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All the other authors declare no conflicts of interest related to this work; E.A. reports lectures for Alexion, Gilead, Baxter, Mundipharma and Fisher & Payckel; S.J. reports lectures for Alexion, Gilead, Baxter, Mundipharma and Fisher & Payckel. SJ is the Editor in Chief of Intensive Care Medicine. He has not taken part in the review or selection process of this article. MC is a Section Editor for Intensive Care Medicine. He has not taken part in the review or selection process of this article.","order":1,"name":"Ethics","label":"Conflicts of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The protocol was first approved by the coordinating center (Prot. CE Humanitas 937\/22; 15\/11\/2022) and subsequently by each participating site, which began enrollment only after formal approval was granted at each site. Written informed consent was obtained from each patient before randomization and surgery.","order":2,"name":"Ethics","label":"Ethical approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}}]}}