{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:57:07Z","timestamp":1770505027077,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2008,6,7]],"date-time":"2008-06-07T00:00:00Z","timestamp":1212796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of the study was to evaluate the safety and efficacy of viscosupplementation with hylan G\u2010F 20\u00a0in patients with mild to moderate osteoarthritis (OA) presenting with persistent knee pain 4\u201312 weeks after arthroscopic meniscectomy. A prospective, multi\u2010centre, open study was carried out in patients with pain due to OA of the knee, not resolved by simple analgesics, 4\u201312 weeks after undergoing arthroscopic meniscectomy. To be eligible, patients had to score \u226550\u00a0mm and \u226490\u00a0mm on both walking pain and patient global assessment visual analogue scales (VAS; 0\u2013100\u00a0mm) at baseline and be radiologically diagnosed pre\u2010operatively with OA grade I or II on the Kellgren\u2010Lawrence scale, with &lt;50% joint space narrowing. Patients received three intra\u2010articular, 2\u00a0ml injections of hylan G\u2010F 20\u00a0in the target knee with an interval of 1 week between injections, and were followed for 52 weeks. The primary efficacy endpoint was the change from baseline in the walking pain VAS score at 26 weeks. Secondary outcome measures were the walking pain VAS scores at all other time points, the WOMAC Index at all time points, and patient and physician global assessment at all time points. The safety of the treatment was assessed using adverse event (AE) reports. A total of 62 patients (mean age 55.4 years, 52% male) were enrolled. The mean walking pain VAS score decreased by 36.8\u00a0mm from baseline at 26 weeks (<jats:italic>P<\/jats:italic> &lt; 0.0001), and also showed statistically significant decreases (<jats:italic>P<\/jats:italic> &lt; 0.0001) at all other time points. The change in WOMAC total and subscale scores from baseline were statistically significant (<jats:italic>P<\/jats:italic> &lt; 0.0001) at all time points, as were the decreases in the physician and patient global assessment VAS scores. There were 18 target knee AEs (mostly pain and\/or swelling and\/or effusion) in 12 patients (19%) considered to be at least possibly related to treatment. The majority of these (78%) were mild or moderate in intensity. One patient (1.6%) experienced a serious adverse event (synovitis) in the target knee that was considered possibly related to study treatment. Hylan G\u2010F 20 provides effective pain relief and improves stiffness and physical function in patients with mild to moderate OA presenting with persistent osteoarthritic pain 4\u201312 weeks after arthroscopic meniscectomy. Symptomatic efficacy was maximised at 12 weeks and maintained at 26 and 52 weeks. The type (pain and\/or swelling and\/or effusion) and the intensity (mostly mild\/moderate) of AEs reported in this study are similar to those reported in other trials in different patient populations, but the incidence was higher (19%). The risk\/benefit of hylan G\u2010F 20\u00a0in this particular population of patients is favourable.<\/jats:p>","DOI":"10.1007\/s00167-008-0556-4","type":"journal-article","created":{"date-parts":[[2008,6,6]],"date-time":"2008-06-06T11:29:35Z","timestamp":1212751775000},"page":"747-752","source":"Crossref","is-referenced-by-count":27,"title":["Multicentre, prospective, open study to evaluate the safety and efficacy of hylan G\u2010F 20\u00a0in knee osteoarthritis subjects presenting with pain following arthroscopic meniscectomy"],"prefix":"10.1002","volume":"16","author":[{"given":"J. P.","family":"Huskin","sequence":"first","affiliation":[{"name":"CHU Li\u00e8ge Sart\u2010Tilman Sce Orthop\u00e9die, B.35 4000 Liege 1 Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Vandekerckhove","sequence":"additional","affiliation":[{"name":"A.Z. St\u2010Jan Orthopedie Ruddershove 10 8000 Brugge Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Delinc\u00e9","sequence":"additional","affiliation":[{"name":"CHU St\u2010Pierre 290 rue Haute 1000 Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Verdonk","sequence":"additional","affiliation":[{"name":"U.Z. Gent 185 De Pintelaan 9000 Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u2010E.","family":"Dubuc","sequence":"additional","affiliation":[{"name":"Cliniques Universitaires Saint\u2010Luc Avenue Hippocrate 10 1200 Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Willems","sequence":"additional","affiliation":[{"name":"Clinique St Joseph Esp\u00e9rance 75 Rue de Hesbaye 4000 Liege Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Hardy","sequence":"additional","affiliation":[{"name":"Dpt Orthop\u00e9die H\u00f4pital Ambroise\u2010Par\u00e9 9 Avenue Charles de Gaulle 92100 Boulogne Billancourt France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. J.","family":"Blanco","sequence":"additional","affiliation":[{"name":"Dpto de Reumatologia Hospital Juan Canalejo Xubias de Arriba 84 15006 A Coruna Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Charrois","sequence":"additional","affiliation":[{"name":"Dpt Orthop\u00e9die Clinique Geoffroy St\u2010Hilaire 59 Rue Geoffroy St\u2010Hilaire 75005 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Handelberg","sequence":"additional","affiliation":[{"name":"Universitair Ziekenhuis Brussel Laarbeeklaan 101 1090 Brussels Belgium"},{"name":"Dienst Orthopedie\u2010Traumatologie Afdelingshoofd Schouderpathologie\u2010Sporttraumatologie Laarbeeklaan 101 1090 Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,6,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1063\u20104584(05)80013\u20105"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529\u20100131(200009)43:9<1905::AID\u2010ANR1>3.0.CO;2\u2010P"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.1041203"},{"key":"e_1_2_6_5_1","first-page":"946","article-title":"Long\u2010 term effects of intraarticular hyaluronan on synovial fluid in osteoarthritis of the knee","volume":"33","author":"Bagga H","year":"2006","journal-title":"J Rheumatol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","unstructured":"BellamyN CampbellJ RobinsonVet al (2006)Viscosupplementation for the treatment of osteoarthritis of the knee.Cochrane Database of Systematic Reviews Issue 2. 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