{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:38:34Z","timestamp":1790386714013,"version":"4.1.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/100010230","name":"Queensland Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001077","name":"Royal Brisbane and Women's Hospital Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001077","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001794","name":"The University of Queensland","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001794","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intensive Care Med"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1007\/s00134-024-07619-w","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T10:02:21Z","timestamp":1727085741000},"page":"1873-1883","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Low-dose clonidine infusion to improve sleep in postoperative patients in the high-dependency unit. A randomised placebo-controlled single-centre trial"],"prefix":"10.1007","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5933-8522","authenticated-orcid":false,"given":"David","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Hallt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alanna","family":"Platz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0256-024X","authenticated-orcid":false,"given":"Alain","family":"Humblet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Lassig-Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine","family":"Stuart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Fourie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Livermore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5224-0821","authenticated-orcid":false,"given":"Bree-Yana","family":"McConnochie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8312-4898","authenticated-orcid":false,"given":"Therese","family":"Starr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kymberley","family":"Herbst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4697-3855","authenticated-orcid":false,"given":"Christine A.","family":"Woods","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8989-9574","authenticated-orcid":false,"given":"Jason M.","family":"Pincus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1570-0707","authenticated-orcid":false,"given":"Michael C.","family":"Reade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,23]]},"reference":[{"key":"7619_CR1","first-page":"1210","volume":"63","author":"RS Friese","year":"2007","unstructured":"Friese RS, Diaz-Arrastia R, McBride D, Frankel H, Gentilello LM (2007) Quantity and quality of sleep in the surgical intensive care unit: are our patients sleeping? J Trauma 63:1210\u20131214","journal-title":"J Trauma"},{"key":"7619_CR2","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1097\/ACO.0000000000000538","volume":"31","author":"X Su","year":"2018","unstructured":"Su X, Wang DX (2018) Improve postoperative sleep: what can we do? Curr Opin Anaesthesiol 31:83\u201388","journal-title":"Curr Opin Anaesthesiol"},{"key":"7619_CR3","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1186\/cc8131","volume":"13","author":"GL Weinhouse","year":"2009","unstructured":"Weinhouse GL, Schwab RJ, Watson PL, Patil N, Vaccaro B, Pandharipande P, Ely EW (2009) Bench-to-bedside review: delirium in ICU patients\u2014importance of sleep deprivation. Crit Care 13:234","journal-title":"Crit Care"},{"key":"7619_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2019.08.001","volume":"48","author":"Y Lu","year":"2019","unstructured":"Lu Y, Li YW, Wang L, Lydic R, Baghdoyan HA, Shi XY, Zhang H (2019) Promoting sleep and circadian health may prevent postoperative delirium: a systematic review and meta-analysis of randomized clinical trials. Sleep Med Rev 48:101207","journal-title":"Sleep Med Rev"},{"key":"7619_CR5","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.ccc.2017.03.013","volume":"33","author":"JR Maldonado","year":"2017","unstructured":"Maldonado JR (2017) Acute brain failure: pathophysiology, diagnosis, management, and sequelae of delirium. Crit Care Clin 33:461\u2013519","journal-title":"Crit Care Clin"},{"key":"7619_CR6","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1097\/SLA.0b013e31818e4776","volume":"249","author":"TN Robinson","year":"2009","unstructured":"Robinson TN, Raeburn CD, Tran ZV, Angles EM, Brenner LA, Moss M (2009) Postoperative delirium in the elderly: risk factors and outcomes. Ann Surg 249:173\u2013178","journal-title":"Ann Surg"},{"key":"7619_CR7","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1097\/CCM.0000000000001952","volume":"44","author":"AH Flannery","year":"2016","unstructured":"Flannery AH, Oyler DR, Weinhouse GL (2016) The impact of interventions to improve sleep on delirium in the ICU: a systematic review and research framework. Crit Care Med 44:2231\u20132240","journal-title":"Crit Care Med"},{"key":"7619_CR8","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-012108","volume":"6","author":"S Kanji","year":"2016","unstructured":"Kanji S, Mera A, Hutton B, Burry L, Rosenberg E, MacDonald E, Luks V (2016) Pharmacological interventions to improve sleep in hospitalised adults: a systematic review. BMJ Open 6:e012108","journal-title":"BMJ Open"},{"key":"7619_CR9","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.1399-6576.2007.01537.x","volume":"52","author":"E Huupponen","year":"2008","unstructured":"Huupponen E, Maksimow A, Lapinlampi P, Sarkela M, Saastamoinen A, Snapir A, Scheinin H, Scheinin M, Merilainen P, Himanen SL, Jaaskelainen S (2008) Electroencephalogram spindle activity during dexmedetomidine sedation and physiological sleep. Acta Anaesthesiol Scand 52:289\u2013294","journal-title":"Acta Anaesthesiol Scand"},{"key":"7619_CR10","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1097\/ALN.0000000000001325","volume":"125","author":"XH Wu","year":"2016","unstructured":"Wu XH, Cui F, Zhang C, Meng ZT, Wang DX, Ma J, Wang GF, Zhu SN, Ma D (2016) Low-dose dexmedetomidine improves sleep quality pattern in elderly patients after noncardiac surgery in the intensive care unit: a pilot randomized controlled trial. Anesthesiology 125:979\u2013991","journal-title":"Anesthesiology"},{"key":"7619_CR11","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1016\/S0140-6736(16)30580-3","volume":"388","author":"X Su","year":"2016","unstructured":"Su X, Meng ZT, Wu XH, Cui F, Li HL, Wang DX, Zhu X, Zhu SN, Maze M, Ma D (2016) Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial. Lancet 388:1893\u20131902","journal-title":"Lancet"},{"key":"7619_CR12","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1111\/j.1440-1819.2003.01207.x","volume":"58","author":"S Miyazaki","year":"2004","unstructured":"Miyazaki S, Uchida S, Mukai J, Nishihara K (2004) Clonidine effects on all-night human sleep: opposite action of low- and medium-dose clonidine on human NREM-REM sleep proportion. Psychiatry Clin Neurosci 58:138\u2013144","journal-title":"Psychiatry Clin Neurosci"},{"key":"7619_CR13","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.5664\/jcsm.9930","volume":"18","author":"OA Bamgbade","year":"2022","unstructured":"Bamgbade OA, Tai-Osagbemi J, Bamgbade DO, Murphy-Akpieyi O, Fadire A, Soni NK, Mumporeze L (2022) Clonidine is better than zopiclone for insomnia treatment in chronic pain patients. J Clin Sleep Med 18:1565\u20131571","journal-title":"J Clin Sleep Med"},{"key":"7619_CR14","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.ccc.2016.12.005","volume":"33","author":"A Marra","year":"2017","unstructured":"Marra A, Ely EW, Pandharipande PP, Patel MB (2017) The ABCDEF bundle in critical care. Crit Care Clin 33:225\u2013243","journal-title":"Crit Care Clin"},{"key":"7619_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208","volume":"95","author":"PA Harris","year":"2019","unstructured":"Harris PA, Taylor R, Minor BL, Elliott V, Fernandez M, O\u2019Neal L, McLeod L, Delacqua G, Delacqua F, Kirby J, Duda SN, Consortium RE (2019) The REDCap consortium: building an international community of software platform partners. J Biomed Inform 95:103208","journal-title":"J Biomed Inform"},{"key":"7619_CR16","doi-asserted-by":"publisher","first-page":"2703","DOI":"10.1001\/jama.286.21.2703","volume":"286","author":"EW Ely","year":"2001","unstructured":"Ely EW, Inouye SK, Bernard GR, Gordon S, Francis J, May L, Truman B, Speroff T, Gautam S, Margolin R, Hart RP, Dittus R (2001) Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU). JAMA 286:2703\u20132710","journal-title":"JAMA"},{"key":"7619_CR17","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1164\/rccm.2107138","volume":"166","author":"CN Sessler","year":"2002","unstructured":"Sessler CN, Gosnell MS, Grap MJ, Brophy GM, O\u2019Neal PV, Keane KA, Tesoro EP, Elswick RK (2002) The Richmond Agitation-Sedation Scale: validity and reliability in adult intensive care unit patients. Am J Respir Crit Care Med 166:1338\u20131344","journal-title":"Am J Respir Crit Care Med"},{"key":"7619_CR18","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1177\/08971900211004828","volume":"35","author":"J Peterson","year":"2022","unstructured":"Peterson J, Thomas W, Michaud C, Parker J (2022) Incidence of fever associated with dexmedetomidine in the adult intensive care unit. J Pharm Pract 35:716\u2013721","journal-title":"J Pharm Pract"},{"key":"7619_CR19","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsx1097","author":"P Fonseca","year":"2017","unstructured":"Fonseca P, Weysen T, Goelema MS, Most EIS, Radha M, Lunsingh Scheurleer C, van den Heuvel L, Aarts RM (2017) Validation of photoplethysmography-based sleep staging compared with polysomnography in healthy middle-aged adults. Sleep. https:\/\/doi.org\/10.1093\/sleep\/zsx1097","journal-title":"Sleep"},{"key":"7619_CR20","unstructured":"(2021) Opioid dose equivalence calculation table. Australian and New Zealand College of Anaesthetists, Melbourne"},{"key":"7619_CR21","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1164\/rccm.201710-1995OC","volume":"197","author":"Y Skrobik","year":"2018","unstructured":"Skrobik Y, Duprey MS, Hill NS, Devlin JW (2018) Low-dose nocturnal dexmedetomidine prevents ICU delirium. a randomized, placebo-controlled trial. Am J Respir Crit Care Med 197:1147\u20131156","journal-title":"Am J Respir Crit Care Med"},{"key":"7619_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101796","volume":"56","author":"JZ Qu","year":"2023","unstructured":"Qu JZ, Mueller A, McKay TB, Westover MB, Shelton KT, Shaefi S, D\u2019Alessandro DA, Berra L, Brown EN, Houle TT, Akeju O, Team MS (2023) Nighttime dexmedetomidine for delirium prevention in non-mechanically ventilated patients after cardiac surgery (MINDDS): a single-centre, parallel-arm, randomised, placebo-controlled superiority trial. EClinicalMedicine 56:101796","journal-title":"EClinicalMedicine"},{"key":"7619_CR23","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/S0140-6736(20)30631-0","volume":"396","author":"A Turan","year":"2020","unstructured":"Turan A, Duncan A, Leung S, Karimi N, Fang J, Mao G, Hargrave J, Gillinov M, Trombetta C, Ayad S, Hassan M, Feider A, Howard-Quijano K, Ruetzler K, Sessler DI, Group DS (2020) Dexmedetomidine for reduction of atrial fibrillation and delirium after cardiac surgery (DECADE): a randomised placebo-controlled trial. Lancet 396:177\u2013185","journal-title":"Lancet"},{"key":"7619_CR24","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1053\/eujp.2001.0270","volume":"6","author":"F Marinangeli","year":"2002","unstructured":"Marinangeli F, Ciccozzi A, Donatelli F, Di Pietro A, Iovinelli G, Rawal N, Paladini A, Varrassi G (2002) Clonidine for treatment of postoperative pain: a dose-finding study. Eur J Pain 6:35\u201342","journal-title":"Eur J Pain"},{"key":"7619_CR25","unstructured":"(2017) Clonidine (anaesthesia). In: Australian Medicines Handbook. Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, The Royal Australian College of General Practitioners, Pharmaceutical Society of Australia"},{"key":"7619_CR26","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1111\/j.1399-6576.1991.tb03241.x","volume":"35","author":"JM Bernard","year":"1991","unstructured":"Bernard JM, Bourreli B, Hommeril JL, Pinaud M (1991) Effects of oral clonidine premedication and postoperative i.v. infusion on haemodynamic and adrenergic responses during recovery from anaesthesia. Acta Anaesthesiol Scand 35:54\u201359","journal-title":"Acta Anaesthesiol Scand"},{"key":"7619_CR27","doi-asserted-by":"publisher","first-page":"431","DOI":"10.4103\/0972-5229.136071","volume":"18","author":"U Srivastava","year":"2014","unstructured":"Srivastava U, Sarkar ME, Kumar A, Gupta A, Agarwal A, Singh TK, Badada V, Dwivedi Y (2014) Comparison of clonidine and dexmedetomidine for short-term sedation of intensive care unit patients. Indian J Crit Care Med 18:431\u2013436","journal-title":"Indian J Crit Care Med"},{"key":"7619_CR28","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1093\/bja\/86.1.5","volume":"86","author":"JE Hall","year":"2001","unstructured":"Hall JE, Uhrich TD, Ebert TJ (2001) Sedative, analgesic and cognitive effects of clonidine infusions in humans. Br J Anaesth 86:5\u201311","journal-title":"Br J Anaesth"},{"key":"7619_CR29","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1186\/cc5966","volume":"11","author":"RS Bourne","year":"2007","unstructured":"Bourne RS, Minelli C, Mills GH, Kandler R (2007) Clinical review: Sleep measurement in critical care patients: research and clinical implications. Crit Care 11:226","journal-title":"Crit Care"},{"key":"7619_CR30","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1097\/CNQ.0b013e318283cff3","volume":"36","author":"AW van der Kooi","year":"2013","unstructured":"van der Kooi AW, Tulen JH, van Eijk MM, de Weerd AW, van Uitert MJ, van Munster BC, Slooter AJ (2013) Sleep monitoring by actigraphy in short-stay ICU patients. Crit Care Nurs Q 36:169\u2013173","journal-title":"Crit Care Nurs Q"},{"key":"7619_CR31","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2020-000572","volume":"7","author":"PR Louzon","year":"2020","unstructured":"Louzon PR, Andrews JL, Torres X, Pyles EC, Ali MH, Du Y, Devlin JW (2020) Characterisation of ICU sleep by a commercially available activity tracker and its agreement with patient-perceived sleep quality. BMJ Open Respir Res 7:e000572","journal-title":"BMJ Open Respir Res"},{"issue":"9","key":"7619_CR32","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1177\/0885066617712197","volume":"34","author":"EL Jeffs","year":"2017","unstructured":"Jeffs EL, Darbyshire JL (2017) Measuring sleep in the intensive care unit: a critical appraisal of the use of subjective methods. J Intensive Care Med 34(9):751\u2013760","journal-title":"J Intensive Care Med"},{"key":"7619_CR33","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1891\/1061-3749.8.2.131","volume":"8","author":"KC Richards","year":"2000","unstructured":"Richards KC, O\u2019Sullivan PS, Phillips RL (2000) Measurement of sleep in critically ill patients. J Nurs Meas 8:131\u2013144","journal-title":"J Nurs Meas"},{"key":"7619_CR34","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/S0964-3397(03)00076-4","volume":"19","author":"U Frisk","year":"2003","unstructured":"Frisk U, Nordstrom G (2003) Patients\u2019 sleep in an intensive care unit\u2013patients\u2019 and nurses\u2019 perception. Intensive Crit Care Nurs 19:342\u2013349","journal-title":"Intensive Crit Care Nurs"},{"key":"7619_CR35","doi-asserted-by":"publisher","first-page":"261","DOI":"10.4037\/ajcc2012111","volume":"21","author":"BB Kamdar","year":"2012","unstructured":"Kamdar BB, Shah PA, King LM, Kho ME, Zhou X, Colantuoni E, Collop NA, Needham DM (2012) Patient-nurse interrater reliability and agreement of the Richards\u2013Campbell sleep questionnaire. Am J Crit Care 21:261\u2013269","journal-title":"Am J Crit Care"},{"key":"7619_CR36","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1007\/s40262-017-0507-7","volume":"56","author":"MAS Weerink","year":"2017","unstructured":"Weerink MAS, Struys M, Hannivoort LN, Barends CRM, Absalom AR, Colin P (2017) Clinical pharmacokinetics and pharmacodynamics of dexmedetomidine. Clin Pharmacokinet 56:893\u2013913","journal-title":"Clin Pharmacokinet"},{"key":"7619_CR37","unstructured":"Yasaei R, Saadabadi A (2023) Clonidine. In: Book clonidine. StatPearls Publishing"},{"key":"7619_CR38","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1111\/j.1524-6175.2005.04133.x","volume":"7","author":"DA Sica","year":"2005","unstructured":"Sica DA, Grubbs R (2005) Transdermal clonidine: therapeutic considerations. J Clin Hypertens (Greenwich) 7:558\u2013562","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"7619_CR39","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s40360-018-0218-1","volume":"19","author":"KR Hov","year":"2018","unstructured":"Hov KR, Neerland BE, Andersen AM, Undseth O, Wyller VB, MacLullich AMJ, Skovlund E, Qvigstad E, Wyller TB (2018) The use of clonidine in elderly patients with delirium; pharmacokinetics and hemodynamic responses. BMC Pharmacol Toxicol 19:29","journal-title":"BMC Pharmacol Toxicol"},{"key":"7619_CR40","doi-asserted-by":"publisher","first-page":"439","DOI":"10.4103\/0970-9185.74581","volume":"26","author":"S Jamadarkhana","year":"2010","unstructured":"Jamadarkhana S, Gopal S (2010) Clonidine in adults as a sedative agent in the intensive care unit. J Anaesthesiol Clin Pharmacol 26:439\u2013445","journal-title":"J Anaesthesiol Clin Pharmacol"},{"key":"7619_CR41","unstructured":"Boehringer Ingelheim (2016) Catapres-TTS\u00ae transdermal therapeutic system: prescribing information"},{"key":"7619_CR42","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1177\/1740774516649595","volume":"13","author":"H Wang","year":"2016","unstructured":"Wang H, Rosner GL, Goodman SN (2016) Quantifying over-estimation in early stopped clinical trials and the \u201cfreezing effect\u201d on subsequent research. Clin Trials 13:621\u2013631","journal-title":"Clin Trials"},{"key":"7619_CR43","doi-asserted-by":"publisher","first-page":"3114","DOI":"10.1097\/CCM.0b013e3181bc7bd5","volume":"37","author":"R Bellomo","year":"2009","unstructured":"Bellomo R, Warrillow SJ, Reade MC (2009) Why we should be wary of single-center trials. Crit Care Med 37:3114\u20133119","journal-title":"Crit Care Med"}],"container-title":["Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-024-07619-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00134-024-07619-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-024-07619-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T03:07:19Z","timestamp":1730862439000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00134-024-07619-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,23]]},"references-count":43,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["7619"],"URL":"https:\/\/doi.org\/10.1007\/s00134-024-07619-w","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4363040\/v1","asserted-by":"object"}]},"ISSN":["0342-4642","1432-1238"],"issn-type":[{"value":"0342-4642","type":"print"},{"value":"1432-1238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,23]]},"assertion":[{"value":"7 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The trial was approved by the Human Research Ethics Committees of the Prince Charles Hospital, Brisbane (ID HREC\/2018\/QPCH\/44026) and University of Queensland (2018002382\/44026) and received local site governance approval by the Royal Brisbane and Women\u2019s Hospital. The study was performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standard"}}]}}