{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:01:42Z","timestamp":1791450102705,"version":"4.3.3"},"reference-count":85,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"CHRU de Tours"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intensive Care Med"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s00134-026-08543-x","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:14:30Z","timestamp":1784556870000},"page":"1881-1894","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prone positioning in ARDS"],"prefix":"10.1007","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6221-4467","authenticated-orcid":false,"given":"Stephan","family":"Ehrmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Gu\u00e9rin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,20]]},"reference":[{"key":"8543_CR1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1097\/00003246-197601000-00003","volume":"4","author":"MA Piehl","year":"1976","unstructured":"Piehl MA, Brown RS (1976) Use of extreme position changes in acute respiratory failure. Crit Care Med 4:13\u201314. https:\/\/doi.org\/10.1097\/00003246-197601000-00003","journal-title":"Crit Care Med"},{"key":"8543_CR2","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1056\/NEJMoa1214103","volume":"368","author":"C Gu\u00e9rin","year":"2013","unstructured":"Gu\u00e9rin C, Reignier J, Richard J-C et al (2013) Prone positioning in severe acute respiratory distress syndrome. N Engl J Med 368:2159\u20132168. https:\/\/doi.org\/10.1056\/NEJMoa1214103","journal-title":"N Engl J Med"},{"key":"8543_CR3","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s13613-020-00650-2","volume":"10","author":"Q Sun","year":"2020","unstructured":"Sun Q, Qiu H, Huang M, Yang Y (2020) Lower mortality of COVID-19 by early recognition and intervention: experience from Jiangsu Province. Ann Intensive Care 10:33. https:\/\/doi.org\/10.1186\/s13613-020-00650-2","journal-title":"Ann Intensive Care"},{"key":"8543_CR4","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1164\/rccm.201703-0548ST","volume":"195","author":"E Fan","year":"2017","unstructured":"Fan E, Del Sorbo L, Goligher EC et al (2017) An Official American Thoracic Society\/European Society of Intensive Care Medicine\/Society of Critical Care Medicine Clinical Practice Guideline: mechanical ventilationin adult patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 195:1253\u20131263. https:\/\/doi.org\/10.1164\/rccm.201703-0548ST","journal-title":"Am J Respir Crit Care Med"},{"key":"8543_CR5","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1007\/s00134-023-07050-7","volume":"49","author":"G Grasselli","year":"2023","unstructured":"Grasselli G, Calfee CS, Camporota L et al (2023) ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies. Intensive Care Med 49:727\u2013759. https:\/\/doi.org\/10.1007\/s00134-023-07050-7","journal-title":"Intensive Care Med"},{"key":"8543_CR6","doi-asserted-by":"publisher","first-page":"2385","DOI":"10.1007\/s00134-020-06306-w","volume":"46","author":"C Gu\u00e9rin","year":"2020","unstructured":"Gu\u00e9rin C, Albert RK, Beitler J et al (2020) Prone position in ARDS patients: why, when, how and for whom. Intensive Care Med 46:2385\u20132396. https:\/\/doi.org\/10.1007\/s00134-020-06306-w","journal-title":"Intensive Care Med"},{"key":"8543_CR7","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1097\/CCM.0000000000005450","volume":"50","author":"T Fossali","year":"2022","unstructured":"Fossali T, Pavlovsky B, Ottolina D et al (2022) Effects of prone position on lung recruitment and ventilation-perfusion matching in patients with COVID-19 acute respiratory distress syndrome: a combined CT scan\/electrical impedance tomography study. Crit Care Med 50:723\u2013732. https:\/\/doi.org\/10.1097\/CCM.0000000000005450","journal-title":"Crit Care Med"},{"key":"8543_CR8","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1186\/s13054-022-04021-0","volume":"26","author":"Y-X Wang","year":"2022","unstructured":"Wang Y-X, Zhong M, Dong M-H et al (2022) Prone positioning improves ventilation-perfusion matching assessed by electrical impedance tomography in patients with ARDS: a prospective physiological study. Crit Care 26:154. https:\/\/doi.org\/10.1186\/s13054-022-04021-0","journal-title":"Crit Care"},{"key":"8543_CR9","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1097\/00000542-199101000-00004","volume":"74","author":"L Gattinoni","year":"1991","unstructured":"Gattinoni L, Pelosi P, Vitale G et al (1991) Body position changes redistribute lung computed-tomographic density in patients with acute respiratory failure. Anesthesiology 74:15\u201323. https:\/\/doi.org\/10.1097\/00000542-199101000-00004","journal-title":"Anesthesiology"},{"key":"8543_CR10","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1186\/s13054-023-04600-9","volume":"27","author":"DL Grieco","year":"2023","unstructured":"Grieco DL, DelleCese L, Menga LS et al (2023) Physiological effects of awake prone position in acute hypoxemic respiratory failure. Crit Care 27:315. https:\/\/doi.org\/10.1186\/s13054-023-04600-9","journal-title":"Crit Care"},{"key":"8543_CR11","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1164\/rccm.200506-899OC","volume":"174","author":"E Galiatsou","year":"2006","unstructured":"Galiatsou E, Kostanti E, Svarna E et al (2006) Prone position augments recruitment and prevents alveolar overinflation in acute lung injury. Am J Respir Crit Care Med 174:187\u2013197. https:\/\/doi.org\/10.1164\/rccm.200506-899OC","journal-title":"Am J Respir Crit Care Med"},{"key":"8543_CR12","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1164\/rccm.201207-1279OC","volume":"188","author":"RA Cornejo","year":"2013","unstructured":"Cornejo RA, D\u00edaz JC, Tobar EA et al (2013) Effects of prone positioning on lung protection in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 188:440\u2013448. https:\/\/doi.org\/10.1164\/rccm.201207-1279OC","journal-title":"Am J Respir Crit Care Med"},{"key":"8543_CR13","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1378\/chest.07-1013","volume":"132","author":"A Vieillard-Baron","year":"2007","unstructured":"Vieillard-Baron A, Charron C, Caille V et al (2007) Prone positioning unloads the right ventricle in severe ARDS. Chest 132:1440\u20131446. https:\/\/doi.org\/10.1378\/chest.07-1013","journal-title":"Chest"},{"key":"8543_CR14","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1164\/rccm.201303-0593OC","volume":"188","author":"M Jozwiak","year":"2013","unstructured":"Jozwiak M, Teboul J-L, Anguel N et al (2013) Beneficial hemodynamic effects of prone positioning in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 188:1428\u20131433. https:\/\/doi.org\/10.1164\/rccm.201303-0593OC","journal-title":"Am J Respir Crit Care Med"},{"key":"8543_CR15","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1186\/s13054-024-05059-y","volume":"28","author":"C Boesing","year":"2024","unstructured":"Boesing C, Rocco PRM, Luecke T, Krebs J (2024) Positive end-expiratory pressure management in patients with severe ARDS: implications of prone positioning and extracorporeal membrane oxygenation. Crit Care 28:277. https:\/\/doi.org\/10.1186\/s13054-024-05059-y","journal-title":"Crit Care"},{"key":"8543_CR16","doi-asserted-by":"publisher","first-page":"11085","DOI":"10.1038\/s41598-022-15122-9","volume":"12","author":"RA Dos Santos","year":"2022","unstructured":"Dos Santos RA, Diaper J, Balogh AL et al (2022) Effect of body position on the redistribution of regional lung aeration during invasive and non-invasive ventilation of COVID-19 patients. Sci Rep 12:11085. https:\/\/doi.org\/10.1038\/s41598-022-15122-9","journal-title":"Sci Rep"},{"key":"8543_CR17","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1186\/s13054-022-04069-y","volume":"26","author":"L Liu","year":"2022","unstructured":"Liu L, Xie J, Wang C et al (2022) Prone position improves lung ventilation-perfusion matching in non-intubated COVID-19 patients: a prospective physiologic study. Crit Care 26:193. https:\/\/doi.org\/10.1186\/s13054-022-04069-y","journal-title":"Crit Care"},{"key":"8543_CR18","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1186\/s12890-024-03411-0","volume":"24","author":"Y Chao","year":"2024","unstructured":"Chao Y, Yuan X, Zhao Z et al (2024) Physiologic effects of prone positioning on gas exchange and ventilation-perfusion matching in awake patients with AHRF. BMC Pulm Med 24:600. https:\/\/doi.org\/10.1186\/s12890-024-03411-0","journal-title":"BMC Pulm Med"},{"key":"8543_CR19","doi-asserted-by":"publisher","first-page":"713","DOI":"10.4187\/respcare.10597","volume":"68","author":"M Jacquet-Largr\u00e8ze","year":"2023","unstructured":"Jacquet-Largr\u00e8ze M, Riad Z, Portran P, Chesnel D, Schweizer R, Ferarris A, Jacquemet L, Ruste M, Fellahi JL (2023) Hemodynamic effects of awake prone positioning with COVID-19 acute respiratory failure. Respir Care 68:713\u2013720. https:\/\/doi.org\/10.4187\/respcare.10597","journal-title":"Respir Care"},{"key":"8543_CR20","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1056\/NEJMoa010043","volume":"345","author":"L Gattinoni","year":"2001","unstructured":"Gattinoni L, Tognoni G, Pesenti A et al (2001) Effect of prone positioning on the survival of patients with acute respiratory failure. N Engl J Med 345:568\u2013573. https:\/\/doi.org\/10.1056\/NEJMoa010043","journal-title":"N Engl J Med"},{"key":"8543_CR21","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1056\/NEJM200005043421801","volume":"342","author":"ARDS Network","year":"2000","unstructured":"Network ARDS, Brower RG, Matthay MA et al (2000) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 342:1301\u20131308. https:\/\/doi.org\/10.1056\/NEJM200005043421801","journal-title":"N Engl J Med"},{"key":"8543_CR22","doi-asserted-by":"publisher","first-page":"2379","DOI":"10.1001\/jama.292.19.2379","volume":"292","author":"C Guerin","year":"2004","unstructured":"Guerin C, Gaillard S, Lemasson S et al (2004) Effects of systematic prone positioning in hypoxemic acute respiratory failure: a randomized controlled trial. JAMA 292:2379\u20132387. https:\/\/doi.org\/10.1001\/jama.292.19.2379","journal-title":"JAMA"},{"key":"8543_CR23","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1164\/rccm.200503-353OC","volume":"173","author":"J Mancebo","year":"2006","unstructured":"Mancebo J, Fern\u00e1ndez R, Blanch L et al (2006) A multicenter trial of prolonged prone ventilation in severe acute respiratory distress syndrome. Am J Respir Crit Care Med 173:1233\u20131239. https:\/\/doi.org\/10.1164\/rccm.200503-353OC","journal-title":"Am J Respir Crit Care Med"},{"key":"8543_CR24","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1001\/jama.2009.1614","volume":"302","author":"P Taccone","year":"2009","unstructured":"Taccone P, Pesenti A, Latini R et al (2009) Prone positioning in patients with moderate and severe acute respiratory distress syndrome: a randomized controlled trial. JAMA 302:1977\u20131984. https:\/\/doi.org\/10.1001\/jama.2009.1614","journal-title":"JAMA"},{"key":"8543_CR25","first-page":"448","volume":"76","author":"L Gattinoni","year":"2010","unstructured":"Gattinoni L, Carlesso E, Taccone P et al (2010) Prone positioning improves survival in severe ARDS: a pathophysiologic review and individual patient meta-analysis. Minerva Anestesiol 76:448\u2013454","journal-title":"Minerva Anestesiol"},{"key":"8543_CR26","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.pulmoe.2022.12.005","volume":"30","author":"D Poole","year":"2024","unstructured":"Poole D, Pisa A, Fumagalli R (2024) Prone position for acute respiratory distress syndrome and the hazards of meta-analysis. Pulmonology 30:529\u2013536. https:\/\/doi.org\/10.1016\/j.pulmoe.2022.12.005","journal-title":"Pulmonology"},{"key":"8543_CR27","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1016\/j.jcrc.2015.07.008","volume":"30","author":"V Scaravilli","year":"2015","unstructured":"Scaravilli V, Grasselli G, Castagna L et al (2015) Prone positioning improves oxygenation in spontaneously breathing nonintubated patients with hypoxemic acute respiratory failure: a retrospective study. J Crit Care 30:1390\u20131394. https:\/\/doi.org\/10.1016\/j.jcrc.2015.07.008","journal-title":"J Crit Care"},{"key":"8543_CR28","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s13054-020-2738-5","volume":"24","author":"L Ding","year":"2020","unstructured":"Ding L, Wang L, Ma W, He H (2020) Efficacy and safety of early prone positioning combined with HFNC or NIV in moderate to severe ARDS: a multi-center prospective cohort study. Crit Care 24:28. https:\/\/doi.org\/10.1186\/s13054-020-2738-5","journal-title":"Crit Care"},{"key":"8543_CR29","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2020-000711","volume":"7","author":"S Winearls","year":"2020","unstructured":"Winearls S, Swingwood EL, Hardaker CL et al (2020) Early conscious prone positioning in patients with COVID-19 receiving continuous positive airway pressure: a retrospective analysis. BMJ Open Respir Res 7:e000711. https:\/\/doi.org\/10.1136\/bmjresp-2020-000711","journal-title":"BMJ Open Respir Res"},{"key":"8543_CR30","doi-asserted-by":"publisher","first-page":"2100265","DOI":"10.1183\/13993003.00265-2021","volume":"59","author":"OR Perez-Nieto","year":"2022","unstructured":"Perez-Nieto OR, Escarraman-Martinez D, Guerrero-Gutierrez MA et al (2022) Awake prone positioning and oxygen therapy in patients with COVID-19: the APRONOX study. Eur Respir J 59:2100265. https:\/\/doi.org\/10.1183\/13993003.00265-2021","journal-title":"Eur Respir J"},{"key":"8543_CR31","doi-asserted-by":"publisher","first-page":"102","DOI":"10.4187\/respcare.09191","volume":"67","author":"I Pavlov","year":"2022","unstructured":"Pavlov I, He H, McNicholas B et al (2022) Awake prone positioning in non-intubated patients with acute hypoxemic respiratory failure due to COVID-19. Respir Care 67:102\u2013114. https:\/\/doi.org\/10.4187\/respcare.09191","journal-title":"Respir Care"},{"key":"8543_CR32","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.jcrc.2020.07.020","volume":"60","author":"J Li","year":"2020","unstructured":"Li J, Pavlov I, Laffey JG et al (2020) Meta-trial of awake prone positioning with nasal high flow therapy: Invitation to join a pandemic collaborative research effort. J Crit Care 60:140\u2013142. https:\/\/doi.org\/10.1016\/j.jcrc.2020.07.020","journal-title":"J Crit Care"},{"key":"8543_CR33","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-041520","volume":"10","author":"E Tavernier","year":"2020","unstructured":"Tavernier E, McNicholas B, Pavlov I et al (2020) Awake prone positioning of hypoxaemic patients with COVID-19: protocol for a randomised controlled open-label superiority meta-trial. BMJ Open 10:e041520. https:\/\/doi.org\/10.1136\/bmjopen-2020-041520","journal-title":"BMJ Open"},{"key":"8543_CR34","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1016\/S2213-2600(21)00356-8","volume":"9","author":"S Ehrmann","year":"2021","unstructured":"Ehrmann S, Li J, Ibarra-Estrada M et al (2021) Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial. Lancet Respir Med 9:1387\u20131395. https:\/\/doi.org\/10.1016\/S2213-2600(21)00356-8","journal-title":"Lancet Respir Med"},{"key":"8543_CR35","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.chest.2022.05.009","volume":"162","author":"G Rampon","year":"2022","unstructured":"Rampon G, Jia S, Agrawal R et al (2022) Smartphone-guided self-prone positioning vs usual care in nonintubated hospital ward patients with COVID-19: a pragmatic randomized clinical trial. Chest 162:782\u2013791. https:\/\/doi.org\/10.1016\/j.chest.2022.05.009","journal-title":"Chest"},{"key":"8543_CR36","doi-asserted-by":"publisher","first-page":"2104","DOI":"10.1001\/jama.2022.7993","volume":"327","author":"W Alhazzani","year":"2022","unstructured":"Alhazzani W, Parhar KKS, Weatherald J et al (2022) Effect of awake prone positioning on endotracheal intubation in patients with COVID-19 and acute respiratory failure: a randomized clinical trial. JAMA 327:2104\u20132113. https:\/\/doi.org\/10.1001\/jama.2022.7993","journal-title":"JAMA"},{"key":"8543_CR37","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2021-068585","volume":"376","author":"M Fralick","year":"2022","unstructured":"Fralick M, Colacci M, Munshi L et al (2022) Prone positioning of patients with moderate hypoxaemia due to covid-19: multicentre pragmatic randomised trial (COVID-PRONE). BMJ 376:e068585. https:\/\/doi.org\/10.1136\/bmj-2021-068585","journal-title":"BMJ"},{"key":"8543_CR38","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1186\/s13054-023-04529-z","volume":"27","author":"M-A Nay","year":"2023","unstructured":"Nay M-A, Hindre R, Perrin C et al (2023) Prone position versus usual care in hypoxemic COVID-19 patients in medical wards: a randomised controlled trial. Crit Care 27:240. https:\/\/doi.org\/10.1186\/s13054-023-04529-z","journal-title":"Crit Care"},{"key":"8543_CR39","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1007\/s00134-024-07545-x","volume":"50","author":"L Liu","year":"2024","unstructured":"Liu L, Sun Q, Zhao H et al (2024) Prolonged vs shorter awake prone positioning for COVID-19 patients with acute respiratory failure: a multicenter, randomised controlled trial. Intensive Care Med 50:1298\u20131309. https:\/\/doi.org\/10.1007\/s00134-024-07545-x","journal-title":"Intensive Care Med"},{"key":"8543_CR40","doi-asserted-by":"publisher","first-page":"e2548201","DOI":"10.1001\/jamanetworkopen.2025.48201","volume":"8","author":"A Harrois","year":"2025","unstructured":"Harrois A, Jouffroy R, Ayed S et al (2025) Awake prone positioning in patients with COVID-19 respiratory failure: a randomized clinical trial. JAMA Netw Open 8:e2548201. https:\/\/doi.org\/10.1001\/jamanetworkopen.2025.48201","journal-title":"JAMA Netw Open"},{"key":"8543_CR41","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1001\/jamainternmed.2025.0011","volume":"185","author":"J Luo","year":"2025","unstructured":"Luo J, Pavlov I, Tavernier E et al (2025) Awake prone positioning in adults with COVID-19: an individual participant data meta-analysis. JAMA Intern Med 185:572\u2013581. https:\/\/doi.org\/10.1001\/jamainternmed.2025.0011","journal-title":"JAMA Intern Med"},{"key":"8543_CR42","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1164\/rccm.202311-2011ST","volume":"209","author":"N Qadir","year":"2024","unstructured":"Qadir N, Sahetya S, Munshi L et al (2024) An update on management of adult patients with acute respiratory distress syndrome: an Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med 209:24\u201336. https:\/\/doi.org\/10.1164\/rccm.202311-2011ST","journal-title":"Am J Respir Crit Care Med"},{"key":"8543_CR43","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1016\/S2213-2600(19)30138-9","volume":"7","author":"JM Constantin","year":"2019","unstructured":"Constantin JM, Jabaudon M, Lefrant JY et al (2019) Personalised mechanical ventilation tailored to lung morphology versus low positive end-expiratory pressure for patients with acute respiratory distress syndrome in France (the LIVE study): a multicentre, single-blind, randomised controlled trial. Lancet Respir Med 7:870\u2013880. https:\/\/doi.org\/10.1016\/S2213-2600(19)30138-9","journal-title":"Lancet Respir Med"},{"key":"8543_CR44","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s13054-025-05340-8","volume":"29","author":"M Fosset","year":"2025","unstructured":"Fosset M, von Wedel D, Redaelli S et al (2025) Subphenotyping prone position responders with machine learning. Crit Care 29:116. https:\/\/doi.org\/10.1186\/s13054-025-05340-8","journal-title":"Crit Care"},{"key":"8543_CR45","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1056\/NEJMoa1005372","volume":"363","author":"L Papazian","year":"2010","unstructured":"Papazian L, Forel JM, Gacouin A et al (2010) Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med 363:1107\u20131116. https:\/\/doi.org\/10.1056\/NEJMoa1005372","journal-title":"N Engl J Med"},{"key":"8543_CR46","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1055\/s-0042-1744304","volume":"43","author":"C Gu\u00e9rin","year":"2022","unstructured":"Gu\u00e9rin C, Cour M, Argaud L (2022) Prone positioning and neuromuscular blocking agents as adjunctive therapies in mechanically ventilated patients with acute respiratory distress syndrome. Semin Respir Crit Care Med 43:453\u2013460. https:\/\/doi.org\/10.1055\/s-0042-1744304","journal-title":"Semin Respir Crit Care Med"},{"key":"8543_CR47","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1056\/NEJMoa1901686","volume":"380","author":"M Moss","year":"2019","unstructured":"Moss M, Huang DT, Brower RG et al (2019) Early neuromuscular blockade in the acute respiratory distress syndrome. N Engl J Med 380:1997\u20132008. https:\/\/doi.org\/10.1056\/NEJMoa1901686","journal-title":"N Engl J Med"},{"key":"8543_CR48","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1186\/s13054-021-03761-9","volume":"25","author":"R Kaur","year":"2021","unstructured":"Kaur R, Vines DL, Mirza S et al (2021) Early versus late awake prone positioning in non-intubated patients with COVID-19. Crit Care 25:340. https:\/\/doi.org\/10.1186\/s13054-021-03761-9","journal-title":"Crit Care"},{"key":"8543_CR49","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/s13613-025-01501-8","volume":"15","author":"Q Sun","year":"2025","unstructured":"Sun Q, Zhang R, Zhang J et al (2025) Impact of awake prone positioning duration on intubation or mortality in COVID-19 patients with acute respiratory failure: secondary analysis of a randomized clinical trial. Ann Intensive Care 15:84. https:\/\/doi.org\/10.1186\/s13613-025-01501-8","journal-title":"Ann Intensive Care"},{"key":"8543_CR50","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1164\/rccm.201803-0589OC","volume":"199","author":"O Roca","year":"2019","unstructured":"Roca O, Caralt B, Messika J et al (2019) A index combining respiratory rate and oxygenation to predict outcome of nasal high-flow therapy. Am J Respir Crit Care Med 199:1368\u20131376. https:\/\/doi.org\/10.1164\/rccm.201803-0589OC","journal-title":"Am J Respir Crit Care Med"},{"key":"8543_CR51","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-026-06081-y","author":"A Caccioppola","year":"2026","unstructured":"Caccioppola A, Ippolito M, Cortegiani A, Gu\u00e9rin C, Grasselli G (2026) Definition and prognostic value of response to prone positioning in ARDS: a systematic review and meta-analysis. Crit Care. https:\/\/doi.org\/10.1186\/s13054-026-06081-y","journal-title":"Crit Care"},{"key":"8543_CR52","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1186\/s13054-022-04064-3","volume":"26","author":"M Ibarra-Estrada","year":"2022","unstructured":"Ibarra-Estrada M, Gamero-Rodr\u00edguez MJ, Garc\u00eda-de-Acilu M et al (2022) Lung ultrasound response to awake prone positioning predicts the need for intubation in patients with COVID-19 induced acute hypoxemic respiratory failure: an observational study. Crit Care 26:189. https:\/\/doi.org\/10.1186\/s13054-022-04064-3","journal-title":"Crit Care"},{"key":"8543_CR53","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.4187\/respcare.09194","volume":"66","author":"F Gonz\u00e1lez-Seguel","year":"2021","unstructured":"Gonz\u00e1lez-Seguel F, Pinto-Concha JJ, Aranis N, Leppe J (2021) Adverse events of prone positioning in mechanically ventilated adults with ARDS. Respir Care 66:1898\u20131911. https:\/\/doi.org\/10.4187\/respcare.09194","journal-title":"Respir Care"},{"key":"8543_CR54","doi-asserted-by":"publisher","first-page":"111","DOI":"10.23736\/S1973-9087.22.07529-3","volume":"59","author":"N Elmer","year":"2023","unstructured":"Elmer N, Rei\u00dfhauer A, Brehm K et al (2023) Long-term complications of prone position ventilation with relevance for acute and postacute rehabilitation: a systematic review of the literature. Eur J Phys Rehabil Med 59:111\u2013121. https:\/\/doi.org\/10.23736\/S1973-9087.22.07529-3","journal-title":"Eur J Phys Rehabil Med"},{"key":"8543_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.aucc.2024.09.002","volume":"38","author":"TC Rollinson","year":"2025","unstructured":"Rollinson TC, McDonald LA, Rose J et al (2025) Complications associated with prone positioning in mechanically ventilated COVID-19 patients: a multicentre, retrospective observational study. Aust Crit Care 38:101117. https:\/\/doi.org\/10.1016\/j.aucc.2024.09.002","journal-title":"Aust Crit Care"},{"key":"8543_CR56","doi-asserted-by":"publisher","first-page":"2141","DOI":"10.1016\/j.bjps.2020.12.057","volume":"74","author":"G Ibarra","year":"2021","unstructured":"Ibarra G, Rivera A, Fernandez-Ibarburu B et al (2021) Prone position pressure sores in the COVID-19 pandemic: the Madrid experience. J Plast Reconstr Aesthet Surg 74:2141\u20132148. https:\/\/doi.org\/10.1016\/j.bjps.2020.12.057","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"8543_CR57","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/s13613-022-01082-w","volume":"12","author":"RA Cornejo","year":"2022","unstructured":"Cornejo RA, Montoya J, Gajardo AIJ et al (2022) Continuous prolonged prone positioning in COVID-19-related ARDS: a multicenter cohort study from Chile. Ann Intensive Care 12:109. https:\/\/doi.org\/10.1186\/s13613-022-01082-w","journal-title":"Ann Intensive Care"},{"key":"8543_CR58","doi-asserted-by":"publisher","DOI":"10.1111\/nicc.70084","volume":"30","author":"L Gay","year":"2025","unstructured":"Gay L, Huot L, Yonis H et al (2025) A bundle of interventions to prevent pressure ulcers during prone position in adult patients with acute respiratory distress syndrome: results of a French stepped-wedge randomized controlled trial. Nurs Crit Care 30:e70084. https:\/\/doi.org\/10.1111\/nicc.70084","journal-title":"Nurs Crit Care"},{"key":"8543_CR59","doi-asserted-by":"publisher","DOI":"10.1016\/j.iccn.2024.103766","volume":"85","author":"F Binda","year":"2024","unstructured":"Binda F, Gambazza S, Marelli F et al (2024) Upper limb peripheral nerve injuries in patients with ARDS requiring prone positioning: a systematic review with proportion meta-analysis. Intensive Crit Care Nurs 85:103766. https:\/\/doi.org\/10.1016\/j.iccn.2024.103766","journal-title":"Intensive Crit Care Nurs"},{"key":"8543_CR60","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s13613-017-0235-z","volume":"7","author":"S Gaudry","year":"2017","unstructured":"Gaudry S, Tuffet S, Lukaszewicz A-C et al (2017) Prone positioning in acute respiratory distress syndrome after abdominal surgery: a multicenter retrospective study. Ann Intensive Care 7:21. https:\/\/doi.org\/10.1186\/s13613-017-0235-z","journal-title":"Ann Intensive Care"},{"key":"8543_CR61","doi-asserted-by":"publisher","first-page":"55","DOI":"10.4037\/ccn2021900","volume":"41","author":"P Ryan","year":"2021","unstructured":"Ryan P, Fine C, DeForge C (2021) An evidence-based protocol for manual prone positioning of patients with ARDS. Crit Care Nurse 41:55\u201360. https:\/\/doi.org\/10.4037\/ccn2021900","journal-title":"Crit Care Nurse"},{"key":"8543_CR62","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2022-071966","volume":"379","author":"J Weatherald","year":"2022","unstructured":"Weatherald J, Parhar KKS, Duhailib ZA et al (2022) Efficacy of awake prone positioning in patients with covid-19 related hypoxemic respiratory failure: systematic review and meta-analysis of randomized trials. BMJ 379:e071966. https:\/\/doi.org\/10.1136\/bmj-2022-071966","journal-title":"BMJ"},{"key":"8543_CR63","doi-asserted-by":"publisher","first-page":"31","DOI":"10.4037\/ccn2023209","volume":"43","author":"C Fusi","year":"2023","unstructured":"Fusi C, Bulleri E, Villa M et al (2023) Awake prone positioning in nonintubated patients with acute hypoxemic respiratory failure. Crit Care Nurse 43:31\u201341. https:\/\/doi.org\/10.4037\/ccn2023209","journal-title":"Crit Care Nurse"},{"key":"8543_CR64","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1001\/jama.2016.0291","volume":"315","author":"G Bellani","year":"2016","unstructured":"Bellani G, Laffey JG, Pham T et al (2016) Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA 315:788\u2013800. https:\/\/doi.org\/10.1001\/jama.2016.0291","journal-title":"JAMA"},{"key":"8543_CR65","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1007\/s00134-017-4996-5","volume":"44","author":"C Gu\u00e9rin","year":"2018","unstructured":"Gu\u00e9rin C, Beuret P, Constantin JM et al (2018) A prospective international observational prevalence study on prone positioning of ARDS patients: the APRONET (ARDS Prone Position Network) study. Intensive Care Med 44:22\u201337. https:\/\/doi.org\/10.1007\/s00134-017-4996-5","journal-title":"Intensive Care Med"},{"key":"8543_CR66","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1016\/j.chest.2020.01.041","volume":"157","author":"A Duggal","year":"2020","unstructured":"Duggal A, Rezoagli E, Pham T et al (2020) Patterns of use of adjunctive therapies in patients with early moderate to severe ARDS: insights from the LUNG SAFE study. Chest 157:1497\u20131505. https:\/\/doi.org\/10.1016\/j.chest.2020.01.041","journal-title":"Chest"},{"key":"8543_CR67","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1513\/AnnalsATS.202201-070RL","volume":"19","author":"X Audhya","year":"2022","unstructured":"Audhya X, Bosch NA, Stevens JP et al (2022) Changes to Hospital Availability of Prone Positioning after the COVID-19 Pandemic. Ann Am Thorac Soc 19:1610\u20131613. https:\/\/doi.org\/10.1513\/AnnalsATS.202201-070RL","journal-title":"Ann Am Thorac Soc"},{"key":"8543_CR68","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1513\/AnnalsATS.202005-571OC","volume":"18","author":"T Klaiman","year":"2021","unstructured":"Klaiman T, Silvestri JA, Srinivasan T et al (2021) Improving prone positioning for severe acute respiratory distress syndrome during the COVID-19 pandemic. an implementation-mapping approach. Ann Am Thorac Soc 18:300\u2013307. https:\/\/doi.org\/10.1513\/AnnalsATS.202005-571OC","journal-title":"Ann Am Thorac Soc"},{"key":"8543_CR69","doi-asserted-by":"publisher","first-page":"4783","DOI":"10.3390\/jcm10204783","volume":"10","author":"W Stilma","year":"2021","unstructured":"Stilma W, van Meenen DMP, Valk CMA et al (2021) Incidence and practice of early prone positioning in invasively ventilated COVID-19 patients\u2014insights from the PRoVENT-COVID observational study. J Clin Med 10:4783. https:\/\/doi.org\/10.3390\/jcm10204783","journal-title":"J Clin Med"},{"key":"8543_CR70","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/s13054-021-03552-2","volume":"25","author":"T Langer","year":"2021","unstructured":"Langer T, Brioni M, Guzzardella A et al (2021) Prone position in intubated, mechanically ventilated patients with COVID-19: a multi-centric study of more than 1000 patients. Crit Care 25:128. https:\/\/doi.org\/10.1186\/s13054-021-03552-2","journal-title":"Crit Care"},{"key":"8543_CR71","doi-asserted-by":"publisher","first-page":"2200","DOI":"10.1007\/s00134-020-06192-2","volume":"46","author":"C Ferrando","year":"2020","unstructured":"Ferrando C, Suarez-Sipmann F, Mellado-Artigas R et al (2020) Clinical features, ventilatory management, and outcome of ARDS caused by COVID-19 are similar to other causes of ARDS. Intensive Care Med 46:2200\u20132211. https:\/\/doi.org\/10.1007\/s00134-020-06192-2","journal-title":"Intensive Care Med"},{"key":"8543_CR72","doi-asserted-by":"publisher","DOI":"10.1097\/CCE.0000000000000695","volume":"4","author":"CH Hochberg","year":"2022","unstructured":"Hochberg CH, Psoter KJ, Sahetya SK et al (2022) Comparing prone positioning use in COVID-19 versus historic acute respiratory distress syndrome. Crit Care Explor 4:e0695. https:\/\/doi.org\/10.1097\/CCE.0000000000000695","journal-title":"Crit Care Explor"},{"key":"8543_CR73","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s13613-025-01422-6","volume":"15","author":"AJ Simpkin","year":"2025","unstructured":"Simpkin AJ, McNicholas BA, Hannon D et al (2025) Effect of early and later prone positioning on outcomes in invasively ventilated COVID-19 patients with acute respiratory distress syndrome: analysis of the prospective COVID-19 critical care consortium cohort study. Ann Intensive Care 15:22. https:\/\/doi.org\/10.1186\/s13613-025-01422-6","journal-title":"Ann Intensive Care"},{"key":"8543_CR74","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1177\/0885066620980399","volume":"36","author":"MC Shelhamer","year":"2021","unstructured":"Shelhamer MC, Wesson PD, Solari IL et al (2021) Prone positioning in moderate to severe acute respiratory distress syndrome due to COVID-19: a cohort study and analysis of physiology. J Intensive Care Med 36:241\u2013252. https:\/\/doi.org\/10.1177\/0885066620980399","journal-title":"J Intensive Care Med"},{"key":"8543_CR75","doi-asserted-by":"publisher","first-page":"216","DOI":"10.4187\/respcare.09577","volume":"67","author":"BY Lee","year":"2022","unstructured":"Lee BY, Lee S-I, Baek MS et al (2022) Lower driving pressure and neuromuscular blocker use are associated with decreased mortality in patients with COVID-19 ARDS. Respir Care 67:216\u2013226. https:\/\/doi.org\/10.4187\/respcare.09577","journal-title":"Respir Care"},{"key":"8543_CR76","doi-asserted-by":"publisher","first-page":"6988","DOI":"10.3390\/jcm11236988","volume":"11","author":"W Stilma","year":"2022","unstructured":"Stilma W, Valk CMA, van Meenen DMP et al (2022) Practice of awake prone positioning in critically ill COVID-19 patients\u2014insights from the PRoAcT\u2013COVID study. J Clin Med 11:6988. https:\/\/doi.org\/10.3390\/jcm11236988","journal-title":"J Clin Med"},{"key":"8543_CR77","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1097\/CCM.0000000000005969","volume":"51","author":"CH Hochberg","year":"2023","unstructured":"Hochberg CH, Psoter KJ, Eakin MN, Hager DN (2023) Declining use of prone positioning after high initial uptake in COVID-19 adult respiratory distress syndrome. Crit Care Med 51:1547\u20131551. https:\/\/doi.org\/10.1097\/CCM.0000000000005969","journal-title":"Crit Care Med"},{"key":"8543_CR78","doi-asserted-by":"publisher","first-page":"175346662110094","DOI":"10.1177\/17534666211009407","volume":"15","author":"W Tan","year":"2021","unstructured":"Tan W, Xu D-Y, Xu M-J et al (2021) The efficacy and tolerance of prone positioning in non-intubation patients with acute hypoxemic respiratory failure and ARDS: a meta-analysis. Ther Adv Respir Dis 15:17534666211009408. https:\/\/doi.org\/10.1177\/17534666211009407","journal-title":"Ther Adv Respir Dis"},{"key":"8543_CR79","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.jointm.2024.07.007","volume":"5","author":"J Wang","year":"2025","unstructured":"Wang J, Chen C, Zhao Z et al (2025) Awake prone positioning and ventilation distribution as assessed by electric impedance tomography in patients with non-COVID-19 acute hypoxemic respiratory failure: a prospective physiology study. J Intensive Med 5:43\u201350. https:\/\/doi.org\/10.1016\/j.jointm.2024.07.007","journal-title":"J Intensive Med"},{"key":"8543_CR80","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s13063-021-05991-2","volume":"23","author":"L Morales-Quinteros","year":"2022","unstructured":"Morales-Quinteros L, Schultz MJ, Serpa-Neto A et al (2022) Awake prone positioning in nonintubated spontaneous breathing ICU patients with acute hypoxemic respiratory failure (PRONELIFE)\u2014protocol for a randomized clinical trial. Trials 23:30. https:\/\/doi.org\/10.1186\/s13063-021-05991-2","journal-title":"Trials"},{"key":"8543_CR81","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1186\/s13054-025-05712-0","volume":"29","author":"C Jung","year":"2025","unstructured":"Jung C, Gillmann H-J, Stueber T (2025) Effectiveness and safety of prolonged prone positioning in adult patients with acute respiratory distress syndrome (ARDS): a systematic review and meta-analysis. Crit Care 29:475. https:\/\/doi.org\/10.1186\/s13054-025-05712-0","journal-title":"Crit Care"},{"key":"8543_CR82","doi-asserted-by":"publisher","first-page":"7261","DOI":"10.3390\/jcm14207261","volume":"14","author":"C-W Hsu","year":"2025","unstructured":"Hsu C-W, Liu S-M, Yang C-Y et al (2025) Different duration of prone positioning treatment for patients with acute respiratory distress syndrome in intensive care unit patients: a prospective randomized clinical study. J Clin Med 14:7261. https:\/\/doi.org\/10.3390\/jcm14207261","journal-title":"J Clin Med"},{"key":"8543_CR83","doi-asserted-by":"publisher","first-page":"2343","DOI":"10.1001\/jama.2023.24491","volume":"330","author":"M Schmidt","year":"2023","unstructured":"Schmidt M, Hajage D, Lebreton G et al (2023) Prone positioning during extracorporeal membrane oxygenation in patients with severe ARDS: the PRONECMO randomized clinical trial. JAMA 330:2343. https:\/\/doi.org\/10.1001\/jama.2023.24491","journal-title":"JAMA"},{"key":"8543_CR84","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.21037\/jtd-23-1808","volume":"16","author":"H Tong","year":"2024","unstructured":"Tong H, Pan F, Zhang X et al (2024) Effect of prone positioning on survival in adult patients receiving venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a prospective multicenter randomized controlled study. J Thorac Dis 16:1368\u20131377. https:\/\/doi.org\/10.21037\/jtd-23-1808","journal-title":"J Thorac Dis"},{"key":"8543_CR85","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2025.111786","volume":"103","author":"P-H Chen","year":"2025","unstructured":"Chen P-H, Lee C-H, Yen W-T et al (2025) Efficacy and safety of prone positioning in patients undergoing extracorporeal membrane oxygenation (ECMO): a systematic review and meta-analysis. J Clin Anesth 103:111786. https:\/\/doi.org\/10.1016\/j.jclinane.2025.111786","journal-title":"J Clin Anesth"}],"container-title":["Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-026-08543-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00134-026-08543-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00134-026-08543-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T13:41:11Z","timestamp":1789047671000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00134-026-08543-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,20]]},"references-count":85,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["8543"],"URL":"https:\/\/doi.org\/10.1007\/s00134-026-08543-x","relation":{},"ISSN":["0342-4642","1432-1238"],"issn-type":[{"value":"0342-4642","type":"print"},{"value":"1432-1238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,20]]},"assertion":[{"value":"9 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Prof. Li discloses research funding from MEKICS Co. Ltd, Vincent Ltd, COPD Foundation, American Association for Respiratory Care, Charles and Margaret Roberts Fund, and the Peter T. Roumbos Founding, and speaker fees from American Association for Respiratory Care, Aerogen Ltd, and Fisher and Paykel Healthcare Ltd. Prof. Ehrmann declares consultancies for Aerogen Ltd, research support, lecture fees and travel support from Aerogen Ltd and Fisher and Paykel Healthcare, intellectual property licensing to JIB. Other authors do not have conflict of interest to disclose.","order":1,"name":"Ethics","label":"Conflicts of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}]}}