{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T11:03:26Z","timestamp":1793271806585,"version":"4.5.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"Fondazione Policlinico Gemelli IRCCS"},{"name":"Medinat Srl"},{"DOI":"10.13039\/501100005743","name":"Universit\u00e0 Cattolica del Sacro Cuore","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005743","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intensive Care Med"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s00134-026-08459-6","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:30:54Z","timestamp":1780392654000},"page":"1235-1247","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Personalized automatic management of tracheal cuff pressure and subglottic secretions drainage to prevent pneumonia in critically ill intubated patients. The MICROINHALO multicenter randomized controlled trial"],"prefix":"10.1007","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8255-0676","authenticated-orcid":false,"given":"Gennaro","family":"De Pascale","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore Lucio","family":"Cutuli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Cortegiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Dalfino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Greco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Baroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clelia","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico Luca","family":"Grieco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reudor","family":"Grinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianmarco","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Pota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Presti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Stufano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloisa Sofia","family":"Tanzarella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Corcione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Pace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Sanguinetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Bove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Urbani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Girardis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Cecconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Servillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Conti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Antonelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The MICROINHALO study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele Oscar","family":"Franchini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Di Gravio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Livanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Montini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Maria","family":"Dell\u2019Anna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Pintaudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Carelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Sarlo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annachiara","family":"Marra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Iacovazzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Merola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Curci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Fiore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Coppolino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moana Rossella","family":"Nespoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Rispoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Fusilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Mainetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Magistrelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Vanoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariachiara","family":"Ippolito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Lapi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Cannizzaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Giarratano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachele","family":"Iannuzziello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Miccolis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Tucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sestilio","family":"De Letteriis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noa","family":"Shney-Dor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa","family":"Igbaria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Serio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Carsetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abele","family":"Donati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Montrucchio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Brazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"8459_CR1","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1007\/s00134-023-07210-9","volume":"49","author":"I Martin-Loeches","year":"2023","unstructured":"Martin-Loeches I, Reyes LF, Nseir S et al (2023) European Network for ICU-Related Respiratory Infections (ENIRRIs): a multinational, prospective, cohort study of nosocomial LRTI. Intensive Care Med 49:1212\u20131222. https:\/\/doi.org\/10.1007\/s00134-023-07210-9","journal-title":"Intensive Care Med"},{"key":"8459_CR2","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1055\/s-0041-1740246","volume":"43","author":"P-H Wicky","year":"2022","unstructured":"Wicky P-H, Martin-Loeches I, Timsit J-F (2022) HAP and VAP after Guidelines. Semin Respir Crit Care Med 43:248\u2013254. https:\/\/doi.org\/10.1055\/s-0041-1740246","journal-title":"Semin Respir Crit Care Med"},{"key":"8459_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.iccn.2024.103854","volume":"86","author":"AM Bourgault","year":"2025","unstructured":"Bourgault AM, De Pascale G, Lou Sole M (2025) Microaspiration in mechanically ventilated adults. Intensive Crit Care Nurs 86:103854. https:\/\/doi.org\/10.1016\/j.iccn.2024.103854","journal-title":"Intensive Crit Care Nurs"},{"key":"8459_CR4","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1017\/ice.2022.88","volume":"43","author":"M Klompas","year":"2022","unstructured":"Klompas M, Branson R, Cawcutt K et al (2022) Strategies to prevent ventilator-associated pneumonia, ventilator-associated events, and nonventilator hospital-acquired pneumonia in acute-care hospitals: 2022 Update. Infect Control Hosp Epidemiol 43:687\u2013713. https:\/\/doi.org\/10.1017\/ice.2022.88","journal-title":"Infect Control Hosp Epidemiol"},{"key":"8459_CR5","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1186\/s13054-014-0512-2","volume":"18","author":"A Rouz\u00e9","year":"2014","unstructured":"Rouz\u00e9 A, Jaillette E, Nseir S (2014) Continuous control of tracheal cuff pressure: an effective measure to prevent ventilator-associated pneumonia? Crit Care 18:512. https:\/\/doi.org\/10.1186\/s13054-014-0512-2","journal-title":"Crit Care"},{"key":"8459_CR6","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.4187\/respcare.07127","volume":"64","author":"A Coppadoro","year":"2019","unstructured":"Coppadoro A, Bellani G, Foti G (2019) Non-pharmacological interventions to prevent ventilator-associated pneumonia: a literature review. Respir Care 64:1586\u20131595. https:\/\/doi.org\/10.4187\/respcare.07127","journal-title":"Respir Care"},{"key":"8459_CR7","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s13613-015-0087-3","volume":"5","author":"S Nseir","year":"2015","unstructured":"Nseir S, Lorente L, Ferrer M et al (2015) Continuous control of tracheal cuff pressure for VAP prevention: a collaborative meta-analysis of individual participant data. Ann Intensive Care 5:43. https:\/\/doi.org\/10.1186\/s13613-015-0087-3","journal-title":"Ann Intensive Care"},{"key":"8459_CR8","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s13756-025-01579-6","volume":"14","author":"Y Wu","year":"2025","unstructured":"Wu Y, Su Y, Zhao L et al (2025) Continuous versus intermittent cuff pressure monitoring in preventing ventilator-associated pneumonia: a multicentre randomised controlled trial. Antimicrob Resist Infect Control 14:66. https:\/\/doi.org\/10.1186\/s13756-025-01579-6","journal-title":"Antimicrob Resist Infect Control"},{"key":"8459_CR9","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1097\/CCM.0000000000005630","volume":"50","author":"B Maertens","year":"2022","unstructured":"Maertens B, Lin F, Chen Y et al (2022) Effectiveness of continuous cuff pressure control in preventing ventilator-associated pneumonia: a systematic review and meta-analysis of randomized controlled trials*. Crit Care Med 50:1430\u20131439. https:\/\/doi.org\/10.1097\/CCM.0000000000005630","journal-title":"Crit Care Med"},{"key":"8459_CR10","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0107-2019","volume":"29","author":"DP Pozuelo-Carrascosa","year":"2020","unstructured":"Pozuelo-Carrascosa DP, Herr\u00e1iz-Adillo \u00c1, Alvarez-Bueno C et al (2020) Subglottic secretion drainage for preventing ventilator-associated pneumonia: an overview of systematic reviews and an updated meta-analysis. Eur Respir Rev 29:190107. https:\/\/doi.org\/10.1183\/16000617.0107-2019","journal-title":"Eur Respir Rev"},{"key":"8459_CR11","doi-asserted-by":"publisher","first-page":"422","DOI":"10.21037\/atm.2018.10.40","volume":"6","author":"J-C Lacherade","year":"2018","unstructured":"Lacherade J-C, Azais M-A, Pouplet C, Colin G (2018) Subglottic secretion drainage for ventilator-associated pneumonia prevention: an underused efficient measure. Ann Transl Med 6:422\u2013422. https:\/\/doi.org\/10.21037\/atm.2018.10.40","journal-title":"Ann Transl Med"},{"key":"8459_CR12","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s10877-014-9583-5","volume":"29","author":"S Efrati","year":"2015","unstructured":"Efrati S, Deutsch I, Weksler N, Gurman GM (2015) Detection of endobronchial intubation by monitoring the CO2 level above the endotracheal cuff. J Clin Monit Comput 29:19\u201323. https:\/\/doi.org\/10.1007\/s10877-014-9583-5","journal-title":"J Clin Monit Comput"},{"key":"8459_CR13","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1213\/ANE.0000000000002358","volume":"125","author":"S Efrati","year":"2017","unstructured":"Efrati S, Bolotin G, Levi L et al (2017) Optimization of endotracheal tube cuff pressure by monitoring CO2 levels in the subglottic space in mechanically ventilated patients: a randomized controlled trial. Anesth Analg 125:1309\u20131315. https:\/\/doi.org\/10.1213\/ANE.0000000000002358","journal-title":"Anesth Analg"},{"key":"8459_CR14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175476","volume":"12","author":"G De Pascale","year":"2017","unstructured":"De Pascale G, Pennisi MA, Vallecoccia MS et al (2017) CO2 driven endotracheal tube cuff control in critically ill patients: a randomized controlled study. PLoS ONE 12:e0175476. https:\/\/doi.org\/10.1371\/journal.pone.0175476","journal-title":"PLoS ONE"},{"key":"8459_CR15","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1186\/s13054-022-04225-4","volume":"26","author":"ES Tanzarella","year":"2022","unstructured":"Tanzarella ES, Lombardi G, Baroni S et al (2022) Use of an innovative cuff pressure control and subglottic secretions drainage system in COVID-19 ARDS patients undergoing pronation. Crit Care 26:338. https:\/\/doi.org\/10.1186\/s13054-022-04225-4","journal-title":"Crit Care"},{"key":"8459_CR16","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1136\/bmj.316.7142.1455","volume":"316","author":"SM Kerry","year":"1998","unstructured":"Kerry SM, Bland JM (1998) Statistics notes: the intracluster correlation coefficient in cluster randomisation. BMJ 316:1455\u20131460. https:\/\/doi.org\/10.1136\/bmj.316.7142.1455","journal-title":"BMJ"},{"key":"8459_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.iccn.2020.103010","volume":"63","author":"S Nseir","year":"2021","unstructured":"Nseir S, Koulenti D, Blot S (2021) How to measure microaspiration of subglottic secretions in clinical research in intubated patients? Intensive Crit Care Nurs 63:103010. https:\/\/doi.org\/10.1016\/j.iccn.2020.103010","journal-title":"Intensive Crit Care Nurs"},{"key":"8459_CR18","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1164\/rccm.201408-1398OC","volume":"191","author":"F Philippart","year":"2015","unstructured":"Philippart F, Gaudry S, Quinquis L et al (2015) randomized intubation with polyurethane or conical cuffs to prevent pneumonia in ventilated patients. Am J Respir Crit Care Med 191:637\u2013645. https:\/\/doi.org\/10.1164\/rccm.201408-1398OC","journal-title":"Am J Respir Crit Care Med"},{"key":"8459_CR19","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1513\/AnnalsATS.201506-346OC","volume":"13","author":"S Deem","year":"2016","unstructured":"Deem S, Yanez D, Sissons-Ross L et al (2016) randomized pilot trial of two modified endotracheal tubes to prevent ventilator-associated pneumonia. Annals ATS 13:72\u201380. https:\/\/doi.org\/10.1513\/AnnalsATS.201506-346OC","journal-title":"Annals ATS"},{"key":"8459_CR20","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/j.1469-0691.2011.03570.x","volume":"18","author":"A-P Magiorakos","year":"2012","unstructured":"Magiorakos A-P, Srinivasan A, Carey RB et al (2012) Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect 18:268\u2013281. https:\/\/doi.org\/10.1111\/j.1469-0691.2011.03570.x","journal-title":"Clin Microbiol Infect"},{"key":"8459_CR21","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1177\/08850666241232369","volume":"39","author":"Y Wu","year":"2024","unstructured":"Wu Y, Li Y, Sun M et al (2024) Continuous versus intermittent control cuff pressure for preventing ventilator-associated pneumonia: an updated meta-analysis. J Intensive Care Med 39:829\u2013839. https:\/\/doi.org\/10.1177\/08850666241232369","journal-title":"J Intensive Care Med"},{"key":"8459_CR22","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.ccm.2018.08.001","volume":"39","author":"A Rouz\u00e9","year":"2018","unstructured":"Rouz\u00e9 A, Martin-Loeches I, Nseir S (2018) Airway devices in ventilator-associated pneumonia pathogenesis and prevention. Clin Chest Med 39:775\u2013783. https:\/\/doi.org\/10.1016\/j.ccm.2018.08.001","journal-title":"Clin Chest Med"},{"key":"8459_CR23","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1164\/rccm.201104-0630OC","volume":"184","author":"S Nseir","year":"2011","unstructured":"Nseir S, Zerimech F, Fournier C et al (2011) Continuous control of tracheal cuff pressure and microaspiration of gastric contents in critically Ill patients. Am J Respir Crit Care Med 184:1041\u20131047. https:\/\/doi.org\/10.1164\/rccm.201104-0630OC","journal-title":"Am J Respir Crit Care Med"},{"key":"8459_CR24","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/2110-5820-4-7","volume":"4","author":"E Jaillette","year":"2014","unstructured":"Jaillette E, Martin-Loeches I, Artigas A, Nseir S (2014) Optimal care and design of the tracheal cuff in the critically ill patient. Ann Intensive Care 4:7. https:\/\/doi.org\/10.1186\/2110-5820-4-7","journal-title":"Ann Intensive Care"},{"key":"8459_CR25","doi-asserted-by":"publisher","first-page":"R77","DOI":"10.1186\/cc13837","volume":"18","author":"L Lorente","year":"2014","unstructured":"Lorente L, Lecuona M, Jim\u00e9nez A et al (2014) Continuous endotracheal tube cuff pressure control system protects against ventilator-associated pneumonia. Crit Care 18:R77. https:\/\/doi.org\/10.1186\/cc13837","journal-title":"Crit Care"},{"key":"8459_CR26","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.chest.2021.03.007","volume":"160","author":"N Marjanovic","year":"2021","unstructured":"Marjanovic N, Boisson M, Asehnoune K et al (2021) Continuous pneumatic regulation of tracheal cuff pressure to decrease ventilator-associated pneumonia in trauma patients who were mechanically ventilated. Chest 160:499\u2013508. https:\/\/doi.org\/10.1016\/j.chest.2021.03.007","journal-title":"Chest"},{"key":"8459_CR27","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1093\/cid\/ciab724","volume":"74","author":"VQ Dat","year":"2022","unstructured":"Dat VQ, Minh Yen L, Thi Loan H et al (2022) Effectiveness of continuous endotracheal cuff pressure control for the prevention of ventilator-associated respiratory infections: an open-label randomized, controlled trial. Clin Infect Dis 74:1795\u20131803. https:\/\/doi.org\/10.1093\/cid\/ciab724","journal-title":"Clin Infect Dis"},{"key":"8459_CR28","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1097\/MCC.0000000000000443","volume":"23","author":"M Klompas","year":"2017","unstructured":"Klompas M (2017) What is new in the prevention of nosocomial pneumonia in the ICU? Curr Opin Crit Care 23:378\u2013384. https:\/\/doi.org\/10.1097\/MCC.0000000000000443","journal-title":"Curr Opin Crit Care"},{"key":"8459_CR29","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1378\/chest.116.5.1339","volume":"116","author":"MH Kollef","year":"1999","unstructured":"Kollef MH, Skubas NJ, Sundt TM (1999) A randomized clinical trial of continuous aspiration of subglottic secretions in cardiac surgery patients. Chest 116:1339\u20131346. https:\/\/doi.org\/10.1378\/chest.116.5.1339","journal-title":"Chest"},{"key":"8459_CR30","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1164\/rccm.200906-0838OC","volume":"182","author":"J-C Lacherade","year":"2010","unstructured":"Lacherade J-C, De Jonghe B, Guezennec P et al (2010) Intermittent subglottic secretion drainage and ventilator-associated pneumonia: a multicenter trial. Am J Respir Crit Care Med 182:910\u2013917. https:\/\/doi.org\/10.1164\/rccm.200906-0838OC","journal-title":"Am J Respir Crit Care Med"},{"key":"8459_CR31","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1164\/rccm.200705-761OC","volume":"176","author":"L Lorente","year":"2007","unstructured":"Lorente L, Lecuona M, Jim\u00e9nez A et al (2007) Influence of an endotracheal tube with polyurethane cuff and subglottic secretion drainage on pneumonia. Am J Respir Crit Care Med 176:1079\u20131083. https:\/\/doi.org\/10.1164\/rccm.200705-761OC","journal-title":"Am J Respir Crit Care Med"},{"key":"8459_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(25)00294-2","author":"MM Treggiari","year":"2025","unstructured":"Treggiari MM, Sharp ES, Ohnuma T et al (2025) Hospital and long-term outcomes for subglottic suction and polyurethane cuff versus standard endotracheal tubes in emergency intubation (PreVent 2): a randomised controlled phase 2 trial. Lancet Respir Med. https:\/\/doi.org\/10.1016\/S2213-2600(25)00294-2","journal-title":"Lancet Respir Med"},{"key":"8459_CR33","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.1097\/01.ccm.0000142575.86468.9b","volume":"32","author":"L Berra","year":"2004","unstructured":"Berra L, De Marchi L, Panigada M et al (2004) Evaluation of continuous aspiration of subglottic secretion in an in vivo study. Crit Care Med 32:2071\u20132078. https:\/\/doi.org\/10.1097\/01.ccm.0000142575.86468.9b","journal-title":"Crit Care Med"},{"key":"8459_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.iccn.2025.104185","volume":"93","author":"S Li","year":"2026","unstructured":"Li S, Li Q, Lu G (2026) Tracheal tube cuff materials, shapes, and coatings in the prevention of ventilator-associated pneumonia: a network meta-analysis and systematic review. Intensive Crit Care Nurs 93:104185. https:\/\/doi.org\/10.1016\/j.iccn.2025.104185","journal-title":"Intensive Crit Care Nurs"}],"container-title":["Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-026-08459-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00134-026-08459-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-026-08459-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T09:17:22Z","timestamp":1781515042000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00134-026-08459-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["8459"],"URL":"https:\/\/doi.org\/10.1007\/s00134-026-08459-6","relation":{},"ISSN":["0342-4642","1432-1238"],"issn-type":[{"value":"0342-4642","type":"print"},{"value":"1432-1238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"14 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Maurizio Cecconi is a Section Editor for Intensive Care Medicine. He has not taken part in the review or selection process of this article. Other authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}