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AdM received an honorarium for a lecture for Pascoe and travel expenses for the Critical Care Reviews Down Under in Melbourne. AdM and AvZ received recently a grant from the EU (MSCA-DN) for the BIO-MICRO project. AvZ received honoraria for advisory board meetings, lectures, research, and travel expenses from AOP Pharma, Abbott, Baxter, Cardinal Health, Danone-Nutricia, Dutch Medical Food, Fresenius Kabi, GE Healthcare, GSK, InBody, and Rousselot. The other authors declare that they have no potential conflicts of interest, any relevant financial activities outside the submitted work, or any other relationships or activities that readers could perceive to have influenced, or that give the appearance of potentially influencing what is written in the submitted work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The study was approved by the ethics committee at Amsterdam UMC, location VUmc (VU University Medical Centre Protocol Record METC-2018.120). The ethics committee approved starting study interventions before obtaining informed consent to avoid treatment delays. All substantial protocol amendments were submitted to the Central Committee on Research Involving Human Subjects and the Medical Ethics Committee of Amsterdam UMC, location VUmc. Approved amendments were communicated to the principal investigators of the participating hospitals.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}