{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:36:33Z","timestamp":1791876993165,"version":"4.3.4"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intensive Care Med"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1007\/s00134-025-07807-2","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T02:03:53Z","timestamp":1739844233000},"page":"353-363","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Liberal vs. restrictive transfusion strategies for acute brain injury: a systematic review and frequentist-Bayesian meta-analysis"],"prefix":"10.1007","volume":"51","author":[{"given":"Pierre-Louis","family":"Blot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Renaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timoth\u00e9e","family":"Ayasse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Collet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Michel","family":"Constantin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1011-7256","authenticated-orcid":false,"given":"Rayan","family":"Bra\u00efk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,17]]},"reference":[{"key":"7807_CR1","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/S1474-4422(17)30371-X","volume":"16","author":"AIR Maas","year":"2017","unstructured":"Maas AIR, Menon DK, Adelson PD et al (2017) Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research. Lancet Neurol 16:987\u20131048. https:\/\/doi.org\/10.1016\/S1474-4422(17)30371-X","journal-title":"Lancet Neurol"},{"key":"7807_CR2","doi-asserted-by":"publisher","first-page":"R128","DOI":"10.1186\/cc11431","volume":"16","author":"MS Sekhon","year":"2012","unstructured":"Sekhon MS, McLean N, Henderson WR et al (2012) Association of hemoglobin concentration and mortality in critically ill patients with severe traumatic brain injury. Crit Care 16:R128. https:\/\/doi.org\/10.1186\/cc11431","journal-title":"Crit Care"},{"key":"7807_CR3","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1097\/ALN.0b013e3182054d06","volume":"114","author":"LG Glance","year":"2011","unstructured":"Glance LG, Dick AW, Mukamel DB et al (2011) Association between intraoperative blood transfusion and mortality and morbidity in patients undergoing noncardiac surgery. Anesthesiology 114:283\u2013292. https:\/\/doi.org\/10.1097\/ALN.0b013e3182054d06","journal-title":"Anesthesiology"},{"key":"7807_CR4","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1182\/blood-2018-10-833988","volume":"133","author":"R Goel","year":"2019","unstructured":"Goel R, Tobian AAR, Shaz BH (2019) Noninfectious transfusion-associated adverse events and their mitigation strategies. Blood 133:1831\u20131839. https:\/\/doi.org\/10.1182\/blood-2018-10-833988","journal-title":"Blood"},{"key":"7807_CR5","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1007\/s00134-019-05884-8","volume":"46","author":"AP Vlaar","year":"2020","unstructured":"Vlaar AP, Oczkowski S, de Bruin S et al (2020) Transfusion strategies in non-bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine. Intensive Care Med 46:673\u2013696. https:\/\/doi.org\/10.1007\/s00134-019-05884-8","journal-title":"Intensive Care Med"},{"key":"7807_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2024.09.016","author":"AO Coz Yataco","year":"2024","unstructured":"Coz Yataco AO, Soghier I, H\u00e9bert PC et al (2024) Red blood cell transfusion in critically ill adults: an American college of chest physicians clinical practice guideline. Chest. https:\/\/doi.org\/10.1016\/j.chest.2024.09.016","journal-title":"Chest"},{"key":"7807_CR7","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1007\/s00134-019-05805-9","volume":"45","author":"GWJ Hawryluk","year":"2019","unstructured":"Hawryluk GWJ, Aguilera S, Buki A et al (2019) A management algorithm for patients with intracranial pressure monitoring: the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC). Intensive Care Med 45:1783\u20131794. https:\/\/doi.org\/10.1007\/s00134-019-05805-9","journal-title":"Intensive Care Med"},{"key":"7807_CR8","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1056\/NEJMoa2404360","volume":"391","author":"AF Turgeon","year":"2024","unstructured":"Turgeon AF, Fergusson DA, Clayton L et al (2024) Liberal or restrictive transfusion strategy in patients with traumatic brain injury. N Engl J Med 391:722\u2013735. https:\/\/doi.org\/10.1056\/NEJMoa2404360","journal-title":"N Engl J Med"},{"key":"7807_CR9","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1001\/jama.2024.20424","volume":"332","author":"FS Taccone","year":"2024","unstructured":"Taccone FS, RynkowskiBittencourt C, M\u00f8ller K et al (2024) Restrictive vs liberal transfusion strategy in patients with acute brain injury: the TRAIN randomized clinical trial. JAMA 332:1623\u20131633. https:\/\/doi.org\/10.1001\/jama.2024.20424","journal-title":"JAMA"},{"key":"7807_CR10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2410962","author":"SW English","year":"2024","unstructured":"English SW, Delaney A, Fergusson DA et al (2024) Liberal or restrictive transfusion strategy in aneurysmal subarachnoid hemorrhage. N Engl J Med. https:\/\/doi.org\/10.1056\/NEJMoa2410962","journal-title":"N Engl J Med"},{"key":"7807_CR11","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","volume":"372","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71. https:\/\/doi.org\/10.1136\/bmj.n71","journal-title":"BMJ"},{"key":"7807_CR12","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1038\/nrneurol.2016.89","volume":"12","author":"T McMillan","year":"2016","unstructured":"McMillan T, Wilson L, Ponsford J et al (2016) The Glasgow Outcome Scale\u201440 years of application and refinement. Nat Rev Neurol 12:477\u2013485. https:\/\/doi.org\/10.1038\/nrneurol.2016.89","journal-title":"Nat Rev Neurol"},{"key":"7807_CR13","doi-asserted-by":"publisher","first-page":"2435","DOI":"10.1089\/neu.2020.7527","volume":"38","author":"L Wilson","year":"2021","unstructured":"Wilson L, Boase K, Nelson LD et al (2021) A manual for the glasgow outcome scale-extended interview. J Neurotrauma 38:2435\u20132446. https:\/\/doi.org\/10.1089\/neu.2020.7527","journal-title":"J Neurotrauma"},{"key":"7807_CR14","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","volume":"5","author":"M Ouzzani","year":"2016","unstructured":"Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A (2016) Rayyan\u2014a web and mobile app for systematic reviews. Syst Rev 5:210. https:\/\/doi.org\/10.1186\/s13643-016-0384-4","journal-title":"Syst Rev"},{"key":"7807_CR15","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898","volume":"366","author":"JAC Sterne","year":"2019","unstructured":"Sterne JAC, Savovi\u0107 J, Page MJ et al (2019) RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ 366:l4898. https:\/\/doi.org\/10.1136\/bmj.l4898","journal-title":"BMJ"},{"key":"7807_CR16","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","volume":"7","author":"R DerSimonian","year":"1986","unstructured":"DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177\u2013188. https:\/\/doi.org\/10.1016\/0197-2456(86)90046-2","journal-title":"Control Clin Trials"},{"key":"7807_CR17","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1002\/sim.6632","volume":"35","author":"DC Hoaglin","year":"2016","unstructured":"Hoaglin DC (2016) Misunderstandings about Q and \u201cCochran\u2019s Q test\u201d in meta-analysis. Stat Med 35:485\u2013495. https:\/\/doi.org\/10.1002\/sim.6632","journal-title":"Stat Med"},{"key":"7807_CR18","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s12874-017-0315-7","volume":"17","author":"J Wetterslev","year":"2017","unstructured":"Wetterslev J, Jakobsen JC, Gluud C (2017) Trial Sequential Analysis in systematic reviews with meta-analysis. BMC Med Res Methodol 17:39. https:\/\/doi.org\/10.1186\/s12874-017-0315-7","journal-title":"BMC Med Res Methodol"},{"key":"7807_CR19","doi-asserted-by":"publisher","first-page":"3875","DOI":"10.1002\/sim.1009","volume":"20","author":"J Hartung","year":"2001","unstructured":"Hartung J, Knapp G (2001) A refined method for the meta-analysis of controlled clinical trials with binary outcome. Stat Med 20:3875\u20133889. https:\/\/doi.org\/10.1002\/sim.1009","journal-title":"Stat Med"},{"key":"7807_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v076.i01","volume":"76","author":"B Carpenter","year":"2017","unstructured":"Carpenter B, Gelman A, Hoffman MD et al (2017) Stan: a probabilistic programming language. J Stat Softw 76:1. https:\/\/doi.org\/10.18637\/jss.v076.i01","journal-title":"J Stat Softw"},{"key":"7807_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v092.i10","volume":"92","author":"QF Gronau","year":"2020","unstructured":"Gronau QF, Singmann H, Wagenmakers E-J (2020) bridgesampling: An R package for estimating normalizing constants. J Stat Softw 92:1\u201329. https:\/\/doi.org\/10.18637\/jss.v092.i10","journal-title":"J Stat Softw"},{"key":"7807_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2022.106845","volume":"31","author":"B Gaastra","year":"2022","unstructured":"Gaastra B, Ren D, Alexander S et al (2022) Evidence-based interconversion of the Glasgow Outcome and modified Rankin scales: pitfalls and best practices. J Stroke Cerebrovasc Dis 31:106845. https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2022.106845","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"7807_CR23","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","volume":"336","author":"GH Guyatt","year":"2008","unstructured":"Guyatt GH, Oxman AD, Vist GE et al (2008) GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 336:924\u2013926. https:\/\/doi.org\/10.1136\/bmj.39489.470347.AD","journal-title":"BMJ"},{"key":"7807_CR24","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s13054-018-2273-9","volume":"23","author":"ALN Gobatto","year":"2019","unstructured":"Gobatto ALN, Link MA, Solla DJ et al (2019) Transfusion requirements after head trauma: a randomized feasibility controlled trial. Crit Care 23:89. https:\/\/doi.org\/10.1186\/s13054-018-2273-9","journal-title":"Crit Care"},{"key":"7807_CR25","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1001\/jama.2014.6490","volume":"312","author":"CS Robertson","year":"2014","unstructured":"Robertson CS, Hannay HJ, Yamal J-M et al (2014) Effect of erythropoietin and transfusion threshold on neurological recovery after traumatic brain injury: a randomized clinical trial. JAMA 312:36\u201347. https:\/\/doi.org\/10.1001\/jama.2014.6490","journal-title":"JAMA"},{"key":"7807_CR26","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1097\/CCM.0b013e31824519ce","volume":"40","author":"B Roozenbeek","year":"2012","unstructured":"Roozenbeek B, Lingsma HF, Lecky FE et al (2012) Prediction of outcome after moderate and severe traumatic brain injury: external validation of the IMPACT and CRASH prognostic models. Crit Care Med 40:1609\u20131617. https:\/\/doi.org\/10.1097\/CCM.0b013e31824519ce","journal-title":"Crit Care Med"},{"key":"7807_CR27","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/1471-2288-3-26","volume":"3","author":"AA Montgomery","year":"2003","unstructured":"Montgomery AA, Peters TJ, Little P (2003) Design, analysis and presentation of factorial randomised controlled trials. BMC Med Res Methodol 3:26. https:\/\/doi.org\/10.1186\/1471-2288-3-26","journal-title":"BMC Med Res Methodol"},{"key":"7807_CR28","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1056\/NEJMoa071533","volume":"357","author":"HL Corwin","year":"2007","unstructured":"Corwin HL, Gettinger A, Fabian TC et al (2007) Efficacy and safety of epoetin alfa in critically ill patients. N Engl J Med 357:965\u2013976. https:\/\/doi.org\/10.1056\/NEJMoa071533","journal-title":"N Engl J Med"},{"key":"7807_CR29","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1097\/CCM.0000000000005809","volume":"51","author":"S Rajagopalan","year":"2023","unstructured":"Rajagopalan S, Sarwal A (2023) Neuromonitoring in critically ill patients. Crit Care Med 51:525\u2013542. https:\/\/doi.org\/10.1097\/CCM.0000000000005809","journal-title":"Crit Care Med"}],"updated-by":[{"DOI":"10.1007\/s00134-025-07882-5","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000}}],"container-title":["Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-025-07807-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00134-025-07807-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-025-07807-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T12:49:14Z","timestamp":1744807754000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00134-025-07807-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["7807"],"URL":"https:\/\/doi.org\/10.1007\/s00134-025-07807-2","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s00134-025-07882-5","asserted-by":"object"}]},"ISSN":["0342-4642","1432-1238"],"issn-type":[{"value":"0342-4642","type":"print"},{"value":"1432-1238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"25 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 April 2025","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original online version of this article was revised: when this article was first published,  the labels for \"liberal\" and \"restrictive\" in Fig. 2 were inadvertently inverted.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2025","order":7,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":8,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":9,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00134-025-07882-5","URL":"https:\/\/doi.org\/10.1007\/s00134-025-07882-5","order":10,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None of the authors reported any financial disclosures or conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}