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CK reports honoraria for speaking\/advisory boards from Shionogi and Gilead. SK received research support from CytoSorbents and Daiichi Sankyo. SK\u00a0also received lecture fees from ADVITOS, Biotest, Daiichi Sankyo, Fresenius Medical Care, Gilead, Mitsubishi Tanabe Pharma, MSD, Pfizer, Shionogi, and ZOLL. SK\u00a0received consultant fees from Fresenius Medical Care, Gilead, MSD, and Pfizer. MO received research funding from Biomerieux and Baxter (paid to institution). CR received speaker fees from MSD, Pfizer, Shionogi, AOP Orphan, bioM\u00e9rieux, and Advanz Pharma. CR received fees as Advisory Board member from Advanz Pharma, bioM\u00e9rieux, and Viatris. JDW has consulted for Biomerieux,\u00a0Menarini, MSD, Pfizer,\u00a0Roche Diagnostics,\u00a0ThermoFisher, and Viatris (fees and honoraria paid to institution).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The study was designed and conducted following the declaration of Helsinki guidelines and received ethics approval from the Royal Brisbane and Women\u2019s Hospital Human Research Ethics Committee (HREC\/13\/QRBW\/1) as the lead site. All other participating sites also obtained individual HREC approval.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors would like to acknowledge and honour the extraordinary contribution of Professor Rinaldo Bellomo not only to this project but to the broader field of medical research dedicated to the care of the critically ill patient. His exceptional career in clinical practise, research, and mentorship has resulted in major advancements in intensive care medicine and has profoundly impacted the careers and lives of many healthcare professionals around the globe. With the present work, we would like to pay tribute to his unique individual.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"In memoriam"}}]}}