{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T21:38:03Z","timestamp":1773610683227,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,5,24]],"date-time":"2005-05-24T00:00:00Z","timestamp":1116892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We conducted a randomized, placebo\u2010controlled, double blinded study to compare the analgesic effects of intraarticular neostigmine, morphine, tenoxicam, clonidine and bupivacaine in 150 patients undergoing arthroscopic knee surgery. General anaesthesia protocol was same in all patients. At the end of the surgical procedure, patients were randomized into six intraarticular groups equally. Group N received 500 \u03bcg neostigmine, Group M received 2\u00a0mg morphine, Group T received 20\u00a0mg tenoxicam, Group C received 1 \u03bcg kg<jats:sup>\u22121<\/jats:sup> clonidine, Group B received 100\u00a0mg bupivacaine and Group S received saline 20\u00a0ml. Visual analog scale scores 0, 30 and 60\u00a0min and 2, 4, 6, 12, 24, 48 and 72 h, time to first analgesic need, analgesic consumption at 48 h and 72 h and side effects were noted. Demographic and operational parameters were similar in six groups. All study groups provided analgesia when compared with saline group (<jats:italic>P<\/jats:italic>&lt;0.05). Duration of analgesia in Group N and C was longer than other groups (<jats:italic>P<\/jats:italic>&lt;0.001). Analgesic consumptions of Group N, C and T were lower than other groups (<jats:italic>P<\/jats:italic>&lt;0.01). Pain scores during 2 h postoperatively were lower in all study groups than the control group (<jats:italic>P<\/jats:italic>&lt;0.001). In Group B, median pain scores were higher than Groups N and C at 0\u00a0min and 30\u00a0min postoperatively (<jats:italic>P<\/jats:italic>&lt;0.001). Side effects were not significantly different among the six groups. We conclude that the most effective drugs that are administered intraarticularly are neostigmine and clonidine among the five drugs we studied. Tenoxicam provided longer analgesia when compared with morphine and bupivacaine, postoperatively.<\/jats:p>","DOI":"10.1007\/s00167-004-0612-7","type":"journal-article","created":{"date-parts":[[2005,5,23]],"date-time":"2005-05-23T10:18:52Z","timestamp":1116843532000},"page":"658-663","source":"Crossref","is-referenced-by-count":39,"title":["Intraarticular analgesia after arthroscopic knee surgery: comparison of neostigmine, clonidine, tenoxicam, morphine and bupivacaine"],"prefix":"10.1002","volume":"13","author":[{"given":"A.","family":"Alagol","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology Trakya University Edirne Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. U.","family":"Calpur","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology Trakya University 22030 Edirne Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. Saral","family":"Usar","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Trakya University Edirne Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Turan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Trakya University Edirne Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Pamukcu","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Trakya University Edirne Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00115550-199924050-00011"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02220608"},{"issue":"1","key":"e_1_2_6_4_1","first-page":"3","article-title":"Postoperative analgesic effect after intra\u2010articular morphine or ropivacaine following knee arthroscopy \u2010 a prospective randomized, doubleblinded study","volume":"15","author":"Muller M","year":"2001","journal-title":"Schmerz"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","unstructured":"Alagol.The use of intraarticular tramadol for postoperative analgesia after arthroscopic knee(2003) surgery: a","DOI":"10.1007\/s00167-003-0454-8"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(95)00188-3"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/79.5.660"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/rapm.2001.23461"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-002-0286-y"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-002-0306-y"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1996.tb05554.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-6576.1999.430804.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/78.2.163"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03013953"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199805000-00023"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199802000-00010"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-8180(00)00189-6"},{"key":"e_1_2_6_18_1","unstructured":"MorganG MikhailSM MurrayJM(2002)Clinical anesthesiology 3rd edn.Lange medical books pp1\u201314"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/03635465980260060601"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167\u2010002\u20100297\u20108"},{"key":"e_1_2_6_21_1","doi-asserted-by":"crossref","unstructured":"CalpurOU OzcanM G\u00fcrb\u00fczH TuranFN(2005)Full artroscopi lateral retinacular release with hook knee and quadriceps pressure\u2010pull test: long term follow up.Knee Surg Sports Traumatol Arthrosc (in press)","DOI":"10.1007\/s00167-003-0474-4"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000081725.81280.17"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199301000-00031"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/83.2.241"},{"issue":"3","key":"e_1_2_6_25_1","first-page":"225","article-title":"Postoperative pain following knee arthroscopy: the effects of intra\u2010articular ketorolac and\/or morphine","volume":"24","author":"Gupta A","year":"1999","journal-title":"Reg Anesth Pain Med"}],"container-title":["Knee Surgery, Sports Traumatology, Arthroscopy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00167-004-0612-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00167-004-0612-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00167-004-0612-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:45:16Z","timestamp":1760877916000},"score":1,"resource":{"primary":{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/10.1007\/s00167-004-0612-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5,24]]},"references-count":24,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["10.1007\/s00167-004-0612-7"],"URL":"https:\/\/doi.org\/10.1007\/s00167-004-0612-7","archive":["Portico"],"relation":{},"ISSN":["0942-2056","1433-7347"],"issn-type":[{"value":"0942-2056","type":"print"},{"value":"1433-7347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5,24]]}}}