{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:00:43Z","timestamp":1792130443260,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Arthrogenic muscle inhibition (AMI) impedes rehabilitation following knee joint injury by preventing activation of the quadriceps. AMI has been attributed to neuronal reflex activity in which altered afferent input originating from the injured joint results in a diminished efferent motor drive to the quadriceps muscles. Beginning to understand the mechanisms responsible for muscle inhibition following joint injury is vital to control or eliminate this phenomenon. Therefore, the purpose of this investigation is to determine if quadriceps AMI is mediated by a presynaptic regulatory mechanism. Eight adults participated in two sessions: in one session their knee was injected with saline and in the other session it was not. The maximum Hoffmann reflex (H\u2010reflex), M\u2010wave, reflex activation history, plasma epinephrine, and norepinephrine were recorded at: baseline, post needle stick, post lidocaine, and 25 and 45\u00a0min post effusion. Measures for the control condition were matched to the effusion condition. The percent of the unconditioned reflex amplitude for reflex activation history and the maximum H\u2010reflex were decreased at 25 and 45\u00a0min post effusion as compared to measures taken at baseline, post needle stick, and post lidocaine (<jats:italic>P<\/jats:italic>&lt;0.05). No differences were noted for the maximum M\u2010wave or plasma epinephrine and norepinephrine levels in either the effusion or noneffusion admission (<jats:italic>P<\/jats:italic>&gt;0.05). No differences were detected at any time interval for any measure during the control admission (<jats:italic>P<\/jats:italic>&gt;0.05). Quadriceps AMI elicited via an experimental knee joint effusion is, at least in part, mediated by a presynaptic mechanism.<\/jats:p>","DOI":"10.1007\/s00167-004-0547-z","type":"journal-article","created":{"date-parts":[[2005,1,31]],"date-time":"2005-01-31T13:28:51Z","timestamp":1107178131000},"page":"370-376","source":"Crossref","is-referenced-by-count":71,"title":["Pre\u2010synaptic modulation of quadriceps arthrogenic muscle inhibition"],"prefix":"10.1002","volume":"13","author":[{"given":"Riann M.","family":"Palmieri","sequence":"first","affiliation":[{"name":"Neuromuscular Research Laboratory Division of Kinesiology University of Michigan 401 Washtenaw Avenue 48109 Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Weltman","sequence":"additional","affiliation":[{"name":"Exercise Physiology Laboratory Department of Human Services University of Virginia PO Box 400407, 210 Emmet Street, South 22904\u20104407 Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey E.","family":"Edwards","sequence":"additional","affiliation":[{"name":"Human Performance Laboratory Department of Physical Education Indiana State University 47809 Terre Haute IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Tom","sequence":"additional","affiliation":[{"name":"Orthopedic Surgery Control Drexel University Health Sciences New College Building, 245\u00a0N 15th St Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan N.","family":"Saliba","sequence":"additional","affiliation":[{"name":"Exercise and Sports Injury Laboratory Department of Human Services University of Virginia PO Box 400407, 210 Emmet Street, South 22904\u20104407 Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny J.","family":"Mistry","sequence":"additional","affiliation":[{"name":"Exercise and Sports Injury Laboratory Department of Human Services University of Virginia PO Box 400407, 210 Emmet Street, South 22904\u20104407 Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Ingersoll","sequence":"additional","affiliation":[{"name":"Exercise and Sports Injury Laboratory Department of Human Services University of Virginia PO Box 400407, 210 Emmet Street, South 22904\u20104407 Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"509","volume-title":"Handbook of physiology","author":"Baldissera 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