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Dr. Alain Combes reports grant from Getinge, and personal fees from Getinge, Baxter, and Xenios outside the submitted work. Dr. Florent Huang reports personal fees from AstraZeneca and lecture fees from GSK and Vifor outside the submitted work. Dr. Darryl Abrams writes for UpToDate. Dr. Saad Nseir reports lecture fees from Mundi Pharma, MSD, Pfizer, Medtronic, Fisher and Peykel, Shionogi, and Biom\u00e9rieux. Dr. Simon Sin Wai Ching reports lecture fees from Getinge, Baxter, and Lifemotion. Dr Dirk W Donker provides institutional research consultancy to the University of Twente from Maquet Critical Care AB and HBOX Therapies GmbH, Aachen, Germany. No other disclosures were reported.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"Institutional Review Board approval was obtained from all participating centers, in accordance with their respective regulations. 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