{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:56:04Z","timestamp":1793051764834,"version":"4.5.0"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT2006514"],"award-info":[{"award-number":["GNT2006514"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intensive Care Med"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s00134-025-08186-4","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:34:39Z","timestamp":1762176879000},"page":"2199-2212","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["The intensive care medicine research agenda for the management of ICU acquired weakness: a multinational, interprofessional perspective"],"prefix":"10.1007","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7379-7343","authenticated-orcid":false,"given":"Sabrina","family":"Eggmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2204-3143","authenticated-orcid":false,"given":"Selina M.","family":"Parry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5555-0777","authenticated-orcid":false,"given":"Tessa","family":"Broadley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9220-9810","authenticated-orcid":false,"given":"Gordon S.","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4220-4672","authenticated-orcid":false,"given":"Amy J.","family":"Bongetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7922-5717","authenticated-orcid":false,"given":"Emma J.","family":"Ridley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Ayre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5551-1401","authenticated-orcid":false,"given":"Michael","family":"Bailey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1650-8939","authenticated-orcid":false,"given":"Rinaldo","family":"Bellomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1633-805X","authenticated-orcid":false,"given":"Sue","family":"Berney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Bradley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8452-2241","authenticated-orcid":false,"given":"Heidi","family":"Buhr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5386-4097","authenticated-orcid":false,"given":"Marion K.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Casey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9818-2484","authenticated-orcid":false,"given":"Lee-anne S.","family":"Chapple","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5676-5497","authenticated-orcid":false,"given":"Bronwen","family":"Connolly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0579-8931","authenticated-orcid":false,"given":"Jai","family":"Darvall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7620-5577","authenticated-orcid":false,"given":"Adam","family":"Deane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9296-4418","authenticated-orcid":false,"given":"Mark A.","family":"Febbraio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0444-8606","authenticated-orcid":false,"given":"Rik","family":"Gosselink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6169-370X","authenticated-orcid":false,"given":"Catherine L.","family":"Granger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2882-1594","authenticated-orcid":false,"given":"Kimberley","family":"Haines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5227-9881","authenticated-orcid":false,"given":"Susan","family":"Hanekom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0553-674X","authenticated-orcid":false,"given":"Michael O.","family":"Harhay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2978-9098","authenticated-orcid":false,"given":"Meg","family":"Harrold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9315-3684","authenticated-orcid":false,"given":"Kate","family":"Hayes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5340-1500","authenticated-orcid":false,"given":"Greet","family":"Hermans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8295-7559","authenticated-orcid":false,"given":"Alisa","family":"Higgins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1712-976X","authenticated-orcid":false,"given":"Snigdha","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3170-031X","authenticated-orcid":false,"given":"Michelle E.","family":"Kho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1801-0667","authenticated-orcid":false,"given":"Bharath","family":"Kumar Tirupakuzhi Vijayaraghavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4816-3023","authenticated-orcid":false,"given":"Kate","family":"Lambell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2239-2263","authenticated-orcid":false,"given":"Jenna K.","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2212-2140","authenticated-orcid":false,"given":"Isabel Anne","family":"Leditschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9194-2033","authenticated-orcid":false,"given":"Itamar","family":"Levinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherene","family":"Magana Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7692-403X","authenticated-orcid":false,"given":"Andrea P.","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9538-0557","authenticated-orcid":false,"given":"Dale M.","family":"Needham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1088-3009","authenticated-orcid":false,"given":"George","family":"Ntoumenopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5178-0364","authenticated-orcid":false,"given":"Peter","family":"Nydahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6517-2175","authenticated-orcid":false,"given":"Bhakti K.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6126-4753","authenticated-orcid":false,"given":"Michelle","family":"Paton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4267-1892","authenticated-orcid":false,"given":"Zudin","family":"Puthucheary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olav","family":"Rooyackers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6683-9584","authenticated-orcid":false,"given":"Stefan J.","family":"Schaller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1520-9387","authenticated-orcid":false,"given":"Ary","family":"Serpa Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2028-2039","authenticated-orcid":false,"given":"Christian","family":"Stoppe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7751-3267","authenticated-orcid":false,"given":"Oystein","family":"Tronstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5261-5192","authenticated-orcid":false,"given":"Ilse","family":"Vanhorebeek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5684-4419","authenticated-orcid":false,"given":"Werner J.","family":"Z\u2019Graggen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9002-2075","authenticated-orcid":false,"given":"Carol L.","family":"Hodgson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"key":"8186_CR1","doi-asserted-by":"publisher","first-page":"S299","DOI":"10.1097\/CCM.0b013e3181b6ef67","volume":"37","author":"RD Stevens","year":"2009","unstructured":"Stevens RD, Marshall SA, Cornblath DR, Hoke A, Needham DM, de Jonghe B, Ali NA, Sharshar T (2009) A framework for diagnosing and classifying intensive care unit-acquired weakness. Crit Care Med 37:S299-308","journal-title":"Crit Care Med"},{"key":"8186_CR2","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1186\/s13054-023-04676-3","volume":"27","author":"N Latronico","year":"2023","unstructured":"Latronico N, Rasulo FA, Eikermann M, Piva S (2023) Illness weakness, polyneuropathy and myopathy: diagnosis, treatment, and long-term outcomes. Crit Care 27:439","journal-title":"Crit Care"},{"key":"8186_CR3","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1007\/s00134-020-05944-4","volume":"46","author":"I Vanhorebeek","year":"2020","unstructured":"Vanhorebeek I, Latronico N, Van den Berghe G (2020) ICU-acquired weakness. Intensive Care Med 46:637\u2013653","journal-title":"Intensive Care Med"},{"key":"8186_CR4","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1136\/thoraxjnl-2017-211073","volume":"73","author":"ZA Puthucheary","year":"2018","unstructured":"Puthucheary ZA, Astin R, McPhail MJW, Saeed S, Pasha Y, Bear DE, Constantin D, Velloso C, Manning S, Calvert L, Singer M, Batterham RL, Gomez-Romero M, Holmes E, Steiner MC, Atherton PJ, Greenhaff P, Edwards LM, Smith K, Harridge SD, Hart N, Montgomery HE (2018) Metabolic phenotype of skeletal muscle in early critical illness. Thorax 73:926\u2013935","journal-title":"Thorax"},{"key":"8186_CR5","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1186\/s13054-023-04664-7","volume":"27","author":"TSO Jameson","year":"2023","unstructured":"Jameson TSO, Caldow MK, Stephens F, Denehy L, Lynch GS, Koopman R, Krajcova A, Urban T, Berney S, Duska F, Puthucheary Z (2023) Inflammation and altered metabolism impede efficacy of functional electrical stimulation in critically ill patients. Crit Care 27:428","journal-title":"Crit Care"},{"key":"8186_CR6","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s13054-022-04253-0","volume":"27","author":"B Fazzini","year":"2023","unstructured":"Fazzini B, M\u00e4rkl T, Costas C, Blobner M, Schaller SJ, Prowle J, Puthucheary Z, Wackerhage H (2023) The rate and assessment of muscle wasting during critical illness: a systematic review and meta-analysis. Crit Care 27:2","journal-title":"Crit Care"},{"key":"8186_CR7","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1007\/s00134-020-05927-5","volume":"46","author":"N Van Aerde","year":"2020","unstructured":"Van Aerde N, Meersseman P, Debaveye Y, Wilmer A, Gunst J, Casaer MP, Bruyninckx F, Wouters PJ, Gosselink R, Van den Berghe G, Hermans G (2020) Five-year impact of ICU-acquired neuromuscular complications: a prospective, observational study. Intensive Care Med 46:1184\u20131193","journal-title":"Intensive Care Med"},{"key":"8186_CR8","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1007\/s00134-017-4757-5","volume":"43","author":"N Latronico","year":"2017","unstructured":"Latronico N, Herridge M, Hopkins RO, Angus D, Hart N, Hermans G, Iwashyna T, Arabi Y, Citerio G, Ely EW, Hall J, Mehta S, Puntillo K, Van den Hoeven J, Wunsch H, Cook D, Dos Santos C, Rubenfeld G, Vincent JL, Van den Berghe G, Azoulay E, Needham DM (2017) The ICM research agenda on intensive care unit-acquired weakness. Intensive Care Med 43:1270\u20131281","journal-title":"Intensive Care Med"},{"key":"8186_CR9","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s40560-024-00744-0","volume":"12","author":"R Fuentes-Aspe","year":"2024","unstructured":"Fuentes-Aspe R, Gutierrez-Arias R, Gonz\u00e1lez-Seguel F, Marzuca-Nassr GN, Torres-Castro R, Najum-Flores J, Seron P (2024) Which factors are associated with acquired weakness in the ICU? An overview of systematic reviews and meta-analyses. J Intensive Care 12:33","journal-title":"J Intensive Care"},{"key":"8186_CR10","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/S0140-6736(24)01304-7","volume":"404","author":"JLM Bels","year":"2024","unstructured":"Bels JLM, Thiessen S, van Gassel RJJ, Beishuizen A, De Bie DA, Fraipont V, Lamote S, Ledoux D, Scheeren C, De Waele E, van Zanten ARH, Bormans-Russell L, van Bussel BCT, Dictus MMJ, Fivez T, Harks I, van der Horst ICC, Jonckheer J, Marechal H, Massion PB, Meex I, Paulus MC, Rinket M, van Santen S, Tartaglia K, Deane AM, Demuydt F, Puthucheary Z, Vloet LCM, Weijs PJM, van Kuijk SMJ, van de Poll MCG, Mesotten D (2024) Effect of high versus standard protein provision on functional recovery in people with critical illness (PRECISe): an investigator-initiated, double-blinded, multicentre, parallel-group, randomised controlled trial in Belgium and the Netherlands. Lancet 404:659\u2013669","journal-title":"Lancet"},{"key":"8186_CR11","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/S0140-6736(22)02469-2","volume":"401","author":"DK Heyland","year":"2023","unstructured":"Heyland DK, Patel J, Compher C, Rice TW, Bear DE, Lee ZY, Gonz\u00e1lez VC, O\u2019Reilly K, Regala R, Wedemire C, Ibarra-Estrada M, Stoppe C, Ortiz-Reyes L, Jiang X, Day AG (2023) The effect of higher protein dosing in critically ill patients with high nutritional risk (EFFORT Protein): an international, multicentre, pragmatic, registry-based randomised trial. Lancet 401:568\u2013576","journal-title":"Lancet"},{"key":"8186_CR12","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1056\/NEJMoa2209083","volume":"387","author":"CL Hodgson","year":"2022","unstructured":"Hodgson CL, Bailey M, Bellomo R, Brickell K, Broadley T, Buhr H, Gabbe BJ, Gould DW, Harrold M, Higgins AM, Hurford S, Iwashyna TJ, Serpa Neto A, Nichol AD, Presneill JJ, Schaller SJ, Sivasuthan J, Tipping CJ, Webb S, Young PJ (2022) Early active mobilization during mechanical ventilation in the ICU. N Engl J Med 387:1747\u20131758","journal-title":"N Engl J Med"},{"key":"8186_CR13","doi-asserted-by":"publisher","first-page":"EVIDoa2400137","DOI":"10.1056\/EVIDoa2400137","volume":"3","author":"ME Kho","year":"2024","unstructured":"Kho ME, Berney S, Pastva AM, Kelly L, Reid JC, Burns KEA, Seely AJ, D\u2019Aragon F, Rochwerg B, Ball I, Fox-Robichaud AE, Karachi T, Lamontagne F, Archambault PM, Tsang JL, Duan EH, Muscedere J, Verceles AC, Serri K, English SW, Reeve BK, Mehta S, Rudkowski JC, Heels-Ansdell D, O\u2019Grady HK, Strong G, Obrovac K, Ajami D, Camposilvan L, Tarride J-E, Thabane L, Herridge MS, Cook DJ (2024) Early in-bed cycle ergometry in mechanically ventilated patients. NEJM Evid 3:EVIDoa2400137","journal-title":"NEJM Evid"},{"key":"8186_CR14","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1164\/rccm.202209-1763OC","volume":"208","author":"WD Schweickert","year":"2023","unstructured":"Schweickert WD, Jablonski J, Bayes B, Chowdhury M, Whitman C, Tian J, Blette B, Tran T, Halpern SD (2023) Structured mobilization for critically Ill patients: a pragmatic cluster-randomized trial. Am J Respir Crit Care Med 208:49\u201358","journal-title":"Am J Respir Crit Care Med"},{"key":"8186_CR15","doi-asserted-by":"crossref","unstructured":"Summers MJ, Chapple LS, Karahalios A, Bellomo R, Chapman MJ, Ferrie S, Finnis ME, French C, Hurford S, Kakho N, Maiden MJ, O'Connor SN, Peake SL, Presneill JJ, Ridley EJ, Tran-Duy A, Williams PJ, Young PJ, Zaloumis S, Deane AM, (2025). Augmented enteral protein during critical illness: the TARGET protein randomized clinical trial. Jama","DOI":"10.1001\/jama.2025.9110"},{"key":"8186_CR16","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1164\/rccm.202112-2780OC","volume":"206","author":"LS Chapple","year":"2022","unstructured":"Chapple LS, Kouw IWK, Summers MJ, Weinel LM, Gluck S, Raith E, Slobodian P, Soenen S, Deane AM, van Loon LJC, Chapman MJ (2022) Muscle protein synthesis after protein administration in critical illness. Am J Respir Crit Care Med 206:740\u2013749","journal-title":"Am J Respir Crit Care Med"},{"key":"8186_CR17","doi-asserted-by":"publisher","first-page":"8345","DOI":"10.1038\/s41467-023-42659-8","volume":"14","author":"A McNelly","year":"2023","unstructured":"McNelly A, Langan A, Bear DE, Page A, Martin T, Seidu F, Santos F, Rooney K, Liang K, Heales SJ, Baldwin T, Alldritt I, Crossland H, Atherton PJ, Wilkinson D, Montgomery H, Prowle J, Pearse R, Eaton S, Puthucheary ZA (2023) A pilot study of alternative substrates in the critically Ill subject using a ketogenic feed. Nat Commun 14:8345","journal-title":"Nat Commun"},{"key":"8186_CR18","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1007\/s00134-025-07949-3","volume":"51","author":"C Uzun Ayar","year":"2025","unstructured":"Uzun Ayar C, G\u00fciza F, Derese I, Pauwels L, Vander Perre S, Pintelon I, Casaer M, Van Aerde N, Hermans G, Derde S, Kreiss L, Van den Berghe G, Vanhorebeek I (2025) Altered muscle transcriptome as molecular basis of long-term muscle weakness in survivors from critical illness. Intensive Care Med 51:1062\u20131077","journal-title":"Intensive Care Med"},{"key":"8186_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.aucc.2025.101235","volume":"38","author":"CL Hodgson","year":"2025","unstructured":"Hodgson CL, Broadley T, Paton M, Higgins AM, Anderson S, Brennan S, Granger CL, Hammond NE, Magana Cruz S, Lang JK, Leditschke IA, Orford NR, Parry SM, Price B, Taylor P, Udy AA, Green SE (2025) Australian clinical practice guideline for physical rehabilitation and mobilisation in adult intensive care units. Aust Crit Care 38:101235","journal-title":"Aust Crit Care"},{"key":"8186_CR20","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/S2213-2600(24)00011-0","volume":"12","author":"M Paton","year":"2024","unstructured":"Paton M, Chan S, Serpa Neto A, Tipping CJ, Stratton A, Lane R, Romero L, Broadley T, Hodgson CL (2024) Association of active mobilisation variables with adverse events and mortality in patients requiring mechanical ventilation in the intensive care unit: a systematic review and meta-analysis. Lancet Respir Med 12:386\u2013398","journal-title":"Lancet Respir Med"},{"key":"8186_CR21","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1002\/rco2.83","volume":"6","author":"S Patel","year":"2023","unstructured":"Patel S, Francis T, Rajaram R, Handslip R, Mumby S, Bear DE, Padhke R, Hart N, Montgomery H, Takata M, Harridge SDR, Patel BV, Puthucheary Z (2023) Programmed myofibre necrosis in critical illness acquired muscle wasting. JCSM Rapid Commun 6:111\u2013121","journal-title":"JCSM Rapid Commun"},{"key":"8186_CR22","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1186\/s13054-025-05396-6","volume":"29","author":"MC Paulus","year":"2025","unstructured":"Paulus MC, Melchers M, van Es A, Kouw IWK, van Zanten ARH (2025) The urea-to-creatinine ratio as an emerging biomarker in critical care: a scoping review and meta-analysis. Crit Care 29:175","journal-title":"Crit Care"},{"key":"8186_CR23","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s13054-024-05222-5","volume":"29","author":"N Yamamoto","year":"2025","unstructured":"Yamamoto N, Tojo K, Mihara T, Maeda R, Sugiura Y, Goto T (2025) Creatinine production rate is an integrative indicator to monitor muscle status in critically ill patients. Crit Care 29:23","journal-title":"Crit Care"},{"key":"8186_CR24","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1097\/CCM.0000000000004486","volume":"48","author":"N Nakanishi","year":"2020","unstructured":"Nakanishi N, Tsutsumi R, Hara K, Takashima T, Nakataki E, Itagaki T, Matsuo M, Oto J, Sakaue H (2020) Urinary titin is a novel biomarker for muscle atrophy in nonsurgical critically Ill patients: a two-center, prospective observational study. Crit Care Med 48:1327\u20131333","journal-title":"Crit Care Med"},{"key":"8186_CR25","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1164\/rccm.201512-2344OC","volume":"194","author":"C Dos Santos","year":"2016","unstructured":"Dos Santos C, Hussain SN, Mathur S, Picard M, Herridge M, Correa J, Bain A, Guo Y, Advani A, Advani SL, Tomlinson G, Katzberg H, Streutker CJ, Cameron JI, Schols A, Gosker HR, Batt J (2016) Mechanisms of chronic muscle wasting and dysfunction after an intensive care unit stay. a pilot study. Am J Respir Crit Care Med 194:821\u2013830","journal-title":"Am J Respir Crit Care Med"},{"key":"8186_CR26","doi-asserted-by":"publisher","first-page":"101066","DOI":"10.1016\/j.aucc.2024.05.003","volume":"38","author":"Y Zhou","year":"2024","unstructured":"Zhou Y, Sun Y, Pan Y, Dai Y, Xiao Y, Yu Y (2024) Risk prediction models for intensive care unit-acquired weakness in critically ill patients: a systematic review. Aust Crit Care 38:101066","journal-title":"Aust Crit Care"},{"key":"8186_CR27","doi-asserted-by":"publisher","first-page":"127","DOI":"10.12688\/f1000research.3933.1","volume":"3","author":"N Latronico","year":"2014","unstructured":"Latronico N, Nattino G, Guarneri B, Fagoni N, Amantini A, Bertolini G, Gi VSI (2014) Validation of the peroneal nerve test to diagnose critical illness polyneuropathy and myopathy in the intensive care unit: the multicentre Italian CRIMYNE-2 diagnostic accuracy study. F1000Res 3:127","journal-title":"F1000Res"},{"key":"8186_CR28","doi-asserted-by":"publisher","first-page":"2298","DOI":"10.1002\/jcsm.13041","volume":"13","author":"P Casey","year":"2022","unstructured":"Casey P, Alasmar M, McLaughlin J, Ang Y, McPhee J, Heire P, Sultan J (2022) The current use of ultrasound to measure skeletal muscle and its ability to predict clinical outcomes: a systematic review. J Cachexia Sarcopenia Muscle 13:2298\u20132309","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"8186_CR29","doi-asserted-by":"publisher","DOI":"10.1111\/nicc.70018","volume":"30","author":"Y Wu","year":"2025","unstructured":"Wu Y, Liu Y, Wang G, Zheng A, Zhang Z, Wei H, Wang X (2025) An optimal cut-off point for the chelsea critical care physical assessment tool to diagnose intensive care unit-acquired weakness in patients with mechanical ventilation: a multicentre observational study. Nurs Crit Care 30:e70018","journal-title":"Nurs Crit Care"},{"key":"8186_CR30","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1164\/rccm.200712-1829OC","volume":"178","author":"NA Ali","year":"2008","unstructured":"Ali NA, O\u2019Brien JM Jr, Hoffmann SP, Phillips G, Garland A, Finley JC, Almoosa K, Hejal R, Wolf KM, Lemeshow S, Connors AF Jr, Marsh CB, Midwest Critical Care C (2008) Acquired weakness, handgrip strength, and mortality in critically ill patients. Am J Respir Crit Care Med 178:261\u2013268","journal-title":"Am J Respir Crit Care Med"},{"key":"8186_CR31","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1136\/thoraxjnl-2020-216720","volume":"76","author":"N Van Aerde","year":"2021","unstructured":"Van Aerde N, Meersseman P, Debaveye Y, Wilmer A, Gunst J, Casaer MP, Wauters J, Wouters PJ, Gosselink R, Van den Berghe G, Hermans G (2021) Five-year outcome of respiratory muscle weakness at intensive care unit discharge: secondary analysis of a prospective cohort study. Thorax 76:561\u2013567","journal-title":"Thorax"},{"key":"8186_CR32","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1007\/s00134-024-07472-x","volume":"50","author":"EC Goligher","year":"2024","unstructured":"Goligher EC, Damiani LF, Patel B (2024) Implementing diaphragm protection during invasive mechanical ventilation. Intensive Care Med 50:1509\u20131512","journal-title":"Intensive Care Med"},{"key":"8186_CR33","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1186\/s40001-024-02024-x","volume":"29","author":"W Yu","year":"2024","unstructured":"Yu W, Dan L, Cai J, Wang Y, Wang Q, Zhang Y, Wang X (2024) Incidence of post-extubation dysphagia among critical care patients undergoing orotracheal intubation: a systematic review and meta-analysis. Eur J Med Res 29:444","journal-title":"Eur J Med Res"},{"key":"8186_CR34","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.clnesp.2025.01.044","volume":"66","author":"A Garc\u00eda-Grimaldo","year":"2025","unstructured":"Garc\u00eda-Grimaldo A, Rodr\u00edguez-Moguel NC, God\u00ednez-Victoria M, Rodr\u00edguez-Llamazares S, R\u00edos-Ayala MA, Cadeza-Aguilar JD, Osuna-Padilla IA (2025) Associations between Intensive care unit acquired weakness with post-extubation dysphagia and other clinical outcomes-a cohort study in critically ill respiratory patients. Clin Nutr ESPEN 66:194\u2013201","journal-title":"Clin Nutr ESPEN"},{"key":"8186_CR35","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1186\/s12871-021-01492-6","volume":"21","author":"JRA de Azevedo","year":"2021","unstructured":"de Azevedo JRA, Lima HCM, Frota PHDB, Nogueira IROM, de Souza SC, Fernandes EAA, Cruz AM (2021) High-protein intake and early exercise in adult intensive care patients: a prospective, randomized controlled trial to evaluate the impact on functional outcomes. BMC Anesthesiol 21:283","journal-title":"BMC Anesthesiol"},{"key":"8186_CR36","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/j.clnu.2020.07.036","volume":"40","author":"K Nakamura","year":"2021","unstructured":"Nakamura K, Nakano H, Naraba H, Mochizuki M, Takahashi Y, Sonoo T, Hashimoto H, Morimura N (2021) High protein versus medium protein delivery under equal total energy delivery in critical care: a randomized controlled trial. Clin Nutr 40:796\u2013803","journal-title":"Clin Nutr"},{"key":"8186_CR37","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s13054-024-05189-3","volume":"29","author":"EJ Ridley","year":"2025","unstructured":"Ridley EJ, Bailey M, Chapman MJ, Chapple LS, Deane AM, Gojanovic M, Higgins AM, Hodgson CL, King VL, Marshall AP, Miller EG, McGuinness SP, Parke RL, Paul E, Udy AA (2025) The impact of a tailored nutrition intervention delivered for the duration of hospitalisation on daily energy delivery for patients with critical illness (INTENT): a phase II randomised controlled trial. Crit Care 29:8","journal-title":"Crit Care"},{"key":"8186_CR38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0268599","volume":"17","author":"W Zhou","year":"2022","unstructured":"Zhou W, Yu L, Fan Y, Shi B, Wang X, Chen T, Yu H, Liu J, Wang X, Liu C, Zheng H (2022) Effect of early mobilization combined with early nutrition on acquired weakness in critically ill patients (EMAS): a dual-center, randomized controlled trial. PLoS ONE 17:e0268599","journal-title":"PLoS ONE"},{"key":"8186_CR39","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1186\/s13054-022-04113-x","volume":"26","author":"TW Davies","year":"2022","unstructured":"Davies TW, van Gassel RJJ, van de Poll M, Gunst J, Casaer MP, Christopher KB, Preiser JC, Hill A, Gundogan K, Reintam-Blaser A, Rousseau AF, Hodgson C, Needham DM, Castro M, Schaller S, McClelland T, Pilkington JJ, Sevin CM, Wischmeyer PE, Lee ZY, Govil D, Li A, Chapple L, Denehy L, Montejo-Gonz\u00e1lez JC, Taylor B, Bear DE, Pearse R, McNelly A, Prowle J, Puthucheary ZA (2022) Core outcome measures for clinical effectiveness trials of nutritional and metabolic interventions in critical illness: an international modified Delphi consensus study evaluation (CONCISE). Crit Care 26:240","journal-title":"Crit Care"},{"key":"8186_CR40","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1513\/AnnalsATS.202406-581OC","volume":"21","author":"BA Connolly","year":"2024","unstructured":"Connolly BA, Barclay M, Davies C, Hart N, Pattison N, Sturmey G, Williamson PR, Needham DM, Denehy L, Blackwood B (2024) PRACTICE: development of a core outcome set for trials of physical rehabilitation in critical Illness. Ann Am Thorac Soc 21:1742\u20131750","journal-title":"Ann Am Thorac Soc"},{"key":"8186_CR41","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1016\/j.clnu.2023.07.011","volume":"42","author":"P Singer","year":"2023","unstructured":"Singer P, Blaser AR, Berger MM, Calder PC, Casaer M, Hiesmayr M, Mayer K, Montejo-Gonzalez JC, Pichard C, Preiser JC, Szczeklik W, van Zanten ARH, Bischoff SC (2023) ESPEN practical and partially revised guideline: clinical nutrition in the intensive care unit. Clin Nutr 42:1671\u20131689","journal-title":"Clin Nutr"},{"key":"8186_CR42","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1177\/0148607115618449","volume":"40","author":"S Ferrie","year":"2016","unstructured":"Ferrie S, Allman-Farinelli M, Daley M, Smith K (2016) Protein requirements in the critically Ill: a randomized controlled trial using parenteral nutrition. JPEN J Parenter Enteral Nutr 40:795\u2013805","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"8186_CR43","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1002\/jpen.1166","volume":"42","author":"K Fetterplace","year":"2018","unstructured":"Fetterplace K, Deane AM, Tierney A, Beach LJ, Knight LD, Presneill J, Rechnitzer T, Forsyth A, Gill BMT, Mourtzakis M, MacIsaac C (2018) Targeted full energy and protein delivery in critically Ill patients: a pilot randomized controlled trial (FEED Trial). JPEN J Parenter Enteral Nutr 42:1252\u20131262","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"8186_CR44","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/S2213-2600(13)70183-8","volume":"1","author":"G Hermans","year":"2013","unstructured":"Hermans G, Casaer MP, Clerckx B, G\u00fciza F, Vanhullebusch T, Derde S, Meersseman P, Derese I, Mesotten D, Wouters PJ, Van Cromphaut S, Debaveye Y, Gosselink R, Gunst J, Wilmer A, Van den Berghe G, Vanhorebeek I (2013) Effect of tolerating macronutrient deficit on the development of intensive-care unit acquired weakness: a subanalysis of the EPaNIC trial. Lancet Respir Med 1:621\u2013629","journal-title":"Lancet Respir Med"},{"key":"8186_CR45","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.clnu.2018.02.012","volume":"38","author":"W Koekkoek","year":"2019","unstructured":"Koekkoek W, van Setten CHC, Olthof LE, Kars J, van Zanten ARH (2019) Timing of PROTein INtake and clinical outcomes of adult critically ill patients on prolonged mechanical VENTilation: the PROTINVENT retrospective study. Clin Nutr 38:883\u2013890","journal-title":"Clin Nutr"},{"key":"8186_CR46","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1093\/ajcn\/nqy373","volume":"109","author":"DE Bear","year":"2019","unstructured":"Bear DE, Langan A, Dimidi E, Wandrag L, Harridge SDR, Hart N, Connolly B, Whelan K (2019) \u03b2-Hydroxy-\u03b2-methylbutyrate and its impact on skeletal muscle mass and physical function in clinical practice: a systematic review and meta-analysis. Am J Clin Nutr 109:1119\u20131132","journal-title":"Am J Clin Nutr"},{"key":"8186_CR47","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/S2213-2600(22)00489-1","volume":"11","author":"BK Patel","year":"2023","unstructured":"Patel BK, Wolfe KS, Patel SB, Dugan KC, Esbrook CL, Pawlik AJ, Stulberg M, Kemple C, Teele M, Zeleny E, Hedeker D, Pohlman AS, Arora VM, Hall JB, Kress JP (2023) Effect of early mobilisation on long-term cognitive impairment in critical illness in the USA: a randomised controlled trial. Lancet Respir Med 11:563\u2013572","journal-title":"Lancet Respir Med"},{"key":"8186_CR48","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1164\/rccm.202312-2289OC","volume":"210","author":"A Serpa Neto","year":"2024","unstructured":"Serpa Neto A, Bailey M, Seller D, Agli A, Bellomo R, Brickell K, Broadley T, Buhr H, Gabbe BJ, Gould DW, Harrold M, Higgins AM, Hurford S, Iwashyna TJ, Nichol AD, Presneill JJ, Schaller SJ, Sivasuthan J, Tipping CJ, Poole A, Parke R, Bradley S, Webb S, Zoungas S, Young PJ, Hodgson CL (2024) Impact of high dose early mobilization on outcomes for patients with diabetes: a secondary analysis of the TEAM trial. Am J Respir Crit Care Med 210:779\u2013787","journal-title":"Am J Respir Crit Care Med"},{"key":"8186_CR49","doi-asserted-by":"publisher","first-page":"e299","DOI":"10.1097\/CCM.0000000000006259","volume":"52","author":"K Jiroutkov\u00e1","year":"2024","unstructured":"Jiroutkov\u00e1 K, Du\u0161ka F, Waldauf P (2024) Should new data on rehabilitation interventions in critically Ill patients change clinical practice? updated meta-analysis of randomized controlled trials. Crit Care Med 52:e299\u2013e303","journal-title":"Crit Care Med"},{"key":"8186_CR50","doi-asserted-by":"publisher","first-page":"e711","DOI":"10.1097\/CCM.0000000000006574","volume":"53","author":"K Lewis","year":"2025","unstructured":"Lewis K, Balas MC, Stollings JL, McNett M, Girard TD, Chanques G, Kho ME, Pandharipande PP, Weinhouse GL, Brummel NE, Chlan LL, Cordoza M, Duby JJ, G\u00e9linas C, Hall-Melnychuk EL, Krupp A, Louzon PR, Tate JA, Young B, Jennings R, Hines A, Ross C, Carayannopoulos KL, Aldrich JM (2025) A focused update to the clinical practice guidelines for the prevention and management of pain, anxiety, agitation\/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU. Crit Care Med 53:e711\u2013e727","journal-title":"Crit Care Med"},{"key":"8186_CR51","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1007\/s00134-024-07532-2","volume":"50","author":"SJ Schaller","year":"2024","unstructured":"Schaller SJ, Scheffenbichler FT, Bein T, Blobner M, Grunow JJ, Hamsen U, Hermes C, Kaltwasser A, Lewald H, Nydahl P, Rei\u00dfhauer A, Renzewitz L, Siemon K, Staudinger T, Ullrich R, Weber-Carstens S, Wrigge H, Zergiebel D, Coldewey SM (2024) Guideline on positioning and early mobilisation in the critically ill by an expert panel. Intensive Care Med 50:1211\u20131227","journal-title":"Intensive Care Med"},{"key":"8186_CR52","doi-asserted-by":"publisher","first-page":"e0262779","DOI":"10.1371\/journal.pone.0262779","volume":"17","author":"S Eggmann","year":"2022","unstructured":"Eggmann S, Irincheeva I, Luder G, Verra ML, Moser A, Bastiaenen CHG, Jakob SM (2022) Cardiorespiratory response to early rehabilitation in critically ill adults: a secondary analysis of a randomised controlled trial. PLoS ONE 17:e0262779","journal-title":"PLoS ONE"},{"key":"8186_CR53","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1016\/S0140-6736(09)60658-9","volume":"373","author":"WD Schweickert","year":"2009","unstructured":"Schweickert WD, Pohlman MC, Pohlman AS, Nigos C, Pawlik AJ, Esbrook CL, Spears L, Miller M, Franczyk M, Deprizio D, Schmidt GA, Bowman A, Barr R, McCallister KE, Hall JB, Kress JP (2009) Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet 373:1874\u20131882","journal-title":"Lancet"},{"key":"8186_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13054-022-04291-8","volume":"27","author":"KE Fuest","year":"2023","unstructured":"Fuest KE, Ulm B, Daum N, Lindholz M, Lorenz M, Blobner K, Langer N, Hodgson C, Herridge M, Blobner M, Schaller SJ (2023) Clustering of critically ill patients using an individualized learning approach enables dose optimization of mobilization in the ICU. Crit Care 27:1","journal-title":"Crit Care"},{"key":"8186_CR55","doi-asserted-by":"publisher","first-page":"EVIDoa2400194","DOI":"10.1056\/EVIDoa2400194","volume":"3","author":"HK O\u2019Grady","year":"2024","unstructured":"O\u2019Grady HK, Hasan H, Rochwerg B, Cook DJ, Takaoka A, Utgikar R, Reid JC, Kho ME (2024) Leg cycle ergometry in critically Ill patients \u2014 an updated systematic review and meta-analysis. NEJM Evid 3:EVIDoa2400194","journal-title":"NEJM Evid"},{"key":"8186_CR56","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1097\/CCM.0000000000005941","volume":"51","author":"N Nakanishi","year":"2023","unstructured":"Nakanishi N, Yoshihiro S, Kawamura Y, Aikawa G, Shida H, Shimizu M, Fujinami Y, Matsuoka A, Watanabe S, Taito S, Inoue S (2023) Effect of neuromuscular electrical stimulation in patients with critical illness: an updated systematic review and meta-analysis of randomized controlled trials. Crit Care Med 51:1386\u20131396","journal-title":"Crit Care Med"},{"key":"8186_CR57","first-page":"772","volume":"59","author":"A Panelli","year":"2023","unstructured":"Panelli A, Grunow JJ, Verfu MA, Bartels HG, Brass Z, Schaller SJ (2023) Outcomes in critically ill patients after diaphragmatic stimulation on ventilator-induced diaphragmatic dysfunction: a systematic review. Eur J Phys Rehabil Med 59:772\u2013781","journal-title":"Eur J Phys Rehabil Med"},{"key":"8186_CR58","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202505-1056OC","author":"M Dres","year":"2025","unstructured":"Dres M, Ewert R, Conrad SA, Ataya A, Shrager J, Mortaza S, Delamaire F, Nilius G, Heine A, Mehta N, Ways J, Evans D, Paulon G, Khandwala F, Berry N, Viele K, Nelson T, Gilbertson M, Similowski T, Gama de Abreu M, Goligher EC (2025) Temporary transvenous diaphragm neurostimulation for weaning from mechanical ventilation (RESCUE-3). Am J Respir Crit Care Med. https:\/\/doi.org\/10.1164\/rccm.202505-1056OC","journal-title":"Am J Respir Crit Care Med"},{"key":"8186_CR59","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1513\/AnnalsATS.201712-961OC","volume":"15","author":"S Vorona","year":"2018","unstructured":"Vorona S, Sabatini U, Al-Maqbali S, Bertoni M, Dres M, Bissett B, Van Haren F, Martin AD, Urrea C, Brace D, Parotto M, Herridge MS, Adhikari NKJ, Fan E, Melo LT, Reid WD, Brochard LJ, Ferguson ND, Goligher EC (2018) Inspiratory muscle rehabilitation in critically Ill adults. a systematic review and meta-analysis. Ann Am Thorac Soc 15:735\u2013744","journal-title":"Ann Am Thorac Soc"},{"key":"8186_CR60","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s40560-024-00741-3","volume":"12","author":"T R\u00e9ginault","year":"2024","unstructured":"R\u00e9ginault T, Martinez Alejos R, Coueron R, Burle J-f, Boyer A, Frison E, Vargas F (2024) Impacts of three inspiratory muscle training programs on inspiratory muscles strength and endurance among intubated and mechanically ventilated patients with difficult weaning: a multicentre randomised controlled trial. J Intensive Care 12:28","journal-title":"J Intensive Care"},{"key":"8186_CR61","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1164\/rccm.202405-1042OC","volume":"211","author":"M Van Hollebeke","year":"2025","unstructured":"Van Hollebeke M, Poddighe D, Hoffman M, Clerckx B, Muller J, Louvaris Z, Hermans G, Gosselink R, Langer D (2025) Similar weaning success rate with high-intensity and sham inspiratory muscle training: a randomized controlled trial (IMweanT). Am J Respir Crit Care Med 211:381\u2013390","journal-title":"Am J Respir Crit Care Med"},{"key":"8186_CR62","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1016\/j.apmr.2021.10.020","volume":"103","author":"W Zhang","year":"2022","unstructured":"Zhang W, Pan H, Zong Y, Wang J, Xie Q (2022) Respiratory muscle training reduces respiratory complications and improves swallowing function after stroke: a systematic review and meta-analysis. Arch Phys Med Rehabil 103:1179\u20131191","journal-title":"Arch Phys Med Rehabil"},{"key":"8186_CR63","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1007\/s00455-024-10700-7","volume":"39","author":"A Kuriyama","year":"2024","unstructured":"Kuriyama A, Watanabe S, Katayama Y, Yasaka T, Ouchi A, Iida Y, Kasai F (2024) Dysphagia rehabilitation in dysphagic patients with acute or critical illness: a systematic review and meta-analysis. Dysphagia 39:1171\u20131182","journal-title":"Dysphagia"},{"key":"8186_CR64","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1097\/CCM.0000000000001652","volume":"44","author":"SJ Shepherd","year":"2016","unstructured":"Shepherd SJ, Newman R, Brett SJ, Griffith DM (2016) Pharmacological therapy for the prevention and treatment of weakness after critical illness: a systematic review. Crit Care Med 44:1198\u20131205","journal-title":"Crit Care Med"},{"key":"8186_CR65","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1186\/s13054-019-2540-4","volume":"23","author":"JJ Grunow","year":"2019","unstructured":"Grunow JJ, Goll M, Carbon NM, Liebl ME, Weber-Carstens S, Wollersheim T (2019) Differential contractile response of critically ill patients to neuromuscular electrical stimulation. Crit Care 23:308","journal-title":"Crit Care"},{"key":"8186_CR66","volume":"2","author":"J McPeake","year":"2020","unstructured":"McPeake J, Boehm LM, Hibbert E, Bakhru RN, Bastin AJ, Butcher BW, Eaton TL, Harris W, Hope AA, Jackson J, Johnson A, Kloos JA, Korzick KA, MacTavish P, Meyer J, Montgomery-Yates A, Quasim T, Slack A, Wade D, Still M, Netzer G, Hopkins RO, Mikkelsen ME, Iwashyna TJ, Haines KJ, Sevin CM (2020) Key components of ICU recovery programs: what did patients report provided benefit? Crit Care Explor 2:e0088","journal-title":"Crit Care Explor"},{"key":"8186_CR67","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1007\/s00134-024-07359-x","volume":"50","author":"T Sharshar","year":"2024","unstructured":"Sharshar T, Grimaldi-Bensouda L, Siami S, Cariou A, Salah AB, Kalfon P, Sonneville R, Meunier-Beillard N, Quenot JP, Megarbane B, Gaudry S, Oueslati H, Robin-Lagandre S, Schwebel C, Mazeraud A, Annane D, Nkam L, Friedman D (2024) A randomized clinical trial to evaluate the effect of post-intensive care multidisciplinary consultations on mortality and the quality of life at 1 year. Intensive Care Med 50:665\u2013677","journal-title":"Intensive Care Med"},{"key":"8186_CR68","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1177\/02692155241241665","volume":"38","author":"BBR Cazeta","year":"2024","unstructured":"Cazeta BBR, de Queiroz RS, Nacimento TS, Ferreira BR, Saquetto MB, Martinez BP, Carvalho VO, Gomes-Neto M (2024) Effects of exercise interventions on functioning and health-related quality of life following hospital discharge for recovery from critical illness: a systematic review and meta-analysis of randomized trials. Clin Rehabil 38:898\u2013909","journal-title":"Clin Rehabil"},{"key":"8186_CR69","doi-asserted-by":"publisher","DOI":"10.1016\/j.aucc.2024.101134","volume":"38","author":"N Leggett","year":"2024","unstructured":"Leggett N, Abdelhamid YA, Deane AM, Emery K, Hutcheon E, Rollinson TC, Preston A, Witherspoon S, Zhang C, Merolli M, Haines KJ (2024) Digital health interventions to improve recovery for intensive care unit survivors: a systematic review. Aust Crit Care 38:101134","journal-title":"Aust Crit Care"},{"key":"8186_CR70","volume":"2","author":"M McNett","year":"2020","unstructured":"McNett M, O\u2019Math\u00fana D, Tucker S, Roberts H, Mion LC, Balas MC (2020) A scoping review of implementation science in adult critical care settings. Crit Care Explor 2:e0301","journal-title":"Crit Care Explor"},{"key":"8186_CR71","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j5748","volume":"360","author":"E Colantuoni","year":"2018","unstructured":"Colantuoni E, Scharfstein DO, Wang C, Hashem MD, Leroux A, Needham DM, Girard TD (2018) Statistical methods to compare functional outcomes in randomized controlled trials with high mortality. BMJ (Clinical research ed) 360:j5748","journal-title":"BMJ (Clinical research ed)"},{"key":"8186_CR72","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1513\/AnnalsATS.202307-599OC","volume":"21","author":"AA da Silva","year":"2024","unstructured":"da Silva AA, Granger CL, Abo S, Sheehan J, Barson E, Beach L, Pound G, Ali Abdelhamid Y, Fetterplace K, Fini NA, Merolli M, Sloan E, Parry SM (2024) \u201cHow do i test the waters? how do i go forward?\u201d: co-designing a supportive pathway after critical illness. Ann Am Thorac Soc 21:916\u2013927","journal-title":"Ann Am Thorac Soc"},{"key":"8186_CR73","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s13613-023-01132-x","volume":"13","author":"RR Bruno","year":"2023","unstructured":"Bruno RR, Wernly B, Bagshaw SM, van den Boogaard M, Darvall JN, De Geer L, de Gopegui Miguelena PR, Heyland DK, Hewitt D, Hope AA, Langlais E, Le Maguet P, Montgomery CL, Papageorgiou D, Seguin P, Geense WW, Silva-Obreg\u00f3n JA, Wolff G, Polzin A, Dannenberg L, Kelm M, Flaatten H, Beil M, Franz M, Sviri S, Leaver S, Guidet B, Boumendil A, Jung C (2023) The clinical frailty scale for mortality prediction of old acutely admitted intensive care patients: a meta-analysis of individual patient-level data. Ann Intensive Care 13:37","journal-title":"Ann Intensive Care"},{"key":"8186_CR74","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1111\/anae.15441","volume":"76","author":"S Bench","year":"2021","unstructured":"Bench S, Stayt L, Shah A, Dhiman P, Czuber-Dochan W (2021) Prevalence and experience of fatigue in survivors of critical illness: a mixed-methods systematic review. Anaesthesia 76:1233\u20131244","journal-title":"Anaesthesia"},{"key":"8186_CR75","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.jcrc.2021.08.002","volume":"66","author":"OD Gustafson","year":"2021","unstructured":"Gustafson OD, Williams MA, McKechnie S, Dawes H, Rowland MJ (2021) Musculoskeletal complications following critical illness: a scoping review. J Crit Care 66:60\u201366","journal-title":"J Crit Care"}],"container-title":["Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-025-08186-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00134-025-08186-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-025-08186-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T22:01:40Z","timestamp":1764885700000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00134-025-08186-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,3]]},"references-count":75,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["8186"],"URL":"https:\/\/doi.org\/10.1007\/s00134-025-08186-4","relation":{},"ISSN":["0342-4642","1432-1238"],"issn-type":[{"value":"0342-4642","type":"print"},{"value":"1432-1238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,3]]},"assertion":[{"value":"7 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This research was funded by the NHMRC Centre of Research Excellence to Transform the Outcomes of Critically Ill Patients (GNT2006514) led by CLH. This content is solely the responsibility of the authors and does not represent the official views of any grant funders. CLH holds an NHMRC Investigator Grant (GNT2033103). SMP is a recipient of Al and Val Rosenstrauss Fellowship. MEK is a principal investigator of multi-centre randomised trials evaluating early exercise with mechanically ventilated patients, with funding from the Canadian Institutes for Health Research, and an equipment loan from Restorative Therapies (Baltimore, MD). DMN is a principal investigator of a multi-centre randomised trial evaluating the combination of early exercise and protein supplementation in the intensive care unit, with funding from the National Institutes of Health and additional support from Baxter Healthcare Corporation and Reck Medical Devices\/Enable ME LLC. ZP has received honoraria for consultancy from GlaxoSmithKline, Lyric Pharmaceuticals, Faraday Pharmaceuticals and Fresenius-Kabi, educational support from Baxter and Nestle Health Science and speaker fees from Orion, Baxter, Sedana, Fresenius-Kabi and Nestle. CS has received consulting fees, reimbursement of travel expenses and honoraria for lectures, presentations or educational events from Fresenius Kabi, Baxter, Abiomed, Nestle and BBRAUN, all of which are unrelated to this work. MKC is chair of the NIHR\/MRC Better Methods Better Research Funding Committee. IV received competitive research grants by the Research Foundation\u2014Flanders [Fonds Wetenschappelijk Onderzoek (FWO)], Belgium (research grant G017325N) and by the Methusalem program of the Flemish government (through the KU Leuven, METH14\/06). LSC has received speaker fees from Nutricia, Nestle, and Fresenius Kabi unrelated to this work. OR has received honoraria for consultancy from Nutricia, Nestl\u00e9, Baxter and Fresenius_kabi and has an institutional grant from Fresenius-Kabi. BKP has received honoraria for lectures, consulting fees, and grant funding from the CHEST organization, Getinge, and the NIH\/NHLBI. Outside of the submitted work, EJR reports unrestricted grants paid to my institution from Baxter Healthcare (United States), Nutricia Australia and Fresenius Kabi Australia and personal fees for speaking from Nestle Australia, Baxter Healthcare (United States), Baxter Healthcare (Australia), Nutricia Australia, Fresenius Kabi and Nestle Australia. EJR has salary support from a National Health and Medical Research Council HMRC Emerging Leadership Investigator Grant.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}