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AF received the Wellcome Trust Discovery Award and the Harry Oppenheimer Fellowship Award. CR reported lecture fees from BD and Laboratoire XO. AU received lecture fees from Integra. GM received several research grants from FWO and IOF in Belgium. SB received lecture fees and has been hired by BRAIN4CARE. All other authors declared no confl icts of interest. CR is a Deputy Editor for Intensive Care Medicine. She has not taken part in the review or selection process of this article.","order":1,"name":"Ethics","label":"conflicts of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}