLF, van de Weerdt EK, van der Velden WJFM et al (2023) Platelet transfusion before CVC placement in patients with thrombocytopenia. N Engl J Med 388:1956\u20131965. https:\/\/doi.org\/10.1056\/NEJMOA2214322","journal-title":"N Engl J Med"},{"key":"7225_CR16","doi-asserted-by":"publisher","DOI":"10.1111\/AAS.14124","author":"CT Anthon","year":"2022","unstructured":"Anthon CT, P\u00e8ne F, Perner A et al (2022) Platelet transfusions and thrombocytopenia in intensive care units: protocol for an international inception cohort study (PLOT-ICU). Acta Anaesthesiol Scand. https:\/\/doi.org\/10.1111\/AAS.14124","journal-title":"Acta Anaesthesiol Scand"},{"key":"7225_CR17","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1136\/BMJ.39335.541782.AD","volume":"335","author":"E von Elm","year":"2007","unstructured":"von Elm E, Altman DG, Egger M et al (2007) Strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. BMJ 335:806\u2013808. https:\/\/doi.org\/10.1136\/BMJ.39335.541782.AD","journal-title":"BMJ"},{"key":"7225_CR18","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/J.JBI.2008.08.010","volume":"42","author":"PA Harris","year":"2009","unstructured":"Harris PA, Taylor R, Thielke R et al (2009) Research electronic data capture (REDCap)\u2014a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inf 42:377\u2013381. https:\/\/doi.org\/10.1016\/J.JBI.2008.08.010","journal-title":"J Biomed Inf"},{"key":"7225_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/J.JBI.2019.103208","author":"PA Harris","year":"2019","unstructured":"Harris PA, Taylor R, Minor BL et al (2019) The REDCap consortium: building an international community of software platform partners. J Biomed Inf. https:\/\/doi.org\/10.1016\/J.JBI.2019.103208","journal-title":"J Biomed Inf"},{"key":"7225_CR20","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1111\/aas.13048","volume":"62","author":"A Granholm","year":"2018","unstructured":"Granholm A, Perner A, Krag M et al (2018) Development and internal validation of the simplified mortality score for the intensive care unit (SMS-ICU). Acta Anaesthesiol Scand 62:336\u2013346. https:\/\/doi.org\/10.1111\/aas.13048","journal-title":"Acta Anaesthesiol Scand"},{"key":"7225_CR21","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1111\/aas.13422","volume":"63","author":"A Granholm","year":"2019","unstructured":"Granholm A, Perner A, Krag M et al (2019) External validation of the simplified mortality score for the intensive care unit (SMS-ICU). Acta Anaesthesiol Scand 63:1216\u20131224. https:\/\/doi.org\/10.1111\/aas.13422","journal-title":"Acta Anaesthesiol Scand"},{"key":"7225_CR22","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1056\/NEJMoa1212772","volume":"368","author":"SJ Stanworth","year":"2013","unstructured":"Stanworth SJ, Estcourt LJ, Powter G et al (2013) A no-prophylaxis platelet-transfusion strategy for hematologic cancers. N Engl J Med 368:1771\u20131780. https:\/\/doi.org\/10.1056\/NEJMoa1212772","journal-title":"N Engl J Med"},{"key":"7225_CR23","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1016\/S0140-6736(12)60689-8","volume":"380","author":"H Wandt","year":"2012","unstructured":"Wandt H, Schaefer-Eckart K, Wendelin K et al (2012) Therapeutic platelet transfusion versus routine prophylactic transfusion in patients with haematological malignancies: an open-label, multicentre, randomised study. Lancet 380:1309\u20131316. https:\/\/doi.org\/10.1016\/S0140-6736(12)60689-8","journal-title":"Lancet"},{"key":"7225_CR24","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1182\/blood-2008-09-178236","volume":"113","author":"NM Heddle","year":"2009","unstructured":"Heddle NM, Cook RJ, Tinmouth A et al (2009) A randomized controlled trial comparing standard- and low dose strategies for transfusion of platelets (SToP) to patients with thrombocytopenia. Blood 113:1564\u20131573. https:\/\/doi.org\/10.1182\/blood-2008-09-178236","journal-title":"Blood"},{"key":"7225_CR25","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1056\/NEJMoa0904084","volume":"362","author":"SJ Slichter","year":"2010","unstructured":"Slichter SJ, Kaufman RM, Assmann SF et al (2010) Dose of prophylactic platelet transfusions and prevention of hemorrhage. N Engl J Med 362:600\u2013613. https:\/\/doi.org\/10.1056\/NEJMoa0904084","journal-title":"N Engl J Med"},{"key":"7225_CR26","doi-asserted-by":"publisher","first-page":"691","DOI":"10.2307\/2337038","volume":"78","author":"NJD Nagelkerke","year":"1991","unstructured":"Nagelkerke NJD (1991) A note on a general definition of the coefficient of determination. Biometrika 78:691. https:\/\/doi.org\/10.2307\/2337038","journal-title":"Biometrika"},{"key":"7225_CR27","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/S00134-014-3227-6\/TABLES\/4","volume":"40","author":"J Labar\u00e8re","year":"2014","unstructured":"Labar\u00e8re J, Bertrand R, Fine MJ (2014) How to derive and validate clinical prediction models for use in intensive care medicine. Intensive Care Med 40:513\u2013527. https:\/\/doi.org\/10.1007\/S00134-014-3227-6\/TABLES\/4","journal-title":"Intensive Care Med"},{"key":"7225_CR28","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1097\/00003246-200006000-00031","volume":"28","author":"S Vanderschueren","year":"2000","unstructured":"Vanderschueren S, De Weerdt A, Malbrain M et al (2000) Thrombocytopenia and prognosis in intensive care. Crit Care Med 28:1871\u20131876. https:\/\/doi.org\/10.1097\/00003246-200006000-00031","journal-title":"Crit Care Med"},{"key":"7225_CR29","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1378\/chest.13-0121","volume":"144","author":"DR Williamson","year":"2013","unstructured":"Williamson DR, Albert M, Heels-Ansdell D et al (2013) Thrombocytopenia in critically Ill patients receiving thromboprophylaxis: frequency, risk factors, and outcomes. Chest 144:1207\u20131215. https:\/\/doi.org\/10.1378\/chest.13-0121","journal-title":"Chest"},{"key":"7225_CR30","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1007\/s12630-013-9933-7","volume":"60","author":"DR Williamson","year":"2013","unstructured":"Williamson DR, Lesur O, T\u00e9trault JP et al (2013) Thrombocytopenia in the critically ill: prevalence, incidence, risk factors, and clinical outcomes. Can J Anesth 60:641\u2013651. https:\/\/doi.org\/10.1007\/s12630-013-9933-7","journal-title":"Can J Anesth"},{"key":"7225_CR31","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.1007\/s00701-022-05277-9","volume":"164","author":"K Lillem\u00e4e","year":"2022","unstructured":"Lillem\u00e4e K, Luostarinen T, Reinikainen M et al (2022) Early thrombocytopenia is associated with an increased risk of mortality in patients with traumatic brain injury treated in the intensive care unit: a Finnish Intensive Care Consortium study. Acta Neurochir (Wien) 164:2731\u20132740. https:\/\/doi.org\/10.1007\/s00701-022-05277-9","journal-title":"Acta Neurochir (Wien)"},{"key":"7225_CR32","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/J.LPM.2006.05.001","volume":"36","author":"Y Aissaoui","year":"2007","unstructured":"Aissaoui Y, Benkabbou A, Alilou M et al (2007) Thrombocytopenia in a surgical intensive care unit: incidence, risk factors and effect on outcome. Presse Med 36:43\u201349. https:\/\/doi.org\/10.1016\/J.LPM.2006.05.001","journal-title":"Presse Med"},{"key":"7225_CR33","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1111\/j.1537-2995.2012.03866.x","volume":"53","author":"SJ Stanworth","year":"2013","unstructured":"Stanworth SJ, Walsh TS, Prescott RJ et al (2013) Thrombocytopenia and platelet transfusion in UK critical care: a multicenter observational study. Transfusion 53:1050\u20131058. https:\/\/doi.org\/10.1111\/j.1537-2995.2012.03866.x","journal-title":"Transfusion"}],"updated-by":[{"DOI":"10.1007\/s00134-023-07291-6","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T00:00:00Z","timestamp":1702252800000}}],"container-title":["Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-023-07225-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00134-023-07225-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-023-07225-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T03:02:31Z","timestamp":1702350151000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00134-023-07225-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,9]]},"references-count":33,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["7225"],"URL":"https:\/\/doi.org\/10.1007\/s00134-023-07225-2","relation":{},"ISSN":["0342-4642","1432-1238"],"issn-type":[{"value":"0342-4642","type":"print"},{"value":"1432-1238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,9]]},"assertion":[{"value":"19 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 December 2023","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00134-023-07291-6","URL":"https:\/\/doi.org\/10.1007\/s00134-023-07291-6","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Department of Intensive Care at Rigshospitalet (CTA, AG, MHM, AP, LR) has received funding for other projects from the Novo Nordisk Foundation, Sygeforsikringen \u2018danmark\u2019, and Pfizer and has conducted contract research for AM-Pharma. FP has received honoraria for consulting and lectures from Gilead and an institutional grant from Alexion Pharma. AP has received honoraria from Novartis for participation in an advisory board. EA has received research grants from MSD Avenir and Alexion and honoraria for lectures from Alexion, Sanofi and Pfizer. . AVDL has received honoraria from Sanofi for participation in an advisory board. PC has received consulting fees from Sanofi, Gilead, Alexion and Janssen and honoraria for lectures from Merck Sharp & Dohme, Gilead, Alexion and Pfizer. PP has received consulting fees from Sanofi and Gilead and honoraria from Merck Sharp & Dohme, Gilead, Mundipharma and Pfizer for academic and educational work. JH has received consulting fees from Paion and honoraria for lectures from the Finnish Medical Association, Laboratory Medicine and Duodecim. EC received fees for lectures and conference talks and had travel and accommodation expenses related to attending scientific meetings covered by Gilead, Shionogi B.V. and Sanofi-Genzyme. ARH has received honoraria from Pfizer for lectures. MHB has received consulting fees from AM-pharma and Inotrem. Full disclosure forms from all authors are available on the publisher\u2019s website.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}