{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T12:04:15Z","timestamp":1793189055622,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,9,4]],"date-time":"2009-09-04T00:00:00Z","timestamp":1252022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Osteochondritis dissecans (OCD) is an acquired, potentially reversible idiopathic disease of subchondral bone resulting in delamination and sequestration. Although juvenile\u2010type OCD lesions typically appear stable on superficial examination, conservative treatment results in cure in approximate 50% of patients. We hypothesized that juvenile\u2010type OCD lesions exhibit an underlying instability despite stability at the articular surface and this underlying instability might underlie the lack of effectiveness of conservative treatment. In this study, osteochondral cylindrical tissue samples obtained from stable juvenile OCD lesions located at the medial femoral condyle (classical site) were examined. Eight patients with symptomatic juvenile\u2010type OCD at the classical site underwent arthroscopy. Osteochondral cylindrical tissue samples were obtained from the central portion using a biopsy needle. The samples underwent macroscopic and microscopic examination. All cylindrical samples demonstrated macroscopic separation. On microscopic examination, no degenerative changes in articular cartilage and no bone necrosis were observed. Histological examination revealed two distinct patterns in the samples: (1) thick homogeneous hyaline cartilage alone with little fibrous tissue surrounding areas of separation and (2) nearly normal, thin hyaline cartilage above a mixed layer of hyaline cartilage and subchondral trabeculae and fibrous\/fibro\u2010cartilaginous tissue at the areas of separation, indicating delayed or nonunion. Pathological findings in stable juvenile OCD lesions indicate an underlying instability at deeper layers of articular cartilage and poor healing at areas of separation. Improved knowledge of the histology of juvenile\u2010type OCD lesions may support surgical treatment. Early marrow stimulation and\/or fixation may be the treatment of choice to promote healing even in macroscopically stable juvenile\u2010type OCD lesions.<\/jats:p>","DOI":"10.1007\/s00167-009-0898-6","type":"journal-article","created":{"date-parts":[[2009,9,3]],"date-time":"2009-09-03T12:36:40Z","timestamp":1251981400000},"page":"723-730","source":"Crossref","is-referenced-by-count":61,"title":["Histological evaluation of juvenile osteochondritis dissecans of the knee: a case series"],"prefix":"10.1002","volume":"18","author":[{"given":"Yasukazu","family":"Yonetani","sequence":"first","affiliation":[{"name":"Department of Sports Orthopaedics Osaka Rosai Hospital 1179\u20103\u00a0Nagasone\u2010cho, Kita\u2010ku, Sakai 591\u20108025 Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norimasa","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Osaka University Graduate School of Medicine 2\u20102 Yamadaoka Suita 565\u20100871 Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Natsuume","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine Osaka Kousei\u2010Nenkin Hospital 4\u20102\u201078, Fukushima\u2010ku, Fukushima 553\u2010003 Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Shiozaki","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Seifuu Hospital 1\u20104\u00a0Kitahanada\u2010cho, Sakai 591\u20108002 Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinari","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Sports Orthopaedics Osaka Rosai Hospital 1179\u20103\u00a0Nagasone\u2010cho, Kita\u2010ku, Sakai 591\u20108025 Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Horibe","sequence":"additional","affiliation":[{"name":"Department of Sports 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