{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:03:09Z","timestamp":1761058989953,"version":"build-2065373602"},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,10,31]],"date-time":"2009-10-31T00:00:00Z","timestamp":1256947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Knee surg. sports traumatol. arthrosc."],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Topical glyceryl trinitrate treatment has demonstrated short\u2010 to mid\u2010term efficacy in chronic noninsertional Achilles tendinopathy. However, the underlying mechanisms are far from being understood. We hypothetized that Achilles tendon capillary blood flow changes immediately after topical glyceryl trinitrate treatment. Fifteen patients (55 \u00b1 15 years, VAS 5.8 \u00b1 2.3) with current mid\u2010portion Achilles tendon pain 36\u00a0months after open surgical Achilles tendon repair for tendon rupture were included. On the Achilles mid\u2010portion, 1.2\u00a0mg topical glyceryl trinitrate was sprayed. Microcirculatory monitoring included capillary blood flow, tendon oxygen saturation and postcapillary venous filling pressures at the insertion and 2, 4 and 6\u00a0cm above the insertion using a combined laser Doppler and spectrophotometry system. Baseline capillary blood\u2010flows of the painful versus the uninjured tendon were increased [108 \u00b1 46 vs. 81 \u00b1 20 (2\u00a0cm above the insertion), 104 \u00b1 40 vs. 76 \u00b1 20 (4\u00a0cm above the insertion), 111 \u00b1 53 vs. 90 \u00b1 21 (6\u00a0cm above the insertion, <jats:italic>P<\/jats:italic> &lt; 0.05)]. However, topical glyceryl trinitrate did not change capillary blood\u2010flow at 2 and 8\u2010mm tissue depths at the painful Achilles tendon or the healthy tendon. Tendon oxygenation was not changed at the painful or the healthy Achilles tendon. Postcapillary venous filling pressure was reduced at 8\u00a0mm at the mid\u2010portion in the painful Achilles tendon only (113 \u00b1 37 vs. 95 \u00b1 31, <jats:italic>P<\/jats:italic> = 0.030). Acute topical glyceryl trinitrate facilitates capillary venous outflow in painful Achilles tendons. However, capillary blood\u2010flow and tendon oxygenation remain unchanged following acute topical glyceryl trinitrate application. Elevated capillary blood\u2010flow at the entire mid\u2010portion is encountered at baseline in previously ruptured painful Achilles tendons even 3 years after surgical repair of the Achilles tendon indicating an altered microcirculatory flow pattern.<\/jats:p>","DOI":"10.1007\/s00167-009-0958-y","type":"journal-article","created":{"date-parts":[[2009,10,30]],"date-time":"2009-10-30T13:03:23Z","timestamp":1256907803000},"page":"977-981","source":"Crossref","is-referenced-by-count":11,"title":["Microcirculatory effects of topical glyceryl trinitrate on the Achilles tendon microcirculation in patients with previous Achilles tendon rupture"],"prefix":"10.1002","volume":"18","author":[{"given":"Rafal","family":"Osadnik","sequence":"first","affiliation":[{"name":"Plastic, Hand and Reconstructive Surgery Hannover Medical School Carl\u2010Neuberg\u2010Str. 1 30625 Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joern","family":"Redeker","sequence":"additional","affiliation":[{"name":"Plastic, Hand and Reconstructive Surgery Hannover Medical School Carl\u2010Neuberg\u2010Str. 1 30625 Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Kraemer","sequence":"additional","affiliation":[{"name":"Plastic, Hand and Reconstructive Surgery Hannover Medical School Carl\u2010Neuberg\u2010Str. 1 30625 Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M.","family":"Vogt","sequence":"additional","affiliation":[{"name":"Plastic, Hand and Reconstructive Surgery Hannover Medical School Carl\u2010Neuberg\u2010Str. 1 30625 Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karsten","family":"Knobloch","sequence":"additional","affiliation":[{"name":"Plastic, Hand and Reconstructive Surgery Hannover Medical School Carl\u2010Neuberg\u2010Str. 1 30625 Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,10,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.3.324"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546508314423"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546505278705"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2006.030437"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2006.030957"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546506293701"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","unstructured":"McCallumSD PaoloniJA MurrelGA(2009)Five years prospective comparison study of topical glyceryl trinitrate treatment of chronic lateral epicondylosis at the elbow.Br J Sports Med [Epub ahead of print] PMID:19553221","DOI":"10.1136\/bjsm.2009.061002"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050027"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2006.034447"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999\u2010008\u20100271\u2010y"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200405000-00005"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3113\/FAI.2007.1064"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2008.053108"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20060"}],"container-title":["Knee Surgery, Sports Traumatology, Arthroscopy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00167-009-0958-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00167-009-0958-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00167-009-0958-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:37:08Z","timestamp":1760873828000},"score":1,"resource":{"primary":{"URL":"https:\/\/esskajournals.onlinelibrary.wiley.com\/doi\/10.1007\/s00167-009-0958-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,31]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.1007\/s00167-009-0958-y"],"URL":"https:\/\/doi.org\/10.1007\/s00167-009-0958-y","archive":["Portico"],"relation":{},"ISSN":["0942-2056","1433-7347"],"issn-type":[{"type":"print","value":"0942-2056"},{"type":"electronic","value":"1433-7347"}],"subject":[],"published":{"date-parts":[[2009,10,31]]}}}