{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:14:00Z","timestamp":1790723640020,"version":"4.1.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K76AG054864"],"award-info":[{"award-number":["K76AG054864"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K23AG034257"],"award-info":[{"award-number":["K23AG034257"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG027472"],"award-info":[{"award-number":["R01AG027472"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["VA-Merit"],"award-info":[{"award-number":["VA-Merit"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intensive Care Med"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1007\/s00134-024-07388-6","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T04:01:58Z","timestamp":1713758518000},"page":"687-696","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Systemic inflammation and delirium during critical illness"],"prefix":"10.1007","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4308-0015","authenticated-orcid":false,"given":"Nathan E.","family":"Brummel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G.","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Brennan","family":"McNeil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratik P.","family":"Pandharipande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onur M.","family":"Orun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rameela","family":"Raman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine B.","family":"Ware","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon R.","family":"Bernard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona E.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Wesley","family":"Ely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy D.","family":"Girard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,22]]},"reference":[{"key":"7388_CR1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association, American Psychiatric Association, DSM-5 Task Force (2013) Diagnostic and statistical manual of mental disorders: DSM-5. American Psychiatric Association, Washington, D.C.","DOI":"10.1176\/appi.books.9780890425596"},{"key":"7388_CR2","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/B978-0-12-804766-8.00019-4","volume":"167","author":"NE Brummel","year":"2019","unstructured":"Brummel NE, Girard TD (2019) Delirium in the critically ill patient. Handb Clin Neurol 167:357\u2013375","journal-title":"Handb Clin Neurol"},{"key":"7388_CR3","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1164\/rccm.200904-0537OC","volume":"180","author":"MA Pisani","year":"2009","unstructured":"Pisani MA, Kong SY, Kasl SV, Murphy TE, Araujo KL, Van Ness PH (2009) Days of delirium are associated with 1-year mortality in an older intensive care unit population. Am J Respir Crit Care Med 180:1092\u20131097","journal-title":"Am J Respir Crit Care Med"},{"key":"7388_CR4","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1097\/CCM.0b013e3181e47be1","volume":"38","author":"TD Girard","year":"2010","unstructured":"Girard TD, Jackson JC, Pandharipande PP, Pun BT, Thompson JL, Shintani AK, Gordon SM, Canonico AE, Dittus RS, Bernard GR, Ely EW (2010) Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Crit Care Med 38:1513\u20131520","journal-title":"Crit Care Med"},{"key":"7388_CR5","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1056\/NEJMoa1301372","volume":"369","author":"PP Pandharipande","year":"2013","unstructured":"Pandharipande PP, Girard TD, Jackson JC, Morandi A, Thompson JL, Pun BT, Brummel NE, Hughes CG, Vasilevskis EE, Shintani AK, Moons KG, Geevarghese SK, Canonico A, Hopkins RO, Bernard GR, Dittus RS, Ely EW, Investigators B-IS (2013) Long-term cognitive impairment after critical illness. N Engl J Med 369:1306\u20131316","journal-title":"N Engl J Med"},{"key":"7388_CR6","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1097\/CCM.0b013e3182a645bd","volume":"42","author":"NE Brummel","year":"2014","unstructured":"Brummel NE, Jackson JC, Pandharipande PP, Thompson JL, Shintani AK, Dittus RS, Gill TM, Bernard GR, Ely EW, Girard TD (2014) Delirium in the ICU and subsequent long-term disability among survivors of mechanical ventilation. Crit Care Med 42:369\u2013377","journal-title":"Crit Care Med"},{"key":"7388_CR7","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1007\/s00401-010-0674-1","volume":"119","author":"J Cerejeira","year":"2010","unstructured":"Cerejeira J, Firmino H, Vaz-Serra A, Mukaetova-Ladinska EB (2010) The neuroinflammatory hypothesis of delirium. Acta Neuropathol 119:737\u2013754","journal-title":"Acta Neuropathol"},{"key":"7388_CR8","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1042\/BST0390945","volume":"39","author":"C Cunningham","year":"2011","unstructured":"Cunningham C (2011) Systemic inflammation and delirium: important co-factors in the progression of dementia. Biochem Soc Trans 39:945\u2013953","journal-title":"Biochem Soc Trans"},{"key":"7388_CR9","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.jpsychores.2008.05.019","volume":"65","author":"AM Maclullich","year":"2008","unstructured":"Maclullich AM, Ferguson KJ, Miller T, de Rooij SE, Cunningham C (2008) Unravelling the pathophysiology of delirium: a focus on the role of aberrant stress responses. J Psychosom Res 65:229\u2013238","journal-title":"J Psychosom Res"},{"key":"7388_CR10","doi-asserted-by":"publisher","first-page":"R297","DOI":"10.1186\/cc10598","volume":"15","author":"M van den Boogaard","year":"2011","unstructured":"van den Boogaard M, Kox M, Quinn KL, van Achterberg T, van der Hoeven JG, Schoonhoven L, Pickkers P (2011) Biomarkers associated with delirium in critically ill patients and their relation with long-term subjective cognitive dysfunction; indications for different pathways governing delirium in inflamed and noninflamed patients. Crit Care 15:R297","journal-title":"Crit Care"},{"key":"7388_CR11","doi-asserted-by":"publisher","first-page":"R78","DOI":"10.1186\/cc10070","volume":"15","author":"S McGrane","year":"2011","unstructured":"McGrane S, Girard TD, Thompson JL, Shintani AK, Woodworth A, Ely EW, Pandharipande PP (2011) Procalcitonin and C-reactive protein levels at admission as predictors of duration of acute brain dysfunction in critically ill patients. Crit Care 15:R78","journal-title":"Crit Care"},{"key":"7388_CR12","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1007\/s00134-012-2678-x","volume":"38","author":"TD Girard","year":"2012","unstructured":"Girard TD, Ware LB, Bernard GR, Pandharipande PP, Thompson JL, Shintani AK, Jackson JC, Dittus RS, Ely EW (2012) Associations of markers of inflammation and coagulation with delirium during critical illness. Intensive Care Med 38:1965\u20131973","journal-title":"Intensive Care Med"},{"key":"7388_CR13","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1097\/CCM.0b013e318275d014","volume":"41","author":"Y Skrobik","year":"2013","unstructured":"Skrobik Y, Leger C, Cossette M, Michaud V, Turgeon J (2013) Factors predisposing to coma and delirium: fentanyl and midazolam exposure; CYP3A5, ABCB1, and ABCG2 genetic polymorphisms; and inflammatory factors. Crit Care Med 41:999\u20131008","journal-title":"Crit Care Med"},{"key":"7388_CR14","doi-asserted-by":"publisher","first-page":"R106","DOI":"10.1186\/cc13887","volume":"18","author":"C Ritter","year":"2014","unstructured":"Ritter C, Tomasi CD, Dal-Pizzol F, Pinto BB, Dyson A, de Miranda AS, Comim CM, Soares M, Teixeira AL, Quevedo J, Singer M (2014) Inflammation biomarkers and delirium in critically ill patients. Crit Care 18:R106","journal-title":"Crit Care"},{"key":"7388_CR15","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.jcrc.2013.09.002","volume":"29","author":"Z Zhang","year":"2014","unstructured":"Zhang Z, Pan L, Deng H, Ni H, Xu X (2014) Prediction of delirium in critically ill patients with elevated C-reactive protein. J Crit Care 29:88\u201392","journal-title":"J Crit Care"},{"key":"7388_CR16","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1097\/CCM.0000000000004139","volume":"48","author":"BA Khan","year":"2020","unstructured":"Khan BA, Perkins AJ, Prasad NK, Shekhar A, Campbell NL, Gao S, Wang S, Khan SH, Marcantonio ER, Twigg HL 3rd, Boustani MA (2020) Biomarkers of delirium duration and delirium severity in the ICU. Crit Care Med 48:353\u2013361","journal-title":"Crit Care Med"},{"key":"7388_CR17","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1097\/SLA.0000000000001885","volume":"265","author":"CG Hughes","year":"2017","unstructured":"Hughes CG, Patel MB, Jackson JC, Girard TD, Geevarghese SK, Norman BC, Thompson JL, Chandrasekhar R, Brummel NE, May AK, Elstad MR, Wasserstein ML, Goodman RB, Moons KG, Dittus RS, Ely EW, Pandharipande PP, Mind-Icu B-ICUi (2017) Surgery and anesthesia exposure is not a risk factor for cognitive impairment after major noncardiac surgery and critical illness. Ann Surg 265:1126\u20131133","journal-title":"Ann Surg"},{"key":"7388_CR18","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.jim.2014.04.006","volume":"408","author":"JA Bastarache","year":"2014","unstructured":"Bastarache JA, Koyama T, Wickersham NE, Ware LB (2014) Validation of a multiplex electrochemiluminescent immunoassay platform in human and mouse samples. J Immunol Methods 408:13\u201323","journal-title":"J Immunol Methods"},{"key":"7388_CR19","doi-asserted-by":"publisher","first-page":"2983","DOI":"10.1001\/jama.289.22.2983","volume":"289","author":"EW Ely","year":"2003","unstructured":"Ely EW, Truman B, Shintani A, Thomason JW, Wheeler AP, Gordon S, Francis J, Speroff T, Gautam S, Margolin R, Sessler CN, Dittus RS, Bernard GR (2003) Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS). JAMA 289:2983\u20132991","journal-title":"JAMA"},{"key":"7388_CR20","doi-asserted-by":"publisher","first-page":"2703","DOI":"10.1001\/jama.286.21.2703","volume":"286","author":"EW Ely","year":"2001","unstructured":"Ely EW, Inouye SK, Bernard GR, Gordon S, Francis J, May L, Truman B, Speroff T, Gautam S, Margolin R, Hart RP, Dittus R (2001) Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU). JAMA 286:2703\u20132710","journal-title":"JAMA"},{"key":"7388_CR21","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/S0140-6736(09)61158-2","volume":"375","author":"WA van Gool","year":"2010","unstructured":"van Gool WA, van de Beek D, Eikelenboom P (2010) Systemic infection and delirium: when cytokines and acetylcholine collide. Lancet 375:773\u2013775","journal-title":"Lancet"},{"key":"7388_CR22","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.1046\/j.1532-5415.2002.50619.x","volume":"50","author":"CJ Wilson","year":"2002","unstructured":"Wilson CJ, Finch CE, Cohen HJ (2002) Cytokines and cognition: the case for a head to toe inflammatory paradigm. JAGS 50:2041\u20132056","journal-title":"JAGS"},{"key":"7388_CR23","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.biopsych.2008.07.024","volume":"65","author":"C Cunningham","year":"2009","unstructured":"Cunningham C, Campion S, Lunnon K, Murray CL, Woods JF, Deacon RM, Rawlins JN, Perry VH (2009) Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease. Biol Psychiatry 65:304\u2013312","journal-title":"Biol Psychiatry"},{"key":"7388_CR24","doi-asserted-by":"crossref","unstructured":"Murray C, Sanderson DJ, Barkus C, Deacon RM, Rawlins JN, Bannerman DM, Cunningham C (2012) Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium. Neurobiol Aging 33:603\u2013616","DOI":"10.1016\/j.neurobiolaging.2010.04.002"},{"key":"7388_CR25","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1001\/archpsyc.58.5.445","volume":"58","author":"A Reichenberg","year":"2001","unstructured":"Reichenberg A, Yirmiya R, Schuld A, Kraus T, Haack M, Morag A, Pollmacher T (2001) Cytokine-associated emotional and cognitive disturbances in humans. Arch Gen Psychiatry 58:445\u2013452","journal-title":"Arch Gen Psychiatry"},{"key":"7388_CR26","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.bbi.2005.04.010","volume":"19","author":"KS Krabbe","year":"2005","unstructured":"Krabbe KS, Reichenberg A, Yirmiya R, Smed A, Pedersen BK, Bruunsgaard H (2005) Low-dose endotoxemia and human neuropsychological functions. Brain Behav Immun 19:453\u2013460","journal-title":"Brain Behav Immun"},{"key":"7388_CR27","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1007\/s00134-010-2004-4","volume":"36","author":"K Plaschke","year":"2010","unstructured":"Plaschke K, Fichtenkamm P, Schramm C, Hauth S, Martin E, Verch M, Karck M, Kopitz J (2010) Early postoperative delirium after open-heart cardiac surgery is associated with decreased bispectral EEG and increased cortisol and interleukin-6. Intensive Care Med 36:2081\u20132089","journal-title":"Intensive Care Med"},{"key":"7388_CR28","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1111\/j.1532-5415.2008.01851.x","volume":"56","author":"BC van Munster","year":"2008","unstructured":"van Munster BC, Korevaar JC, Zwinderman AH, Levi M, Wiersinga WJ, De Rooij SE (2008) Time-course of cytokines during delirium in elderly patients with hip fractures. J Am Geriatr Soc 56:1704\u20131709","journal-title":"J Am Geriatr Soc"},{"key":"7388_CR29","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1001\/archinte.167.15.1655","volume":"167","author":"JA Kellum","year":"2007","unstructured":"Kellum JA, Kong L, Fink MP, Weissfeld LA, Yealy DM, Pinsky MR, Fine J, Krichevsky A, Delude RL, Angus DC, Gen IMSI (2007) Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study. Arch Intern Med 167:1655\u20131663","journal-title":"Arch Intern Med"},{"key":"7388_CR30","doi-asserted-by":"publisher","first-page":"L455","DOI":"10.1152\/ajplung.00093.2013","volume":"305","author":"SC Christiaans","year":"2013","unstructured":"Christiaans SC, Wagener BM, Esmon CT, Pittet JF (2013) Protein C and acute inflammation: a clinical and biological perspective. Am J Physiol Lung Cell Mol Physiol 305:L455-466","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"7388_CR31","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1056\/NEJMoa050935","volume":"353","author":"E Abraham","year":"2005","unstructured":"Abraham E, Laterre PF, Garg R, Levy H, Talwar D, Trzaskoma BL, Francois B, Guy JS, Bruckmann M, Rea-Neto A, Rossaint R, Perrotin D, Sablotzki A, Arkins N, Utterback BG, Macias WL, Administration of Drotrecogin Alfa in Early Stage Severe Sepsis Study G (2005) Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death. N Engl J Med 353:1332\u20131341","journal-title":"N Engl J Med"},{"key":"7388_CR32","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1056\/NEJM200103083441001","volume":"344","author":"GR Bernard","year":"2001","unstructured":"Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, Fisher CJ Jr, Recombinant Human Protein C Worldwide Evaluation in Severe Sepsis Study Group (2001) Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 344:699\u2013709","journal-title":"N Engl J Med"},{"key":"7388_CR33","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1056\/NEJMoa1202290","volume":"366","author":"VM Ranieri","year":"2012","unstructured":"Ranieri VM, Thompson BT, Barie PS, Dhainaut JF, Douglas IS, Finfer S, Gardlund B, Marshall JC, Rhodes A, Artigas A, Payen D, Tenhunen J, Al-Khalidi HR, Thompson V, Janes J, Macias WL, Vangerow B, Williams MD (2012) Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med 366:2055\u20132064","journal-title":"N Engl J Med"},{"key":"7388_CR34","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1227\/01.NEU.0000363148.49779.68","volume":"66","author":"AL Petraglia","year":"2010","unstructured":"Petraglia AL, Marky AH, Walker C, Thiyagarajan M, Zlokovic BV (2010) Activated protein C is neuroprotective and mediates new blood vessel formation and neurogenesis after controlled cortical impact. Neurosurgery 66:165\u2013171","journal-title":"Neurosurgery"},{"key":"7388_CR35","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1164\/rccm.201912-2449OC","volume":"203","author":"NE Brummel","year":"2021","unstructured":"Brummel NE, Hughes CG, Thompson JL, Jackson JC, Pandharipande P, McNeil JB, Raman R, Orun OM, Ware LB, Bernard GR, Ely EW, Girard TD (2021) Inflammation and coagulation during critical illness and long-term cognitive impairment and disability. Am J Respir Crit Care Med 203:699\u2013706","journal-title":"Am J Respir Crit Care Med"},{"key":"7388_CR36","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1186\/s12871-022-01690-w","volume":"22","author":"M Arbabi","year":"2022","unstructured":"Arbabi M, Ziaei E, Amini B, Ghadimi H, Rashidi F, Shohanizad N, Moradi S, Beikmarzehei A, Hasanzadeh A, Parsaei A (2022) Delirium risk factors in hospitalized patient: a comprehensive evaluation of underlying diseases and medications in different wards of a large Urban Hospital Center in Iran. BMC Anesthesiol 22:147","journal-title":"BMC Anesthesiol"},{"key":"7388_CR37","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1007\/s10072-020-04887-4","volume":"42","author":"D D'Ardes","year":"2021","unstructured":"D\u2019Ardes D, Carrarini C, Russo M, Dono F, Speranza R, Digiovanni A, Martinotti G, Di Iorio A, Onofrj M, Cipollone F, Bonanni L (2021) Low molecular weight heparin in COVID-19 patients prevents delirium and shortens hospitalization. Neurol Sci 42:1527\u20131530","journal-title":"Neurol Sci"}],"container-title":["Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-024-07388-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00134-024-07388-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-024-07388-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T10:04:25Z","timestamp":1715162665000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00134-024-07388-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,22]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["7388"],"URL":"https:\/\/doi.org\/10.1007\/s00134-024-07388-6","relation":{},"ISSN":["0342-4642","1432-1238"],"issn-type":[{"value":"0342-4642","type":"print"},{"value":"1432-1238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,22]]},"assertion":[{"value":"10 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"CGH is a consultant for Sedana Medical and has received research grant from Kohler Chemie GMBH. PP has received a research grant from Hospira. WE has received research grants and\/or honoraria from Hospira, Orion, Pfizer, Abbott, and Kohler Chemie GMBH. The remaining authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}